Conserved Protein Domain Family
IHO1

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pfam15771: IHO1 
Interactor of HORMAD1 protein 1
Interactor of HORMAD1 protein 1 (IHO1, previously known as coiled-coil domain-containing protein 36 or DUF4700) is required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. It is thought to function, in collaboration with SPO11-auxiliary proteins MEI4 and REC114, through the formation of DSB-promoting recombinosomes on chromatin at the onset of meiosis.
Statistics
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PSSM-Id: 464859
Aligned: 14 rows
Threshold Bit Score: 777.453
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003409712  19 GAIKSSNWNNNQTDYSSLSDSQFLFGSQFCPENSETLSAPLDIGTHLRHPKQSQQNSLDSEPSIFTKYQTKPQLFGGDRT 98 
EGW08946      48 SITKPSNWNSNQTDCSSPSDSQFLFGSQFCPENSESLSASLDIGAYSRHPKQTQQNSVDNEPSIFTKYQTKPQLFGGDTK 127
Q6PDM4        19 GITKPSNWNNNQTDCS-LSDSQFLFGSQFCPENSETLLPSLDAGACLRHPKQTQQNSVDSEPSIFIKYQAKPQLLGGDTK 97  house mouse
EDL77175      19 GLTKPSNWNSNQTDCSSLSDSQFLFGSQFCPENSETLLPPLDAGTYLRYPKQTQQNSVDNEPSIFTKYQAKPQLFGGDTK 98 
EHB14801      19 GTTKSSHWNNNQTDYSALSDSQFLFGSQFCPENSETLSAPLDLGAHLRHSKQLQQNSVDSEPSIFTKYQTKPQLFGGETK 98 
XP_017199304  19 GNTKASVSNNNQTDYSSLSDSQFLFGSQFCPENSETLSAPLDFGAHLRQQKQSQQNSLDSEPSIFTKYQTKPQLFGGNAK 98 
XP_005222900  19 GATKSSNWNNNQTDYSSLSDSQFLFGSQFCPEGSQTLSTPVDSEVHLRHPKQSQQNSLDSEPSIFTKYQTKPQLLGGDPK 98 
XP_006107035  19 GTTKSSNWANNPGDYSSLSDSQFLFGSQFCPESSETLSAPLDVGVHLRDPKPLQKGSLDNEPSIFTKYQTKPQLFEEDIN 98 
XP_004760731  19 GTTKSSSWNNNQADYSSLSDSQFLFGSQFCPESSETLSAPLD-GVHVRHPKQSQQNSLDSEPSIFTKYQTKPPLFGADAN 97 
XP_001494416  19 GNTKSSNWNSNQTDHSSLSDSQFLFGSQFCPESSETLSAPLDFGAHLRRPKQSQQNSLESEPSVFTKYQTKPQLFGGDKK 98 
XP_003409712  99 DGGLFPPPLSVGKSKGLLEQFEEKKKLAKDKCDSETLCSFISRVRESIHRLQTSVEKSEEHLSSRSQTILDSLETVAKTL 178
EGW08946     128 DEGLFSLPLPVGKSKGLLKQFEEKKRRATDKCDSEMLYNFVSHFQEVIHKLQTSVEKSEENLSSRSQSILDSLETVAKTF 207
Q6PDM4        98 DESLFSLPLPVGKSKGLSKQFEEKKRRATDQSDSETLHSFVSHFPEVINKLQTSVEKTEENLSSRSQSILDSVETIAKTF 177 house mouse
EDL77175      99 GEGLFSLPLPVGKPKGLSKQFEEKKRRATDQSDSETLHNFVSHFPEVIHKLQTAVEKSEEHLSSRSQSILDSVETIAKTF 178
EHB14801      99 DRGLFSLPLPVGKSKCLLKQFEEKNKTAKDKCDSESLYNFLSQVRENIQRLQTSVDKSEEHLTSRSQSILDSLETVAKTL 178
XP_017199304  99 DGDLFPLPLPVGKSKGLLEQFEEKKKTAKDKCDSETLYNFVSNVRESIHKLQTSVEKSEEHLTIRSQSILDSLETVAKTL 178
XP_005222900  99 DGGLFPLPLSLGKPKGLLEQFEEKKKSAKDKCDSETLYNFISHIKESIHKLQTSVEESEEHLSSRSQSILDSLETVAKTW 178
XP_006107035  99 DGGLFPLPLPVGKSKGLLEQFEEKKKIAKDKCDSETLYSFISHVRESIHKLQTSVEKSEEHLSSRSQSILDSLETVAKTL 178
XP_004760731  98 DRGLFPPPLSVGKAKGLLEQFEEKKKRAKDKCDSETLYNLISHIRESIHRLQTSVEKSEEHLSSRSQSILDGLETLAKTL 177
XP_001494416  99 DGGLFPLPLSVGKSKGLLEQFEEKKKRAKDRCDSEALYNFISHTRESIYRLQTSVEKSEEHLSSRSQSILDSLETVAKTL 178
XP_003409712 179 QETSKAQSDLVLEAVQDKGSTEQTILEMQKRFEARQAEFIEMKSNLKHLEVLVAQQNKEFQKLCEHLVQLNVPSVLADLK 258
EGW08946     208 QESAQVQRDLIFDAMRDKGNMEQAILELQRSSETRQAEFMEMKSNLKNLEVLVTQQSKDFQQLCEKLGQLNVPGVLEELK 287
Q6PDM4       178 QETARVQHDLMVESVRDKGSMEQAILEIQRTCAARQAEFMEMKSTLKNLEVLVVEQTKNLQQFCDNLSQLIVPGILEELK 257 house mouse
EDL77175     179 QETARVQHDLMVEAVKDKGSVEQAVLEIQRACAARQAEFMEMKSTLKNLEVLVVQQSKDFQQFCDNLGQLIVPSVLGELK 258
EHB14801     179 QETARVQSDLRFEAIQEKGNAEQAILEMQKKFEARQTEFIEMKSSLKHLEVLVAQQNKDFQQLCEHLGQLHMPDVLEELK 258
XP_017199304 179 QETARTQSDLVFEAVQEKGNTEQAILELQKKFEAKQAEILEMKSNLKHLEVLVAQQSKDFQQLCEQLGQLNVPSVLAELK 258
XP_005222900 179 QETAKAQSGLMLEIVQDKGNVDQAILELQKRLEARQAEFTEMKSDLKHLEVLVIQQSKDFQQLCEHLGQLNMPSVLAELK 258
XP_006107035 179 QETARAQRDLVLETAQDKGRVEQAVLELRREFQARQAEIVEMKSGLKHLEAVATQQSNYVQQLCEQLARLDVPGTLAELK 258
XP_004760731 178 QETVRAQSDLVLETVHDKGNMEQVIFEIQKRFEARQAEFIEMRSDLKHLEALVAQQSKDFQQLCEQLGQLNVASVLAELK 257
XP_001494416 179 QETAQAQSDLVLETAQDKGNMEQAILEMQKRFEARQAEFSEMKSNLKHLEVLVAQQNKDFQQLCEQLGQLNVPSILAELK 258
XP_003409712 259 KFiSAPRVHEHVKDSASQTSPAPAQSLNFTRQEKSASEgpvmwqAQLLPaawnpSVGSLWPRESGVWGKGGKSDILQEeA 338
EGW08946     288 KL-SAPRLVGHLKDSTSQTSPALAQSLHFTGQEKCTSE------AQVSP-----TGSSQRPREFGVWDEGAESGVFQK-A 354
Q6PDM4       258 KFtSVPQVAGHLKDSTSQTSPSLTQSLHFTRQEKHPSEepatwqAQEAPag-npSTSSQRPGECGVWDEGAESGVFQK-A 335 house mouse
EDL77175     259 KFtSVPQVVGHLKDSASQTSPSLTQSHHYPRQEPYPSEepatwqGQEPPag-nsSRGSQRPTEFGVWDEGAESDVFQK-A 336
EHB14801     259 RLiSAPQVPRHVKDSASQTSPSLAQSLSFIKQSKLTCEepvawqIQAAPaagncSAGFLRPGEFGVWGKQAKSDSLQEkA 338
XP_017199304 259 RWiSVPQVPRHVRDSTSQTSPLLARNLSFTGQEQYALEdpvpwqAQGLPgagnpSRGSSQPGKFDVWGEGAKNGAPQEeA 338
XP_005222900 259 RLtSIALTPKHVKDSASQTSPPLAQSLSFPRQDKYTSEkpvtwqAQALPaacslSVGSPRPREFAVWGEGSKRDALQEeA 338
XP_006107035 259 SFlAGPRAPTHVRDSTSQTSPPRAQSLSPAPQAq----------AQALPar-dlRMGALRPGESDVWGEGAKRAALPEe- 326
XP_004760731 258 RLiSDPRVAGHVKDSTSQTSPPLAQSLHFTRQGRYASEeavlwpAQAPAavrtrSMGSLQPGEFGVCGERAESGALQEeA 337
XP_001494416 259 RLiSVPQVPRHVKDSTSQTSPPLAQSLNFTRQDKYASEepilwqAQALPaarilNRGSLQPGEFGVWGERAKNDTLQKeA 338
XP_003409712 339 TLPAAGLSKGNKHVQDKEVQTNSEHCVLTKIERKNHGLSILGHKVPGNRDLVSQGASRLvs---lDLNNFAASTENSCQE 415
EGW08946     355 ALLTDEPHRGNEHVKNNAMQTYYKNWVITTRSLTNHCASLPSQKADHDEDLVADEASQL------DLNKFESRVKNACPQ 428
Q6PDM4       336 ALPTDGLHRGDGHVKNKTVPTYCKNWVMTTRSVSNHFSNLPSQRAGNGQGLMAQGASQR------DVSKFEARVKNACPE 409 house mouse
EDL77175     337 TLPTDRPHRGSEHVKGKAVQTYCKNWVMTSRSLSNHFS-VPDQKAGSEQDLTAPGASQL------DCES-EARVEGICPT 408
EHB14801     339 ALPAVEPCKGNEQVKDKEMQTNCQDLAVTKTSPKNHGSSIPDHKACADRDLVSQGGSQLis---lDLNDVTNSIQNVCPE 415
XP_017199304 339 ALPGAQPREGNGCAKDQAMQPHSNNQGVSKSHPENPGSHIPGYRIPGDRDQVSQGASQLis---lDLNTFATSIENAYPK 415
XP_005222900 339 VQPAVGTGKRNRQIKGRAVKTNCQN-SVTKTGSENCGSAILGHKVPKDRDPVFQGDSQLisrgykDLNNSATSIKNTSQK 417
XP_006107035 327 ---AVGEGKRSRGVRDKAVQTSLKSQLLPKTSSENC----------GGRKLVAQGALRLls---lDVNNFVTS-----PK 385
XP_004760731 338 MRQAAGTSRSNRRVKDRAVQTNRRNWTGPKTSSENHGAGSPGPEVLGGKDWVSPGASRLlp---lDSNKFAASIKNTCPK 414
XP_001494416 339 ALLAVGTGKRNRPVKDKAVQTNCKNLAITKTGSENHSLDIQGHKVPGDRDLVSPGASQLis---lDLNNFATSIKNTCQE 415
XP_003409712 416 YHAKDVFSCDPRGQsLITEPK-GRTVERGKKGKQWQPRKAHKGRLLARKREQTPSKTCAVLSKNQSPQPPVSVPKRPSLE 494
EGW08946     429 IEAQNMCSSDLFEQ-SATEQK-DRTRGKERKGKKQHPRKSQRGRLLARKQEQTPRKACAFVSRHCRTQTSVSSPQGSIIC 506
Q6PDM4       410 YGPQSMCSFDSLEQ-SATEQK-GRPCRKRRRGKKQQPQRSKRGGLLDRKQGQTSKAACAFIARHHCPQSPVCDPQGPLIC 487 house mouse
EDL77175     409 YEAQSKCALDSFEQ-SAAEQKrGRTCRKRRRGKKPQPRRAKRGRLLARVQKQTSGEACAITAERPCPQSSVCSSQGPLIC 487
EHB14801     416 YQAQSIFFCDPCQQ-LVTEQK-GKTVERGRKSKKQQPRKAHRGRVPARKREQTPSKTRAFNPKYQSTLSPVSGPGRPPTG 493
XP_017199304 416 HQTKSMSSSDPCEQ-VVTEQK-GRAIESRGKGMRQQTRRACRGRPIARKQEQAPSETHALKSKYQSPQPPVSVPQSGPLG 493
XP_005222900 418 WQAKGAFSCHPCEQrLVTEQK-GVTVERGKKDK-QQPRKAPRRRSLRRKQEQMPSKTCVSNSKY--PRPPVSSPQSSPWG 493
XP_006107035 386 CQTKGVFSRDPCEQrLVTGEH-RR--------RGRPPRSTHRGRPPTRRQEQPRSTACAFSSRC--PQPPGPGSQGSPPE 454
XP_004760731 415 CQAAGVSPCDPREQrLVTAQK-SRPVERGRKGRKQAPRKSQRGRLRARKQEQAPSKTCAVIPKY--PQPPVSGPQSPPLE 491
XP_001494416 416 LQAKGLFSCDPCEQqLVTEQK-GRAVERVAKGKKQQPRKVQRGRLLARKQEQTPSKTCAFSSKY--PQPPVSGPQRLPVE 492
XP_003409712 495 qqepl--qqplrLLRSRSPAKPAGPTLGGAVMPGKTAKAVQGRLLQLRRLPSQDNGLL--SSSSQGDHQMSWFSNLN--L 568
EGW08946     507 ------------WRAPRIAMKSARPILGRIVRTNKTARATPGSIQQSTQCSSPVCESL--SSSSQEDQQINWFSDLS--L 570
Q6PDM4       488 ------------WLTPRSSTKSTCHILGGTGETSQTARAAQGNLVQHSQRSST-------DSSSQGDQQINWFSDLS--L 546 house mouse
EDL77175     488 ------------WPPLRSSTKSACHILGGRGETSMTAGAVQGSLLKSSQHSST-------DSSSQEDQQINWFSDIS--L 546
EHB14801     494 qqell--aqalcLQGPRSSPKSVCPALGRRVKPSKTARAVRGGALQFTTCSSKGNRLLpkESSFQRDHQMSWFSDLN--L 569
XP_017199304 494 qqepl--thvlpLQGVRSPSKPVHPVLRGTVMPTKTARAARGNCLQFNRSSSQDNSLL--SGSSQGDHQMSWFSDLS--L 567
XP_005222900 494 qqetl--aqplqLWGPRSPTNLVCSAQGGTVMPSKTTRAEQGNLVQCSGHSSQDNSLL--FPSFQGDHKMSWFSDLNdlN 569
XP_006107035 455 qqepraqplcrgFQG-RNPTQ---PARGGALRP-RMAQAAPRALPQLSGHSPQDSSQR--SDSSQGDPQMSWFSDLN--P 525
XP_004760731 492 qqkpr--aqplhLWGPNSPTKPVSAILGGRVMRTKAVRAAQGDLLELSGLSSQDNSLL--ATSSQGDHQMSWFSDLN--L 565
XP_001494416 493 qqepl--dqplhLRRPRSPTKPVCPALGGTVMPSKTVRAAQGNLLQFSRHSSQDNSLL--SNSSQGDHRMSWFSDLN--L 566
XP_003409712 569 RSSESPLCKEPGKNLLYDLAFDSSDD 594
EGW08946     571 ENPEPPLCKKGGKNLLCDPDFDSSDD 596
Q6PDM4       547 ENLEPPQCKKGGTNLLCDPDFDSSDD 572 house mouse
EDL77175     547 ENLEPPLCKKGGKNLLSDPDFDSSDD 572
EHB14801     570 ENSEPAQCKEAGKNLLYHLGFDSSDD 595
XP_017199304 568 GRSEPPLRKEPGKHFLYDLGFDSSDD 593
XP_005222900 570 PRAESLQSQESGKNILYDLGFDSSDD 595
XP_006107035 526 ESPQAPQPRQPGKAVFYHLGFDSSDE 551
XP_004760731 566 GSSDPPVCKEPGKSMLYDLGFDSSDD 591
XP_001494416 567 GSSEPPLCKEPGKNTLYDLGFDSSDD 592
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