See
Genome Information for Mus musculus
In this time course pregnant CD-1 (outbred) dams were exposed to MeHg as monomethylmercuric chloride intraperitoneally on 9 d.p.c. The test dose of 5.0 mg/kg MeHg was selected as a dose with an estimated 20% increased risk for encephalopathy in term fetuses, with no evidence of maternal toxicosis. Exposed embryos were co-treated with PK11195, a nontoxic ligand of the mitochondrial peripheral-type benzodiazepine receptor (Bzrp) that effectively suppresses developmental toxicity induced with MeHg. The anticipated remediation with 5.0 mg/kg and 4.0 mg/kg PK11195 is <10% malformations. Sampling intervals ranged from 3.0h to 6.0h post-exposure. All measurements were on RNA from the embryonic forebrain (prosencephalon).
Keywords = time series
Keywords = mercury
Keywords = PK11195
Keywords = embryo
Keywords = Fetal Minamata Disease
Keywords: time-course
| Accession | PRJNA87175; GEO: GSE1077 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus |
| Submission | Registration date: 11-Mar-2004
Systems Analysis Laboratory, Birth Defects Center, University of Louisville |
| Relevance | Model Organism |
Project Data:
| Resource Name | Number
of Links |
|---|
| GEO DataSets | 2 |
GEO Data Details| Parameter | Value |
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| Data volume, Spots | 21438 |
| Data volume, Processed Mbytes | 1 |