NCBI
National Center for
Biotechnology Information
Search
8C13:
Crystal structure of pVHL:ElonginC:ElonginB complex bound to PROTAC JW48
PDB ID:
8C13
Download
MMDB ID:
224985
PDB Deposition Date:
2022/12/20
Updated in MMDB:
2022/12
Experimental Method:
x-ray diffraction
Resolution:
2.3 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 8C13: trimeric; determined by author and by software (PISA)
Molecular Components in 8C13
Label
Count
Molecule
Proteins (3 molecules)
J
1
Elongin-b
(Gene symbol:
ELOB
)
K
1
Elongin-c
(Gene symbol:
ELOC
)
L
1
VON Hippel-lindau Disease Tumor Suppressor
(Gene symbol:
VHL
)
Chemical and Non-standard biopolymers (1 molecule)
1
1
(2~{S},4~{R})-1-[(2~{S})-2-[3-[2-[2-[2-(acetamidomethyl)-4-(6,7-dihydro-5~{H}-pyrrolo[1,2-a]imidazol-2-yl)phenoxy]ethoxy]ethoxy]propanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303