6GIN: Crystal structure of the ACVR1 (ALK2) kinase in complex with an Quinazolinone based ALK2 inhibitor with a 4-morpholinophenyl solvent accessible group

PDB ID: 6GINDownload
MMDB ID: 162572
PDB Deposition Date: 2018/5/14
Updated in MMDB: 2018/09
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 6GIN: dimeric; determined by author and by software (PISA)
Molecular Components in 6GIN
Label Count Molecule
Proteins (2 molecules)
2
Activin Receptor Type-1
(Gene symbol: ACVR1)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
2
3-(4-morpholin-4-ylphenyl)-6-quinolin-4-yl-quinazolin-4-one3-(4-morpholin-4-ylphenyl)-6-quinolin-4-yl-quinazolin-4-one
2
6
SULFATE IONSULFATE ION
3
4
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303