4X5Y: Menin in complex with MI-503

PDB ID: 4X5YDownload
MMDB ID: 128651
PDB Deposition Date: 2014/12/6
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.59  Å
Source Organism:
Similar Structures:
Biological Unit for 4X5Y: monomeric; determined by author and by software (PISA)
Molecular Components in 4X5Y
Label Count Molecule
Protein (1 molecule)
1
Menin
(Gene symbol: MEN1)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
1
4-methyl-1-(1H-pyrazol-4-ylmethyl)-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile4-methyl-1-(1H-pyrazol-4-ylmethyl)-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile
2
3
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
3
1
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
4
3
SULFATE IONSULFATE ION
5
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
6
1
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303