4PHU: Crystal structure of Human GPR40 bound to allosteric agonist TAK-875

PDB ID: 4PHUDownload
MMDB ID: 121540
PDB Deposition Date: 2014/5/7
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 2.332  Å
Source Organism:
Similar Structures:
Biological Unit for 4PHU: monomeric; determined by author and by software (PISA)
Molecular Components in 4PHU
Label Count Molecule
Protein (1 molecule)
1
Free Fatty Acid Receptor 1,lysozyme
(Gene symbol: FFAR1)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
1
[(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid[(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid
2
5
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
3
1
PENTAETHYLENE GLYCOLPENTAETHYLENE GLYCOL
4
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303