4O0V: Back Pocket Flexibility Provides Group-ii Pak Selectivity For Type 1 Kinase Inhibitors

PDB ID: 4O0VDownload
MMDB ID: 117541
PDB Deposition Date: 2013/12/14
Updated in MMDB: 2014/03
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 4O0V: monomeric; determined by author and by software (PISA)
Molecular Components in 4O0V
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase PAK 4
(Gene symbol: PAK4)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
1-({1-(2-Aminopyrimidin-4-Yl)-2-[(2-Methoxyethyl)amino]-1h-Benzimidazol-6-Yl}ethynyl)cyclohexanol1-({1-(2-Aminopyrimidin-4-Yl)-2-[(2-Methoxyethyl)amino]-1h-Benzimidazol-6-Yl}ethynyl)cyclohexanol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303