4D4L: human PFKFB3 in complex with a pyrrolopyrimidone compound

PDB ID: 4D4LDownload
MMDB ID: 135602
PDB Deposition Date: 2014/10/29
Updated in MMDB: 2024/05
Experimental Method:
x-ray diffraction
Resolution: 3.16  Å
Source Organism:
Similar Structures:
Biological Unit for 4D4L: dimeric; determined by author and by software (PISA)
Molecular Components in 4D4L
Label Count Molecule
Proteins (2 molecules)
2
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
(Gene symbol: PFKFB3)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
2
PHOSPHONIC ACIDPHOSPHONIC ACID
2
2
PHOSPHATE IONPHOSPHATE ION
3
2
6-O-phosphono-beta-D-fructofuranose6-O-phosphono-beta-D-fructofuranose
4
2
5-(4-chlorophenyl)-7-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one5-(4-chlorophenyl)-7-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303