3DPE: Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor

PDB ID: 3DPEDownload
MMDB ID: 69959
PDB Deposition Date: 2008/7/8
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 3DPE: monomeric; determined by author and by software (PISA)
Molecular Components in 3DPE
Label Count Molecule
Protein (1 molecule)
1
Neutrophil Collagenase
(Gene symbol: MMP8)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
CALCIUM IONCALCIUM ION
2
2
ZINC IONZINC ION
3
1
N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]methyl}-4-oxo-3,5,6,8-tetrahydro-4H-thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidine-2-carboxamide 7,7-dioxideN-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]methyl}-4-oxo-3,5,6,8-tetrahydro-4H-thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidine-2-carboxamide 7,7-dioxide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303