2W7X: Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel Chk2 inhibitor PV1019

PDB ID: 2W7XDownload
MMDB ID: 76799
PDB Deposition Date: 2009/1/6
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.07  Å
Source Organism:
Similar Structures:
Biological Unit for 2W7X: dimeric; determined by author and by software (PQS)
Molecular Components in 2W7X
Label Count Molecule
Proteins (2 molecules)
2
Serine/threonine-protein Kinase Chk2
(Gene symbol: CHEK2)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
2
N-[4-[(E)-N-carbamimidamido-C-methyl-carbonimidoyl]phenyl]-7-nitro-1H-indole-2-carboxamideN-[4-[(E)-N-carbamimidamido-C-methyl-carbonimidoyl]phenyl]-7-nitro-1H-indole-2-carboxamide
2
2
MAGNESIUM IONMAGNESIUM ION
3
2
NITRATE IONNITRATE ION
4
4
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303