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Conserved domains on  [gi|1034626926|ref|XP_016883747|]
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ubiquitin carboxyl-terminal hydrolase 16 isoform X2 [Homo sapiens]

Protein Classification

zf-UBP and Peptidase_C19K domain-containing protein( domain architecture ID 10489803)

zf-UBP and Peptidase_C19K domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 622-819 9.07e-85

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


:

Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 271.57  E-value: 9.07e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 622 REVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRrqcngpkanikgerkhvytnAKKQMLISLAPPVLTLHLKRFQQ 701
Cdd:cd02667   103 RSDEIKSECSIESCLKQFTEVEILEGNNKFACENCTK--------------------AKKQYLISKLPPVLVIHLKRFQQ 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 702 AGF-NLRKVNKHIKFPEILDLAPFCTLKCkNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHgDI 780
Cdd:cd02667   163 PRSaNLRKVSRHVSFPEILDLAPFCDPKC-NSSEDKSSVLYRLYGVVEHSGTMRSGHYVAYVKVRPPQQRLSDLTKS-KP 240

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1034626926 781 PQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYE 819
Cdd:cd02667   241 AADEAGPGSGQWYYISDSDVREVSLEEVLKSEAYLLFYE 279
Peptidase_C19 super family cl02553
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
 196-401 4.82e-49

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


The actual alignment was detected with superfamily member cd02667:

Pssm-ID: 470612 [Multi-domain]  Cd Length: 279  Bit Score: 174.50  E-value: 4.82e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkieppdlaltepleinleppgpltlamsqflnemqetkkgvv 275
Cdd:cd02667     1 GLSNLGNTCFFNAVMQNLSQTPALRELLSE-------------------------------------------------- 30

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 276 TPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRaeehqrvskgilkafgnstekldeelknkvkdyekkksmpSFVD 355
Cdd:cd02667    31 TPKELFSQVCRKAPQFKGYQQQDSHELLRYLLDGLR----------------------------------------TFID 70

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1034626926 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDK 401
Cdd:cd02667    71 SIFGGELTSTIMCESCGTVSLVYEPFLDLSLPRSDEIKSECSIESC 116
zf-UBP pfam02148
Zn-finger in ubiquitin-hydrolases and other protein;
48-123 6.48e-20

Zn-finger in ubiquitin-hydrolases and other protein;


:

Pssm-ID: 460464  Cd Length: 63  Bit Score: 83.85  E-value: 6.48e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034626926  48 CQDCKTDNkvkdkaeeeteekpSVWLCLKCGHQGCGRnSQEQHALKHYLTPRsepHCLVLSLDNWSVWCYVCDNEV 123
Cdd:pfam02148   1 CSLCGNTS--------------NLWLCLTCGHVGCGR-YQNSHALEHYEETG---HPLAVNLSTLTVYCYPCDDYV 58
 
Name Accession Description Interval E-value
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 622-819 9.07e-85

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 271.57  E-value: 9.07e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 622 REVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRrqcngpkanikgerkhvytnAKKQMLISLAPPVLTLHLKRFQQ 701
Cdd:cd02667   103 RSDEIKSECSIESCLKQFTEVEILEGNNKFACENCTK--------------------AKKQYLISKLPPVLVIHLKRFQQ 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 702 AGF-NLRKVNKHIKFPEILDLAPFCTLKCkNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHgDI 780
Cdd:cd02667   163 PRSaNLRKVSRHVSFPEILDLAPFCDPKC-NSSEDKSSVLYRLYGVVEHSGTMRSGHYVAYVKVRPPQQRLSDLTKS-KP 240

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1034626926 781 PQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYE 819
Cdd:cd02667   241 AADEAGPGSGQWYYISDSDVREVSLEEVLKSEAYLLFYE 279
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-401 4.82e-49

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 174.50  E-value: 4.82e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkieppdlaltepleinleppgpltlamsqflnemqetkkgvv 275
Cdd:cd02667     1 GLSNLGNTCFFNAVMQNLSQTPALRELLSE-------------------------------------------------- 30

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 276 TPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRaeehqrvskgilkafgnstekldeelknkvkdyekkksmpSFVD 355
Cdd:cd02667    31 TPKELFSQVCRKAPQFKGYQQQDSHELLRYLLDGLR----------------------------------------TFID 70

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1034626926 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDK 401
Cdd:cd02667    71 SIFGGELTSTIMCESCGTVSLVYEPFLDLSLPRSDEIKSECSIESC 116
UBP12 COG5560
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
196-820 2.43e-35

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227847 [Multi-domain]  Cd Length: 823  Bit Score: 144.26  E-value: 2.43e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSQTPVLRE--LLKEVKMsgtivkieppdlalteplEINLEPP----GPLTLAMSQFLNEMQE 269
Cdd:COG5560   267 GLRNLGNTCYMNSALQCLMHTWELRDyfLSDEYEE------------------SINEENPlgmhGSVASAYADLIKQLYD 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 270 TKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMraeeHQRVSKGILKAFG---NSTEKLDEELKNKVKD--Y 344
Cdd:COG5560   329 GNLHAFTPSGFKKTIGSFNEEFSGYDQQDSQEFIAFLLDGL----HEDLNRIIKKPYTskpDLSPGDDVVVKKKAKEcwW 404

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 345 EKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSV-----NDKNLKKTVEDEDQDSEEEKD 419
Cdd:COG5560   405 EHLKRNDSIITDLFQGMYKSTLTCPGCGSVSITFDPFMDLTLPLPVSMVWKHTIvvfpeSGRRQPLKIELDASSTIRGLK 484

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 420 NdsYIKERSDIpSGTSKHLQKKAKKQAKKQAKNQrrqqkiQGKVLhLNDIctidHPEDSEYEAEMSLQG------EVNIK 493
Cdd:COG5560   485 K--LVDAEYGK-LGCFEIKVMCIYYGGNYNMLEP------ADKVL-LQDI----PQTDFVYLYETNDNGievpvvHLRIE 550

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 494 SNHISQEGVMHKEYCVNQKDLN-GQAKMIESVtdnQKSTEEVDMKNINMDNDLEVLTSSPTRNLNGAYL---TEGSNGEV 569
Cdd:COG5560   551 KGYKSKRLFGDPFLQLNVLIKAsIYDKLVKEF---EELLVLVEMKKTDVDLVSEQVRLLREESSPSSWLkleTEIDTKRE 627

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 570 DISNgfknlNLNAALHPDEINIEILNdshtPGTKVYEVVNEDpetafCTLANREVFNTDEC-SIQHCLYQFTRNEKLRDA 648
Cdd:COG5560   628 EQVE-----EEGQMNFNDAVVISCEW----EEKRYLSLFSYD-----PLWTIREIGAAERTiTLQDCLNEFSKPEQLGLS 693

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 649 NKLLCEVCtrrqcngpkaniKGERKhvytnAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPeILDLapfcTLK 728
Cdd:COG5560   694 DSWYCPGC------------KEFRQ-----ASKQMELWRLPMILIIHLKRFSSVRSFRDKIDDLVEYP-IDDL----DLS 751

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 729 CKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqdfemESKGQWFHISDTHVQAVPTTKV 808
Cdd:COG5560   752 GVEYMVDDPRLIYDLYAVDNHYGGLSGGHYTAYARN----------------------FANNGWYLFDDSRITEVDPEDS 809

                         650
                  ....*....|..
gi 1034626926 809 LNSQAYLLFYER 820
Cdd:COG5560   810 VTSSAYVLFYRR 821
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
631-818 9.88e-34

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 131.80  E-value: 9.88e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 631 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQcngpkanikgerkhvytNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVN 710
Cdd:pfam00443 163 SLQICFLQFSKLEELDDEEKYYCDKCGCKQ-----------------DAIKQLKISRLPPVLIIHLKRFSYNRSTWEKLN 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 711 KHIKFPEILDLAPFCTLKCKnvAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqdfemESKG 790
Cdd:pfam00443 226 TEVEFPLELDLSRYLAEELK--PKTNNLQDYRLVAVVVHSGSLSSGHYIAYIKA----------------------YENN 281

                         170       180
                  ....*....|....*....|....*....
gi 1034626926 791 QWFHISDTHVQAV-PTTKVLNSQAYLLFY 818
Cdd:pfam00443 282 RWYKFDDEKVTEVdEETAVLSSSAYILFY 310
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
196-393 2.60e-26

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 110.22  E-value: 2.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKieppdlaltEPLEINLeppgplTLAMSQFLNEMQE-TKKGV 274
Cdd:pfam00443   2 GLVNLGNTCYMNSVLQSLFSIPPFRDYLLRISPLSEDSR---------YNKDINL------LCALRDLFKALQKnSKSSS 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 275 VTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGmraeehqrvskgilkafgnstekLDEELKNKVkdyekKKSMPSFV 354
Cdd:pfam00443  67 VSPKMFKKSLGKLNPDFSGYKQQDAQEFLLFLLDG-----------------------LHEDLNGNH-----STENESLI 118

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1034626926 355 DRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQS 393
Cdd:pfam00443 119 TDLFRGQLKSRLKCLSCGEVSETFEPFSDLSLPIPGDSA 157
zf-UBP pfam02148
Zn-finger in ubiquitin-hydrolases and other protein;
48-123 6.48e-20

Zn-finger in ubiquitin-hydrolases and other protein;


Pssm-ID: 460464  Cd Length: 63  Bit Score: 83.85  E-value: 6.48e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034626926  48 CQDCKTDNkvkdkaeeeteekpSVWLCLKCGHQGCGRnSQEQHALKHYLTPRsepHCLVLSLDNWSVWCYVCDNEV 123
Cdd:pfam02148   1 CSLCGNTS--------------NLWLCLTCGHVGCGR-YQNSHALEHYEETG---HPLAVNLSTLTVYCYPCDDYV 58
ZnF_UBP smart00290
Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger;
47-114 2.62e-08

Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger;


Pssm-ID: 197632  Cd Length: 50  Bit Score: 50.83  E-value: 2.62e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034626926   47 ICQDCKTDNKVkdkaeeeteekpsvWLCLKCGHQGCGRnSQEQHALKHYltpRSEPHCLVLSLDNWSV 114
Cdd:smart00290   1 RCSVCGTIENL--------------WLCLTCGQVGCGR-YQNGHALEHF---EETGHPLVVKLGTQRV 50
 
Name Accession Description Interval E-value
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 622-819 9.07e-85

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 271.57  E-value: 9.07e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 622 REVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRrqcngpkanikgerkhvytnAKKQMLISLAPPVLTLHLKRFQQ 701
Cdd:cd02667   103 RSDEIKSECSIESCLKQFTEVEILEGNNKFACENCTK--------------------AKKQYLISKLPPVLVIHLKRFQQ 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 702 AGF-NLRKVNKHIKFPEILDLAPFCTLKCkNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHgDI 780
Cdd:cd02667   163 PRSaNLRKVSRHVSFPEILDLAPFCDPKC-NSSEDKSSVLYRLYGVVEHSGTMRSGHYVAYVKVRPPQQRLSDLTKS-KP 240

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1034626926 781 PQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYE 819
Cdd:cd02667   241 AADEAGPGSGQWYYISDSDVREVSLEEVLKSEAYLLFYE 279
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-401 4.82e-49

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 174.50  E-value: 4.82e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkieppdlaltepleinleppgpltlamsqflnemqetkkgvv 275
Cdd:cd02667     1 GLSNLGNTCFFNAVMQNLSQTPALRELLSE-------------------------------------------------- 30

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 276 TPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRaeehqrvskgilkafgnstekldeelknkvkdyekkksmpSFVD 355
Cdd:cd02667    31 TPKELFSQVCRKAPQFKGYQQQDSHELLRYLLDGLR----------------------------------------TFID 70

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1034626926 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDK 401
Cdd:cd02667    71 SIFGGELTSTIMCESCGTVSLVYEPFLDLSLPRSDEIKSECSIESC 116
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
 624-819 1.30e-39

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 147.24  E-value: 1.30e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 624 VFNTDECSIQHCLYQFTRNEKLRDANKLLCEvctrrqcngpkanikgerKHVYTNAKKQMLISLAPPVLTLHLKRFQQAG 703
Cdd:cd02257    93 VKGLPQVSLEDCLEKFFKEEILEGDNCYKCE------------------KKKKQEATKRLKIKKLPPVLIIHLKRFSFNE 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 704 -FNLRKVNKHIKFPEILDLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGT-MRSGHYTAYAKartanshlsnlvlhgdip 781
Cdd:cd02257   155 dGTKEKLNTKVSFPLELDLSPYLSEGEKDSDSDNGSYKYELVAVVVHSGTsADSGHYVAYVK------------------ 216

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1034626926 782 qdfeMESKGQWFHISDTHVQAVPTTKVL-----NSQAYLLFYE 819
Cdd:cd02257   217 ----DPSDGKWYKFNDDKVTEVSEEEVLefgslSSSAYILFYE 255
Peptidase_C19E cd02661
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 631-818 8.32e-39

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239126 [Multi-domain]  Cd Length: 304  Bit Score: 146.27  E-value: 8.32e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 631 SIQHCLYQFTRNEKLRDANKLLCEVCTRrqcngpkanikgerkhvYTNAKKQMLISLAPPVLTLHLKRFQqaGFNLRKVN 710
Cdd:cd02661   163 SLEDALEQFTKPEQLDGENKYKCERCKK-----------------KVKASKQLTIHRAPNVLTIHLKRFS--NFRGGKIN 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 711 KHIKFPEILDLAPFCTlkckNVAEENTRvlYSLYGVVEHSGT-MRSGHYTAYAKArtanshlsnlvlhgdipqdfemeSK 789
Cdd:cd02661   224 KQISFPETLDLSPYMS----QPNDGPLK--YKLYAVLVHSGFsPHSGHYYCYVKS-----------------------SN 274

                         170       180
                  ....*....|....*....|....*....
gi 1034626926 790 GQWFHISDTHVQAVPTTKVLNSQAYLLFY 818
Cdd:cd02661   275 GKWYNMDDSKVSPVSIETVLSQKAYILFY 303
UBP12 COG5560
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
196-820 2.43e-35

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227847 [Multi-domain]  Cd Length: 823  Bit Score: 144.26  E-value: 2.43e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSQTPVLRE--LLKEVKMsgtivkieppdlalteplEINLEPP----GPLTLAMSQFLNEMQE 269
Cdd:COG5560   267 GLRNLGNTCYMNSALQCLMHTWELRDyfLSDEYEE------------------SINEENPlgmhGSVASAYADLIKQLYD 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 270 TKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMraeeHQRVSKGILKAFG---NSTEKLDEELKNKVKD--Y 344
Cdd:COG5560   329 GNLHAFTPSGFKKTIGSFNEEFSGYDQQDSQEFIAFLLDGL----HEDLNRIIKKPYTskpDLSPGDDVVVKKKAKEcwW 404

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 345 EKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSV-----NDKNLKKTVEDEDQDSEEEKD 419
Cdd:COG5560   405 EHLKRNDSIITDLFQGMYKSTLTCPGCGSVSITFDPFMDLTLPLPVSMVWKHTIvvfpeSGRRQPLKIELDASSTIRGLK 484

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 420 NdsYIKERSDIpSGTSKHLQKKAKKQAKKQAKNQrrqqkiQGKVLhLNDIctidHPEDSEYEAEMSLQG------EVNIK 493
Cdd:COG5560   485 K--LVDAEYGK-LGCFEIKVMCIYYGGNYNMLEP------ADKVL-LQDI----PQTDFVYLYETNDNGievpvvHLRIE 550

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 494 SNHISQEGVMHKEYCVNQKDLN-GQAKMIESVtdnQKSTEEVDMKNINMDNDLEVLTSSPTRNLNGAYL---TEGSNGEV 569
Cdd:COG5560   551 KGYKSKRLFGDPFLQLNVLIKAsIYDKLVKEF---EELLVLVEMKKTDVDLVSEQVRLLREESSPSSWLkleTEIDTKRE 627

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 570 DISNgfknlNLNAALHPDEINIEILNdshtPGTKVYEVVNEDpetafCTLANREVFNTDEC-SIQHCLYQFTRNEKLRDA 648
Cdd:COG5560   628 EQVE-----EEGQMNFNDAVVISCEW----EEKRYLSLFSYD-----PLWTIREIGAAERTiTLQDCLNEFSKPEQLGLS 693

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 649 NKLLCEVCtrrqcngpkaniKGERKhvytnAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPeILDLapfcTLK 728
Cdd:COG5560   694 DSWYCPGC------------KEFRQ-----ASKQMELWRLPMILIIHLKRFSSVRSFRDKIDDLVEYP-IDDL----DLS 751

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 729 CKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqdfemESKGQWFHISDTHVQAVPTTKV 808
Cdd:COG5560   752 GVEYMVDDPRLIYDLYAVDNHYGGLSGGHYTAYARN----------------------FANNGWYLFDDSRITEVDPEDS 809

                         650
                  ....*....|..
gi 1034626926 809 LNSQAYLLFYER 820
Cdd:COG5560   810 VTSSAYVLFYRR 821
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
631-818 9.88e-34

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 131.80  E-value: 9.88e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 631 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQcngpkanikgerkhvytNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVN 710
Cdd:pfam00443 163 SLQICFLQFSKLEELDDEEKYYCDKCGCKQ-----------------DAIKQLKISRLPPVLIIHLKRFSYNRSTWEKLN 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 711 KHIKFPEILDLAPFCTLKCKnvAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqdfemESKG 790
Cdd:pfam00443 226 TEVEFPLELDLSRYLAEELK--PKTNNLQDYRLVAVVVHSGSLSSGHYIAYIKA----------------------YENN 281

                         170       180
                  ....*....|....*....|....*....
gi 1034626926 791 QWFHISDTHVQAV-PTTKVLNSQAYLLFY 818
Cdd:pfam00443 282 RWYKFDDEKVTEVdEETAVLSSSAYILFY 310
Peptidase_C19R cd02674
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 626-819 1.11e-33

A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239139 [Multi-domain]  Cd Length: 230  Bit Score: 129.33  E-value: 1.11e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 626 NTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCngpkanikgerkhvytnAKKQMLISLAPPVLTLHLKRFQQAGFN 705
Cdd:cd02674    80 DAPKVTLEDCLRLFTKEETLDGDNAWKCPKCKKKRK-----------------ATKKLTISRLPKVLIIHLKRFSFSRGS 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 706 LRKVNKHIKFP-EILDLAPFCtlkckNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqdf 784
Cdd:cd02674   143 TRKLTTPVTFPlNDLDLTPYV-----DTRSFTGPFKYDLYAVVNHYGSLNGGHYTAYCKN-------------------- 197

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1034626926 785 emESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYE 819
Cdd:cd02674   198 --NETNDWYKFDDSRVTKVSESSVVSSSAYILFYE 230
Peptidase_C19D cd02660
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 626-818 4.98e-29

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239125 [Multi-domain]  Cd Length: 328  Bit Score: 118.63  E-value: 4.98e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 626 NTDECSIQHCLYQFTRNEKLRDANkLLCEVCtrrqcngpkanikgerkHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFN 705
Cdd:cd02660   172 VSGTPTLSDCLDRFTRPEKLGDFA-YKCSGC-----------------GSTQEATKQLSIKKLPPVLCFQLKRFEHSLNK 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 706 L-RKVNKHIKFPEILDLAPFCTLKCKNVAEEN---TRVLYSLYGVVEHSGTMRSGHYTAYAKARtanshlsnlvlhgdip 781
Cdd:cd02660   234 TsRKIDTYVQFPLELNMTPYTSSSIGDTQDSNsldPDYTYDLFAVVVHKGTLDTGHYTAYCRQG---------------- 297

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1034626926 782 qdfemesKGQWFHISDTHVQAVPTTKVLNSQAYLLFY 818
Cdd:cd02660   298 -------DGQWFKFDDAMITRVSEEEVLKSQAYLLFY 327
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
196-393 2.60e-26

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 110.22  E-value: 2.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKieppdlaltEPLEINLeppgplTLAMSQFLNEMQE-TKKGV 274
Cdd:pfam00443   2 GLVNLGNTCYMNSVLQSLFSIPPFRDYLLRISPLSEDSR---------YNKDINL------LCALRDLFKALQKnSKSSS 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 275 VTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGmraeehqrvskgilkafgnstekLDEELKNKVkdyekKKSMPSFV 354
Cdd:pfam00443  67 VSPKMFKKSLGKLNPDFSGYKQQDAQEFLLFLLDG-----------------------LHEDLNGNH-----STENESLI 118

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1034626926 355 DRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQS 393
Cdd:pfam00443 119 TDLFRGQLKSRLKCLSCGEVSETFEPFSDLSLPIPGDSA 157
peptidase_C19C cd02659
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 631-821 5.40e-24

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239124 [Multi-domain]  Cd Length: 334  Bit Score: 103.88  E-value: 5.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 631 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQcngpkanikgerkhvytNAKKQMLISLAPPVLTLHLKRFQqagFNL---- 706
Cdd:cd02659   152 NLEESLDAYVQGETLEGDNKYFCEKCGKKV-----------------DAEKGVCFKKLPPVLTLQLKRFE---FDFetmm 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 707 -RKVNKHIKFPEILDLAPFC--TLKCKNVAEENTRV---LYSLYGVVEHSGTMRSGHYTAYAKARTanshlsnlvlhgdi 780
Cdd:cd02659   212 rIKINDRFEFPLELDMEPYTekGLAKKEGDSEKKDSesyIYELHGVLVHSGDAHGGHYYSYIKDRD-------------- 277

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034626926 781 pqdfemesKGQWFHISDTHV----------------------QAVPTTKVLNSQAYLLFYERI 821
Cdd:cd02659   278 --------DGKWYKFNDDVVtpfdpndaeeecfggeetqktyDSGPRAFKRTTNAYMLFYERK 332
Peptidase_C19F cd02662
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 630-819 1.47e-21

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239127 [Multi-domain]  Cd Length: 240  Bit Score: 94.36  E-value: 1.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 630 CSIQHCLYQFTRNEKLRDANkllCEVCtrrqcngpkanikgerkhvytnakkQMLISLAPPVLTLHLKRFQQAGFN-LRK 708
Cdd:cd02662    96 TTLEHCLDDFLSTEIIDDYK---CDRC-------------------------QTVIVRLPQILCIHLSRSVFDGRGtSTK 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 709 VNKHIKFPEILdlapfctlkcknvaeenTRVLYSLYGVVEHSGTMRSGHYTAYAKARTanSHLSNLVLHGDIPQDFEMES 788
Cdd:cd02662   148 NSCKVSFPERL-----------------PKVLYRLRAVVVHYGSHSSGHYVCYRRKPL--FSKDKEPGSFVRMREGPSST 208

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1034626926 789 KGQWFHISDTHVQAVPTTKVL-NSQAYLLFYE 819
Cdd:cd02662   209 SHPWWRISDTTVKEVSESEVLeQKSAYMLFYE 240
zf-UBP pfam02148
Zn-finger in ubiquitin-hydrolases and other protein;
48-123 6.48e-20

Zn-finger in ubiquitin-hydrolases and other protein;


Pssm-ID: 460464  Cd Length: 63  Bit Score: 83.85  E-value: 6.48e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034626926  48 CQDCKTDNkvkdkaeeeteekpSVWLCLKCGHQGCGRnSQEQHALKHYLTPRsepHCLVLSLDNWSVWCYVCDNEV 123
Cdd:pfam02148   1 CSLCGNTS--------------NLWLCLTCGHVGCGR-YQNSHALEHYEETG---HPLAVNLSTLTVYCYPCDDYV 58
Peptidase_C19E cd02661
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-397 4.21e-19

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239126 [Multi-domain]  Cd Length: 304  Bit Score: 88.87  E-value: 4.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLkevkmsgtivkieppdlaLTEPLEINLEPPGPLTL-AMSQFLNEMQETKKGV 274
Cdd:cd02661     3 GLQNLGNTCFLNSVLQCLTHTPPLANYL------------------LSREHSKDCCNEGFCMMcALEAHVERALASSGPG 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 275 VTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRaeehqrvsKGILKAFGNStEKLDEELKnkvkdyekkksMPSFV 354
Cdd:cd02661    65 SAPRIFSSNLKQISKHFRIGRQEDAHEFLRYLLDAMQ--------KACLDRFKKL-KAVDPSSQ-----------ETTLV 124

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1034626926 355 DRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKS 397
Cdd:cd02661   125 QQIFGGYLRSQVKCLNCKHVSNTYDPFLDLSLDIKGADSLEDA 167
Peptidase_C19L cd02668
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 631-804 4.55e-16

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239133 [Multi-domain]  Cd Length: 324  Bit Score: 80.16  E-value: 4.55e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 631 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQcngpkanikgerkhvytNAKKQMLISLAPPVLTLHLKRF---QQAGfNLR 707
Cdd:cd02668   157 TLEECIDEFLKEEQLTGDNQYFCESCNSKT-----------------DATRRIRLTTLPPTLNFQLLRFvfdRKTG-AKK 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 708 KVNKHIKFPEILDLAPFCTLKcknvaEENTRVlYSLYGVVEHSGT-MRSGHYTAyakartansHLSNlvlhgdipqdfem 786
Cdd:cd02668   219 KLNASISFPEILDMGEYLAES-----DEGSYV-YELSGVLIHQGVsAYSGHYIA---------HIKD------------- 270

                         170
                  ....*....|....*...
gi 1034626926 787 ESKGQWFHISDTHVQAVP 804
Cdd:cd02668   271 EQTGEWYKFNDEDVEEMP 288
Peptidase_C19H cd02664
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 630-819 9.83e-16

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239129 [Multi-domain]  Cd Length: 327  Bit Score: 79.07  E-value: 9.83e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 630 CSIQHCLYQFTRNEKLRDANKLLCEVCTRRQcngpkanikgerkhvytNAKKQMLISLAPPVLTLHLKRFQ--QAGFNLR 707
Cdd:cd02664   134 PSVQDLLNYFLSPEKLTGDNQYYCEKCASLQ-----------------DAEKEMKVTGAPEYLILTLLRFSydQKTHVRE 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 708 KVNKHIKFPEILDL-----------APFCTLKCKNVAEE--NTRVLYSLYGVVEHSGT-MRSGHYTAYakARTANSHLSN 773
Cdd:cd02664   197 KIMDNVSINEVLSLpvrveskssesPLEKKEEESGDDGElvTRQVHYRLYAVVVHSGYsSESGHYFTY--ARDQTDADST 274

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034626926 774 LVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQ-------AYLLFYE 819
Cdd:cd02664   275 GQECPEPKDAEENDESKNWYLFNDSRVTFSSFESVQNVTsrfpkdtPYILFYE 327
Peptidase_C19G cd02663
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 629-819 1.18e-15

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239128 [Multi-domain]  Cd Length: 300  Bit Score: 78.51  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 629 ECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQcngpkanikgerkhvytNAKKQMLISLAPPVLTLHLKRFQQAGfnlrK 708
Cdd:cd02663   146 NTSITSCLRQFSATETLCGRNKFYCDECCSLQ-----------------EAEKRMKIKKLPKILALHLKRFKYDE----Q 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 709 VNKHIK------FPeiLDLAPFCTlkcKNVAEENTRvLYSLYGVVEH--SGTMRsGHYTAYAKartanshlsnlvlhgdi 780
Cdd:cd02663   205 LNRYIKlfyrvvFP--LELRLFNT---TDDAENPDR-LYELVAVVVHigGGPNH-GHYVSIVK----------------- 260

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1034626926 781 pqdfemeSKGQWFHISDTHVQAVPTTKVLN--------SQAYLLFYE 819
Cdd:cd02663   261 -------SHGGWLLFDDETVEKIDENAVEEffgdspnqATAYVLFYQ 300
Peptidase_C19O cd02671
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 638-763 1.26e-15

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239136 [Multi-domain]  Cd Length: 332  Bit Score: 78.78  E-value: 1.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 638 QFTRNEKLRDANKLLCEVCtrrqcngpkanikgerkHVYTNAKKQMLISLAPPVLTLHLKRFQQAGF------NLRKVNK 711
Cdd:cd02671   188 QFASVERIVGEDKYFCENC-----------------HHYTEAERSLLFDKLPEVITIHLKCFAANGSefdcygGLSKVNT 250

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034626926 712 HIkfpeildLAPFcTLKCKNVAEENTRVLYSLYGVVEHSG-TMRSGHYTAYAK 763
Cdd:cd02671   251 PL-------LTPL-KLSLEEWSTKPKNDVYRLFAVVMHSGaTISSGHYTAYVR 295
Peptidase_C19A cd02657
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-427 1.99e-15

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239122 [Multi-domain]  Cd Length: 305  Bit Score: 77.76  E-value: 1.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVkieppdlaltepleinLEPPGPLTLAMSQFLNEMQETKKGvV 275
Cdd:cd02657     1 GLTNLGNTCYLNSTLQCLRSVPELRDALKNYNPARRGA----------------NQSSDNLTNALRDLFDTMDKKQEP-V 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 276 TPKELFSQVCKKAVRFK------GYQQQDSQELLRYLLDGMRAEehqrvskgilkafgnstekldeelknkvkdYEKKKS 349
Cdd:cd02657    64 PPIEFLQLLRMAFPQFAekqnqgGYAQQDAEECWSQLLSVLSQK------------------------------LPGAGS 113

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 350 MPSFVDRIFGGELTSMIMCDQCRTVSLVH-ESFLDLSLPVlddqSGKKSVN--DKNLKKTVEDEDQDSEEEKDNDS-YIK 425
Cdd:cd02657   114 KGSFIDQLFGIELETKMKCTESPDEEEVStESEYKLQCHI----SITTEVNylQDGLKKGLEEEIEKHSPTLGRDAiYTK 189


                  ..
gi 1034626926 426 ER 427
Cdd:cd02657   190 TS 191
Peptidase_C19D cd02660
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 195-397 2.05e-14

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239125 [Multi-domain]  Cd Length: 328  Bit Score: 75.10  E-value: 2.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 195 KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLaltepleinleppgpLTLAMSQFLNEMQET-KKG 273
Cdd:cd02660     1 RGLINLGATCFMNVILQALLHNPLLRNYFLSDRHSCTCLSCSPNSC---------------LSCAMDEIFQEFYYSgDRS 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 274 VVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDgmraeehqrvskgilkafgnsteKLDEELKNKVKDYEKKKSMPSF 353
Cdd:cd02660    66 PYGPINLLYLSWKHSRNLAGYSQQDAHEFFQFLLD-----------------------QLHTHYGGDKNEANDESHCNCI 122

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1034626926 354 VDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPvLDDQSGKKS 397
Cdd:cd02660   123 IHQTFSGSLQSSVTCQRCGGVSTTVDPFLDLSLD-IPNKSTPSW 165
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
 196-400 6.49e-14

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 72.52  E-value: 6.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSqtpvlrellkevkmsgtivkieppdlaltepleinleppgpltlamsqflnemqetkkgvv 275
Cdd:cd02257     1 GLNNLGNTCYLNSVLQALF------------------------------------------------------------- 19

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 276 tpkelfsqvckkavrfkgYQQQDSQELLRYLLDgmraeehqrvskgilkafgnsteKLDEELKNKVKDYEKKKSMPSFVD 355
Cdd:cd02257    20 ------------------SEQQDAHEFLLFLLD-----------------------KLHEELKKSSKRTSDSSSLKSLIH 58

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1034626926 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVND 400
Cdd:cd02257    59 DLFGGKLESTIVCLECGHESVSTEPELFLSLPLPVKGLPQVSLED 103
Peptidase_C19G cd02663
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-388 7.62e-12

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239128 [Multi-domain]  Cd Length: 300  Bit Score: 66.95  E-value: 7.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSQTPVLrELLKevkmsgtivkieppDLaltepleinleppgpltlaMSQFLNemQETKKGVV 275
Cdd:cd02663     1 GLENFGNTCYCNSVLQALYFENLL-TCLK--------------DL-------------------FESISE--QKKRTGVI 44

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 276 TPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDgmraeehqRVSKGILKafgnstEKLDEELKNKVKDYEKKKSMPSFVD 355
Cdd:cd02663    45 SPKKFITRLKRENELFDNYMHQDAHEFLNFLLN--------EIAEILDA------ERKAEKANRKLNNNNNAEPQPTWVH 110

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1034626926 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 388
Cdd:cd02663   111 EIFQGILTNETRCLTCETVSSRDETFLDLSIDV 143
COG5077 COG5077
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ...
 673-809 8.76e-12

Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227409 [Multi-domain]  Cd Length: 1089  Bit Score: 69.13  E-value: 8.76e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926  673 KHVYTNAKKQMLISLAPPVLTLHLKRFQqAGF---NLRKVNKHIKFPEILDLAPFCTLKCKNvaEENTRVLYSLYGVVEH 749
Cdd:COG5077    363 KHGLQDAKKGVIFESLPPVLHLQLKRFE-YDFerdMMVKINDRYEFPLEIDLLPFLDRDADK--SENSDAVYVLYGVLVH 439

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926  750 SGTMRSGHYTAYAKArtanshlsnlvlhgdipqdfemESKGQWFHISDTHVQAVPTTKVL 809
Cdd:COG5077    440 SGDLHEGHYYALLKP----------------------EKDGRWYKFDDTRVTRATEKEVL 477
peptidase_C19C cd02659
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-393 2.45e-11

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239124 [Multi-domain]  Cd Length: 334  Bit Score: 65.74  E-value: 2.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLkevkmsgtivkieppdlaLTEPLEINLEPPGPLTLAM-SQFLnEMQETKKGV 274
Cdd:cd02659     4 GLKNQGATCYMNSLLQQLYMTPEFRNAV------------------YSIPPTEDDDDNKSVPLALqRLFL-FLQLSESPV 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 275 VTPKelfsqVCKKAVRFKG-----YQQQDSQELLRYLLDgmraeehqrvskgilkafgnsteKLDEELknkvkdyeKKKS 349
Cdd:cd02659    65 KTTE-----LTDKTRSFGWdslntFEQHDVQEFFRVLFD-----------------------KLEEKL--------KGTG 108

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1034626926 350 MPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQS 393
Cdd:cd02659   109 QEGLIKNLFGGKLVNYIICKECPHESEREEYFLDLQVAVKGKKN 152
Peptidase_C19A cd02657
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 665-819 1.74e-10

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239122 [Multi-domain]  Cd Length: 305  Bit Score: 63.12  E-value: 1.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 665 KANIKGERKHVYTnakKQMLISLAPPVLTLHLKRFQ---QAGFNLrKVNKHIKFPEILDLAPFCTLKCknvaeentrvLY 741
Cdd:cd02657   176 KHSPTLGRDAIYT---KTSRISRLPKYLTVQFVRFFwkrDIQKKA-KILRKVKFPFELDLYELCTPSG----------YY 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 742 SLYGVVEHSG-TMRSGHYTAYAKArtanshlsnlvlhgdipqdfemESKGQWFHISDTHVQAVPTTKVLN-------SQA 813
Cdd:cd02657   242 ELVAVITHQGrSADSGHYVAWVRR----------------------KNDGKWIKFDDDKVSEVTEEDILKlsgggdwHIA 299


                  ....*.
gi 1034626926 814 YLLFYE 819
Cdd:cd02657   300 YILLYK 305
COG5533 COG5533
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
671-821 4.95e-10

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444284 [Multi-domain]  Cd Length: 284  Bit Score: 61.36  E-value: 4.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 671 ERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNlRKVNKHIKfpEILDLaPFCTLKCKNVaEENTRvlYSLYGVVEHS 750
Cdd:COG5533   162 EELEVQAKQEYEVSFVKLPKILTIQLKRFANLGGN-QKIDTEVD--EKFEL-PVKHDQILNI-VKETY--YDLVGFVLHQ 234

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034626926 751 GTMRSGHYTAYAKartanshlsnlvlhgdipqdfemeSKGQWFHISDTHVQAVPTTKVLNS---QAYLLFYERI 821
Cdd:COG5533   235 GSLEGGHYIAYVK------------------------KGGKWEKANDSDVTPVSEEEAINEkakNAYLYFYERI 284
ZnF_UBP smart00290
Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger;
47-114 2.62e-08

Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger;


Pssm-ID: 197632  Cd Length: 50  Bit Score: 50.83  E-value: 2.62e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034626926   47 ICQDCKTDNKVkdkaeeeteekpsvWLCLKCGHQGCGRnSQEQHALKHYltpRSEPHCLVLSLDNWSV 114
Cdd:smart00290   1 RCSVCGTIENL--------------WLCLTCGQVGCGR-YQNGHALEHF---EETGHPLVVKLGTQRV 50
Peptidase_C19O cd02671
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-395 4.38e-08

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239136 [Multi-domain]  Cd Length: 332  Bit Score: 55.67  E-value: 4.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkMSGTIVKIEppdlALTEPLEINLEppgpltLAMSQFLNEMqetkkgvv 275
Cdd:cd02671    26 GLNNLGNTCYLNSVLQVLYFCPGFKHGLKH--LVSLISSVE----QLQSSFLLNPE------KYNDELANQA-------- 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 276 tPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRaeehqrvskgilkafgnstekldeelknkvkdyekkksmpSFVD 355
Cdd:cd02671    86 -PRRLLNALREVNPMYEGYLQHDAQEVLQCILGNIQ----------------------------------------ELVE 124

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1034626926 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGK 395
Cdd:cd02671   125 KDFQGQLVLRTRCLECETFTERREDFQDISVPVQESELSK 164
Peptidase_C19L cd02668
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-400 4.70e-08

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239133 [Multi-domain]  Cd Length: 324  Bit Score: 55.50  E-value: 4.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEppgpLTLAMSQflneMQETKKGVV 275
Cdd:cd02668     1 GLKNLGATCYVNSFLQLWFMNLEFRKAVYECNSTEDAELKNMPPDKPHEPQTIIDQ----LQLIFAQ----LQFGNRSVV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 276 TPKELFsqvckKAVRFKGYQQQDSQELLRYLLDGMRAeehqrvskgilkafgnsteKLDEELKNKVKdyekkksmpSFVD 355
Cdd:cd02668    73 DPSGFV-----KALGLDTGQQQDAQEFSKLFLSLLEA-------------------KLSKSKNPDLK---------NIVQ 119

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1034626926 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVND 400
Cdd:cd02668   120 DLFRGEYSYVTQCSKCGRESSLPSKFYELELQLKGHKTLEECIDE 164
Peptidase_C19R cd02674
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-388 9.08e-07

A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239139 [Multi-domain]  Cd Length: 230  Bit Score: 50.75  E-value: 9.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSQtpvlrellkevkmsgtivkieppdlaltepleinleppgpltlamsqflnemqetkkgvv 275
Cdd:cd02674     1 GLRNLGNTCYMNSILQCLSA------------------------------------------------------------ 20

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 276 tpkelfsqvckkavrfkgyQQQDSQELLRYLLDGMRaeehqrvskgilkafgnstekldeelknkvkdyekkksmpSFVD 355
Cdd:cd02674    21 -------------------DQQDAQEFLLFLLDGLH----------------------------------------SIIV 41

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1034626926 356 RIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 388
Cdd:cd02674    42 DLFQGQLKSRLTCLTCGKTSTTFEPFTYLSLPI 74
Peptidase_C19B cd02658
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 676-819 1.34e-06

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239123 [Multi-domain]  Cd Length: 311  Bit Score: 51.17  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 676 YTNAKKQMLISLAPPVLTLHLKRFQ-QAGFNLRKVNKHIKFPEILDLAPfctlkcknvaeentrvlYSLYGVVEHSGT-M 753
Cdd:cd02658   203 KTTATKTTGFKTFPDYLVINMKRFQlLENWVPKKLDVPIDVPEELGPGK-----------------YELIAFISHKGTsV 265

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034626926 754 RSGHYTAYAKARTANshlsnlvlhgdipqdfemesKGQWFHISDTHVQAVPTTKVLNSQAYLLFYE 819
Cdd:cd02658   266 HSGHYVAHIKKEIDG--------------------EGKWVLFNDEKVVASQDPPEMKKLGYIYFYQ 311
Peptidase_C19M cd02669
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 670-819 5.36e-05

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239134 [Multi-domain]  Cd Length: 440  Bit Score: 46.54  E-value: 5.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 670 GERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKvNKHI-KFP-EILDLAPFCTlkcKNVAEENTRVLYSLYGVV 747
Cdd:cd02669   314 GKTETELKDSLKRYLISRLPKYLIFHIKRFSKNNFFKEK-NPTIvNFPiKNLDLSDYVH---FDKPSLNLSTKYNLVANI 389

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034626926 748 EHSGT-MRSGHYTAYakartanshlsnlVLHgdipqdfemESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYE 819
Cdd:cd02669   390 VHEGTpQEDGTWRVQ-------------LRH---------KSTNKWFEIQDLNVKEVLPQLIFLSESYIQIWE 440
Peptidase_C19N cd02670
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 685-763 8.27e-05

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239135 [Multi-domain]  Cd Length: 241  Bit Score: 44.83  E-value: 8.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034626926 685 ISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEILDLAPF----------CTLKCKNVAEEN----TRVLY--SLYGVVE 748
Cdd:cd02670    95 FAKAPSCLIICLKRYGKTEGKAQKMFKKILIPDEIDIPDFvaddpracskCQLECRVCYDDKdfspTCGKFklSLCSAVC 174

                          90
                  ....*....|....*.
gi 1034626926 749 HSGTMR-SGHYTAYAK 763
Cdd:cd02670   175 HRGTSLeTGHYVAFVR 190
Peptidase_C19F cd02662
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 196-227 2.51e-04

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239127 [Multi-domain]  Cd Length: 240  Bit Score: 43.51  E-value: 2.51e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1034626926 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVK 227
Cdd:cd02662     1 GLVNLGNTCFMNSVLQALASLPSLIEYLEEFL 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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