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Conserved domains on  [gi|1034590840|ref|XP_016877754|]
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P protein isoform X27 [Homo sapiens]

Protein Classification

transporter permease( domain architecture ID 229430)

transporter permease similar to ArsB/NhaD family permeases, which typically contain 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsB_NhaD_permease super family cl21473
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 346-652 5.68e-82

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


The actual alignment was detected with superfamily member cd01116:

Pssm-ID: 473875 [Multi-domain]  Cd Length: 413  Bit Score: 265.27  E-value: 5.68e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 346 LAGVYALIIFEIVHRTLAAMLGSLAALAALaVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRL 425
Cdd:cd01116     1 FIITYALIIFEKVHRTVAALAGALWLVILG-LATLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 426 SRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSnqe 505
Cdd:cd01116    80 SKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS--- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 506 lrKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIvelkheihvwrltaqrispasreetavrrlllg 585
Cdd:cd01116   157 --AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA--------------------------------- 201

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034590840 586 kvlalehllarrlhtfhrqisqedknwetnIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVP 652
Cdd:cd01116   202 ------------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPLG 238
 
Name Accession Description Interval E-value
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 346-652 5.68e-82

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 265.27  E-value: 5.68e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 346 LAGVYALIIFEIVHRTLAAMLGSLAALAALaVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRL 425
Cdd:cd01116     1 FIITYALIIFEKVHRTVAALAGALWLVILG-LATLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 426 SRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSnqe 505
Cdd:cd01116    80 SKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS--- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 506 lrKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIvelkheihvwrltaqrispasreetavrrlllg 585
Cdd:cd01116   157 --AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA--------------------------------- 201

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034590840 586 kvlalehllarrlhtfhrqisqedknwetnIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVP 652
Cdd:cd01116   202 ------------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPLG 238
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
338-564 3.43e-51

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 183.02  E-value: 3.43e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 338 QVTIATAILAGVYALIIFEI--VHRTLAAMLGSLAALAALAVigdrpSLTHVVEWIDFETLALLFGMMILVAIFSETGFF 415
Cdd:COG1055     1 MMILALAIFVLTYLLIILEPrgLNRAVAALLGAALLLLLGVV-----SLEDALEAIDWNTILFLLGMMIIVAILDESGFF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 416 DYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDP 495
Cdd:COG1055    76 EWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNP 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034590840 496 PNVIIVSnqelrKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYwnRKLYNKEPSEIVELKHEIHVWRL 564
Cdd:COG1055   156 TNIMIAS-----AGGLSFLDFLANLFPPSLVSLLVTLLVLYLLF--RKELPAAPDLEDDPKEAIKDRRL 217
CitMHS pfam03600
Citrate transporter;
350-570 4.44e-48

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 172.50  E-value: 4.44e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 350 YALIIFEIVHRTLAAMLGSLAALAALAVigdrpSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGR 429
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVL-----TPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 430 VWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNqelrkM 509
Cdd:pfam03600  76 PRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASA-----L 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034590840 510 GLDFAGFTAHMFIGICLVLLV-CFPLLRLLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRIS 570
Cdd:pfam03600 151 GLSFGDFGFFMFPPVGVALLLvGLLPLLLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAIS 212
PLN00136 PLN00136
silicon transporter; Provisional
 391-540 3.99e-11

silicon transporter; Provisional


Pssm-ID: 215070 [Multi-domain]  Cd Length: 482  Bit Score: 65.79  E-value: 3.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 391 IDFETLALLFGMMILVAIFSETGFFDYCA-VKAYRLSRGRvwAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLN 469
Cdd:PLN00136   61 IDLPILGLLFATMVVGSYLKNAGMFKHLGrLLAWRSQGGR--DLLCRVCVVTALASALFTNDTCCVVLTEFVLELAAERN 138

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034590840 470 LDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLdFAGFTAHMFIG--ICLVLLVCfpllrlLYW 540
Cdd:PLN00136  139 LPAKPFLLALASSANIGSSATPIGNPQNLVIAFNSKITFPKF-LLGILPAMLAGmaVNMVMLLC------MYW 204
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 384-535 6.09e-06

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 49.26  E-value: 6.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 384 LTHVVEW-------IDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIM--LCLIAAVLSAFLDNVTTM 454
Cdd:TIGR00785 285 FLGIVTWkdiqknkVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLvlVVLFYIILYFFASNTAHT 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 455 LLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVII-----VSNQELRKMGLDFAgftahmFIGICLVLL 529
Cdd:TIGR00785 365 AALVPIFFSVASAQGIPLELLALALALSASLMGFLTPYATPPNAIAygsgyVKIKDMWRVGAIIG------IVGLIVLLL 438


                  ....*.
gi 1034590840 530 VCFPLL 535
Cdd:TIGR00785 439 VGTLWW 444
 
Name Accession Description Interval E-value
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 346-652 5.68e-82

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 265.27  E-value: 5.68e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 346 LAGVYALIIFEIVHRTLAAMLGSLAALAALaVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRL 425
Cdd:cd01116     1 FIITYALIIFEKVHRTVAALAGALWLVILG-LATLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 426 SRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSnqe 505
Cdd:cd01116    80 SKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS--- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 506 lrKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIvelkheihvwrltaqrispasreetavrrlllg 585
Cdd:cd01116   157 --AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA--------------------------------- 201

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034590840 586 kvlalehllarrlhtfhrqisqedknwetnIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVP 652
Cdd:cd01116   202 ------------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPLG 238
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
338-564 3.43e-51

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 183.02  E-value: 3.43e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 338 QVTIATAILAGVYALIIFEI--VHRTLAAMLGSLAALAALAVigdrpSLTHVVEWIDFETLALLFGMMILVAIFSETGFF 415
Cdd:COG1055     1 MMILALAIFVLTYLLIILEPrgLNRAVAALLGAALLLLLGVV-----SLEDALEAIDWNTILFLLGMMIIVAILDESGFF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 416 DYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDP 495
Cdd:COG1055    76 EWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNP 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034590840 496 PNVIIVSnqelrKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYwnRKLYNKEPSEIVELKHEIHVWRL 564
Cdd:COG1055   156 TNIMIAS-----AGGLSFLDFLANLFPPSLVSLLVTLLVLYLLF--RKELPAAPDLEDDPKEAIKDRRL 217
CitMHS pfam03600
Citrate transporter;
350-570 4.44e-48

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 172.50  E-value: 4.44e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 350 YALIIFEIVHRTLAAMLGSLAALAALAVigdrpSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGR 429
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVL-----TPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 430 VWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNqelrkM 509
Cdd:pfam03600  76 PRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASA-----L 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034590840 510 GLDFAGFTAHMFIGICLVLLV-CFPLLRLLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRIS 570
Cdd:pfam03600 151 GLSFGDFGFFMFPPVGVALLLvGLLPLLLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAIS 212
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 350-565 6.60e-46

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 167.81  E-value: 6.60e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 350 YALIIFEIVHRTLAAMLGSLAALAALAVigdrpSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGR 429
Cdd:cd00625     1 YVLIRPEKLPRAVVALLGAVLLVLLGVV-----SPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 430 VWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQelrkm 509
Cdd:cd00625    76 RRLLLLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPPVPLLLALAFAANIGGAATPIGNPPNLIIASLS----- 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034590840 510 GLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIVELKHEIHVWRLT 565
Cdd:cd00625   151 GLGFLDFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEDKLTVLAEPLPARPLLK 206
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 382-564 1.39e-27

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 115.07  E-value: 1.39e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 382 PSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGrVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVT 461
Cdd:cd01117    30 ISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGS-PRRLLFLLVLLSGILSALLTNDTACLVFTPIV 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 462 IRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSnqelrKMGLDFAGFTAHM--FIGICLVLLVCfpLLRLLY 539
Cdd:cd01117   109 LELARVAGLPPIPLLLALATAANIGSAATPIGNPQNLLIAS-----ESGISFPFFLAAMapLALLGLLLLLI--LLLVLF 181

                         170       180
                  ....*....|....*....|....*
gi 1034590840 540 WnRKLYNKEPSEIVELKHEIHVWRL 564
Cdd:cd01117   182 P-GELKGLPLDKATKEEGVGARKLA 205
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
400-576 6.56e-17

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 82.89  E-value: 6.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 400 FGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLD-----PRQ 474
Cdd:COG0471     1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEkrskfGSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 475 VLIAEVIFTNIGGAATAIGDPPNVIIVSN-QELRKMGLDFAGFTAHMF-IGICLVLLVCFPLLRLLywnrklynkePSEI 552
Cdd:COG0471    81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLlEEATGIPISFFEWMLVGLpVALVGLLLLWLVLYRLL----------PPEI 150

                         170       180
                  ....*....|....*....|....
gi 1034590840 553 VELKHEIHVWRLTAQRISPASREE 576
Cdd:COG0471   151 KEVPGSKEVIREELAELGPLSRRE 174
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 398-539 8.26e-15

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 76.85  E-value: 8.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 398 LLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLI 477
Cdd:cd01115    51 LFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLM 130

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034590840 478 AEVIFTNIGGAATAIGDPPNVIIVSnqELRKMGLDFAGFTAHMFIGIcLVLLVCFPLLRLLY 539
Cdd:cd01115   131 PLAFAASIGGMLTLIGTPPNLVASG--YLESLGGQGFSFFEFTPIGL-PLLIIGLLYLWFIF 189
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
381-540 1.43e-14

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 76.32  E-value: 1.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 381 RPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPV 460
Cdd:COG1055   258 RVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPL 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 461 TIRLCEVLNLDPrqVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYW 540
Cdd:COG1055   338 IPDLGATGNPEP--LWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISFGEFLKVGLPLTLLTLLIALLYLLLLYF 415
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 386-535 9.43e-14

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 73.44  E-value: 9.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 386 HVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLc 465
Cdd:cd00625   252 EVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASL- 330

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 466 evlnLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIGICLVLLVCFPLL 535
Cdd:cd00625   331 ----APPEPAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGISFGEFLKVGLPLTLLSLVVSLLYL 396
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
384-537 1.06e-12

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 70.18  E-value: 1.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 384 LTHVVEW------IDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRG-RVWAMIIMLCLIAAVLSAFLDNVTTMLL 456
Cdd:COG0471   211 LTGVLTWkdayksIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGlSPLLLLLLLALLTLLLTEFASNTATAAL 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 457 FTPVTIRLCEVLNLDPRQVLIAeVIFTNIGGAATAIGDPPNVII-----VSNQELRKMGLDFagftahMFIGICLVLLVC 531
Cdd:COG0471   291 LLPIAISLAQALGVNPLPLALA-VAFAASCAFLLPVGTPPNAIVygsgyYKFKDFLKVGLPL------NLIGLVVLLLLG 363


                  ....*.
gi 1034590840 532 FPLLRL 537
Cdd:COG0471   364 PLWWPL 369
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 399-539 1.17e-12

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 70.37  E-value: 1.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 399 LFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIA 478
Cdd:cd01118    58 LIGVILLSLLLDEEGFFEWVAALAARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNRTLPF 137

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034590840 479 EVIFTNIGGAATA---IGDPPNVIIVSNqelrkMGLDFAGFTAHMFIGICLVLLVCFPLLRLLY 539
Cdd:cd01118   138 LYACAFIADAASLplpISNLVNIVTAGY-----FGIGFTEYAALMFLPSIVSILATYVVLYLFF 196
PLN00136 PLN00136
silicon transporter; Provisional
 391-540 3.99e-11

silicon transporter; Provisional


Pssm-ID: 215070 [Multi-domain]  Cd Length: 482  Bit Score: 65.79  E-value: 3.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 391 IDFETLALLFGMMILVAIFSETGFFDYCA-VKAYRLSRGRvwAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLN 469
Cdd:PLN00136   61 IDLPILGLLFATMVVGSYLKNAGMFKHLGrLLAWRSQGGR--DLLCRVCVVTALASALFTNDTCCVVLTEFVLELAAERN 138

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034590840 470 LDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLdFAGFTAHMFIG--ICLVLLVCfpllrlLYW 540
Cdd:PLN00136  139 LPAKPFLLALASSANIGSSATPIGNPQNLVIAFNSKITFPKF-LLGILPAMLAGmaVNMVMLLC------MYW 204
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 378-516 1.57e-09

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 60.34  E-value: 1.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 378 IGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLF 457
Cdd:cd01116   255 LADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWISALLSAFIDNIPVTATM 334

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034590840 458 TPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGF 516
Cdd:cd01116   335 IPIVKDLASQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEF 393
CitMHS pfam03600
Citrate transporter;
341-477 4.12e-09

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 58.86  E-value: 4.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 341 IATAILAGVYALIIFEIVhrtlaAMLGSLAALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAV 420
Cdd:pfam03600 207 LLLAISALVLALVILGFL-----LLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALAD 281

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034590840 421 KAYRLSrgRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLI 477
Cdd:pfam03600 282 ALGGLS--GLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 391-539 4.50e-08

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 55.67  E-value: 4.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 391 IDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRG-RVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLN 469
Cdd:cd01115   239 IDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLGGlPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLG 318

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034590840 470 LDPRQVLIAEVIftnIGGAA--TAIGDPPNVIIVSNQELRKMglDFagFTAHMFIGIcLVLLVCFPLLRLLY 539
Cdd:cd01115   319 LPPEALLLAVAI---GASCAfmLPVGTPPNAIVLGPGGYKFS--DF--AKVGLPLSI-LSLVVSVTMIPLIW 382
PRK15445 PRK15445
arsenical efflux pump membrane protein ArsB;
378-476 1.97e-07

arsenical efflux pump membrane protein ArsB;


Pssm-ID: 185342  Cd Length: 427  Bit Score: 54.02  E-value: 1.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 378 IGDRPSLTHVVeWidFETLALLfGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLF 457
Cdd:PRK15445   42 LGDVPVVWGIV-W--NATLTFI-AIIIISLLLDEAGFFEWAALHVARWAKGNGRKLFVYIVLLGAAVAALFANDGAALIL 117

                          90
                  ....*....|....*....
gi 1034590840 458 TPVTIRLCEVLNLDPRQVL 476
Cdd:PRK15445  118 TPIVLAMLLALGFSKKATL 136
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 384-535 6.09e-06

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 49.26  E-value: 6.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 384 LTHVVEW-------IDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIM--LCLIAAVLSAFLDNVTTM 454
Cdd:TIGR00785 285 FLGIVTWkdiqknkVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLvlVVLFYIILYFFASNTAHT 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 455 LLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVII-----VSNQELRKMGLDFAgftahmFIGICLVLL 529
Cdd:TIGR00785 365 AALVPIFFSVASAQGIPLELLALALALSASLMGFLTPYATPPNAIAygsgyVKIKDMWRVGAIIG------IVGLIVLLL 438


                  ....*.
gi 1034590840 530 VCFPLL 535
Cdd:TIGR00785 439 VGTLWW 444
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 384-500 7.92e-04

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 42.36  E-value: 7.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590840 384 LTHVVEWID-------FETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAM--IIMLCLIAAVLSAFLDNVTTM 454
Cdd:pfam00939 306 LLRILDWKDivknkgaWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMafIIILSLFYLSHYLFASATAHT 385

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1034590840 455 LLFTPVTIRLCEVLNLDPRQVLIAEVIF-TNIGGAATAIGDPPNVII 500
Cdd:pfam00939 386 AAMLPIFAAVAQAIPGAPPLLAALLLGFaISLGGFLTPYGTGPGPIY 432
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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