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Conserved domains on  [gi|1034656057|ref|XP_016867846|]
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serum paraoxonase/arylesterase 2 isoform X2 [Homo sapiens]

Protein Classification

Arylesterase domain-containing protein( domain architecture ID 10484254)

Arylesterase domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 97-182 1.50e-47

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


:

Pssm-ID: 334656  Cd Length: 86  Bit Score: 153.39  E-value: 1.50e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034656057  97 NDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHV 176
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 1034656057 177 LEKHTN 182
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 36-226 1.56e-12

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 66.07  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034656057  36 FDLASFNPHGIstFIDNDDTvyLFVVNHpefknTVEIFKFEEAENSLLHLKTVKHELLPSVNDItAVGPA-HFYATNDHY 114
Cdd:COG3386    44 FAEPSGRPNGL--AFDPDGR--LLVADH-----GRGLVRFDPADGEVTVLADEYGKPLNRPNDG-VVDPDgRLYFTDMGE 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034656057 115 FSDPflkyletylnlhwANVVYYSPN-EVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVL-- 191
Cdd:COG3386   114 YLPT-------------GALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDADGTLGNRRVFad 180

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1034656057 192 --ELDTLVDNLSIDpSSGDIWVgCHPNGQKLFVYDPN 226
Cdd:COG3386   181 lpDGPGGPDGLAVD-ADGNLWV-ALWGGGGVVRFDPD 215
 
Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 97-182 1.50e-47

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


Pssm-ID: 334656  Cd Length: 86  Bit Score: 153.39  E-value: 1.50e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034656057  97 NDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHV 176
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 1034656057 177 LEKHTN 182
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 36-226 1.56e-12

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 66.07  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034656057  36 FDLASFNPHGIstFIDNDDTvyLFVVNHpefknTVEIFKFEEAENSLLHLKTVKHELLPSVNDItAVGPA-HFYATNDHY 114
Cdd:COG3386    44 FAEPSGRPNGL--AFDPDGR--LLVADH-----GRGLVRFDPADGEVTVLADEYGKPLNRPNDG-VVDPDgRLYFTDMGE 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034656057 115 FSDPflkyletylnlhwANVVYYSPN-EVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVL-- 191
Cdd:COG3386   114 YLPT-------------GALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDADGTLGNRRVFad 180

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1034656057 192 --ELDTLVDNLSIDpSSGDIWVgCHPNGQKLFVYDPN 226
Cdd:COG3386   181 lpDGPGGPDGLAVD-ADGNLWV-ALWGGGGVVRFDPD 215
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 134-179 3.68e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 37.95  E-value: 3.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034656057 134 VVYYSPNEVKV----VAEGFDSANGINISPDDKYIYVADILAHEIHVLEK 179
Cdd:cd14962    80 VFVFDRDGKFLraigAGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDL 129
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
142-218 8.57e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 36.98  E-value: 8.57e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034656057 142 VKVVAEGfDSANGINISPDDKYIYVADILAHEIHVLEKHTNmnlTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQ 218
Cdd:COG3391   103 VATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSVIDTATG---KVVATIPVGAGPHGIAVDPDGKRLYVANSGSNT 175
 
Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 97-182 1.50e-47

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


Pssm-ID: 334656  Cd Length: 86  Bit Score: 153.39  E-value: 1.50e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034656057  97 NDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHV 176
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 1034656057 177 LEKHTN 182
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 36-226 1.56e-12

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 66.07  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034656057  36 FDLASFNPHGIstFIDNDDTvyLFVVNHpefknTVEIFKFEEAENSLLHLKTVKHELLPSVNDItAVGPA-HFYATNDHY 114
Cdd:COG3386    44 FAEPSGRPNGL--AFDPDGR--LLVADH-----GRGLVRFDPADGEVTVLADEYGKPLNRPNDG-VVDPDgRLYFTDMGE 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034656057 115 FSDPflkyletylnlhwANVVYYSPN-EVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVL-- 191
Cdd:COG3386   114 YLPT-------------GALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDADGTLGNRRVFad 180

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1034656057 192 --ELDTLVDNLSIDpSSGDIWVgCHPNGQKLFVYDPN 226
Cdd:COG3386   181 lpDGPGGPDGLAVD-ADGNLWV-ALWGGGGVVRFDPD 215
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 97-226 2.30e-06

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 47.64  E-value: 2.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034656057  97 NDItAVGPA-HFYATNDHYFSDPflkyletylNLHWANVVYYSPN-EVKVVAEGFDSANGINISPDDKYIYVADILAHEI 174
Cdd:pfam08450  89 NDG-KVDPDgRFWFGTMGDDEAP---------GGDPGALYRLDPDgKLTRVLDGLTISNGLAWSPDGRTLYFADSPARKI 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034656057 175 HVLE-KHTNMNLTQLKVL----ELDTLVDNLSIDpSSGDIWVgCHPNGQKLFVYDPN 226
Cdd:pfam08450 159 WAYDyDLDGGLISNRRVFadfkPGLGRPDGMAVD-AEGNVWV-ARWGGGKVVRFDPD 213
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
140-227 7.51e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 7.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034656057 140 NEVKVVAEGfDSANGINISPDDKYIYVADILAHEIHVLekhtnmnltqlkVLELDT----LVDNLSIDPSSGDIWVgcHP 215
Cdd:COG3391   143 KVVATIPVG-AGPHGIAVDPDGKRLYVANSGSNTVSVI------------VSVIDTatgkVVATIPVGGGPVGVAV--SP 207

                          90
                  ....*....|..
gi 1034656057 216 NGQKLFVYDPNN 227
Cdd:COG3391   208 DGRRLYVANRGS 219
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 134-179 3.68e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 37.95  E-value: 3.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034656057 134 VVYYSPNEVKV----VAEGFDSANGINISPDDKYIYVADILAHEIHVLEK 179
Cdd:cd14962    80 VFVFDRDGKFLraigAGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDL 129
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
142-218 8.57e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 36.98  E-value: 8.57e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034656057 142 VKVVAEGfDSANGINISPDDKYIYVADILAHEIHVLEKHTNmnlTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQ 218
Cdd:COG3391   103 VATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSVIDTATG---KVVATIPVGAGPHGIAVDPDGKRLYVANSGSNT 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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