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Conserved domains on  [gi|1034646479|ref|XP_016865453|]
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adhesion G-protein coupled receptor V1 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
 5925-6164 3.14e-31

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15040:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 253  Bit Score: 125.76  E-value: 3.14e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5925 GLCLAVLSHIFCARY-SMFAAKLLTHMMAASLGTQILFLASAYASPQLAEesCSAMAAVTHYLYLCQFSWMLIQSVNFWY 6003
Cdd:cd15040     18 GLLLTIITYILFRKLrKRKPTKILLNLCLALLLANLLFLFGINSTDNPVL--CTAVAALLHYFLLASFMWMLVEALLLYL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6004 VLVM-NDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSmsqiyglihGDLCFIPNVYAALFtAALVPLTCLVVV- 6081
Cdd:cd15040     96 RLVKvFGTYPRHFILKYALIGWGLPLIIVIITLAVDPDSYGNS---------SGYCWLSNGNGLYY-AFLGPVLLIILVn 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6082 FVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFIL 6161
Cdd:cd15040    166 LVIFVLVLRKLLRLSAKRNKKKRKKTKAQLRAAVSLFFLLGLTWIFGILAIFGARVVFQYLFAIFNSLQGFFIFIFHCLR 245


                   ...
gi 1034646479 6162 HNQ 6164
Cdd:cd15040    246 NKE 248
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4290-4494 5.86e-18

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 92.55  E-value: 5.86e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4290 VNITIIRSSGDFG-HVRLWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQgrg 4368
Cdd:TIGR00845  418 VALTVVRRGGDLTnTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVG--- 494

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4369 ydftiQENGLQIDQPPE----IGNISIVRIIIMKNDNAeGIIEFDPKYtaFEVEEDVGLIMIPVVRLHGTYGYVTADFIS 4444
Cdd:TIGR00845  495 -----SEDGILEANHVSavaqLASPNTATVTILDDDHA-GIFTFEEDV--FHVSESIGIMEVKVLRTSGARGTVIVPYRT 566

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4445 QSSSASPGGVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILL 4494
Cdd:TIGR00845  567 VEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 1346-1495 4.83e-17

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


:

Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 81.66  E-value: 4.83e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1346 PSRNNTIANFTFSAWVMPNANTNGF-IIAKDDGNGSIYygvkIQTNESHVTLSLHYKTLGSNATYIAKTTVmkylEESVW 1424
Cdd:pfam13385   10 PDALLPTSDFTVSAWVKPDSLPGWArAIISSSGGGGYS----LGLDGDGRLRFAVNGGNGGWDTVTSGASV----PLGQW 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034646479 1425 LHLLIILEDGIIEFYLDGNAMPRGikSLKGEAITDGPGILRIGAGINGNDRFTGLMQDVRSYERKLTLEEI 1495
Cdd:pfam13385   82 THVAVTYDGGTLRLYVNGVLVGSS--TLTGGPPPGTGGPLYIGRSPGGDDYFNGLIDEVRIYDRALSAAEI 150
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1729-1946 1.31e-15

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 84.84  E-value: 1.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1729 HITVEEEDGEIRLLVIRAQGLLGR-VTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKVE 1807
Cdd:TIGR00845  408 HYTCLENCGTVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVR 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1808 LLNLeggaelfRVdgsgsGDGDMEFFLPTIHKRASLGVASQILVTIAASDHAhGVFEFSPESLFVSgtepeDGYSTVTLN 1887
Cdd:TIGR00845  488 LSNL-------RV-----GSEDGILEANHVSAVAQLASPNTATVTILDDDHA-GIFTFEEDVFHVS-----ESIGIMEVK 549

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034646479 1888 VIRHHGTLSPVTL-HWNIDSDPDG---DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAF 1946
Cdd:TIGR00845  550 VLRTSGARGTVIVpYRTVEGTARGggkDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTF 612
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2494-2674 3.05e-15

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 83.69  E-value: 3.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2494 GQAVAGSDYEPvTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLislleVHLMNISASLKNQPTI----------GQPN 2563
Cdd:TIGR00845  442 GTANAGSDYEF-TEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFY-----VRLSNLRVGSEDGILEanhvsavaqlASPN 515

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2564 ISTVVIaLNGDAFGVFviynispnTSEDGLFvEVQEQPQTlVELMIHRTGGSLGQVAVEWRVVGGTATEGL-DFIGAGEI 2642
Cdd:TIGR00845  516 TATVTI-LDDDHAGIF--------TFEEDVF-HVSESIGI-MEVKVLRTSGARGTVIVPYRTVEGTARGGGkDFEDTCGE 584

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1034646479 2643 LTFAEGETKKTVILTILDDSEPEDDESIIVSL 2674
Cdd:TIGR00845  585 LEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1626-1808 3.53e-13

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 77.14  E-value: 3.53e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1626 DFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYFRVTL--VSAIPGDGKLGSTPTSGASIDPEKETTDITIKASDHPy 1703
Cdd:TIGR00845  449 DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsnLRVGSEDGILEANHVSAVAQLASPNTATVTILDDDHA- 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1704 GLLQFSTglppqpkdamtlpassvPHITVEEEDGEIRLLVIRAQGLLGRVTAEFRTVSLTA-FSPEDYQNVAGTLEFQPG 1782
Cdd:TIGR00845  528 GIFTFEE-----------------DVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTArGGGKDFEDTCGELEFEND 590

                          170       180
                   ....*....|....*....|....*.
gi 1034646479 1783 ERYKYIFINITDNSIPELEKSFKVEL 1808
Cdd:TIGR00845  591 ETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1000-1207 1.39e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 75.21  E-value: 1.39e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1000 NDDPI-YFAEPRVVRVQE--GETANFTVLRNGSVDVTCMVQYATKDGKATARErDFIPVEKgeTLIFEVGSRQQSISIFV 1076
Cdd:TIGR00845  396 NDPVSkIFFEPGHYTCLEncGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGS-DYEFTEG--TLVFKPGETQKEFRIGI 472

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1077 NEDGIPETDEPFYIILLN-----------STGDTVVYQYG---VATVIIeANDDPNGIFSLE-PIDKAVEEGKTNAFWIL 1141
Cdd:TIGR00845  473 IDDDIFEEDEHFYVRLSNlrvgsedgileANHVSAVAQLAspnTATVTI-LDDDHAGIFTFEeDVFHVSESIGIMEVKVL 551

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034646479 1142 RHRGYFGSVSVSWQLfQNDSALQPGQEFYETSGTVNFMDGEEAKPIILHAFPDKIPEFNEFYFLKL 1207
Cdd:TIGR00845  552 RTSGARGTVIVPYRT-VEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3799-4011 2.62e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 74.06  E-value: 2.62e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3799 ENTTTLQLQIARDKGLLGDIA-IHLRAQpnfllhvDNQATENEDYVLQETIIIMKENIKEAHAEVSILPDDLPELEEGFI 3877
Cdd:TIGR00845  413 ENCGTVALTVVRRGGDLTNTVyVDYRTE-------DGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFY 485

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3878 VTITEVNLVNSDFSTGQPSVRRPGM----EIAEIMIEENDDPrGIFMF-----HVTRGAGEVitayevppplnvlQVPVV 3948
Cdd:TIGR00845  486 VRLSNLRVGSEDGILEANHVSAVAQlaspNTATVTILDDDHA-GIFTFeedvfHVSESIGIM-------------EVKVL 551

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034646479 3949 RLAGSFGAVNVYWKASPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISL 4011
Cdd:TIGR00845  552 RTSGARGTVIVPYRTVEGTArgGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2968-3180 3.18e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 74.06  E-value: 3.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2968 IEWQQSRFEVNETHGSLTLVAQRSREPLGHVSLFVY-AQNLEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEGD 3046
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYrTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEED 481

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3047 EKFQLILTNPSPGLELG---KNTIALIIVLAN----------DDGPGVLSFNNSEhfflreptaLYVQESVAVLYIVREP 3113
Cdd:TIGR00845  482 EHFYVRLSNLRVGSEDGileANHVSAVAQLASpntatvtildDDHAGIFTFEEDV---------FHVSESIGIMEVKVLR 552

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034646479 3114 AQGLFGTVTVQFIVTEVNSSNESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3180
Cdd:TIGR00845  553 TSGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEP 619
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1998-2204 1.38e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 71.75  E-value: 1.38e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1998 LSIIRLKGLMGK-VLVSYATLDdmekppyfppnlARATQGRDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIE 2076
Cdd:TIGR00845  420 LTVVRRGGDLTNtVYVDYRTED------------GTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVR 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2077 LLNstlvAKVQSRsipNSPRLGPKVETIAQL-------IIIANDDAFGTLQLSAPIVRVAENhVGPI-INVTRTGGAFAD 2148
Cdd:TIGR00845  488 LSN----LRVGSE---DGILEANHVSAVAQLaspntatVTILDDDHAGIFTFEEDVFHVSES-IGIMeVKVLRTSGARGT 559

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034646479 2149 VSVKFKAVPITAIAG-EDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQL 2204
Cdd:TIGR00845  560 VIVPYRTVEGTARGGgKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 53-236 1.53e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 71.75  E-value: 1.53e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479   53 LIIERIGEPANVTAIVSLYGED----AG-DFFDTYAAAFIPAGETNRTVYIAVCDDDLPEPDETFIFHLT---------- 117
Cdd:TIGR00845  420 LTVVRRGGDLTNTVYVDYRTEDgtanAGsDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSnlrvgsedgi 499

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  118 LQKPSANVK--LGWPRTVTVTILSNDNAfGIISFNMlPSIAVSEPKGRnesMPLTLIREKGTYGMVMVTFE-VEGGPNPP 194
Cdd:TIGR00845  500 LEANHVSAVaqLASPNTATVTILDDDHA-GIFTFEE-DVFHVSESIGI---MEVKVLRTSGARGTVIVPYRtVEGTARGG 574

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1034646479  195 DEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQL 236
Cdd:TIGR00845  575 GKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2139-2322 9.02e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 69.05  E-value: 9.02e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2139 VTRTGGAFAD-VSVKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQLMNETTGG------ 2211
Cdd:TIGR00845  422 VVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSedgile 501

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2212 -------ARLGALTEAVIIIeASDDPYGLFGFQITKLIVEEpefNSVKVNLPIIRNSGTLGNVTVQWvATINGQlATG-- 2282
Cdd:TIGR00845  502 anhvsavAQLASPNTATVTI-LDDDHAGIFTFEEDVFHVSE---SIGIMEVKVLRTSGARGTVIVPY-RTVEGT-ARGgg 575

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1034646479 2283 -DLRVVSGNVTFAPGETIQTLLLEVLADDVPEIEEVIQVQL 2322
Cdd:TIGR00845  576 kDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3591-3732 1.69e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 68.28  E-value: 1.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3591 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPKGGAEIGINDS--------------VTITILSNDDA 3656
Cdd:TIGR00845  448 SDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEDGILEAnhvsavaqlaspntATVTILDDDHA 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3657 yGIVAFaQNSLYKQVEEMeqdSLVTLNVERLKGTYGRI-----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTILA 3731
Cdd:TIGR00845  528 -GIFTF-EEDVFHVSESI---GIMEVKVLRTSGARGTVivpyrTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVD 602


                   .
gi 1034646479 3732 D 3732
Cdd:TIGR00845  603 D 603
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2605-2788 7.03e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 66.35  E-value: 7.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2605 VELMIHRTGGSLGQ-VAVEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSEPEDDESIIVSL----VYTEG 2679
Cdd:TIGR00845  418 VALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsnlrVGSED 497

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2680 GsrILPSSDTVRVNILAN----------DNVAGIVSFQTASRSVIGHEGeILQFHVIRTFPGRGNVTVNWKIIGQNLELN 2749
Cdd:TIGR00845  498 G--ILEANHVSAVAQLASpntatvtildDDHAGIFTFEEDVFHVSESIG-IMEVKVLRTSGARGTVIVPYRTVEGTARGG 574

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1034646479 2750 FANFS---GQLFFPEGSLNTTLFVHLLDDNIPEEKEVYQVIL 2788
Cdd:TIGR00845  575 GKDFEdtcGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 859-1092 3.01e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.49  E-value: 3.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  859 VLSSHGERE-SKLGSATIVNITILKNDDPHGIieFVSDGLIVMInESKGdaiysAVYDVVRNRGnfGDVSVSWVV----- 932
Cdd:TIGR00845  371 ILKKHAADAaRKAVSMHEVATDDEENDPVSKI--FFEPGHYTCL-ENCG-----TVALTVVRRG--GDLTNTVYVdyrte 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  933 --SPDFTQDVFPVQGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVILLN--------------GTGGAKVGNRTTATLR 996
Cdd:TIGR00845  441 dgTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNlrvgsedgileanhVSAVAQLASPNTATVT 520

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  997 IRRNDDPIYFA-EPRVVRVQEG-ETANFTVLRNGSVDVTCMVQYATKDGKATARERDFIPVEkGEtLIFEVGSRQQSISI 1074
Cdd:TIGR00845  521 ILDDDHAGIFTfEEDVFHVSESiGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGKDFEDTC-GE-LEFENDETEKTIRV 598

                          250
                   ....*....|....*...
gi 1034646479 1075 FVNEDGIPETDEPFYIIL 1092
Cdd:TIGR00845  599 KIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1503-1693 3.31e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.49  E-value: 3.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKL--VSVYGGARISEENT-----------TARLTIQKSD 1569
Cdd:TIGR00845  446 AGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsnLRVGSEDGILEANHvsavaqlaspnTATVTILDDD 525

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1570 NAnGLFGFTGACIpEIAEEGSTISCVVERTRGALDYVHV-FYTISQIETDGinylVDDFANASGTITFLPWQRSEVLNIY 1648
Cdd:TIGR00845  526 HA-GIFTFEEDVF-HVSESIGIMEVKVLRTSGARGTVIVpYRTVEGTARGG----GKDFEDTCGELEFENDETEKTIRVK 599

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1034646479 1649 VLDDDIPELNEYFRVTLVSA--IPGDGKLGSTPTSGASIDPEKETTD 1693
Cdd:TIGR00845  600 IVDDEEYEKNDTFFIELGEPrwAKRGIKAALLLNETITDDDQKLTSK 646
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 5046-5342 2.12e-06

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 54.80  E-value: 2.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5046 VSYQTTAGSAKPLEDFEPVQnGELFFQKFQTEVDFEITIINDQLSEIEEFFYINLTSVEIRglqkfdvnwsprlnldfsv 5125
Cdd:TIGR00845  435 VDYRTEDGTANAGSDYEFTE-GTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVG------------------- 494

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5126 avitildndDLAGMdisfpettvavavdttlipvetesttylstsktttilqptnvvaivTEATGVSAIpeklvtlhgtp 5205
Cdd:TIGR00845  495 ---------SEDGI----------------------------------------------LEANHVSAV----------- 508

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5206 AVSEKPDVATVTANVSIH-GTFSLGPSIVYIEEEMknGTFntaEVLIRRTGGFTGNVSItvktfgercaqmepnalPFRG 5284
Cdd:TIGR00845  509 AQLASPNTATVTILDDDHaGIFTFEEDVFHVSESI--GIM---EVKVLRTSGARGTVIV-----------------PYRT 566

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034646479 5285 IYGisnlTWAVEEEDFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQ 5342
Cdd:TIGR00845  567 VEG----TARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPR 620
Calx-beta super family cl02522
Calx-beta domain;
4038-4128 5.92e-06

Calx-beta domain;


The actual alignment was detected with superfamily member pfam03160:

Pssm-ID: 413355 [Multi-domain]  Cd Length: 91  Bit Score: 48.01  E-value: 5.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4038 GVFGFEEKTVMIDESlssddpDSYVTLTVVRSPG-GKGTVRLE-WTIDEKAKHN--LSPLNGTLHFDETESQKTIVLHTL 4113
Cdd:pfam03160    2 GVIGFEPPTYQVSEN------DGVAEVCVVRMSGtLRRTVVVPyRTEDGTATAGddYEPVEGELVFGPGETEKCINVTII 75

                           90
                   ....*....|....*
gi 1034646479 4114 QDTVLEEDRRFTIQL 4128
Cdd:pfam03160   76 DDDVYEGDENFFVLL 90
GPS super family cl02559
GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for ...
 5859-5901 6.59e-05

GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for auto-proteolysis, so is thus named, GPS. The GPS motif is a conserved sequence of ~40 amino acids containing canonical cysteine and tryptophan residues, and is the most highly conserved part of the domain. In most, if not all, cell-adhesion GPCRs these undergo autoproteolysis in the GPS between a conserved aliphatic residue (usually a leucine) and a threonine, serine, or cysteine residue. In higher eukaryotes this motif is found embedded in the C-terminal beta-stranded part of a GAIN domain - GPCR-Autoproteolysis INducing (GAIN). The GAIN-GPS domain adopts a fold in which the GPS motif, at the C-terminus, forms five beta-strands that are tightly integrated into the overall GAIN domain. The GPS motif, evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations. The GAIN-GPS domain is both necessary and sufficient functionally for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment in the GPS to catalyze peptide bond hydrolysis. In the cell-adhesion GPCRs and PKD proteins, the GPS motif is always located at the end of their long N-terminal extracellular regions, immediately before the first transmembrane helix of the respective protein.


The actual alignment was detected with superfamily member smart00303:

Pssm-ID: 470616  Cd Length: 49  Bit Score: 43.53  E-value: 6.59e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1034646479  5859 TSLCLLWNQAAASWlsDSQFCKVVEETADYVECACSHMSVYAV 5901
Cdd:smart00303    2 NPICVFWDESSGEW--STRGCELLETNGTHTTCSCNHLTTFAV 42
Calx-beta super family cl02522
Calx-beta domain;
2849-2931 1.79e-04

Calx-beta domain;


The actual alignment was detected with superfamily member pfam03160:

Pssm-ID: 413355 [Multi-domain]  Cd Length: 91  Bit Score: 43.78  E-value: 1.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2849 TIQLFINREFGSL-GAINVTYTTVPGMlslknqtvgnlAEPEVDFVPIIGFLILEEGETAAAINITILEDDVPELEEYFL 2927
Cdd:pfam03160   19 VAEVCVVRMSGTLrRTVVVPYRTEDGT-----------ATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFF 87


                   ....
gi 1034646479 2928 VNLT 2931
Cdd:pfam03160   88 VLLS 91
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 3402-3443 2.35e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 41.69  E-value: 2.35e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034646479 3402 FVLHQKLPVRGVLTVALFNKGGSVFLAISQANArlNSLLFRW 3443
Cdd:pfam03736    2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSG--DSVIYRW 41
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 5299-5393 3.02e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 47.86  E-value: 3.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5299 DFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQ--IVEEKDDTGFAAFAM-----VIITGSDlHN 5371
Cdd:TIGR00845  449 DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEdgILEANHVSAVAQLASpntatVTILDDD-HA 527

                           90       100
                   ....*....|....*....|....*...
gi 1034646479 5372 GIIGFSE------ESQSGLELRegaVMR 5393
Cdd:TIGR00845  528 GIFTFEEdvfhvsESIGIMEVK---VLR 552
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 330-487 3.60e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 47.48  E-value: 3.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  330 TVVFPPFIHESHLKFQIVDDTIPEIAESFHI------------MLLKDTLQGDAVLISPSVVQVTIKPNDKPyGVLSFNS 397
Cdd:TIGR00845  456 TLVFKPGETQKEFRIGIIDDDIFEEDEHFYVrlsnlrvgsedgILEANHVSAVAQLASPNTATVTILDDDHA-GIFTFEE 534

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  398 VLFERTVIIDEdrisryEEITVVRNGGTHGNVSANWvLTRNSTdPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDLP 477
Cdd:TIGR00845  535 DVFHVSESIGI------MEVKVLRTSGARGTVIVPY-RTVEGT-ARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEY 606

                          170
                   ....*....|
gi 1034646479  478 EEAEAYLLQI 487
Cdd:TIGR00845  607 EKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4977-5100 7.95e-03

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 42.86  E-value: 7.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4977 EAFVLHLSGVQSSAPGG----------AQLRSGFI----VAEIEPMGVFQFSTSSrnIIVSEDTQMIRLHVQRLFGFHSD 5042
Cdd:TIGR00845  482 EHFYVRLSNLRVGSEDGileanhvsavAQLASPNTatvtILDDDHAGIFTFEEDV--FHVSESIGIMEVKVLRTSGARGT 559

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034646479 5043 LIkVSYQTTAGSAK-PLEDFEPVQnGELFFQKFQTEVDFEITIINDQLSEIEEFFYINL 5100
Cdd:TIGR00845  560 VI-VPYRTVEGTARgGGKDFEDTC-GELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
 
Name Accession Description Interval E-value
7tmB2_Adhesion cd15040
adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G ...
 5925-6164 3.14e-31

adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G protein-coupled receptors; The B2 subfamily of class B GPCRs consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320168 [Multi-domain]  Cd Length: 253  Bit Score: 125.76  E-value: 3.14e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5925 GLCLAVLSHIFCARY-SMFAAKLLTHMMAASLGTQILFLASAYASPQLAEesCSAMAAVTHYLYLCQFSWMLIQSVNFWY 6003
Cdd:cd15040     18 GLLLTIITYILFRKLrKRKPTKILLNLCLALLLANLLFLFGINSTDNPVL--CTAVAALLHYFLLASFMWMLVEALLLYL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6004 VLVM-NDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSmsqiyglihGDLCFIPNVYAALFtAALVPLTCLVVV- 6081
Cdd:cd15040     96 RLVKvFGTYPRHFILKYALIGWGLPLIIVIITLAVDPDSYGNS---------SGYCWLSNGNGLYY-AFLGPVLLIILVn 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6082 FVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFIL 6161
Cdd:cd15040    166 LVIFVLVLRKLLRLSAKRNKKKRKKTKAQLRAAVSLFFLLGLTWIFGILAIFGARVVFQYLFAIFNSLQGFFIFIFHCLR 245


                   ...
gi 1034646479 6162 HNQ 6164
Cdd:cd15040    246 NKE 248
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4290-4494 5.86e-18

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 92.55  E-value: 5.86e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4290 VNITIIRSSGDFG-HVRLWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQgrg 4368
Cdd:TIGR00845  418 VALTVVRRGGDLTnTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVG--- 494

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4369 ydftiQENGLQIDQPPE----IGNISIVRIIIMKNDNAeGIIEFDPKYtaFEVEEDVGLIMIPVVRLHGTYGYVTADFIS 4444
Cdd:TIGR00845  495 -----SEDGILEANHVSavaqLASPNTATVTILDDDHA-GIFTFEEDV--FHVSESIGIMEVKVLRTSGARGTVIVPYRT 566

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4445 QSSSASPGGVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILL 4494
Cdd:TIGR00845  567 VEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 1346-1495 4.83e-17

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 81.66  E-value: 4.83e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1346 PSRNNTIANFTFSAWVMPNANTNGF-IIAKDDGNGSIYygvkIQTNESHVTLSLHYKTLGSNATYIAKTTVmkylEESVW 1424
Cdd:pfam13385   10 PDALLPTSDFTVSAWVKPDSLPGWArAIISSSGGGGYS----LGLDGDGRLRFAVNGGNGGWDTVTSGASV----PLGQW 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034646479 1425 LHLLIILEDGIIEFYLDGNAMPRGikSLKGEAITDGPGILRIGAGINGNDRFTGLMQDVRSYERKLTLEEI 1495
Cdd:pfam13385   82 THVAVTYDGGTLRLYVNGVLVGSS--TLTGGPPPGTGGPLYIGRSPGGDDYFNGLIDEVRIYDRALSAAEI 150
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1729-1946 1.31e-15

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 84.84  E-value: 1.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1729 HITVEEEDGEIRLLVIRAQGLLGR-VTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKVE 1807
Cdd:TIGR00845  408 HYTCLENCGTVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVR 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1808 LLNLeggaelfRVdgsgsGDGDMEFFLPTIHKRASLGVASQILVTIAASDHAhGVFEFSPESLFVSgtepeDGYSTVTLN 1887
Cdd:TIGR00845  488 LSNL-------RV-----GSEDGILEANHVSAVAQLASPNTATVTILDDDHA-GIFTFEEDVFHVS-----ESIGIMEVK 549

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034646479 1888 VIRHHGTLSPVTL-HWNIDSDPDG---DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAF 1946
Cdd:TIGR00845  550 VLRTSGARGTVIVpYRTVEGTARGggkDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTF 612
Calx-beta pfam03160
Calx-beta domain;
4273-4360 2.50e-15

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 74.59  E-value: 2.50e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4273 GRFAFSHEQLRVSEA-QRVNITIIRSSGDF-GHVRLWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEILDDDYPE 4350
Cdd:pfam03160    2 GVIGFEPPTYQVSENdGVAEVCVVRMSGTLrRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYE 81

                           90
                   ....*....|
gi 1034646479 4351 GPEEFSLTIT 4360
Cdd:pfam03160   82 GDENFFVLLS 91
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2494-2674 3.05e-15

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 83.69  E-value: 3.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2494 GQAVAGSDYEPvTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLislleVHLMNISASLKNQPTI----------GQPN 2563
Cdd:TIGR00845  442 GTANAGSDYEF-TEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFY-----VRLSNLRVGSEDGILEanhvsavaqlASPN 515

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2564 ISTVVIaLNGDAFGVFviynispnTSEDGLFvEVQEQPQTlVELMIHRTGGSLGQVAVEWRVVGGTATEGL-DFIGAGEI 2642
Cdd:TIGR00845  516 TATVTI-LDDDHAGIF--------TFEEDVF-HVSESIGI-MEVKVLRTSGARGTVIVPYRTVEGTARGGGkDFEDTCGE 584

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1034646479 2643 LTFAEGETKKTVILTILDDSEPEDDESIIVSL 2674
Cdd:TIGR00845  585 LEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 4273-4360 5.48e-15

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 73.44  E-value: 5.48e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  4273 GRFAFSHEQLRVSEAQ-RVNITIIRSSGDFGHVRLWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEILDDDYPEG 4351
Cdd:smart00237    2 GSVGFEQPVYTVSESDgEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEK 81


                    ....*....
gi 1034646479  4352 PEEFSLTIT 4360
Cdd:smart00237   82 DETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
1728-1808 5.81e-14

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 70.74  E-value: 5.81e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1728 PHITVEEEDGEIRLLVIRAQGLLGR-VTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKV 1806
Cdd:pfam03160    9 PTYQVSENDGVAEVCVVRMSGTLRRtVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFV 88


                   ..
gi 1034646479 1807 EL 1808
Cdd:pfam03160   89 LL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1728-1809 5.96e-14

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 70.36  E-value: 5.96e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  1728 PHITVEEEDGEIRLLVIRAQGLLGRVTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKVE 1807
Cdd:smart00237    9 PVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVR 88


                    ..
gi 1034646479  1808 LL 1809
Cdd:smart00237   89 LS 90
7tm_2 pfam00002
7 transmembrane receptor (Secretin family); This family is known as Family B, the ...
 5921-6154 1.65e-13

7 transmembrane receptor (Secretin family); This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteriztic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.


Pssm-ID: 459625 [Multi-domain]  Cd Length: 248  Bit Score: 73.85  E-value: 1.65e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5921 ICISGLCLAVLSHIFCA--RYSMFAAKLLTHMMAASLGTQILFLA------SAYASPQLAEESCSAMAAVTHYLYLCQFS 5992
Cdd:pfam00002   12 YSLSLVALLLAIAIFLLfrKLHCTRNYIHLNLFASFILRALLFLVgdavlfNKQDLDHCSWVGCKVVAVFLHYFFLANFF 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5993 WMLIQSV--NFWYVLVMNdehTERRYLLFF-LLSWGLPA-FVVILLIVILKGIYHQsmsqiyglihgDLCFIpNVYAALF 6068
Cdd:pfam00002   92 WMLVEGLylYTLLVEVFF---SERKYFWWYlLIGWGVPAlVVGIWAGVDPKGYGED-----------DGCWL-SNENGLW 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6069 TAALVP-LTCLVVVFVVFIHAYQV--------KPQWKAYDDVFR-GRTNAAEIPL-----ILYLFALISVTWLWgglhma 6133
Cdd:pfam00002  157 WIIRGPiLLIILVNFIIFINIVRIlvqklretNMGKSDLKQYRRlAKSTLLLLPLlgitwVFGLFAFNPENTLR------ 230

                          250       260
                   ....*....|....*....|.
gi 1034646479 6134 yrhFWMLVLFVIFNSLQGLYV 6154
Cdd:pfam00002  231 ---VVFLYLFLILNSFQGFFV 248
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1626-1808 3.53e-13

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 77.14  E-value: 3.53e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1626 DFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYFRVTL--VSAIPGDGKLGSTPTSGASIDPEKETTDITIKASDHPy 1703
Cdd:TIGR00845  449 DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsnLRVGSEDGILEANHVSAVAQLASPNTATVTILDDDHA- 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1704 GLLQFSTglppqpkdamtlpassvPHITVEEEDGEIRLLVIRAQGLLGRVTAEFRTVSLTA-FSPEDYQNVAGTLEFQPG 1782
Cdd:TIGR00845  528 GIFTFEE-----------------DVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTArGGGKDFEDTCGELEFEND 590

                          170       180
                   ....*....|....*....|....*.
gi 1034646479 1783 ERYKYIFINITDNSIPELEKSFKVEL 1808
Cdd:TIGR00845  591 ETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1000-1207 1.39e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 75.21  E-value: 1.39e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1000 NDDPI-YFAEPRVVRVQE--GETANFTVLRNGSVDVTCMVQYATKDGKATARErDFIPVEKgeTLIFEVGSRQQSISIFV 1076
Cdd:TIGR00845  396 NDPVSkIFFEPGHYTCLEncGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGS-DYEFTEG--TLVFKPGETQKEFRIGI 472

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1077 NEDGIPETDEPFYIILLN-----------STGDTVVYQYG---VATVIIeANDDPNGIFSLE-PIDKAVEEGKTNAFWIL 1141
Cdd:TIGR00845  473 IDDDIFEEDEHFYVRLSNlrvgsedgileANHVSAVAQLAspnTATVTI-LDDDHAGIFTFEeDVFHVSESIGIMEVKVL 551

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034646479 1142 RHRGYFGSVSVSWQLfQNDSALQPGQEFYETSGTVNFMDGEEAKPIILHAFPDKIPEFNEFYFLKL 1207
Cdd:TIGR00845  552 RTSGARGTVIVPYRT-VEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3799-4011 2.62e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 74.06  E-value: 2.62e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3799 ENTTTLQLQIARDKGLLGDIA-IHLRAQpnfllhvDNQATENEDYVLQETIIIMKENIKEAHAEVSILPDDLPELEEGFI 3877
Cdd:TIGR00845  413 ENCGTVALTVVRRGGDLTNTVyVDYRTE-------DGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFY 485

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3878 VTITEVNLVNSDFSTGQPSVRRPGM----EIAEIMIEENDDPrGIFMF-----HVTRGAGEVitayevppplnvlQVPVV 3948
Cdd:TIGR00845  486 VRLSNLRVGSEDGILEANHVSAVAQlaspNTATVTILDDDHA-GIFTFeedvfHVSESIGIM-------------EVKVL 551

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034646479 3949 RLAGSFGAVNVYWKASPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISL 4011
Cdd:TIGR00845  552 RTSGARGTVIVPYRTVEGTArgGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2605-2674 2.86e-12

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 65.74  E-value: 2.86e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  2605 VELMIHRTGGSLGQVAVEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSEPEDDESIIVSL 2674
Cdd:smart00237   20 VEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2968-3180 3.18e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 74.06  E-value: 3.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2968 IEWQQSRFEVNETHGSLTLVAQRSREPLGHVSLFVY-AQNLEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEGD 3046
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYrTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEED 481

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3047 EKFQLILTNPSPGLELG---KNTIALIIVLAN----------DDGPGVLSFNNSEhfflreptaLYVQESVAVLYIVREP 3113
Cdd:TIGR00845  482 EHFYVRLSNLRVGSEDGileANHVSAVAQLASpntatvtildDDHAGIFTFEEDV---------FHVSESIGIMEVKVLR 552

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034646479 3114 AQGLFGTVTVQFIVTEVNSSNESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3180
Cdd:TIGR00845  553 TSGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEP 619
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1998-2204 1.38e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 71.75  E-value: 1.38e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1998 LSIIRLKGLMGK-VLVSYATLDdmekppyfppnlARATQGRDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIE 2076
Cdd:TIGR00845  420 LTVVRRGGDLTNtVYVDYRTED------------GTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVR 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2077 LLNstlvAKVQSRsipNSPRLGPKVETIAQL-------IIIANDDAFGTLQLSAPIVRVAENhVGPI-INVTRTGGAFAD 2148
Cdd:TIGR00845  488 LSN----LRVGSE---DGILEANHVSAVAQLaspntatVTILDDDHAGIFTFEEDVFHVSES-IGIMeVKVLRTSGARGT 559

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034646479 2149 VSVKFKAVPITAIAG-EDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQL 2204
Cdd:TIGR00845  560 VIVPYRTVEGTARGGgKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 53-236 1.53e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 71.75  E-value: 1.53e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479   53 LIIERIGEPANVTAIVSLYGED----AG-DFFDTYAAAFIPAGETNRTVYIAVCDDDLPEPDETFIFHLT---------- 117
Cdd:TIGR00845  420 LTVVRRGGDLTNTVYVDYRTEDgtanAGsDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSnlrvgsedgi 499

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  118 LQKPSANVK--LGWPRTVTVTILSNDNAfGIISFNMlPSIAVSEPKGRnesMPLTLIREKGTYGMVMVTFE-VEGGPNPP 194
Cdd:TIGR00845  500 LEANHVSAVaqLASPNTATVTILDDDHA-GIFTFEE-DVFHVSESIGI---MEVKVLRTSGARGTVIVPYRtVEGTARGG 574

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1034646479  195 DEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQL 236
Cdd:TIGR00845  575 GKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1883-2077 1.64e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 71.75  E-value: 1.64e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1883 TVTLNVIRHHGTLSpVTLHWNIDSDpDG------DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAF---------- 1946
Cdd:TIGR00845  417 TVALTVVRRGGDLT-NTVYVDYRTE-DGtanagsDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFyvrlsnlrvg 494

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1947 -----SVSVLSVSSGSLGAHINATLTVLaSDDPYGIFIFSEKNrpVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMe 2021
Cdd:TIGR00845  495 sedgiLEANHVSAVAQLASPNTATVTIL-DDDHAGIFTFEEDV--FHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGT- 570

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034646479 2022 kppyfppnlARATqGRDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIEL 2077
Cdd:TIGR00845  571 ---------ARGG-GKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1976-2078 8.74e-11

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 61.50  E-value: 8.74e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  1976 GIFIFSEKNrpVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMekppyfppnlarATQGRDYIPASGFALFGANQSEA 2055
Cdd:smart00237    2 GSVGFEQPV--YTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGT------------ATAGSDYEPVPGELTFPPGETEK 67

                            90       100
                    ....*....|....*....|...
gi 1034646479  2056 TIAISILDDDEPERSESVFIELL 2078
Cdd:smart00237   68 EIRIKIIDDDIYEKDETFYVRLS 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2139-2322 9.02e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 69.05  E-value: 9.02e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2139 VTRTGGAFAD-VSVKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQLMNETTGG------ 2211
Cdd:TIGR00845  422 VVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSedgile 501

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2212 -------ARLGALTEAVIIIeASDDPYGLFGFQITKLIVEEpefNSVKVNLPIIRNSGTLGNVTVQWvATINGQlATG-- 2282
Cdd:TIGR00845  502 anhvsavAQLASPNTATVTI-LDDDHAGIFTFEEDVFHVSE---SIGIMEVKVLRTSGARGTVIVPY-RTVEGT-ARGgg 575

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1034646479 2283 -DLRVVSGNVTFAPGETIQTLLLEVLADDVPEIEEVIQVQL 2322
Cdd:TIGR00845  576 kDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3591-3732 1.69e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 68.28  E-value: 1.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3591 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPKGGAEIGINDS--------------VTITILSNDDA 3656
Cdd:TIGR00845  448 SDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEDGILEAnhvsavaqlaspntATVTILDDDHA 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3657 yGIVAFaQNSLYKQVEEMeqdSLVTLNVERLKGTYGRI-----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTILA 3731
Cdd:TIGR00845  528 -GIFTF-EEDVFHVSESI---GIMEVKVLRTSGARGTVivpyrTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVD 602


                   .
gi 1034646479 3732 D 3732
Cdd:TIGR00845  603 D 603
Calx-beta pfam03160
Calx-beta domain;
2605-2674 1.93e-10

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 60.73  E-value: 1.93e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034646479 2605 VELMIHRTGGSL-GQVAVEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSEPEDDESIIVSL 2674
Cdd:pfam03160   20 AEVCVVRMSGTLrRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFVLL 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2605-2788 7.03e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 66.35  E-value: 7.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2605 VELMIHRTGGSLGQ-VAVEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSEPEDDESIIVSL----VYTEG 2679
Cdd:TIGR00845  418 VALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsnlrVGSED 497

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2680 GsrILPSSDTVRVNILAN----------DNVAGIVSFQTASRSVIGHEGeILQFHVIRTFPGRGNVTVNWKIIGQNLELN 2749
Cdd:TIGR00845  498 G--ILEANHVSAVAQLASpntatvtildDDHAGIFTFEEDVFHVSESIG-IMEVKVLRTSGARGTVIVPYRTVEGTARGG 574

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1034646479 2750 FANFS---GQLFFPEGSLNTTLFVHLLDDNIPEEKEVYQVIL 2788
Cdd:TIGR00845  575 GKDFEdtcGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
Calx-beta pfam03160
Calx-beta domain;
1976-2077 1.21e-09

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 58.42  E-value: 1.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1976 GIFIFSEKNrpVKVEEATQNITLSIIRLKG-LMGKVLVSYATLDDMekppyfppnlarATQGRDYIPASGFALFGANQSE 2054
Cdd:pfam03160    2 GVIGFEPPT--YQVSENDGVAEVCVVRMSGtLRRTVVVPYRTEDGT------------ATAGDDYEPVEGELVFGPGETE 67

                           90       100
                   ....*....|....*....|...
gi 1034646479 2055 ATIAISILDDDEPERSESVFIEL 2077
Cdd:pfam03160   68 KCINVTIIDDDVYEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2966-3054 2.00e-09

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 57.65  E-value: 2.00e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  2966 GVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSLFVYAQNLEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEG 3045
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEK 81


                    ....*....
gi 1034646479  3046 DEKFQLILT 3054
Cdd:smart00237   82 DETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
2966-3054 2.34e-09

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 57.64  E-value: 2.34e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2966 GVIEWQQSRFEVNETHGSLTLVAQRSREPL-GHVSLFVYAQNLEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPE 3044
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTLrRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYE 81

                           90
                   ....*....|
gi 1034646479 3045 GDEKFQLILT 3054
Cdd:pfam03160   82 GDENFFVLLS 91
Calx-beta pfam03160
Calx-beta domain;
1004-1092 7.62e-09

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 56.10  E-value: 7.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1004 IYFaEPRVVRVQE--GETANFTVLRNGSVDVTCMVQYATKDGKATArERDFIPVEkgETLIFEVGSRQQSISIFVNEDGI 1081
Cdd:pfam03160    4 IGF-EPPTYQVSEndGVAEVCVVRMSGTLRRTVVVPYRTEDGTATA-GDDYEPVE--GELVFGPGETEKCINVTIIDDDV 79

                           90
                   ....*....|.
gi 1034646479 1082 PETDEPFYIIL 1092
Cdd:pfam03160   80 YEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 3590-3631 1.22e-07

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 52.64  E-value: 1.22e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1034646479  3590 HSDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQL 3631
Cdd:smart00237   48 GSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 859-1092 3.01e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.49  E-value: 3.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  859 VLSSHGERE-SKLGSATIVNITILKNDDPHGIieFVSDGLIVMInESKGdaiysAVYDVVRNRGnfGDVSVSWVV----- 932
Cdd:TIGR00845  371 ILKKHAADAaRKAVSMHEVATDDEENDPVSKI--FFEPGHYTCL-ENCG-----TVALTVVRRG--GDLTNTVYVdyrte 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  933 --SPDFTQDVFPVQGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVILLN--------------GTGGAKVGNRTTATLR 996
Cdd:TIGR00845  441 dgTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNlrvgsedgileanhVSAVAQLASPNTATVT 520

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  997 IRRNDDPIYFA-EPRVVRVQEG-ETANFTVLRNGSVDVTCMVQYATKDGKATARERDFIPVEkGEtLIFEVGSRQQSISI 1074
Cdd:TIGR00845  521 ILDDDHAGIFTfEEDVFHVSESiGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGKDFEDTC-GE-LEFENDETEKTIRV 598

                          250
                   ....*....|....*...
gi 1034646479 1075 FVNEDGIPETDEPFYIIL 1092
Cdd:TIGR00845  599 KIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1503-1693 3.31e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.49  E-value: 3.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKL--VSVYGGARISEENT-----------TARLTIQKSD 1569
Cdd:TIGR00845  446 AGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsnLRVGSEDGILEANHvsavaqlaspnTATVTILDDD 525

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1570 NAnGLFGFTGACIpEIAEEGSTISCVVERTRGALDYVHV-FYTISQIETDGinylVDDFANASGTITFLPWQRSEVLNIY 1648
Cdd:TIGR00845  526 HA-GIFTFEEDVF-HVSESIGIMEVKVLRTSGARGTVIVpYRTVEGTARGG----GKDFEDTCGELEFENDETEKTIRVK 599

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1034646479 1649 VLDDDIPELNEYFRVTLVSA--IPGDGKLGSTPTSGASIDPEKETTD 1693
Cdd:TIGR00845  600 IVDDEEYEKNDTFFIELGEPrwAKRGIKAALLLNETITDDDQKLTSK 646
Calx-beta pfam03160
Calx-beta domain;
3591-3631 5.06e-07

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 50.71  E-value: 5.06e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034646479 3591 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQL 3631
Cdd:pfam03160   50 DDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1006-1093 6.46e-07

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 50.72  E-value: 6.46e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  1006 FAEPRVVRVQEGE-TANFTVLRNGSVDVTCMVQYATKDGKATArERDFIPVEKgeTLIFEVGSRQQSISIFVNEDGIPET 1084
Cdd:smart00237    5 GFEQPVYTVSESDgEVEVCVVRTGGARGPVVVPYSTEDGTATA-GSDYEPVPG--ELTFPPGETEKEIRIKIIDDDIYEK 81


                    ....*....
gi 1034646479  1085 DEPFYIILL 1093
Cdd:smart00237   82 DETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 3917-4011 1.15e-06

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 49.95  E-value: 1.15e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  3917 GIFMF-----HVTRGAGEVitayevppplnvlQVPVVRLAGSFGAVNVYWKASPDSA-GLEDFKPSHGILEFADKQVTAM 3990
Cdd:smart00237    2 GSVGFeqpvyTVSESDGEV-------------EVCVVRTGGARGPVVVPYSTEDGTAtAGSDYEPVPGELTFPPGETEKE 68

                            90       100
                    ....*....|....*....|.
gi 1034646479  3991 IEITIIDDAEFELTETFNISL 4011
Cdd:smart00237   69 IRIKIIDDDIYEKDETFYVRL 89
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 5046-5342 2.12e-06

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 54.80  E-value: 2.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5046 VSYQTTAGSAKPLEDFEPVQnGELFFQKFQTEVDFEITIINDQLSEIEEFFYINLTSVEIRglqkfdvnwsprlnldfsv 5125
Cdd:TIGR00845  435 VDYRTEDGTANAGSDYEFTE-GTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVG------------------- 494

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5126 avitildndDLAGMdisfpettvavavdttlipvetesttylstsktttilqptnvvaivTEATGVSAIpeklvtlhgtp 5205
Cdd:TIGR00845  495 ---------SEDGI----------------------------------------------LEANHVSAV----------- 508

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5206 AVSEKPDVATVTANVSIH-GTFSLGPSIVYIEEEMknGTFntaEVLIRRTGGFTGNVSItvktfgercaqmepnalPFRG 5284
Cdd:TIGR00845  509 AQLASPNTATVTILDDDHaGIFTFEEDVFHVSESI--GIM---EVKVLRTSGARGTVIV-----------------PYRT 566

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034646479 5285 IYGisnlTWAVEEEDFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQ 5342
Cdd:TIGR00845  567 VEG----TARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPR 620
Calx-beta pfam03160
Calx-beta domain;
4038-4128 5.92e-06

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 48.01  E-value: 5.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4038 GVFGFEEKTVMIDESlssddpDSYVTLTVVRSPG-GKGTVRLE-WTIDEKAKHN--LSPLNGTLHFDETESQKTIVLHTL 4113
Cdd:pfam03160    2 GVIGFEPPTYQVSEN------DGVAEVCVVRMSGtLRRTVVVPyRTEDGTATAGddYEPVEGELVFGPGETEKCINVTII 75

                           90
                   ....*....|....*
gi 1034646479 4114 QDTVLEEDRRFTIQL 4128
Cdd:pfam03160   76 DDDVYEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 4038-4128 6.04e-06

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 47.63  E-value: 6.04e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  4038 GVFGFEEKTVMIDESlssddpDSYVTLTVVRSPGGKGTVRLEW-TIDEKAK--HNLSPLNGTLHFDETESQKTIVLHTLQ 4114
Cdd:smart00237    2 GSVGFEQPVYTVSES------DGEVEVCVVRTGGARGPVVVPYsTEDGTATagSDYEPVPGELTFPPGETEKEIRIKIID 75

                            90
                    ....*....|....
gi 1034646479  4115 DTVLEEDRRFTIQL 4128
Cdd:smart00237   76 DDIYEKDETFYVRL 89
Calx-beta pfam03160
Calx-beta domain;
5009-5101 1.01e-05

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 47.24  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5009 GVFQFStsSRNIIVSEDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPLEDFEPVqNGELFFQKFQTEVDFEITIINDQ 5088
Cdd:pfam03160    2 GVIGFE--PPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRTEDGTATAGDDYEPV-EGELVFGPGETEKCINVTIIDDD 78

                           90
                   ....*....|...
gi 1034646479 5089 LSEIEEFFYINLT 5101
Cdd:pfam03160   79 VYEGDENFFVLLS 91
LamGL smart00560
LamG-like jellyroll fold domain;
1355-1491 1.04e-05

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 48.57  E-value: 1.04e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  1355 FTFSAWVMPNANTNGFIIAKDdgngsiYYGVKIQTNESHVTLSLHYKTLGSNATYIaktTVMKYLEESVWLHLLIIL--E 1432
Cdd:smart00560    3 FTLEAWVKLESAGGSQPIITG------AAVAQPTISEKALTFFLRAKSVQGWQTAR---TGATADWIGVWVHLAGVYdgG 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034646479  1433 DGIIEFYLDGnamprgikSLKGEAITDGPGI-------LRIGAGINGNDRFTGLMQDVRSYERKLT 1491
Cdd:smart00560   74 AGKLSLYVNG--------VEVATSETQPSPSsgnlpqgGRILLGGAGGENFSGRLDEVRVYNRALT 131
Calx-beta pfam03160
Calx-beta domain;
1573-1665 2.51e-05

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 46.09  E-value: 2.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1573 GLFGFTGACIPEIAEEGSTISCVVeRTRGALD-YVHV-FYTISQIETDGinylvDDFANASGTITFLPWQRSEVLNIYVL 1650
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVV-RMSGTLRrTVVVpYRTEDGTATAG-----DDYEPVEGELVFGPGETEKCINVTII 75

                           90
                   ....*....|....*
gi 1034646479 1651 DDDIPELNEYFRVTL 1665
Cdd:pfam03160   76 DDDVYEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2232-2323 4.61e-05

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 45.32  E-value: 4.61e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  2232 GLFGFQITKLIVEEpefNSVKVNLPIIRNSGTLGNVTVQWVaTINGQlATG--DLRVVSGNVTFAPGETIQTLLLEVLAD 2309
Cdd:smart00237    2 GSVGFEQPVYTVSE---SDGEVEVCVVRTGGARGPVVVPYS-TEDGT-ATAgsDYEPVPGELTFPPGETEKEIRIKIIDD 76

                            90
                    ....*....|....
gi 1034646479  2310 DVPEIEEVIQVQLT 2323
Cdd:smart00237   77 DIYEKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 37-117 4.88e-05

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 45.32  E-value: 4.88e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479    37 GQTEFVVNETSTTViRLIIERIGEpANVTAIVSLYGED----AG-DFFDTYAAAFIPAGETNRTVYIAVCDDDLPEPDET 111
Cdd:smart00237    7 EQPVYTVSESDGEV-EVCVVRTGG-ARGPVVVPYSTEDgtatAGsDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDET 84


                    ....*.
gi 1034646479   112 FIFHLT 117
Cdd:smart00237   85 FYVRLS 90
PTX cd00152
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their ...
 1343-1498 5.16e-05

Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.


Pssm-ID: 238086  Cd Length: 201  Bit Score: 48.03  E-value: 5.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1343 KYHPSRNNTIANFTFSAWVMPNANTNGFIIakddgngsIYYGVKIQTNEshvtLSLHYKTLGSNATYIAKTTVMKYLEES 1422
Cdd:cd00152     21 KLKPELPKPLQAFTLCLWVYTDLSTREYSL--------FSYATKGQDNE----LLLYKEKDGGYSLYIGGKEVTFKVPES 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1423 V--WLHLLIILE--DGIIEFYLDGNAMPRGIKSlKGEAITDGPGIL------RIGAGINGNDRFTGLMQDVRSYERKLTL 1492
Cdd:cd00152     89 DgaWHHICVTWEstSGIAELWVNGKLSVRKSLK-KGYTVGPGGSIIlgqeqdSYGGGFDATQSFVGEISDVNMWDSVLSP 167


                   ....*.
gi 1034646479 1493 EEIYEL 1498
Cdd:cd00152    168 EEIKNV 173
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
 5859-5901 6.59e-05

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


Pssm-ID: 197639  Cd Length: 49  Bit Score: 43.53  E-value: 6.59e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1034646479  5859 TSLCLLWNQAAASWlsDSQFCKVVEETADYVECACSHMSVYAV 5901
Cdd:smart00303    2 NPICVFWDESSGEW--STRGCELLETNGTHTTCSCNHLTTFAV 42
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 5008-5101 1.64e-04

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 43.78  E-value: 1.64e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  5008 MGVFQFSTSsrNIIVSEDTQMIRLHVQRlfgfHSDLIK---VSYQTTAGSAKPLEDFEPVQnGELFFQKFQTEVDFEITI 5084
Cdd:smart00237    1 AGSVGFEQP--VYTVSESDGEVEVCVVR----TGGARGpvvVPYSTEDGTATAGSDYEPVP-GELTFPPGETEKEIRIKI 73

                            90
                    ....*....|....*..
gi 1034646479  5085 INDQLSEIEEFFYINLT 5101
Cdd:smart00237   74 IDDDIYEKDETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
2849-2931 1.79e-04

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 43.78  E-value: 1.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2849 TIQLFINREFGSL-GAINVTYTTVPGMlslknqtvgnlAEPEVDFVPIIGFLILEEGETAAAINITILEDDVPELEEYFL 2927
Cdd:pfam03160   19 VAEVCVVRMSGTLrRTVVVPYRTEDGT-----------ATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFF 87


                   ....
gi 1034646479 2928 VNLT 2931
Cdd:pfam03160   88 VLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1596-1665 2.01e-04

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 43.40  E-value: 2.01e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034646479  1596 VERTRGALDYVHV-FYTISQIETDGinylvDDFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYFRVTL 1665
Cdd:smart00237   24 VVRTGGARGPVVVpYSTEDGTATAG-----SDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2851-2931 2.24e-04

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 43.40  E-value: 2.24e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  2851 QLFINREFGSLGAINVTYTTVPGmlslkNQTVGnlaepeVDFVPIIGFLILEEGETAAAINITILEDDVPELEEYFLVNL 2930
Cdd:smart00237   21 EVCVVRTGGARGPVVVPYSTEDG-----TATAG------SDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89


                    .
gi 1034646479  2931 T 2931
Cdd:smart00237   90 S 90
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 3402-3443 2.35e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 41.69  E-value: 2.35e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034646479 3402 FVLHQKLPVRGVLTVALFNKGGSVFLAISQANArlNSLLFRW 3443
Cdd:pfam03736    2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSG--DSVIYRW 41
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 5299-5393 3.02e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 47.86  E-value: 3.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5299 DFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQ--IVEEKDDTGFAAFAM-----VIITGSDlHN 5371
Cdd:TIGR00845  449 DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEdgILEANHVSAVAQLASpntatVTILDDD-HA 527

                           90       100
                   ....*....|....*....|....*...
gi 1034646479 5372 GIIGFSE------ESQSGLELRegaVMR 5393
Cdd:TIGR00845  528 GIFTFEEdvfhvsESIGIMEVK---VLR 552
Calx-beta pfam03160
Calx-beta domain;
145-236 3.22e-04

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 43.01  E-value: 3.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  145 GIISFNmLPSIAVSEPKGRNEsmpLTLIREKGTY-GMVMVTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDD 223
Cdd:pfam03160    2 GVIGFE-PPTYQVSENDGVAE---VCVVRMSGTLrRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDD 77

                           90
                   ....*....|...
gi 1034646479  224 EVPENDEIFLIQL 236
Cdd:pfam03160   78 DVYEGDENFFVLL 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 330-487 3.60e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 47.48  E-value: 3.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  330 TVVFPPFIHESHLKFQIVDDTIPEIAESFHI------------MLLKDTLQGDAVLISPSVVQVTIKPNDKPyGVLSFNS 397
Cdd:TIGR00845  456 TLVFKPGETQKEFRIGIIDDDIFEEDEHFYVrlsnlrvgsedgILEANHVSAVAQLASPNTATVTILDDDHA-GIFTFEE 534

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  398 VLFERTVIIDEdrisryEEITVVRNGGTHGNVSANWvLTRNSTdPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDLP 477
Cdd:TIGR00845  535 DVFHVSESIGI------MEVKVLRTSGARGTVIVPY-RTVEGT-ARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEY 606

                          170
                   ....*....|
gi 1034646479  478 EEAEAYLLQI 487
Cdd:TIGR00845  607 EKNDTFFIEL 616
Calx-beta pfam03160
Calx-beta domain;
3920-4011 1.26e-03

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 41.08  E-value: 1.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3920 MFHVTRGAGEVitayevppplnvlQVPVVRLAGSF-GAVNV-YWKASPDSAGLEDFKPSHGILEFADKQVTAMIEITIID 3997
Cdd:pfam03160   10 TYQVSENDGVA-------------EVCVVRMSGTLrRTVVVpYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID 76

                           90
                   ....*....|....
gi 1034646479 3998 DAEFELTETFNISL 4011
Cdd:pfam03160   77 DDVYEGDENFFVLL 90
Calx-beta pfam03160
Calx-beta domain;
2238-2323 5.57e-03

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 39.54  E-value: 5.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2238 ITKLIVEEPEFNSVK----VNLPIIRNSGTL-GNVTVQWVaTINGQlATG--DLRVVSGNVTFAPGETIQTLLLEVLADD 2310
Cdd:pfam03160    1 AGVIGFEPPTYQVSEndgvAEVCVVRMSGTLrRTVVVPYR-TEDGT-ATAgdDYEPVEGELVFGPGETEKCINVTIIDDD 78

                           90
                   ....*....|...
gi 1034646479 2311 VPEIEEVIQVQLT 2323
Cdd:pfam03160   79 VYEGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 901-979 5.75e-03

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 39.16  E-value: 5.75e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479   901 INESKGdaiySAVYDVVRNRGNFGDVSVSWVV---SPDFTQDVFPVQGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVI 977
Cdd:smart00237   13 VSESDG----EVEVCVVRTGGARGPVVVPYSTedgTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVR 88


                    ..
gi 1034646479   978 LL 979
Cdd:smart00237   89 LS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 416-488 6.99e-03

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 39.16  E-value: 6.99e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034646479   416 EITVVRNGGTHGNVSANWvltrnSTDPSPVTA--DIRPSSGVLHFAQGQMLATIPLTVVDDDLPEEAEAYLLQIL 488
Cdd:smart00237   21 EVCVVRTGGARGPVVVPY-----STEDGTATAgsDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRLS 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4977-5100 7.95e-03

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 42.86  E-value: 7.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4977 EAFVLHLSGVQSSAPGG----------AQLRSGFI----VAEIEPMGVFQFSTSSrnIIVSEDTQMIRLHVQRLFGFHSD 5042
Cdd:TIGR00845  482 EHFYVRLSNLRVGSEDGileanhvsavAQLASPNTatvtILDDDHAGIFTFEEDV--FHVSESIGIMEVKVLRTSGARGT 559

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034646479 5043 LIkVSYQTTAGSAK-PLEDFEPVQnGELFFQKFQTEVDFEITIINDQLSEIEEFFYINL 5100
Cdd:TIGR00845  560 VI-VPYRTVEGTARgGGKDFEDTC-GELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
 
Name Accession Description Interval E-value
7tmB2_Adhesion cd15040
adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G ...
 5925-6164 3.14e-31

adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G protein-coupled receptors; The B2 subfamily of class B GPCRs consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320168 [Multi-domain]  Cd Length: 253  Bit Score: 125.76  E-value: 3.14e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5925 GLCLAVLSHIFCARY-SMFAAKLLTHMMAASLGTQILFLASAYASPQLAEesCSAMAAVTHYLYLCQFSWMLIQSVNFWY 6003
Cdd:cd15040     18 GLLLTIITYILFRKLrKRKPTKILLNLCLALLLANLLFLFGINSTDNPVL--CTAVAALLHYFLLASFMWMLVEALLLYL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6004 VLVM-NDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSmsqiyglihGDLCFIPNVYAALFtAALVPLTCLVVV- 6081
Cdd:cd15040     96 RLVKvFGTYPRHFILKYALIGWGLPLIIVIITLAVDPDSYGNS---------SGYCWLSNGNGLYY-AFLGPVLLIILVn 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6082 FVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFIL 6161
Cdd:cd15040    166 LVIFVLVLRKLLRLSAKRNKKKRKKTKAQLRAAVSLFFLLGLTWIFGILAIFGARVVFQYLFAIFNSLQGFFIFIFHCLR 245


                   ...
gi 1034646479 6162 HNQ 6164
Cdd:cd15040    246 NKE 248
7tm_classB cd13952
class B family of seven-transmembrane G protein-coupled receptors; The class B of ...
 5917-6158 1.18e-29

class B family of seven-transmembrane G protein-coupled receptors; The class B of seven-transmembrane GPCRs is classified into three major subfamilies: subfamily B1 (secretin-like receptor family), B2 (adhesion family), and B3 (Methuselah-like family). The class B receptors have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi or prokaryotes. The B1 subfamily comprises receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the subfamily B1 receptors preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. The subfamily B2 consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Furthermore, the subfamily B3 includes Methuselah (Mth) protein, which was originally identified in Drosophila as a GPCR affecting stress resistance and aging, and its closely related proteins.


Pssm-ID: 410627 [Multi-domain]  Cd Length: 260  Bit Score: 121.55  E-value: 1.18e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5917 TSGFICIS--GLCLAVLSHIFCARYSMFAAKLLTHMMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYLCQFSWM 5994
Cdd:cd13952      8 TYIGCSLSlvGLLLTIITYLLFPKLRNLRGKILINLCLSLLLAQLLFLIGQLLTSSDRPVLCKALAILLHYFLLASFFWM 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5995 LIQSVNFWYVLVM-NDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSMSqiyglIHGDLCFIPNVYAALFtAALV 6073
Cdd:cd13952     88 LVEAFDLYRTFVKvFGSSERRRFLKYSLYGWGLPLLIVIITAIVDFSLYGPSPG-----YGGEYCWLSNGNALLW-AFYG 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6074 PLTCLVVV-FVVFIH-AYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTWLWGGL-HMAYRHFWMLVLFVIFNSLQ 6150
Cdd:cd13952    162 PVLLILLVnLVFFILtVRILLRKLRETPKQSERKSDRKQLRAYLKLFPLMGLTWIFGILaPFVGGSLVFWYLFDILNSLQ 241


                   ....*...
gi 1034646479 6151 GLYVFMVY 6158
Cdd:cd13952    242 GFFIFLIF 249
7tmB3_Methuselah-like cd15039
Methuselah-like subfamily B3, member of the class B family of seven-transmembrane G ...
 5916-6158 8.96e-21

Methuselah-like subfamily B3, member of the class B family of seven-transmembrane G protein-coupled receptors; The subfamily B3 of class B GPCRs consists of Methuselah (Mth) and its closely related proteins found in bilateria. Mth was originally identified in Drosophila as a GPCR affecting stress resistance and aging. In addition to the seven transmembrane helices, Mth contains an N-terminal extracellular domain involved in ligand binding, and a third intracellular loop (IC3) required for the specificity of G-protein coupling. Drosophila Mth mutants showed an increase in average lifespan by 35% and greater resistance to a variety of stress factors, including starvation, high temperature, and paraquat-induced oxidative toxicity. Moreover, mutations in two endogenous peptide ligands of Methuselah, Stunted A and B, showed an increased in lifespan and resistance to oxidative stress induced by dietary paraquat. These results strongly suggest that the Stunted-Methuselah system plays important roles in stress response and aging.


Pssm-ID: 410632 [Multi-domain]  Cd Length: 270  Bit Score: 95.76  E-value: 8.96e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5916 FTSGFICISGLCLAVlshIFCArYSMFAA------KLLTHMMAASLGTQILFLASAYASPQlAEESCSAMAAVTHYLYLC 5989
Cdd:cd15039      7 LTLIGLIISLVFLLL---TLAV-YALLPElrnlhgKCLMCLVLSLFVAYLLLLIGQLLSSG-DSTLCVALGILLHFFFLA 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5990 QFSWMLIQSVNFWYVLVM-----NDEHTERRYLLFFLLSWGLPAFVVILLIVI--LKGIYHQSMSqiYGlihGDLCFIPN 6062
Cdd:cd15039     82 AFFWLNVMSFDIWRTFRGkrsssSRSKERKRFLRYSLYAWGVPLLLVAVTIIVdfSPNTDSLRPG--YG---EGSCWISN 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6063 VYAALFTAAlVPLTCLVVVFVVF-----IHAYQVKpqWKAYDDVFRGRTNAAEIPLILYLFALISVTWLWGGLHMAYRHF 6137
Cdd:cd15039    157 PWALLLYFY-GPVALLLLFNIILfiltaIRIRKVK--KETAKVQSRLRSDKQRFRLYLKLFVIMGVTWILEIISWFVGGS 233

                          250       260
                   ....*....|....*....|..
gi 1034646479 6138 -WMLVLFVIFNSLQGLYVFMVY 6158
Cdd:cd15039    234 sVLWYIFDILNGLQGVFIFLIF 255
7tmB2_GPR112 cd15997
Probable G protein-coupled receptor 112, member of the class B2 family of seven-transmembrane ...
 5944-6170 1.41e-18

Probable G protein-coupled receptor 112, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR112 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR64, GPR97, GPR114, and GPR126. GPR112 is specifically expressed in normal enterochromatin cells and gastrointestinal neuroendocrine carcinoma cells, but its biological function is unknown. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320663  Cd Length: 269  Bit Score: 89.33  E-value: 1.41e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5944 AKLLTHMMAASLGTQILFLA----SAYASPQLaeesCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLL- 6018
Cdd:cd15997     38 SKILINLCTALLMLNLVFLLnswlSSFNNYGL----CITVAAFLHYFLLASFTWMGLEAVHMYFALVKVFNIYIPNYILk 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6019 FFLLSWGLPAFVVILLIVILKGIYHQSMSQIYGLIHGDLCFIPN---VYAALFTAALVPLTCLVVVFVVF---IHAYQVK 6092
Cdd:cd15997    114 FCIAGWGIPAVVVALVLAINKDFYGNELSSDSLHPSTPFCWIQDdvvFYISVVAYFCLIFLCNISMFITVliqIRSMKAK 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6093 PQWKAYDDVFrgrtnaaeiplILYLFALISVTWL----WGGLHMAY--RHFWMLVLFVIFNSLQGLYVFMVYfilhnqmc 6166
Cdd:cd15997    194 KPSRNWKQGF-----------LHDLKSVASLTFLlgltWGFAFFAWgpVRIFFLYLFSICNTLQGFFIFVFH-------- 254


                   ....
gi 1034646479 6167 CPMK 6170
Cdd:cd15997    255 CLMK 258
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4290-4494 5.86e-18

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 92.55  E-value: 5.86e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4290 VNITIIRSSGDFG-HVRLWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQgrg 4368
Cdd:TIGR00845  418 VALTVVRRGGDLTnTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVG--- 494

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4369 ydftiQENGLQIDQPPE----IGNISIVRIIIMKNDNAeGIIEFDPKYtaFEVEEDVGLIMIPVVRLHGTYGYVTADFIS 4444
Cdd:TIGR00845  495 -----SEDGILEANHVSavaqLASPNTATVTILDDDHA-GIFTFEEDV--FHVSESIGIMEVKVLRTSGARGTVIVPYRT 566

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4445 QSSSASPGGVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILL 4494
Cdd:TIGR00845  567 VEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
7tmB2_GPR126-like_Adhesion_VIII cd15258
orphan GPR126 and related proteins, group VIII adhesion GPCRs, member of the class B2 family ...
 5926-6161 1.16e-17

orphan GPR126 and related proteins, group VIII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Group VIII adhesion GPCRs include orphan GPCRs such as GPR56, GPR64, GPR97, GPR112, GPR114, and GPR126. GPR56 is involved in the regulation of oligodendrocyte development and myelination in the central nervous system via coupling to G(12/13) proteins, which leads to the activation of RhoA GTPase. GPR126, on the other hand, is required for Schwann cells, but not oligodendrocyte myelination in the peripheral nervous system. Gpr64 is mainly expressed in the epididymis of male reproductive tract, and targeted deletion of GPR64 causes sperm stasis and efferent duct blockage due to abnormal fluid reabsorption, resulting in male infertility. GPR64 is also over-expressed in Ewing's sarcoma (ES), as well as upregulated in other carcinomas from kidney, prostate or lung, and promotes invasiveness and metastasis in ES via the upregulation of placental growth factor (PGF) and matrix metalloproteinase (MMP) 1. GPR97 is identified as a lymphatic adhesion receptor that is specifically expressed in lymphatic endothelium, but not in blood vascular endothelium, and is shown to regulate migration of lymphatic endothelial cells via the small GTPases RhoA and cdc42. GPR112 is specifically expressed in normal enterochromatin cells and gastrointestinal neuroendocrine carcinoma cells, but its biological function is unknown. GPR114 is mainly found in granulocytes (polymorphonuclear leukocytes), and GPR114-transfected cells induced an increase in cAMP levels via coupling to G(s) protein. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320386 [Multi-domain]  Cd Length: 267  Bit Score: 86.70  E-value: 1.16e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5926 LCLAVLSHIFCARYS-MFAAKLLTHMMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYV 6004
Cdd:cd15258     19 LAITILTYIAFRKLRrDYPSKIHMNLCAALLLLNLAFLLSSWIASFGSDGLCIAVAVALHYFLLACLTWMGLEAFHLYLL 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6005 LVMNDEHTERRYLL-FFLLSWGLPAFVVILLIVILKGIYHQSMSQIYGLIHGD-LCFIPNVYAALFTAA----LVPLTCL 6078
Cdd:cd15258     99 LVKVFNTYIRRYILkLCLVGWGLPALLVTLVLSVRSDNYGPITIPNGEGFQNDsFCWIRDPVVFYITVVgyfgLTFLFNM 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6079 VVVFVVFIHAYQVKPQwkayDDVFRGRTNAAEIPLILYLFALISVTW-----LWGGLHMAYrhfwmLVLFVIFNSLQGLY 6153
Cdd:cd15258    179 VMLATVLVQICRLREK----AQATPRKRALHDLLTLLGLTFLLGLTWglaffAWGPFNLPF-----LYLFAIFNSLQGFF 249


                   ....*...
gi 1034646479 6154 VFMVYFIL 6161
Cdd:cd15258    250 IFIWYCSM 257
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 1346-1495 4.83e-17

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 81.66  E-value: 4.83e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1346 PSRNNTIANFTFSAWVMPNANTNGF-IIAKDDGNGSIYygvkIQTNESHVTLSLHYKTLGSNATYIAKTTVmkylEESVW 1424
Cdd:pfam13385   10 PDALLPTSDFTVSAWVKPDSLPGWArAIISSSGGGGYS----LGLDGDGRLRFAVNGGNGGWDTVTSGASV----PLGQW 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034646479 1425 LHLLIILEDGIIEFYLDGNAMPRGikSLKGEAITDGPGILRIGAGINGNDRFTGLMQDVRSYERKLTLEEI 1495
Cdd:pfam13385   82 THVAVTYDGGTLRLYVNGVLVGSS--TLTGGPPPGTGGPLYIGRSPGGDDYFNGLIDEVRIYDRALSAAEI 150
7tmB2_GPR114 cd15443
orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G ...
 5955-6164 9.22e-16

orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR114 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include GPR56, GPR64, GPR97, GPR112, and GPR126. GPR114 is mainly found in granulocytes (polymorphonuclear leukocytes), and GPR114-transfected cells induced an increase in cAMP levels via coupling to G(s) protein. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320559 [Multi-domain]  Cd Length: 268  Bit Score: 80.96  E-value: 9.22e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5955 LGTQILFLASAYASPQLA----EESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLL-FFLLSWGLPAF 6029
Cdd:cd15443     45 LGSLFLLNGSFLLSPPLAtsqsTWLCRAAAALLHYSLLCCLTWMAIEGFHLYLLLVKVYNIYIRRYVLkLCVLGWGLPAL 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6030 VVILLIVILKGIY-HQSMSQIYGLIHGDLCFI--PNVYAALFTAalvpLTCLVVVF--VVFIHAYQVKPQWKAYDDVFRG 6104
Cdd:cd15443    125 IVLLVLIFKREAYgPHTIPTGTGYQNASMCWItsSKVHYVLVLG----YAGLTSLFnlVVLAWVVRMLRRLRSRKQELGE 200

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6105 RTnAAEIPLILYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQ 6164
Cdd:cd15443    201 RA-RRDWVTVLGLTCLLGTTWALAFFSFGVFLIPQLFLFTIINSLYGFFICLWYCTQRRR 259
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1729-1946 1.31e-15

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 84.84  E-value: 1.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1729 HITVEEEDGEIRLLVIRAQGLLGR-VTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKVE 1807
Cdd:TIGR00845  408 HYTCLENCGTVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVR 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1808 LLNLeggaelfRVdgsgsGDGDMEFFLPTIHKRASLGVASQILVTIAASDHAhGVFEFSPESLFVSgtepeDGYSTVTLN 1887
Cdd:TIGR00845  488 LSNL-------RV-----GSEDGILEANHVSAVAQLASPNTATVTILDDDHA-GIFTFEEDVFHVS-----ESIGIMEVK 549

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034646479 1888 VIRHHGTLSPVTL-HWNIDSDPDG---DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAF 1946
Cdd:TIGR00845  550 VLRTSGARGTVIVpYRTVEGTARGggkDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTF 612
Calx-beta pfam03160
Calx-beta domain;
4273-4360 2.50e-15

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 74.59  E-value: 2.50e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4273 GRFAFSHEQLRVSEA-QRVNITIIRSSGDF-GHVRLWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEILDDDYPE 4350
Cdd:pfam03160    2 GVIGFEPPTYQVSENdGVAEVCVVRMSGTLrRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYE 81

                           90
                   ....*....|
gi 1034646479 4351 GPEEFSLTIT 4360
Cdd:pfam03160   82 GDENFFVLLS 91
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2494-2674 3.05e-15

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 83.69  E-value: 3.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2494 GQAVAGSDYEPvTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLislleVHLMNISASLKNQPTI----------GQPN 2563
Cdd:TIGR00845  442 GTANAGSDYEF-TEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFY-----VRLSNLRVGSEDGILEanhvsavaqlASPN 515

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2564 ISTVVIaLNGDAFGVFviynispnTSEDGLFvEVQEQPQTlVELMIHRTGGSLGQVAVEWRVVGGTATEGL-DFIGAGEI 2642
Cdd:TIGR00845  516 TATVTI-LDDDHAGIF--------TFEEDVF-HVSESIGI-MEVKVLRTSGARGTVIVPYRTVEGTARGGGkDFEDTCGE 584

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1034646479 2643 LTFAEGETKKTVILTILDDSEPEDDESIIVSL 2674
Cdd:TIGR00845  585 LEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 4273-4360 5.48e-15

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 73.44  E-value: 5.48e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  4273 GRFAFSHEQLRVSEAQ-RVNITIIRSSGDFGHVRLWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEILDDDYPEG 4351
Cdd:smart00237    2 GSVGFEQPVYTVSESDgEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEK 81


                    ....*....
gi 1034646479  4352 PEEFSLTIT 4360
Cdd:smart00237   82 DETFYVRLS 90
7tmB2_CELSR_Adhesion_IV cd15441
cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 ...
 5920-6161 1.44e-14

cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. Celsr3 is expressed in both the developing and adult mouse brain. It has been functionally implicated in proper neuron migration and axon guidance in the CNS.


Pssm-ID: 320557 [Multi-domain]  Cd Length: 254  Bit Score: 77.29  E-value: 1.44e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5920 FICISGLCLAVLSHIFCARYSmfaakLLTHMMAASLGTQILFLASAYASPQLAeeSCSAMAAVTHYLYLCQFSWMLIQSV 5999
Cdd:cd15441     18 LLVIAFLVLSCLRGLQSNSNS-----IHKNLVACLLLAELLFLLGINQTENLF--PCKLIAILLHYFYLSAFSWLLVESL 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6000 NFWYVL--VMNDEHTERRYllFFLLSWGLPAFVVILLIVILKGIYHQSmsqiyglihgDLCFIpNVYAALFTAALVPLTC 6077
Cdd:cd15441     91 HLYRMLtePRDINHGHMRF--YYLLGYGIPAIIVGLSVGLRPDGYGNP----------DFCWL-SVNETLIWSFAGPIAF 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6078 LVVV-FVVFIHAY----QVKPQWKAYDDVFRGrtnaaeIPLILYLFALISVTWLWGGL----HMAYRHFwmlvLFVIFNS 6148
Cdd:cd15441    158 VIVItLIIFILALrascTLKRHVLEKASVRTD------LRSSFLLLPLLGATWVFGLLavneDSELLHY----LFAGLNF 227

                          250
                   ....*....|...
gi 1034646479 6149 LQGLYVFMVYFIL 6161
Cdd:cd15441    228 LQGLFIFLFYCIF 240
7tmB2_GPR64 cd15444
orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B ...
 5942-6158 1.89e-14

orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors; GPR64 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR97, GPR112, GPR114, and GPR126. GPR64 is mainly expressed in the epididymis of male reproductive tract, and targeted deletion of GPR64 causes sperm stasis and efferent duct blockage due to abnormal fluid reabsorption, resulting in male infertility. GPR64 is also over-expressed in Ewing's sarcoma (ES), as well as upregulated in other carcinomas from kidney, prostate or lung, and promotes invasiveness and metastasis in ES via the upregulation of placental growth factor (PGF) and matrix metalloproteinase (MMP) 1. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320560 [Multi-domain]  Cd Length: 271  Bit Score: 77.17  E-value: 1.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5942 FAAKLLTHMMAASLGTQILFLASAY-ASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLL-F 6019
Cdd:cd15444     36 YPSKILIQLCVALLLLNLVFLLDSWiALYKDIVGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILkF 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6020 FLLSWGLPAFVVILLIVILKGIYH-QSMSQIYGLIHGDLCFIPNvyAALFTAALVPLTCLVVVF------VVFIHAYQVK 6092
Cdd:cd15444    116 CIVGWGVPAVVVAIVLAVSKDNYGlGSYGKSPNGSTDDFCWINN--NIVFYITVVGYFCVIFLLnismfiVVLVQLCRIK 193

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034646479 6093 PQWKAYddvFRGRTNAAEIPLILYLFALISVTW-----LWGGLHMAYrhfwmLVLFVIFNSLQGLYVFMVY 6158
Cdd:cd15444    194 KQKQLG---AQRKTSLQDLRSVAGITFLLGITWgfaffAWGPVNLAF-----MYLFAIFNTLQGFFIFIFY 256
7tmB2_GPR126 cd15996
orphan adhesion receptor GPR126, member of the class B2 family of seven-transmembrane G ...
 5942-6158 2.10e-14

orphan adhesion receptor GPR126, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR126 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR64, GPR97, GPR112, and GPR114. GPR126 is required in Schwann cells for proper differentiation and myelination via G-Protein Activation. GPR126 is believed to couple to G(s)-protein, which leads to activation of adenylate cyclase for cAMP production. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320662  Cd Length: 271  Bit Score: 77.24  E-value: 2.10e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5942 FAAKLLTHMMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLL-FF 6020
Cdd:cd15996     36 YPSKILMNLSTALLFLNLVFLLDGWIASFEIDELCITVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTYIRRYILkFC 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6021 LLSWGLPAFVV-ILLIVILKGIYHQSMSQIYGLIHGD-LCFIPNVYAALFTAA-------LVPLTCLVVVFVVFIHAYQV 6091
Cdd:cd15996    116 IIGWGLPALIVsIVLASTNDNYGYGYYGKDKDGQGGDeFCWIKNPVVFYVTCAayfgimfLMNVAMFIVVMVQICGRNGK 195

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034646479 6092 KPQWKAYDDVFRGRTNaaeiplILYLFALISVTW-----LWGGLHMAYrhfwmLVLFVIFNSLQGLYVFMVY 6158
Cdd:cd15996    196 RSNRTLREEILRNLRS------VVSLTFLLGMTWgfaffAWGPVNLAF-----MYLFTIFNSLQGLFIFVFH 256
7tmB2_GPR133-like_Adhesion_V cd15933
orphan GPR133 and related proteins, group V adhesion GPCRs, member of class B2 family of ...
 5921-6161 2.45e-14

orphan GPR133 and related proteins, group V adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group V adhesion GPCRs include orphan receptors GPR133, GPR144, and closely related proteins. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the G(s) protein, leading to activation of adenylate cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320599 [Multi-domain]  Cd Length: 252  Bit Score: 76.60  E-value: 2.45e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5921 ICISGLCLAVLSHIFCARYSMFAAKLLTHMMAASLGTQILFLASAYASPQlaEESCSAMAAVTHYLYLCQFSWMLIQSVN 6000
Cdd:cd15933     14 ISIACLALTLIIFLVLRVLSSDRFQIHKNLCVALLLAQILLLAGEWAEGN--KVACKVVAILLHFFFMAAFSWMLVEGLH 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6001 FWYVLV-MNDEHTERRYllFFLLSWGLPAFVVILLIVILKGIYHQS----MSQIYGLIhgdLCFIPNVYAALFTAALVpL 6075
Cdd:cd15933     92 LYLMIVkVFNYKSKMRY--YYFIGWGLPAIIVAISLAILFDDYGSPnvcwLSLDDGLI---WAFVGPVIFIITVNTVI-L 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6076 TCLVVVFVVF--IHAYQVKPQWKAYDDVFRGrtnaaeiplILYLFALISVTWLWG-------GLHMAYrhfwmlvLFVIF 6146
Cdd:cd15933    166 ILVVKITVSLstNDAKKSQGTLAQIKSTAKA---------SVVLLPILGLTWLFGvlvvnsqTIVFQY-------IFVIL 229

                          250
                   ....*....|....*
gi 1034646479 6147 NSLQGLYVFMVYFIL 6161
Cdd:cd15933    230 NSLQGLMIFLFHCVL 244
Calx-beta pfam03160
Calx-beta domain;
1728-1808 5.81e-14

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 70.74  E-value: 5.81e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1728 PHITVEEEDGEIRLLVIRAQGLLGR-VTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKV 1806
Cdd:pfam03160    9 PTYQVSENDGVAEVCVVRMSGTLRRtVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFV 88


                   ..
gi 1034646479 1807 EL 1808
Cdd:pfam03160   89 LL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1728-1809 5.96e-14

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 70.36  E-value: 5.96e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  1728 PHITVEEEDGEIRLLVIRAQGLLGRVTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKVE 1807
Cdd:smart00237    9 PVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVR 88


                    ..
gi 1034646479  1808 LL 1809
Cdd:smart00237   89 LS 90
7tm_2 pfam00002
7 transmembrane receptor (Secretin family); This family is known as Family B, the ...
 5921-6154 1.65e-13

7 transmembrane receptor (Secretin family); This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteriztic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.


Pssm-ID: 459625 [Multi-domain]  Cd Length: 248  Bit Score: 73.85  E-value: 1.65e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5921 ICISGLCLAVLSHIFCA--RYSMFAAKLLTHMMAASLGTQILFLA------SAYASPQLAEESCSAMAAVTHYLYLCQFS 5992
Cdd:pfam00002   12 YSLSLVALLLAIAIFLLfrKLHCTRNYIHLNLFASFILRALLFLVgdavlfNKQDLDHCSWVGCKVVAVFLHYFFLANFF 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5993 WMLIQSV--NFWYVLVMNdehTERRYLLFF-LLSWGLPA-FVVILLIVILKGIYHQsmsqiyglihgDLCFIpNVYAALF 6068
Cdd:pfam00002   92 WMLVEGLylYTLLVEVFF---SERKYFWWYlLIGWGVPAlVVGIWAGVDPKGYGED-----------DGCWL-SNENGLW 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6069 TAALVP-LTCLVVVFVVFIHAYQV--------KPQWKAYDDVFR-GRTNAAEIPL-----ILYLFALISVTWLWgglhma 6133
Cdd:pfam00002  157 WIIRGPiLLIILVNFIIFINIVRIlvqklretNMGKSDLKQYRRlAKSTLLLLPLlgitwVFGLFAFNPENTLR------ 230

                          250       260
                   ....*....|....*....|.
gi 1034646479 6134 yrhFWMLVLFVIFNSLQGLYV 6154
Cdd:pfam00002  231 ---VVFLYLFLILNSFQGFFV 248
7tmB2_Latrophilin_Adhesion_I cd15252
Latrophilins and similar receptors, group I adhesion GPCRs, member of class B2 family of ...
 5921-6165 1.79e-13

Latrophilins and similar receptors, group I adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; Group I adhesion GPCRs consist of latrophilins (also called lectomedins or latrotoxin receptors) and ETL (EGF-TM7-latrophilin-related protein. These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320380 [Multi-domain]  Cd Length: 257  Bit Score: 74.08  E-value: 1.79e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5921 ICISGLCLAVLSHIFCARYSMFAAKLLTH--MMAASLGTQILFLASAYASPQlaEESCSAMAAVTHYLYLCQFSWMLIQS 5998
Cdd:cd15252     12 IIISLVCLAICIFTFWFFRGLQSDRTTIHknLCISLFLAELVFLIGINTTTN--KIFCSVIAGLLHYFFLAAFAWMFIEG 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5999 VNFWYVL--VMNDEHTERRYllFFLLSWGLPAFVVIllivILKGIYHQSmsqiYGLihGDLCFIPN----VYAALFTAAL 6072
Cdd:cd15252     90 IQLYLMLveVFENEGSRHKN--FYIFGYGSPAVIVG----VSAALGYRY----YGT--TKVCWLSTenyfIWSFIGPATL 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6073 VPLTCL----VVVFVVFIHAYQVKPQWKAYDDvfrgrTNAAEIPLILYLFaLISVTWLWGGLHMAYRHFWMLVLFVIFNS 6148
Cdd:cd15252    158 IILLNLiflgVAIYKMFRHTAGLKPEVSCLEN-----IRSWARGAIALLF-LLGLTWIFGVLHINHASVVMAYLFTVSNS 231

                          250
                   ....*....|....*..
gi 1034646479 6149 LQGLYVFMVYFILHNQM 6165
Cdd:cd15252    232 LQGMFIFLFHCVLSRKV 248
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1626-1808 3.53e-13

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 77.14  E-value: 3.53e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1626 DFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYFRVTL--VSAIPGDGKLGSTPTSGASIDPEKETTDITIKASDHPy 1703
Cdd:TIGR00845  449 DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsnLRVGSEDGILEANHVSAVAQLASPNTATVTILDDDHA- 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1704 GLLQFSTglppqpkdamtlpassvPHITVEEEDGEIRLLVIRAQGLLGRVTAEFRTVSLTA-FSPEDYQNVAGTLEFQPG 1782
Cdd:TIGR00845  528 GIFTFEE-----------------DVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTArGGGKDFEDTCGELEFEND 590

                          170       180
                   ....*....|....*....|....*.
gi 1034646479 1783 ERYKYIFINITDNSIPELEKSFKVEL 1808
Cdd:TIGR00845  591 ETEKTIRVKIVDDEEYEKNDTFFIEL 616
7tmB2_Latrophilin-3 cd16005
Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled ...
 5921-6165 8.80e-13

Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320671 [Multi-domain]  Cd Length: 258  Bit Score: 72.28  E-value: 8.80e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5921 ICISGLCLAVLSHIFCARYSMFAAKLLTH--MMAASLGTQILFLASAYASPQLAeeSCSAMAAVTHYLYLCQFSWMLIQS 5998
Cdd:cd16005     12 ILLSLVCLLICIFTFCFFRGLQSDRNTIHknLCISLFVAELLFLIGINRTDQPI--ACAVFAALLHFFFLAAFTWMFLEG 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5999 VNFWYVL--VMNDEHTERRYllFFLLSWGLPAFVVILLIVIlkgIYHQSMSQIYGLIHGDLCFIPN-VYAALFTAALVPL 6075
Cdd:cd16005     90 VQLYIMLveVFESEHSRRKY--FYLVGYGMPALIVAVSAAV---DYRSYGTDKVCWLRLDTYFIWSfIGPATLIIMLNVI 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6076 TCLVVVFVVFIHAYQVKPQWKAYDDVFRGRTNAaeipliLYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVF 6155
Cdd:cd16005    165 FLGIALYKMFHHTAILKPESGCLDNIKSWVIGA------IALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIF 238

                          250
                   ....*....|
gi 1034646479 6156 MVYFILHNQM 6165
Cdd:cd16005    239 IFHCVLQKKV 248
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1000-1207 1.39e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 75.21  E-value: 1.39e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1000 NDDPI-YFAEPRVVRVQE--GETANFTVLRNGSVDVTCMVQYATKDGKATARErDFIPVEKgeTLIFEVGSRQQSISIFV 1076
Cdd:TIGR00845  396 NDPVSkIFFEPGHYTCLEncGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGS-DYEFTEG--TLVFKPGETQKEFRIGI 472

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1077 NEDGIPETDEPFYIILLN-----------STGDTVVYQYG---VATVIIeANDDPNGIFSLE-PIDKAVEEGKTNAFWIL 1141
Cdd:TIGR00845  473 IDDDIFEEDEHFYVRLSNlrvgsedgileANHVSAVAQLAspnTATVTI-LDDDHAGIFTFEeDVFHVSESIGIMEVKVL 551

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034646479 1142 RHRGYFGSVSVSWQLfQNDSALQPGQEFYETSGTVNFMDGEEAKPIILHAFPDKIPEFNEFYFLKL 1207
Cdd:TIGR00845  552 RTSGARGTVIVPYRT-VEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
7tmB2_latrophilin-like_invertebrate cd15440
invertebrate latrophilin-like receptors, member of the class B2 family of seven-transmembrane ...
 5976-6165 1.59e-12

invertebrate latrophilin-like receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors; This subgroup includes latrophilin-like proteins that are found in invertebrates such as insects and worms. Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of vertebrate latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320556 [Multi-domain]  Cd Length: 259  Bit Score: 71.14  E-value: 1.59e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5976 CSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLLFFLLSWGLPAFVVIllivILKGIYHQSmsqiYGLihG 6055
Cdd:cd15440     67 CGVIAGLLHYFFLAAFSWMLLEGFQLYVMLVEVFEPEKSRIKWYYLFGYGLPALIVA----VSAGVDPTG----YGT--E 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6056 DLCFI----PNVYAALFTAALVPLTCLVV----VFVVFIHAyQVKPQWKAYDdvfRGRTNAAEIPLILYLFALISVTWLW 6127
Cdd:cd15440    137 DHCWLstenGFIWSFVGPVIVVLLANLVFlgmaIYVMCRHS-SRSASKKDAS---KLKNIRGWLKGSIVLVVLLGLTWTF 212

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1034646479 6128 GGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQM 6165
Cdd:cd15440    213 GLLFINQESIVMAYIFTILNSLQGLFIFIFHCVLNEKV 250
7tmB2_GPR133 cd15256
orphan adhesion receptor GPR133, member of the class B2 family of seven-transmembrane G ...
 5923-6165 1.79e-12

orphan adhesion receptor GPR133, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR133 is an orphan receptor that belongs to the group V adhesion-GPCRs together with GPR144. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the Gs protein, leading to activation of adenylyl cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320384 [Multi-domain]  Cd Length: 260  Bit Score: 71.11  E-value: 1.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5923 ISGLCLAV----------LSHIFCARYSMFAaklltHMMAASLGTQILFLASAYASPqlAEESCSAMAAVTHYLYLCQFS 5992
Cdd:cd15256     14 LSIFCLAItlvtfavlssVSTIRNQRYHIHA-----NLSFAVLVAQILLLISFRFEP--GTLPCKIMAILLHFFFLSAFA 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5993 WMLIQSVNFWYVLVMNDEHTERRYLLFFLLSWGLPafvviLLIVIlkgIYHQSMSQIYGliHGDLCFIPNVYAALFTAAL 6072
Cdd:cd15256     87 WMLVEGLHLYSMVIKVFGSEESKHFYYYGIGWGSP-----LLICI---ISLTSALDSYG--ESDNCWLSLENGAIWAFVA 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6073 VPLTCLVVVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEI--PLILYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQ 6150
Cdd:cd15256    157 PALFVIVVNIGILIAVTRVISRISADNYKVHGDANAFKLtaKAVAVLLPILGSSWVFGVLAVNTHALVFQYMFAIFNSLQ 236

                          250
                   ....*....|....*
gi 1034646479 6151 GLYVFMVYFILHNQM 6165
Cdd:cd15256    237 GFFIFLFHCLLNSEV 251
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3799-4011 2.62e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 74.06  E-value: 2.62e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3799 ENTTTLQLQIARDKGLLGDIA-IHLRAQpnfllhvDNQATENEDYVLQETIIIMKENIKEAHAEVSILPDDLPELEEGFI 3877
Cdd:TIGR00845  413 ENCGTVALTVVRRGGDLTNTVyVDYRTE-------DGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFY 485

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3878 VTITEVNLVNSDFSTGQPSVRRPGM----EIAEIMIEENDDPrGIFMF-----HVTRGAGEVitayevppplnvlQVPVV 3948
Cdd:TIGR00845  486 VRLSNLRVGSEDGILEANHVSAVAQlaspNTATVTILDDDHA-GIFTFeedvfHVSESIGIM-------------EVKVL 551

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034646479 3949 RLAGSFGAVNVYWKASPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISL 4011
Cdd:TIGR00845  552 RTSGARGTVIVPYRTVEGTArgGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2605-2674 2.86e-12

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 65.74  E-value: 2.86e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  2605 VELMIHRTGGSLGQVAVEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSEPEDDESIIVSL 2674
Cdd:smart00237   20 VEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2968-3180 3.18e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 74.06  E-value: 3.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2968 IEWQQSRFEVNETHGSLTLVAQRSREPLGHVSLFVY-AQNLEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEGD 3046
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYrTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEED 481

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3047 EKFQLILTNPSPGLELG---KNTIALIIVLAN----------DDGPGVLSFNNSEhfflreptaLYVQESVAVLYIVREP 3113
Cdd:TIGR00845  482 EHFYVRLSNLRVGSEDGileANHVSAVAQLASpntatvtildDDHAGIFTFEEDV---------FHVSESIGIMEVKVLR 552

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034646479 3114 AQGLFGTVTVQFIVTEVNSSNESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3180
Cdd:TIGR00845  553 TSGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEP 619
7tmB2_GPR97 cd15442
orphan adhesion receptor GPR97, member of the class B2 family of seven-transmembrane G ...
 5975-6162 6.41e-12

orphan adhesion receptor GPR97, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR97 is an orphan receptor that has been classified into the group VIII of adhesion GPCRs. Other members of the Group VII include GPR56, GPR64, GPR112, GPR114, and GPR126. GPR97 is identified as a lymphatic adhesion receptor that is specifically expressed in lymphatic endothelium, but not in blood vascular endothelium, and is shown to regulate migration of lymphatic endothelial cells via the small GTPases RhoA and cdc42. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320558 [Multi-domain]  Cd Length: 277  Bit Score: 69.83  E-value: 6.41e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5975 SCSAMAAVTHYLYLCQFSWMLIQSVNFwYVLVMNDEHTERRYLL--FFLLSWGLPAFVVILLIVIlkGIYHQ-SMSQIYG 6051
Cdd:cd15442     73 LCKALGGVTHYFLLCCFTWMAIEAFHL-YLLAIKVFNTYIHHYFakLCLVGWGFPALVVTITGSI--NSYGAyTIMDMAN 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6052 LIHGDLCFIPNVYAALFTAALVPLTCLVVVF--VVF-IHAYQVKPQWKAydDVFRGRTNAAEIPL-ILYLFALISVTWLW 6127
Cdd:cd15442    150 RTTLHLCWINSKHLTVHYITVCGYFGLTFLFntVVLgLVAWKIFHLQSA--TAGKEKCQAWKGGLtVLGLSCLLGVTWGL 227

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1034646479 6128 GGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILH 6162
Cdd:cd15442    228 AFFTYGSMSVPTVYIFALLNSLQGLFIFIWFVILY 262
7tmB2_CELSR1 cd15991
Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of ...
 5976-6174 9.81e-12

Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320657 [Multi-domain]  Cd Length: 254  Bit Score: 68.72  E-value: 9.81e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5976 CSAMAAVTHYLYLCQFSWMLIQSVNFWYVL--VMNDEHTERRYllFFLLSWGLPAfvvillivILKGIYHQSMSQIYGli 6053
Cdd:cd15991     67 CTVVAILLHYFYMSTFAWMFVEGLHIYRMLteVRNINTGHMRF--YYVVGWGIPA--------IITGLAVGLDPQGYG-- 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6054 HGDLCFIpNVYAALFTAALVPLTCLVVV-FVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLfaLISVTWLWGGLHM 6132
Cdd:cd15991    135 NPDFCWL-SVQDTLIWSFAGPIGIVVIInTVIFVLAAKASCGRRQRYFEKSGVISMLRTAFLLLL--LISATWLLGLMAV 211

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1034646479 6133 AYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQMCCPMKASYT 6174
Cdd:cd15991    212 NSDTLSFHYLFAIFSCLQGIFIFFFHCIFNKEVRKHLKNVLT 253
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1998-2204 1.38e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 71.75  E-value: 1.38e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1998 LSIIRLKGLMGK-VLVSYATLDdmekppyfppnlARATQGRDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIE 2076
Cdd:TIGR00845  420 LTVVRRGGDLTNtVYVDYRTED------------GTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVR 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2077 LLNstlvAKVQSRsipNSPRLGPKVETIAQL-------IIIANDDAFGTLQLSAPIVRVAENhVGPI-INVTRTGGAFAD 2148
Cdd:TIGR00845  488 LSN----LRVGSE---DGILEANHVSAVAQLaspntatVTILDDDHAGIFTFEEDVFHVSES-IGIMeVKVLRTSGARGT 559

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034646479 2149 VSVKFKAVPITAIAG-EDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQL 2204
Cdd:TIGR00845  560 VIVPYRTVEGTARGGgKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
7tmB2_Latrophilin-1 cd16007
Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled ...
 5921-6165 1.45e-11

Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320673 [Multi-domain]  Cd Length: 258  Bit Score: 68.41  E-value: 1.45e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5921 ICISGLCLAVLSHIFCARYSMFAAKLLTH--MMAASLGTQILFLASAYASPQlaEESCSAMAAVTHYLYLCQFSWMLIQS 5998
Cdd:cd16007     12 IVISLVCLAICISTFCFLRGLQTDRNTIHknLCINLFLAELLFLIGIDKTQY--QIACPIFAGLLHFFFLAAFSWLCLEG 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5999 VNFWYVL--VMNDEHTERRYllFFLLSWGLPAFVVillivilkGIYHQSMSQIYGLIHGDLCFIPNVYAALFTAalvPLT 6076
Cdd:cd16007     90 VQLYLMLveVFESEYSRKKY--YYLCGYCFPALVV--------GISAAIDYRSYGTEKACWLRVDNYFIWSFIG---PVS 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6077 CLVVVFVVFI---------HAYQVKPQWKAYDDVfrgrtNAAEIPLILYLFaLISVTWLWGGLHMAYRHFWMLVLFVIFN 6147
Cdd:cd16007    157 FVIVVNLVFLmvtlhkmirSSSVLKPDSSRLDNI-----KSWALGAITLLF-LLGLTWAFGLLFINKESVVMAYLFTTFN 230

                          250
                   ....*....|....*...
gi 1034646479 6148 SLQGLYVFMVYFILHNQM 6165
Cdd:cd16007    231 AFQGMFIFIFHCALQKKV 248
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 53-236 1.53e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 71.75  E-value: 1.53e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479   53 LIIERIGEPANVTAIVSLYGED----AG-DFFDTYAAAFIPAGETNRTVYIAVCDDDLPEPDETFIFHLT---------- 117
Cdd:TIGR00845  420 LTVVRRGGDLTNTVYVDYRTEDgtanAGsDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSnlrvgsedgi 499

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  118 LQKPSANVK--LGWPRTVTVTILSNDNAfGIISFNMlPSIAVSEPKGRnesMPLTLIREKGTYGMVMVTFE-VEGGPNPP 194
Cdd:TIGR00845  500 LEANHVSAVaqLASPNTATVTILDDDHA-GIFTFEE-DVFHVSESIGI---MEVKVLRTSGARGTVIVPYRtVEGTARGG 574

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1034646479  195 DEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQL 236
Cdd:TIGR00845  575 GKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1883-2077 1.64e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 71.75  E-value: 1.64e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1883 TVTLNVIRHHGTLSpVTLHWNIDSDpDG------DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAF---------- 1946
Cdd:TIGR00845  417 TVALTVVRRGGDLT-NTVYVDYRTE-DGtanagsDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFyvrlsnlrvg 494

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1947 -----SVSVLSVSSGSLGAHINATLTVLaSDDPYGIFIFSEKNrpVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMe 2021
Cdd:TIGR00845  495 sedgiLEANHVSAVAQLASPNTATVTIL-DDDHAGIFTFEEDV--FHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGT- 570

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034646479 2022 kppyfppnlARATqGRDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIEL 2077
Cdd:TIGR00845  571 ---------ARGG-GKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4206-4397 1.69e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 71.36  E-value: 1.69e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4206 EFAETSGKLTMRDEQSAVIVVIQALNDDIPEEKSFYEFQLTAVSEG---GVLS----------ESSSTANITVVASDSPy 4272
Cdd:TIGR00845  449 DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGsedGILEanhvsavaqlASPNTATVTILDDDHA- 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4273 GRFAFSHEQLRVSEAQ-RVNITIIRSSGDFGHVRLWYKTMSGTAEAGL-DFVPAAGELLFEAGEMRKSLHVEILDDDYPE 4350
Cdd:TIGR00845  528 GIFTFEEDVFHVSESIgIMEVKVLRTSGARGTVIVPYRTVEGTARGGGkDFEDTCGELEFENDETEKTIRVKIVDDEEYE 607

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1034646479 4351 GPEEFSLTITKVELQGRGYDFTI--QENGLQIDQPPEIGNISIVRIIIM 4397
Cdd:TIGR00845  608 KNDTFFIELGEPRWAKRGIKAALllNETITDDDQKLTSKEEEERRIAEM 656
7tmB2_GPR144 cd15255
orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G ...
 5949-6165 1.89e-11

orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR144 is an orphan receptor that belongs to the group V adhesion-GPCRs together with GPR133. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the Gs protein, leading to activation of adenylyl cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320383 [Multi-domain]  Cd Length: 263  Bit Score: 68.34  E-value: 1.89e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5949 HMMAASLGTQILFLASAYASPQlaEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLLFFLLSWGLPa 6028
Cdd:cd15255     42 NLIFALAAAEFLLMFSEWAKGN--QVACWAVTALLHLFFLAAFSWMLVEGLLLWSKVVAVNMSEDRRMKFYYVTGWGLP- 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6029 fvVILLIVILKGIYHQSMSQiyglIHGDLCFIPNVYAALFTAALVPLTCLVVVF--VVFI-------HAYQVKPQWKAYD 6099
Cdd:cd15255    119 --VVIVAVTLATSFNKYVAD----QHCWLNVQTDIIWAFVGPVLFVLTVNTFVLfrVVMVtvssarrRAKMLTPSSDLEK 192

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034646479 6100 DVFRgRTNAAEIPlILYLFALISVTWLWGGL-HMAYRhfwMLVLFVIFNSLQGLYVFMVYFILHNQM 6165
Cdd:cd15255    193 QIGI-QIWATAKP-VLVLLPVLGLTWLCGVLvHLSDV---WAYVFITLNSFQGLYIFLVYAIYNSEV 254
7tmB2_ETL cd15437
Epidermal Growth Factor, latrophilin and seven transmembrane domain-containing protein 1; ...
 5976-6165 2.24e-11

Epidermal Growth Factor, latrophilin and seven transmembrane domain-containing protein 1; member of the class B2 family of seven-transmembrane G protein-coupled receptors; ETL (EGF-TM7-latrophilin-related protein) belongs to Group I adhesion GPCRs, which also include latrophilins (also called lectomedins or latrotoxin receptors). All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. ETL, for instance, contains EGF-like repeats, which also present in other EGF-TM7 adhesion GPCRs, such as Cadherin EGF LAG seven-pass G-type receptors (CELSR1-3), EGF-like module receptors (EMR1-3), CD97, and Flamingo. ETL is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320553 [Multi-domain]  Cd Length: 258  Bit Score: 67.98  E-value: 2.24e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5976 CSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLLFFLLSWGLPAFVVillivilkGIYHQSMSQIYGLihG 6055
Cdd:cd15437     67 CSIIAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYGSPAVVV--------GISAALGYKYYGT--T 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6056 DLCFIPN----VYAALFTAALVPLTCL----VVVFVVFIHAYQVKPQWKAYDDVfRGRTNAAeipliLYLFALISVTWLW 6127
Cdd:cd15437    137 KVCWLSTennfIWSFIGPACLIILVNLlafgVIIYKVFRHTAMLKPEVSCYENI-RSCARGA-----LALLFLLGATWIF 210

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1034646479 6128 GGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQM 6165
Cdd:cd15437    211 GVLHVVYGSVVTAYLFTISNAFQGMFIFIFLCVLSRKI 248
7tmB2_CD97 cd15438
CD97 antigen, member of the class B2 family of seven-transmembrane G protein-coupled receptors; ...
 5926-6164 2.67e-11

CD97 antigen, member of the class B2 family of seven-transmembrane G protein-coupled receptors; group II adhesion GPCRs, including the leukocyte cell-surface antigen CD97 and the epidermal growth factor (EGF)-module-containing, mucin-like hormone receptor (EMR1-4), are primarily expressed in cells of the immune system. All EGF-TM7 receptors, which belong to the B2 subfamily B2 of adhesion GPCRs, are members of group II, except for ETL (EGF-TM7-latrophilin related protein), which is classified into group I. Members of the EGF-TM7 receptors are characterized by the presence of varying numbers of N-terminal EGF-like domains, which play critical roles in ligand recognition and cell adhesion, linked by a stalk region to a class B seven-transmembrane domain. In the case of CD97, alternative splicing results in three isoforms possessing either three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. For example, CD97, which is involved in angiogenesis and the migration and invasion of tumor cells, has been shown to promote cell aggregation in a GPS proteolysis-dependent manner. CD97 is widely expressed on lymphocytes, monocytes, macrophages, dendritic cells, granulocytes and smooth muscle cells as well as in a variety of human tumors including colorectal, gastric, esophageal pancreatic, and thyroid carcinoma. EMR2 shares strong sequence homology with CD97, differing by only six amino acids. However, unlike CD97, EMR2 is not found in those of CD97-positive tumor cells and is not expressed on lymphocytes but instead on monocytes, macrophages and granulocytes. CD97 has three known ligands: CD55, decay-accelerating factor for regulation of complement system; chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix; and the integrin alpha5beta1, which play a role in angiogenesis. Although EMR2 does not effectively interact with CD55, the fourth EGF-like domain of this receptor binds to chondroitin sulfate to mediate cell attachment.


Pssm-ID: 320554 [Multi-domain]  Cd Length: 261  Bit Score: 67.87  E-value: 2.67e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5926 LCLAVLSHIFCARYSMFAAKLLTHMMAASLGTQILFLASAYA-SPQLAeesCSAMAAVTHYLYLCQFSWMLIQSVNFWY- 6003
Cdd:cd15438     19 LFLCILTFLFCRSIRGTRNTIHLHLCLSLFLAHLIFLLGINNtNNQVA---CAVVAGLLHYFFLAAFCWMSLEGVELYLm 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6004 -VLVMNDEHTERRYLlfFLLSWGLPAFVVILLIVILKGIY----HQSMSQIYGLI---HGDLCFIPNVYAALFtaalvpl 6075
Cdd:cd15438     96 vVQVFNTQSLKKRYL--LLIGYGVPLVIVAISAAVNSKGYgtqrHCWLSLERGFLwsfLGPVCLIILVNAIIF------- 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6076 tcLVVVFVVFIHAYQVKPQWKAYDdvfrgRTNAAEIPLILYLFALiSVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVF 6155
Cdd:cd15438    167 --VITVWKLAEKFSSINPDMEKLR-----KIRALTITAIAQLCIL-GCTWIFGFFQFSDSTLVMSYLFTILNSLQGLFIF 238


                   ....*....
gi 1034646479 6156 MVYFILHNQ 6164
Cdd:cd15438    239 LLHCLLSKQ 247
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3894-4128 4.75e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 70.21  E-value: 4.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3894 QPSVRRPGMEIAEIMIEENDDPRGIFM----FHVTRGAGEVitayevppplnvlQVPVVRLAGSFG-AVNVYWKASPDSA 3968
Cdd:TIGR00845  378 DAARKAVSMHEVATDDEENDPVSKIFFepghYTCLENCGTV-------------ALTVVRRGGDLTnTVYVDYRTEDGTA 444

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3969 GL-EDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISLISVAGG--------------GRLGDDVVVTVVIPQN 4033
Cdd:TIGR00845  445 NAgSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDD 524

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4034 DSPfGVFGFEEKTVMIDESLssddpdSYVTLTVVRSPGGKGTVRLE-WTIDEKAKHNLSPLNGT---LHFDETESQKTIV 4109
Cdd:TIGR00845  525 DHA-GIFTFEEDVFHVSESI------GIMEVKVLRTSGARGTVIVPyRTVEGTARGGGKDFEDTcgeLEFENDETEKTIR 597

                          250
                   ....*....|....*....
gi 1034646479 4110 LHTLQDTVLEEDRRFTIQL 4128
Cdd:TIGR00845  598 VKIVDDEEYEKNDTFFIEL 616
7tmB2_Latrophilin-2 cd16006
Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled ...
 5921-6165 5.16e-11

Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320672 [Multi-domain]  Cd Length: 258  Bit Score: 66.86  E-value: 5.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5921 ICISGLCLAVLSHIFCARYSMFAAKLLTHM---MAASLGTQILFLASAYASPQLAeesCSAMAAVTHYLYLCQFSWMLIQ 5997
Cdd:cd16006     12 IVISLVCLAICIFTFCFFRGLQSDRNTIHKnlcINLFIAEFIFLIGIDKTEYKIA---CPIFAGLLHFFFLAAFAWMCLE 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5998 SVNFWYVL--VMNDEHTERRYllFFLLSWGLPAFVVillivilkGIYHQSMSQIYGLIHGDLCFIPNVYAALFTAALVPL 6075
Cdd:cd16006     89 GVQLYLMLveVFESEYSRKKY--YYVAGYLFPATVV--------GVSAAIDYKSYGTEKACWLRVDNYFIWSFIGPVTFI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6076 TCLVVVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVF 6155
Cdd:cd16006    159 ILLNLIFLVITLCKMVKHSNTLKPDSSRLENIKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLFTIFNAFQGMFIF 238

                          250
                   ....*....|
gi 1034646479 6156 MVYFILHNQM 6165
Cdd:cd16006    239 IFHCALQKKV 248
7tmB2_Latrophilin cd15436
Latrophilins, member of the class B2 family of seven-transmembrane G protein-coupled receptors; ...
 5921-6161 5.47e-11

Latrophilins, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320552 [Multi-domain]  Cd Length: 258  Bit Score: 66.74  E-value: 5.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5921 ICISGLCLAVLSHIFCARYSMFAAKLLTH--MMAASLGTQILFLASAYASPQlaEESCSAMAAVTHYLYLCQFSWMLIQS 5998
Cdd:cd15436     12 IVISLVCLLICIFTFCFFRGLQTDRNTIHknLCINLFIAELLFLIGINRTQY--TIACPIFAGLLHFFFLAAFCWLCLEG 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5999 VNFWYVL--VMNDEHTERRYllFFLLSWGLPAFVVILLIVIlkgIYHQSMSQIYGLIHGDLCFIPNVYAALFTAALVPLT 6076
Cdd:cd15436     90 VQLYLLLveVFESEYSRRKY--FYLCGYSFPALVVAVSAAI---DYRSYGTEKACWLRVDNYFIWSFIGPVTFVITLNLV 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6077 CLVVVFVVFIHAYQVKPQWKAYDDVFRGRTNAAeipliLYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFM 6156
Cdd:cd15436    165 FLVITLHKMVSHSDLLKPDSSRLDNIKSWALGA-----IALLFLLGLTWSFGLMFINEESVVMAYLFTIFNAFQGVFIFI 239


                   ....*
gi 1034646479 6157 VYFIL 6161
Cdd:cd15436    240 FHCAL 244
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1976-2078 8.74e-11

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 61.50  E-value: 8.74e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  1976 GIFIFSEKNrpVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMekppyfppnlarATQGRDYIPASGFALFGANQSEA 2055
Cdd:smart00237    2 GSVGFEQPV--YTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGT------------ATAGSDYEPVPGELTFPPGETEK 67

                            90       100
                    ....*....|....*....|...
gi 1034646479  2056 TIAISILDDDEPERSESVFIELL 2078
Cdd:smart00237   68 EIRIKIIDDDIYEKDETFYVRLS 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2139-2322 9.02e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 69.05  E-value: 9.02e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2139 VTRTGGAFAD-VSVKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQLMNETTGG------ 2211
Cdd:TIGR00845  422 VVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSedgile 501

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2212 -------ARLGALTEAVIIIeASDDPYGLFGFQITKLIVEEpefNSVKVNLPIIRNSGTLGNVTVQWvATINGQlATG-- 2282
Cdd:TIGR00845  502 anhvsavAQLASPNTATVTI-LDDDHAGIFTFEEDVFHVSE---SIGIMEVKVLRTSGARGTVIVPY-RTVEGT-ARGgg 575

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1034646479 2283 -DLRVVSGNVTFAPGETIQTLLLEVLADDVPEIEEVIQVQL 2322
Cdd:TIGR00845  576 kDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3591-3732 1.69e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 68.28  E-value: 1.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3591 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPKGGAEIGINDS--------------VTITILSNDDA 3656
Cdd:TIGR00845  448 SDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEDGILEAnhvsavaqlaspntATVTILDDDHA 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3657 yGIVAFaQNSLYKQVEEMeqdSLVTLNVERLKGTYGRI-----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTILA 3731
Cdd:TIGR00845  528 -GIFTF-EEDVFHVSESI---GIMEVKVLRTSGARGTVivpyrTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVD 602


                   .
gi 1034646479 3732 D 3732
Cdd:TIGR00845  603 D 603
Calx-beta pfam03160
Calx-beta domain;
2605-2674 1.93e-10

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 60.73  E-value: 1.93e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034646479 2605 VELMIHRTGGSL-GQVAVEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSEPEDDESIIVSL 2674
Cdd:pfam03160   20 AEVCVVRMSGTLrRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFVLL 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2605-2788 7.03e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 66.35  E-value: 7.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2605 VELMIHRTGGSLGQ-VAVEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSEPEDDESIIVSL----VYTEG 2679
Cdd:TIGR00845  418 VALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsnlrVGSED 497

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2680 GsrILPSSDTVRVNILAN----------DNVAGIVSFQTASRSVIGHEGeILQFHVIRTFPGRGNVTVNWKIIGQNLELN 2749
Cdd:TIGR00845  498 G--ILEANHVSAVAQLASpntatvtildDDHAGIFTFEEDVFHVSESIG-IMEVKVLRTSGARGTVIVPYRTVEGTARGG 574

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1034646479 2750 FANFS---GQLFFPEGSLNTTLFVHLLDDNIPEEKEVYQVIL 2788
Cdd:TIGR00845  575 GKDFEdtcGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
7tmB2_EMR cd15439
epidermal growth factor-like module-containing mucin-like hormone receptors, member of the ...
 5921-6164 7.26e-10

epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors; group II adhesion GPCRs, including the epidermal growth factor (EGF)-module-containing, mucin-like hormone receptor (EMR1-4) and the leukocyte cell-surface antigen CD97, are primarily expressed in cells of the immune system. All EGF-TM7 receptors, which belong to the B2 subfamily of adhesion GPCRs, are members of group II, except for ETL (EGF-TM7-latrophilin related protein), which is classified into group I. Members of the EGF-TM7 receptors are characterized by the presence of varying number of N-terminal EGF-like domains, which play critical roles in ligand recognition and cell adhesion, linked by a stalk region to a class B seven-transmembrane domain. In the case of EMR2, alternative splicing results in four isoforms possessing either two (EGF1,2), three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. EMR2 shares strong sequence homology with CD97, differing by only six amino acids. CD97 is widely expressed on lymphocytes, monocytes, macrophages, dendritic cells, granulocytes and smooth muscle cells as well as in a variety of human tumors including colorectal, gastric, esophageal pancreatic, and thyroid carcinoma. However, unlike CD97, EMR2 is not found in those of CD97-positive tumor cells and is not expressed on lymphocytes but instead on monocytes, macrophages and granulocytes. CD97 has three known ligands: CD55, decay-accelerating factor for regulation of complement system; chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix; and the integrin alpha5beta1, which play a role in angiogenesis. Although EMR2 does not effectively interact with CD55, the fourth EGF-like domain of this receptor binds to chondroitin sulfate to mediate cell attachment.


Pssm-ID: 320555 [Multi-domain]  Cd Length: 263  Bit Score: 63.51  E-value: 7.26e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5921 ICISGLCL--AVLSHIFCARYSMFAAKLLTHMMAASLGTQILFLASA-YASPQLAeesCSAMAAVTHYLYLCQFSWMLIQ 5997
Cdd:cd15439     12 LIISLLCLflAILTFLLCRSIRNTSTSLHLQLSLCLFLADLLFLVGIdRTDNKVL---CSIIAGFLHYLFLACFAWMFLE 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5998 SVNFWYVL----VMNDEHTER-RYLLFFLLSWGLPAFVVilliVILKGIYHQSMS-QIYGLIHGDLCFIPNVYAALFTAA 6071
Cdd:cd15439     89 AVHLFLTVrnlkVVNYFSSHRfKKRFMYPVGYGLPAVIV----AISAAVNPQGYGtPKHCWLSMEKGFIWSFLGPVCVII 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6072 LVPLTCLVVVFvvfihayqvkpqWKAYD-------DVFRGR-TNAAEIPLILYLFALiSVTWLWGGLH-------MAYrh 6136
Cdd:cd15439    165 VINLVLFCLTL------------WILREklsslnaEVSTLKnTRLLTFKAIAQLFIL-GCTWILGLFQvgpvatvMAY-- 229

                          250       260
                   ....*....|....*....|....*...
gi 1034646479 6137 fwmlvLFVIFNSLQGLYVFMVYFILHNQ 6164
Cdd:cd15439    230 -----LFTITNSLQGVFIFLVHCLLNRQ 252
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 4404-4495 8.08e-10

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 58.81  E-value: 8.08e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  4404 GIIEFDPkyTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQSSSASpGGVDYILHGSTVTFQHGQNLSFINISIIDDNE 4483
Cdd:smart00237    2 GSVGFEQ--PVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTAT-AGSDYEPVPGELTFPPGETEKEIRIKIIDDDI 78

                            90
                    ....*....|..
gi 1034646479  4484 SEFEEPIEILLT 4495
Cdd:smart00237   79 YEKDETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
1976-2077 1.21e-09

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 58.42  E-value: 1.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1976 GIFIFSEKNrpVKVEEATQNITLSIIRLKG-LMGKVLVSYATLDDMekppyfppnlarATQGRDYIPASGFALFGANQSE 2054
Cdd:pfam03160    2 GVIGFEPPT--YQVSENDGVAEVCVVRMSGtLRRTVVVPYRTEDGT------------ATAGDDYEPVEGELVFGPGETE 67

                           90       100
                   ....*....|....*....|...
gi 1034646479 2055 ATIAISILDDDEPERSESVFIEL 2077
Cdd:pfam03160   68 KCINVTIIDDDVYEGDENFFVLL 90
7tmB2_BAI_Adhesion_VII cd15251
brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 ...
 5923-6165 1.57e-09

brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediate direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320379  Cd Length: 253  Bit Score: 62.27  E-value: 1.57e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5923 ISGLCLAVLSHIFCARYSMFAAK---LLTHMMAASLGTQILFLASAyaSPQLAEESCSAMAAVTHYLYLCQFSWMLIQSv 5999
Cdd:cd15251     14 VSCLALLTLLAIYAAFWRYIRSErsiILINFCLSIISSNILILVGQ--TQTLNKGVCTMTAAFLHFFFLSSFCWVLTEA- 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6000 nfW--YVLVMNDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSMSQIYGLIHGDLcfipnVYAALFTAALVPLTC 6077
Cdd:cd15251     91 --WqsYMAVTGRMRTRLIRKRFLCLGWGLPALVVAVSVGFTRTKGYGTSSYCWLSLEGGL-----LYAFVGPAAAVVLVN 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6078 LVVVFVVFihayqvkPQWKAYDdvfrGRTNAAEIPL--ILYLFALISVTWLWGGLHMAYRHFWML-VLFVIFNSLQGLYV 6154
Cdd:cd15251    164 MVIGILVF-------NKLVSRD----GISDNAMASLwsSCVVLPLLALTWMSAVLAMTDRRSVLFqILFAVFDSLQGFVI 232

                          250
                   ....*....|.
gi 1034646479 6155 FMVYFILHNQM 6165
Cdd:cd15251    233 VMVHCILRREV 243
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2966-3054 2.00e-09

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 57.65  E-value: 2.00e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  2966 GVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSLFVYAQNLEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEG 3045
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEK 81


                    ....*....
gi 1034646479  3046 DEKFQLILT 3054
Cdd:smart00237   82 DETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
2966-3054 2.34e-09

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 57.64  E-value: 2.34e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2966 GVIEWQQSRFEVNETHGSLTLVAQRSREPL-GHVSLFVYAQNLEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPE 3044
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTLrRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYE 81

                           90
                   ....*....|
gi 1034646479 3045 GDEKFQLILT 3054
Cdd:pfam03160   82 GDENFFVLLS 91
7tmB2_EMR_Adhesion_II cd15931
EGF-like module receptors, group II adhesion GPCRs, member of class B2 family of ...
 5926-6165 2.42e-09

EGF-like module receptors, group II adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group II adhesion GPCRs, including the leukocyte cell-surface antigen CD97 and the epidermal growth factor (EGF)-module-containing, mucin-like hormone receptor (EMR1-4), are primarily expressed in cells of the immune system. All EGF-TM7 receptors, which belong to the B2 subfamily B2 of adhesion GPCRs, are members of group II, except for ETL (EGF-TM7-latrophilin related protein), which is classified into group I. Members of the EGF-TM7 receptors are characterized by the presence of varying numbers of N-terminal EGF-like domains, which play critical roles in ligand recognition and cell adhesion, linked by a stalk region to a class B seven-transmembrane domain. In the case of CD97, alternative splicing results in three isoforms possessing either three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. On the other hand, EMR2 generates four isoforms possessing either two (EGF1,2), three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. For example, CD97, which is involved in angiogenesis and the migration and invasion of tumor cells, has been shown to promote cell aggregation in a GPS proteolysis-dependent manner. CD97 is widely expressed on lymphocytes, monocytes, macrophages, dendritic cells, granulocytes and smooth muscle cells as well as in a variety of human tumors including colorectal, gastric, esophageal pancreatic, and thyroid carcinoma. EMR2 shares strong sequence homology with CD97, differing by only six amino acids. However, unlike CD97, EMR2 is not found in those of CD97-positive tumor cells and is not expressed on lymphocytes but instead on monocytes, macrophages and granulocytes. CD97 has three known ligands: CD55, decay-accelerating factor for regulation of complement system; chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix; and the integrin alpha5beta1, which play a role in angiogenesis. Although EMR2 does not effectively interact with CD55, the fourth EGF-like domain of this receptor binds to chondroitin sulfate to mediate cell attachment.


Pssm-ID: 320597 [Multi-domain]  Cd Length: 262  Bit Score: 61.76  E-value: 2.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5926 LCLAVLSHIFCARYSMFAAKLLTHMMAASLGTQILFLAS-AYASPQLAeesCSAMAAVTHYLYLCQFSWMLIQSVNFwYV 6004
Cdd:cd15931     19 LGLAIFTFLLCRWIPKINTTAHLHLCLCLSMSHTLFLAGiEYVENELA---CTVMAGLLHYLFLASFVWMLLEALQL-HL 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6005 LVMN---DEHTERRYL---LFFLLSWGLPAFVVILLIVILKGIYHQS----MSQIYGLIH---GDLCFIPNVYAALFTAA 6071
Cdd:cd15931     95 LVRRltkVQVIQRDGLprpLLCLIGYGVPFLIVGVSALVYSDGYGEAkmcwLSQERGFNWsflGPVIAIIGINWILFCAT 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6072 LVPLTCLVVvfvvfihayQVKPQWKAYDDvfrgrTNAAEIPLILYLFaLISVTWLWGGLHMAYRHFWMLVLFVIFNSLQG 6151
Cdd:cd15931    175 LWCLRQTLS---------NMNSDISQLKD-----TRLLTFKAVAQLF-ILGCTWVLGLFQTNPVALVFQYLFTILNSLQG 239

                          250
                   ....*....|....
gi 1034646479 6152 LYVFMVYFILHNQM 6165
Cdd:cd15931    240 AFLFLVHCLLNKEV 253
Calx-beta pfam03160
Calx-beta domain;
1004-1092 7.62e-09

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 56.10  E-value: 7.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1004 IYFaEPRVVRVQE--GETANFTVLRNGSVDVTCMVQYATKDGKATArERDFIPVEkgETLIFEVGSRQQSISIFVNEDGI 1081
Cdd:pfam03160    4 IGF-EPPTYQVSEndGVAEVCVVRMSGTLRRTVVVPYRTEDGTATA-GDDYEPVE--GELVFGPGETEKCINVTIIDDDV 79

                           90
                   ....*....|.
gi 1034646479 1082 PETDEPFYIIL 1092
Cdd:pfam03160   80 YEGDENFFVLL 90
Calx-beta pfam03160
Calx-beta domain;
4404-4488 8.74e-09

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 55.72  E-value: 8.74e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4404 GIIEFDPkyTAFEVEEDVGLIMIPVVRLHGTY-GYVTADFISQSSSASpGGVDYILHGSTVTFQHGQNLSFINISIIDDN 4482
Cdd:pfam03160    2 GVIGFEP--PTYQVSENDGVAEVCVVRMSGTLrRTVVVPYRTEDGTAT-AGDDYEPVEGELVFGPGETEKCINVTIIDDD 78


                   ....*.
gi 1034646479 4483 ESEFEE 4488
Cdd:pfam03160   79 VYEGDE 84
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2891-3081 4.55e-08

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 60.19  E-value: 4.55e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2891 DFVPIIGFLILEEGETAAAINITILEDDVPELEEYFLVNLTYV------GLTMAASTSFPPRLDSEgLTAQVIIDANDGA 2964
Cdd:TIGR00845  449 DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLrvgsedGILEANHVSAVAQLASP-NTATVTILDDDHA 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2965 rGVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSLFVYAQNLEAQVGL-DYIFTPMILHFADGERYKNVNIMILDDDIP 3043
Cdd:TIGR00845  528 -GIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGkDFEDTCGELEFENDETEKTIRVKIVDDEEY 606

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1034646479 3044 EGDEKFQLILTNPSPGLELGKNTIALIIVLANDDGPGV 3081
Cdd:TIGR00845  607 EKNDTFFIELGEPRWAKRGIKAALLLNETITDDDQKLT 644
7tmB2_GPR128 cd15257
orphan adhesion receptor GPR128, member of the class B2 family of seven-transmembrane G ...
 5976-6158 7.74e-08

orphan adhesion receptor GPR128, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR128 is an orphan receptor of the adhesion family (subclass B2) that belongs to the class B GPCRs. Expression of GPR128 was detected in the mouse intestinal mucosa and is thought to be involved in energy balance, as its knockout mice showed a decrease in body weight gain and an increase in intestinal contraction frequency compared to wild-type controls. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320385 [Multi-domain]  Cd Length: 303  Bit Score: 57.96  E-value: 7.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5976 CSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLLFF-LLSWGLPAFVVillIVILKGIYHQSMS---QIYG 6051
Cdd:cd15257     93 CTAVAALLHYFLLVTFMWNAVYSAQLYLLLIRMMKPLPEMFILQAsAIGWGIPAVVV---AITLGATYRFPTSlpvFTRT 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6052 LIHGDLCFI----PN--VYAALFTAALVPLT-CLVVVFVVFIHAYQvKPQWKAYDD-VFRGRTNAAEIPLILYLFALISV 6123
Cdd:cd15257    170 YRQEEFCWLaaldKNfdIKKPLLWGFLLPVGlILITNVILFIMTSQ-KVLKKNNKKlTTKKRSYMKKIYITVSVAVVFGI 248

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1034646479 6124 TWLWGGLHMAYRHFWMLV---LFVIFNSLQGLYVFMVY 6158
Cdd:cd15257    249 TWILGYLMLVNNDLSKLVfsyIFCITNTTQGVQIFILY 286
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 3590-3631 1.22e-07

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 52.64  E-value: 1.22e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1034646479  3590 HSDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQL 3631
Cdd:smart00237   48 GSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89
7tmB2_BAI1 cd15990
brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 ...
 5976-6165 1.64e-07

brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediates direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320656  Cd Length: 267  Bit Score: 56.54  E-value: 1.64e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5976 CSAMAAVTHYLYLCQFSWMLIQSvnfWYVLVMNDEHTERRYLL--FFLLSWGLPAFVVILLIVILKGIYHQSMSQIYGLI 6053
Cdd:cd15990     71 CTLVAAFLHFFFLSSFCWVLTEA---WQSYMAVTGRLRNRIIRkrFLCLGWGLPALVVAISVGFTKAKGYGTVNYCWLSL 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6054 HGDLcfipnVYAALFTAALVPLTCLVVVFVVFihaYQVKPQWKAYDDVFRGRTNAAEIPLILYLfALISVTWLWGGLHMA 6133
Cdd:cd15990    148 EGGL-----LYAFVGPAAAVVLVNMVIGILVF---NKLVSKDGITDKKLKERAGASLWSSCVVL-PLLALTWMSAVLAIT 218

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1034646479 6134 YRHFWML-VLFVIFNSLQGLYVFMVYFILHNQM 6165
Cdd:cd15990    219 DRRSALFqILFAVFDSLEGFVIVMVHCILRREV 251
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 859-1092 3.01e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.49  E-value: 3.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  859 VLSSHGERE-SKLGSATIVNITILKNDDPHGIieFVSDGLIVMInESKGdaiysAVYDVVRNRGnfGDVSVSWVV----- 932
Cdd:TIGR00845  371 ILKKHAADAaRKAVSMHEVATDDEENDPVSKI--FFEPGHYTCL-ENCG-----TVALTVVRRG--GDLTNTVYVdyrte 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  933 --SPDFTQDVFPVQGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVILLN--------------GTGGAKVGNRTTATLR 996
Cdd:TIGR00845  441 dgTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNlrvgsedgileanhVSAVAQLASPNTATVT 520

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  997 IRRNDDPIYFA-EPRVVRVQEG-ETANFTVLRNGSVDVTCMVQYATKDGKATARERDFIPVEkGEtLIFEVGSRQQSISI 1074
Cdd:TIGR00845  521 ILDDDHAGIFTfEEDVFHVSESiGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGKDFEDTC-GE-LEFENDETEKTIRV 598

                          250
                   ....*....|....*...
gi 1034646479 1075 FVNEDGIPETDEPFYIIL 1092
Cdd:TIGR00845  599 KIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1503-1693 3.31e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.49  E-value: 3.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKL--VSVYGGARISEENT-----------TARLTIQKSD 1569
Cdd:TIGR00845  446 AGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsnLRVGSEDGILEANHvsavaqlaspnTATVTILDDD 525

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1570 NAnGLFGFTGACIpEIAEEGSTISCVVERTRGALDYVHV-FYTISQIETDGinylVDDFANASGTITFLPWQRSEVLNIY 1648
Cdd:TIGR00845  526 HA-GIFTFEEDVF-HVSESIGIMEVKVLRTSGARGTVIVpYRTVEGTARGG----GKDFEDTCGELEFENDETEKTIRVK 599

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1034646479 1649 VLDDDIPELNEYFRVTLVSA--IPGDGKLGSTPTSGASIDPEKETTD 1693
Cdd:TIGR00845  600 IVDDEEYEKNDTFFIELGEPrwAKRGIKAALLLNETITDDDQKLTSK 646
7tmB2_CELSR2 cd15992
Cadherin EGF LAG seven-pass G-type receptor 2, member of the class B2 family of ...
 5976-6161 3.52e-07

Cadherin EGF LAG seven-pass G-type receptor 2, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320658  Cd Length: 255  Bit Score: 55.21  E-value: 3.52e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5976 CSAMAAVTHYLYLCQFSWMLIQSVNFWYVL--VMNDEHTERRYllFFLLSWGLPAFVVILLIvilkGIYHQSmsqiYGli 6053
Cdd:cd15992     67 CTVIAILLHFFYLCTFSWLFLEGLHIYRMLseVRDINYGPMRF--YYLIGWGVPAFITGLAV----GLDPEG----YG-- 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6054 HGDLCFIpNVYAALFTAALVPLTcLVVVFVVFIHAYQVKPQWKAYDDVFRGRT-NAAEIPLILYLFALISVTWLWGGLHM 6132
Cdd:cd15992    135 NPDFCWL-SIYDTLIWSFAGPVA-FAVSMNVFLYILSSRASCSAQQQSFEKKKgPVSGLRTAFTVLLLVSVTCLLALLSV 212

                          170       180
                   ....*....|....*....|....*....
gi 1034646479 6133 AYRHFWMLVLFVIFNSLQGLYVFMVYFIL 6161
Cdd:cd15992    213 NSDVILFHYLFAGFNCLQGPFIFLSHVVL 241
Calx-beta pfam03160
Calx-beta domain;
3591-3631 5.06e-07

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 50.71  E-value: 5.06e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034646479 3591 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQL 3631
Cdd:pfam03160   50 DDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFVLL 90
7tmB1_hormone_R cd15041
The subfamily B1 of hormone receptors (secretin-like), member of the class B family ...
 5975-6158 5.22e-07

The subfamily B1 of hormone receptors (secretin-like), member of the class B family seven-transmembrane G protein-coupled receptors; The B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of this subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. Moreover, the B1 subfamily receptors play key roles in hormone homeostasis and are promising drug targets in various human diseases including diabetes, osteoporosis, obesity, neurodegenerative conditions (Alzheimer###s and Parkinson's), cardiovascular disease, migraine, and psychiatric disorders (anxiety, depression). Furthermore, the subfamilies B2 and B3 consist of receptors that are capable of interacting with epidermal growth factors (EGF) and the Drosophila melanogaster Methuselah gene product (Mth), respectively. The class B GPCRs have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi, or prokaryotes.


Pssm-ID: 341321 [Multi-domain]  Cd Length: 273  Bit Score: 54.92  E-value: 5.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5975 SCSAMAAVTHYLYLCQFSWMLIQSVnFWYVLVMNDEHTERRYL-LFFLLSWGLPaFVVILLIVILKGIYHQSMsqiygli 6053
Cdd:cd15041     81 GCKLLSVLKRYFKSANYFWMLCEGL-YLHRLIVVAFFSEPSSLkLYYAIGWGLP-LVIVVIWAIVRALLSNES------- 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6054 hgdlCFIPNVYAALFTAALVP-LTCLVVVFVVFIH-------------AYQVKPQWKAYddvfrgRTNAAEIPLI-LYLF 6118
Cdd:cd15041    152 ----CWISYNNGHYEWILYGPnLLALLVNLFFLINilrilltklrshpNAEPSNYRKAV------KATLILIPLFgIQYL 221

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1034646479 6119 ALISVTWLWGGLHMAYRHFwmlvlFVIFNSLQGLYVFMVY 6158
Cdd:cd15041    222 LTIYRPPDGSEGELVYEYF-----NAILNSSQGFFVAVIY 256
7tmB2_GPR113 cd15253
orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G ...
 5920-6170 5.29e-07

orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR113 is an orphan receptor that belongs to group VI adhesion-GPCRs along with GPR110, GPR111, GPR115, and GPR116. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. GPR113 contains a hormone binding domain and one EGF (epidermal grown factor) domain, and is primarily expressed in a subset of taste receptor cells. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320381 [Multi-domain]  Cd Length: 271  Bit Score: 54.77  E-value: 5.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5920 FICISGLCLAVLSHIFC-------------ARYSMFAAKLLTHMMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYL 5986
Cdd:cd15253      6 FLSQVGLGASILALLLClgiyrlvwrsvvrNKISYFRHMTLVNIAFSLLLADTCFLGATFLSAGHESPLCLAAAFLCHFF 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5987 YLCQFSWMLIQSVNFWYVLVMNDEHTERRYLLFFLLSWGlpaFVVILLIVILKGIYHQSMSQiygLIHGDLCFIPNVYAA 6066
Cdd:cd15253     86 YLATFFWMLVQALMLFHQLLFVFHQLAKRSVLPLMVTLG---YLCPLLIAAATVAYYYPKRQ---YLHEGACWLNGESGA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6067 LFTAAlVPLTCLVVVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISV---TWLWGGLHMAYR-----HFw 6138
Cdd:cd15253    160 IYAFS-IPVLAIVLVNLLVLFVVLMKLMRPSVSEGPPPEERKALLSIFKALLVLTPVfglTWGLGVATLTGEssqvsHY- 237

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1034646479 6139 mlvLFVIFNSLQGlyVFMVYFilhnqmCCPMK 6170
Cdd:cd15253    238 ---GFAILNAFQG--VFILLF------GCLMD 258
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1006-1093 6.46e-07

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 50.72  E-value: 6.46e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  1006 FAEPRVVRVQEGE-TANFTVLRNGSVDVTCMVQYATKDGKATArERDFIPVEKgeTLIFEVGSRQQSISIFVNEDGIPET 1084
Cdd:smart00237    5 GFEQPVYTVSESDgEVEVCVVRTGGARGPVVVPYSTEDGTATA-GSDYEPVPG--ELTFPPGETEKEIRIKIIDDDIYEK 81


                    ....*....
gi 1034646479  1085 DEPFYIILL 1093
Cdd:smart00237   82 DETFYVRLS 90
7tmB2_GPR56 cd15995
orphan adhesion receptor GPR56, member of the class B2 family of seven-transmembrane G ...
 5923-6159 8.14e-07

orphan adhesion receptor GPR56, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR56 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR64, GPR97, GPR112, GPR114, and GPR126. GPR56 is involved in the regulation of oligodendrocyte development and myelination in the central nervous system via coupling to G(12/13) proteins, which leads to the activation of RhoA GTPase. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320661  Cd Length: 269  Bit Score: 54.45  E-value: 8.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5923 ISGL-CLAVLSHIFCARYSMFAAKLLTHM--MAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSV 5999
Cdd:cd15995     14 ISALaSVFTIAFYLCSRRKPRDYTIYVHMnlLLAIFLLDTSFLISEPLALTGSEAACRAGGMFLHFSLLACLTWMGIEGY 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6000 NFwYVLVMNDEHTERRYLLFFL--LSWGLPAFVVILLIVILKGIYHQSMSQIY----GLIHGDLCFIP----NVYAALFT 6069
Cdd:cd15995     94 NL-YRLVVEVFNTYVPHFLLKLcaVGWGLPIFLVTLIFLVDQDNYGPIILAVHrspeKVTYATICWITdsliSNITNLGL 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6070 AALVPLTCLVVVFVVFIHAYQVKP---QWKaYDDVFRGRTNAAEIPLILYLFALISVTWlwgglhmayrHFWMLVLFVIF 6146
Cdd:cd15995    173 FSLVFLFNMAMLATMVVEILRLRPrthKWS-HVLTLLGLSLVLGIPWALAFFSFASGTF----------QLVIVYLFTII 241

                          250
                   ....*....|...
gi 1034646479 6147 NSLQGLYVFMVYF 6159
Cdd:cd15995    242 NSLQGFLIFLWYW 254
7tmB2_BAI2 cd15988
brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 ...
 5923-6165 1.04e-06

brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediates direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320654 [Multi-domain]  Cd Length: 291  Bit Score: 54.19  E-value: 1.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5923 ISGLCLAVLSHIFCARYSMFAAK---LLTHMMAASLGTQILFLASAyaSPQLAEESCSAMAAVTHYLYLCQFSWMLIQSv 5999
Cdd:cd15988     14 VSCMALLILLAIYAAFWRFIRSErsiILLNFCLSILASNILILVGQ--SQTLSKGVCTMTAAFLHFFFLSSFCWVLTEA- 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6000 nfW--YVLVMNDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSMSQIYGLIHGDLcfipnVYAALFTAALVPLTC 6077
Cdd:cd15988     91 --WqsYLAVIGRMRTRLVRKRFLCLGWGLPALVVAVSVGFTRTKGYGTASYCWLSLEGGL-----LYAFVGPAAVIVLVN 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6078 LVVVFVVFIH-------AYQVKPQWKAYDDVFRGR----------------TNAAEIPLILYLFA------LISVTWLWG 6128
Cdd:cd15988    164 MLIGIIVFNKlmsrdgiSDKSKKQRAGSEAEPCSSlllkcskcgvvssaamSSATASSAMASLWSscvvlpLLALTWMSA 243

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1034646479 6129 GLHMAYRHFWML-VLFVIFNSLQGLYVFMVYFILHNQM 6165
Cdd:cd15988    244 VLAMTDRRSILFqVLFAVFNSVQGFVIITVHCFLRREV 281
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 3917-4011 1.15e-06

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 49.95  E-value: 1.15e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  3917 GIFMF-----HVTRGAGEVitayevppplnvlQVPVVRLAGSFGAVNVYWKASPDSA-GLEDFKPSHGILEFADKQVTAM 3990
Cdd:smart00237    2 GSVGFeqpvyTVSESDGEV-------------EVCVVRTGGARGPVVVPYSTEDGTAtAGSDYEPVPGELTFPPGETEKE 68

                            90       100
                    ....*....|....*....|.
gi 1034646479  3991 IEITIIDDAEFELTETFNISL 4011
Cdd:smart00237   69 IRIKIIDDDIYEKDETFYVRL 89
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 5046-5342 2.12e-06

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 54.80  E-value: 2.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5046 VSYQTTAGSAKPLEDFEPVQnGELFFQKFQTEVDFEITIINDQLSEIEEFFYINLTSVEIRglqkfdvnwsprlnldfsv 5125
Cdd:TIGR00845  435 VDYRTEDGTANAGSDYEFTE-GTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVG------------------- 494

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5126 avitildndDLAGMdisfpettvavavdttlipvetesttylstsktttilqptnvvaivTEATGVSAIpeklvtlhgtp 5205
Cdd:TIGR00845  495 ---------SEDGI----------------------------------------------LEANHVSAV----------- 508

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5206 AVSEKPDVATVTANVSIH-GTFSLGPSIVYIEEEMknGTFntaEVLIRRTGGFTGNVSItvktfgercaqmepnalPFRG 5284
Cdd:TIGR00845  509 AQLASPNTATVTILDDDHaGIFTFEEDVFHVSESI--GIM---EVKVLRTSGARGTVIV-----------------PYRT 566

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034646479 5285 IYGisnlTWAVEEEDFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQ 5342
Cdd:TIGR00845  567 VEG----TARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPR 620
Calx-beta pfam03160
Calx-beta domain;
4038-4128 5.92e-06

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 48.01  E-value: 5.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4038 GVFGFEEKTVMIDESlssddpDSYVTLTVVRSPG-GKGTVRLE-WTIDEKAKHN--LSPLNGTLHFDETESQKTIVLHTL 4113
Cdd:pfam03160    2 GVIGFEPPTYQVSEN------DGVAEVCVVRMSGtLRRTVVVPyRTEDGTATAGddYEPVEGELVFGPGETEKCINVTII 75

                           90
                   ....*....|....*
gi 1034646479 4114 QDTVLEEDRRFTIQL 4128
Cdd:pfam03160   76 DDDVYEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 4038-4128 6.04e-06

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 47.63  E-value: 6.04e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  4038 GVFGFEEKTVMIDESlssddpDSYVTLTVVRSPGGKGTVRLEW-TIDEKAK--HNLSPLNGTLHFDETESQKTIVLHTLQ 4114
Cdd:smart00237    2 GSVGFEQPVYTVSES------DGEVEVCVVRTGGARGPVVVPYsTEDGTATagSDYEPVPGELTFPPGETEKEIRIKIID 75

                            90
                    ....*....|....
gi 1034646479  4115 DTVLEEDRRFTIQL 4128
Cdd:smart00237   76 DDIYEKDETFYVRL 89
7tmB2_GPR116-like_Adhesion_VI cd15932
orphan GPR116 and related proteins, group IV adhesion GPCRs, member of the class B2 family of ...
 5951-6155 9.15e-06

orphan GPR116 and related proteins, group IV adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; group VI adhesion GPCRs consist of orphan receptors GPR110, GPR111, GPR113, GPR115, GPR116, and closely related proteins. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. GPR110 possesses a SEA box in the N-terminal has been identified as an oncogene over-expressed in lung and prostate cancer. GPR113 contains a hormone binding domain and one EGF (epidermal grown factor) domain. GPR112 has extremely long N-terminus (about 2,400 amino acids) containing a number of Ser/Thr-rich glycosylation sites and a pentraxin (PTX) domain. GPR116 has two C2-set immunoglobulin-like repeats, which is found in the members of the immunoglobulin superfamily of cell surface proteins, and a SEA (sea urchin sperm protein, enterokinase, and a grin)-box, which is present in the extracellular domain of the transmembrane mucin (MUC) family and known to enhance O-glycosylation. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320598 [Multi-domain]  Cd Length: 268  Bit Score: 51.16  E-value: 9.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5951 MAASL-GTQILFLASAYAS-PQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLL--FFLLSWGL 6026
Cdd:cd15932     49 IALSLlIADIWFIIGAAIStPPNPSPACTAATFFIHFFYLALFFWMLTLGLLLFYRLVLVFHDMSKSTMMaiAFSLGYGC 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6027 PAFVVILLIvilkGIYHQSmsqiYGLIHGDLCFIP-NVYAALFTAALVPLTCLVVVFVVFIHAYqVKPQWKAYDDVFRGR 6105
Cdd:cd15932    129 PLIIAIITV----AATAPQ----GGYTRKGVCWLNwDKTKALLAFVIPALAIVVVNFIILIVVI-FKLLRPSVGERPSKD 199

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034646479 6106 TNAAEIPL---ILYLFALISVTWLWG-GLHMAYRHFWMLVLFVIFNSLQGLYVF 6155
Cdd:cd15932    200 EKNALVQIgksVAILTPLLGLTWGFGlGTMIDPKSLAFHIIFAILNSFQGFFIL 253
7tmF_Frizzled_SMO cd13951
class F frizzled/smoothened family, member of the 7-transmembrane G protein-coupled receptor ...
 5975-6086 1.01e-05

class F frizzled/smoothened family, member of the 7-transmembrane G protein-coupled receptor superfamily; The class F G protein-coupled receptors includes the frizzled (FZD) family of seven-transmembrane proteins consisting of 10 isoforms (FZD1-10) in mammals. The FZDs are activated by the wingless/int-1 (WNT) family of secreted lipoglycoproteins and preferentially couple to stimulatory G proteins of the Gs family, which activate adenylate cyclase, but can also couple to G proteins of the Gi/Gq families. In the WNT/beta-catenin signaling pathway, the WNT ligand binds to FZD and a lipoprotein receptor-related protein (LRP) co-receptor. This leads to the stabilization and translocation of beta-catenin to the nucleus, where it induces the activation of TCF/LEF family transcription factors. The conserved cytoplasmic motif of FZD, Lys-Thr-X-X-X-Trp, is required for activation of the WNT/beta-catenin pathway, and for membrane localization and phosphorylation of Dsh (dishevelled) protein, a key component of the WNT pathway that relays the WNT signals from the activated receptor to downstream effector proteins. Also included in the class F family is the closely related smoothened (SMO), which is a transmembrane G protein-coupled receptor that acts as the transducer of the hedgehog (HH) signaling pathway. SMO is activated by the hedgehog (HH) family of proteins acting on the 12-transmembrane domain receptor patched (PTCH), which constitutively inhibits SMO. Thus, in the absence of HH proteins, PTCH inhibits SMO signaling. On the other hand, binding of HH to the PTCH receptor activates its internalization and degradation, thereby releasing the PTCH inhibition of SMO. This allows SMO to trigger intracellular signaling and the subsequent activation of the Gli family of zinc finger transcriptional factors and induction of HH target gene expression (PTCH, Gli1, cyclin, Bcl-2, etc). The WNT and HH signaling pathways play critical roles in many developmental processes, such as cell-fate determination, cell proliferation, neural patterning, stem cell renewal, tissue homeostasis and repair, and tumorigenesis, among many others.


Pssm-ID: 320089  Cd Length: 314  Bit Score: 51.55  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5975 SCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMN--DEHTERRYLLFFLLSWGLPAFVVILLIVIlkgiyhqsmsqiyGL 6052
Cdd:cd13951     93 PCAIVFLLTYYFGMAASIWWVILTLTWFLSAGLKwsSEAIEKKSSYFHLVAWGLPAVLTIAVLVL-------------RK 159

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1034646479 6053 IHGD----LCFIPNV-YAALFTAALVPLTCLVVVFVVFI 6086
Cdd:cd13951    160 VDGDeltgICFVGNQnLDALRGFVLAPLFLYLILGTVFL 198
Calx-beta pfam03160
Calx-beta domain;
5009-5101 1.01e-05

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 47.24  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5009 GVFQFStsSRNIIVSEDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPLEDFEPVqNGELFFQKFQTEVDFEITIINDQ 5088
Cdd:pfam03160    2 GVIGFE--PPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRTEDGTATAGDDYEPV-EGELVFGPGETEKCINVTIIDDD 78

                           90
                   ....*....|...
gi 1034646479 5089 LSEIEEFFYINLT 5101
Cdd:pfam03160   79 VYEGDENFFVLLS 91
LamGL smart00560
LamG-like jellyroll fold domain;
1355-1491 1.04e-05

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 48.57  E-value: 1.04e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  1355 FTFSAWVMPNANTNGFIIAKDdgngsiYYGVKIQTNESHVTLSLHYKTLGSNATYIaktTVMKYLEESVWLHLLIIL--E 1432
Cdd:smart00560    3 FTLEAWVKLESAGGSQPIITG------AAVAQPTISEKALTFFLRAKSVQGWQTAR---TGATADWIGVWVHLAGVYdgG 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034646479  1433 DGIIEFYLDGnamprgikSLKGEAITDGPGI-------LRIGAGINGNDRFTGLMQDVRSYERKLT 1491
Cdd:smart00560   74 AGKLSLYVNG--------VEVATSETQPSPSsgnlpqgGRILLGGAGGENFSGRLDEVRVYNRALT 131
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2117-2204 1.22e-05

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 46.86  E-value: 1.22e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  2117 GTLQLSAPIVRVAENhVGPI-INVTRTGGAFADVSVKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPE 2195
Cdd:smart00237    2 GSVGFEQPVYTVSES-DGEVeVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYE 80


                    ....*....
gi 1034646479  2196 LEESFLVQL 2204
Cdd:smart00237   81 KDETFYVRL 89
Calx-beta pfam03160
Calx-beta domain;
1573-1665 2.51e-05

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 46.09  E-value: 2.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1573 GLFGFTGACIPEIAEEGSTISCVVeRTRGALD-YVHV-FYTISQIETDGinylvDDFANASGTITFLPWQRSEVLNIYVL 1650
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVV-RMSGTLRrTVVVpYRTEDGTATAG-----DDYEPVEGELVFGPGETEKCINVTII 75

                           90
                   ....*....|....*
gi 1034646479 1651 DDDIPELNEYFRVTL 1665
Cdd:pfam03160   76 DDDVYEGDENFFVLL 90
7tmE_cAMP_R_Slime_mold cd14940
slime mold cyclic AMP receptor, member of the class E family of seven-transmembrane G ...
 5917-6163 2.60e-05

slime mold cyclic AMP receptor, member of the class E family of seven-transmembrane G protein-coupled receptors; This family represents the class E of seven-transmembrane G-protein coupled receptors found in soil-living amoebas, commonly referred to as slime molds. The class E family includes cAMP receptors (cAR1-4) and cAMP receptors-like proteins (CrlA-C) from Dictyostelium discoideum, and their highly homologous cAMP receptors (TasA and TasB) from Polysphondylium pallidum. So far, four subtypes of cAMP receptors (cAR1-4) have been identified that play an essential role in the detection and transmit of the periodic extracellular cAMP waves that regulate chemotactic cell movement during Dictyostelium development, from the unicellular amoeba aggregate into many multicellular slugs and then differentiate into a sporocarp, a fruiting body with cells specialized for different functions. These four subtypes differ in their expression levels and patterns during development. cAR1 is high-affinity receptor that is the first one to be expressed highly during early aggregation and continues to be expressed at low levels during later developmental stages. cAR1 detects extracellular cAMP and is coupled to G-alpha2 protein. Cells lacking cAR1 fail to aggregate, demonstrating that cAR1 is responsible for aggregation. During later aggregation the high-affinity cAR3 receptor is expressed at low levels. Nonetheless, cells lacking cAR3 do not show an obviously altered pattern of development and are still able to aggregate into fruiting bodies. In contrast, cAR2 and cAR4 are low affinity receptors expressed predominantly after aggregation in pre-stalk cells. cAR2 is essential for normal tip formation and deletion of the receptor arrests development at the mound stage. On the other hand, CAR4 regulates axial patterning and cellular differentiation, and deletion of the receptor results in defects during culmination. Furthermore, three cAMP receptor-like proteins (CrlA-C) were identified in Dictyostelium that show limited sequence similarity to the cAMP receptors. Of these CrlA is thought to be required for normal cell growth and tip formation in developing aggregates.


Pssm-ID: 320094 [Multi-domain]  Cd Length: 256  Bit Score: 49.66  E-value: 2.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5917 TSGFICISGlCLAVLSHIFCAR-YSMFAAKLLTHMMAASLGTQI------LFLASAYASPQlaeesCSAMAAVTHYLYLC 5989
Cdd:cd14940      8 FADFSSIIG-CLFVLVGFWLLKlLRNHITRVISCFCLTSLLKDIiytmltLTQSARPDGFL-----CYLYAIVITYGSLS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5990 QFSWMLIQSVNFWYVLVMNDEHTERRYLLFFLLSWGLPAFVVIllIVILKGIYHQSmsqiyglihGDLCFIPNVYAALFT 6069
Cdd:cd14940     82 CWLWTLCLAISIYLLIVKREPEPEKFEKYYHFVCWGLPLISTI--IMLIKHHYGPV---------GNWCWIGNQYTGYRF 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6070 AAL-VPLTCL-----VVVFVVFIHAYQVKPQWKAYDdvfRGRTNAAEIPLILYLFALiSVTWLWGGLH-----MAYRHFW 6138
Cdd:cd14940    151 GLFyGPFFIIfgisaVLVGLTSHYTYQVIHNWVSDN---KDLHKTYQFKLVNYIIVF-LLCWIFAVINriqnaLNPFPFA 226

                          250       260
                   ....*....|....*....|....*
gi 1034646479 6139 MLVLFVIFNSLQGLYVFMVyFILHN 6163
Cdd:cd14940    227 LNLLHTYLSPSHGFYASVV-FIYNN 250
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2232-2323 4.61e-05

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 45.32  E-value: 4.61e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  2232 GLFGFQITKLIVEEpefNSVKVNLPIIRNSGTLGNVTVQWVaTINGQlATG--DLRVVSGNVTFAPGETIQTLLLEVLAD 2309
Cdd:smart00237    2 GSVGFEQPVYTVSE---SDGEVEVCVVRTGGARGPVVVPYS-TEDGT-ATAgsDYEPVPGELTFPPGETEKEIRIKIIDD 76

                            90
                    ....*....|....
gi 1034646479  2310 DVPEIEEVIQVQLT 2323
Cdd:smart00237   77 DIYEKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 37-117 4.88e-05

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 45.32  E-value: 4.88e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479    37 GQTEFVVNETSTTViRLIIERIGEpANVTAIVSLYGED----AG-DFFDTYAAAFIPAGETNRTVYIAVCDDDLPEPDET 111
Cdd:smart00237    7 EQPVYTVSESDGEV-EVCVVRTGG-ARGPVVVPYSTEDgtatAGsDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDET 84


                    ....*.
gi 1034646479   112 FIFHLT 117
Cdd:smart00237   85 FYVRLS 90
PTX cd00152
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their ...
 1343-1498 5.16e-05

Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.


Pssm-ID: 238086  Cd Length: 201  Bit Score: 48.03  E-value: 5.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1343 KYHPSRNNTIANFTFSAWVMPNANTNGFIIakddgngsIYYGVKIQTNEshvtLSLHYKTLGSNATYIAKTTVMKYLEES 1422
Cdd:cd00152     21 KLKPELPKPLQAFTLCLWVYTDLSTREYSL--------FSYATKGQDNE----LLLYKEKDGGYSLYIGGKEVTFKVPES 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 1423 V--WLHLLIILE--DGIIEFYLDGNAMPRGIKSlKGEAITDGPGIL------RIGAGINGNDRFTGLMQDVRSYERKLTL 1492
Cdd:cd00152     89 DgaWHHICVTWEstSGIAELWVNGKLSVRKSLK-KGYTVGPGGSIIlgqeqdSYGGGFDATQSFVGEISDVNMWDSVLSP 167


                   ....*.
gi 1034646479 1493 EEIYEL 1498
Cdd:cd00152    168 EEIKNV 173
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
 5859-5901 6.59e-05

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


Pssm-ID: 197639  Cd Length: 49  Bit Score: 43.53  E-value: 6.59e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1034646479  5859 TSLCLLWNQAAASWlsDSQFCKVVEETADYVECACSHMSVYAV 5901
Cdd:smart00303    2 NPICVFWDESSGEW--STRGCELLETNGTHTTCSCNHLTTFAV 42
7tmB2_BAI3 cd15989
brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 ...
 5918-6165 1.27e-04

brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediates direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320655 [Multi-domain]  Cd Length: 293  Bit Score: 47.76  E-value: 1.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5918 SGFICISGLCLAVLSHIFCARYSMFAAKLLTHMMAASLGTQILFLASAYASPQlaEESCSAMAAVTHYLYLCQFSWMLIQ 5997
Cdd:cd15989     14 CGLSCLALITLAVVYAALWRYIRSERSIILINFCLSIISSNILILVGQTQTHN--KGICTMTTAFLHFFFLASFCWVLTE 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5998 SvnfW--YVLVMNDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSMSQIYGLIHGDLcfipnVYAALFTAALVPL 6075
Cdd:cd15989     92 A---WqsYMAVTGKIRTRLIRKRFLCLGWGLPALVVAISMGFTKAKGYGTPHYCWLSLEGGL-----LYAFVGPAAAVVL 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6076 TCLVVVFVVF--------IHAYQVKPQWKAYDDVFRGRT--------------------NA-AEIPLILYLFALISVTWL 6126
Cdd:cd15989    164 VNMVIGILVFnklvsrdgILDKKLKHRAGQMSEPHSGLTlkcakcgvvsttalsattasNAmASLWSSCVVLPLLALTWM 243

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 1034646479 6127 WGGLHMA-YRHFWMLVLFVIFNSLQGLYVFMVYFILHNQM 6165
Cdd:cd15989    244 SAVLAMTdKRSILFQILFAVFDSLQGFVIVMVHCILRREV 283
Calx-beta pfam03160
Calx-beta domain;
2117-2205 1.56e-04

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 43.78  E-value: 1.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2117 GTLQLSAPIVRVAENhVGPI-INVTRTGGAFA-DVSVKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVIND-IY 2193
Cdd:pfam03160    2 GVIGFEPPTYQVSEN-DGVAeVCVVRMSGTLRrTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDdVY 80

                           90
                   ....*....|..
gi 1034646479 2194 pELEESFLVQLM 2205
Cdd:pfam03160   81 -EGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 5008-5101 1.64e-04

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 43.78  E-value: 1.64e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  5008 MGVFQFSTSsrNIIVSEDTQMIRLHVQRlfgfHSDLIK---VSYQTTAGSAKPLEDFEPVQnGELFFQKFQTEVDFEITI 5084
Cdd:smart00237    1 AGSVGFEQP--VYTVSESDGEVEVCVVR----TGGARGpvvVPYSTEDGTATAGSDYEPVP-GELTFPPGETEKEIRIKI 73

                            90
                    ....*....|....*..
gi 1034646479  5085 INDQLSEIEEFFYINLT 5101
Cdd:smart00237   74 IDDDIYEKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 153-236 1.77e-04

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 43.78  E-value: 1.77e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479   153 PSIAVSEPKGRNEsmpLTLIREKGTYGMVMVTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIF 232
Cdd:smart00237    9 PVYTVSESDGEVE---VCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETF 85


                    ....
gi 1034646479   233 LIQL 236
Cdd:smart00237   86 YVRL 89
Calx-beta pfam03160
Calx-beta domain;
2849-2931 1.79e-04

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 43.78  E-value: 1.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2849 TIQLFINREFGSL-GAINVTYTTVPGMlslknqtvgnlAEPEVDFVPIIGFLILEEGETAAAINITILEDDVPELEEYFL 2927
Cdd:pfam03160   19 VAEVCVVRMSGTLrRTVVVPYRTEDGT-----------ATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFF 87


                   ....
gi 1034646479 2928 VNLT 2931
Cdd:pfam03160   88 VLLS 91
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2755-2930 1.91e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 48.25  E-value: 1.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2755 GQLFFPEGSLNTTLFVHLLDDNIPEEKEVYQVILYDVRTQDSCLTFLGVPPAGIALLDAQGYAAVLTVEasDEPHGVlnF 2834
Cdd:TIGR00845  455 GTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEDGILEANHVSAVAQLASPNTATVTILD--DDHAGI--F 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2835 ALSSRFVLLQEANITIQLFINREFGSLGAINVTYTTVPGMLSlknqtvgnlaEPEVDFVPIIGFLILEEGETAAAINITI 2914
Cdd:TIGR00845  531 TFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTAR----------GGGKDFEDTCGELEFENDETEKTIRVKI 600

                          170
                   ....*....|....*.
gi 1034646479 2915 LEDDVPELEEYFLVNL 2930
Cdd:TIGR00845  601 VDDEEYEKNDTFFIEL 616
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1596-1665 2.01e-04

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 43.40  E-value: 2.01e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034646479  1596 VERTRGALDYVHV-FYTISQIETDGinylvDDFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYFRVTL 1665
Cdd:smart00237   24 VVRTGGARGPVVVpYSTEDGTATAG-----SDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2851-2931 2.24e-04

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 43.40  E-value: 2.24e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  2851 QLFINREFGSLGAINVTYTTVPGmlslkNQTVGnlaepeVDFVPIIGFLILEEGETAAAINITILEDDVPELEEYFLVNL 2930
Cdd:smart00237   21 EVCVVRTGGARGPVVVPYSTEDG-----TATAG------SDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89


                    .
gi 1034646479  2931 T 2931
Cdd:smart00237   90 S 90
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 3402-3443 2.35e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 41.69  E-value: 2.35e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034646479 3402 FVLHQKLPVRGVLTVALFNKGGSVFLAISQANArlNSLLFRW 3443
Cdd:pfam03736    2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSG--DSVIYRW 41
7tmB1_DH_R cd15263
insect diuretic hormone receptors, member of the class B family of seven-transmembrane G ...
 5915-6039 2.99e-04

insect diuretic hormone receptors, member of the class B family of seven-transmembrane G protein-coupled receptors; This group includes G protein-coupled receptors that specifically bind to insect diuretic hormones found in Manduca sexta (moth) and Acheta domesticus (the house cricket), among others. Insect diuretic hormone and their GPCRs play critical roles in the regulation of water and ion balance. Thus they are attractive targets for developing new insecticides. Activation of the diuretic hormone receptors stimulate adenylate cyclase, thereby increasing cAMP levels in Malpighian tube. They belong to the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of Gs family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx.


Pssm-ID: 320391 [Multi-domain]  Cd Length: 272  Bit Score: 46.59  E-value: 2.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5915 FFTSGFICISGLCLAVLshIF-------CARYSMFAAKLLTHMMAASLGTQILFLASayaSPQLAEESCSAMAAVTHYLY 5987
Cdd:cd15263      8 YFIGYSLSLVALSLALW--IFlyfkdlrCLRNTIHTNLMFTYILADLTWILTLTLQV---SIGEDQKSCIILVVLLHYFH 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034646479 5988 LCQFSWMLIQSVnFWYVLVMNDEHTER-RYLLFFLLSWGLPAfVVILLIVILK 6039
Cdd:cd15263     83 LTNFFWMFVEGL-YLYMLVVETFSGENiKLRVYAFIGWGIPA-VVIVIWAIVK 133
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 5299-5393 3.02e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 47.86  E-value: 3.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5299 DFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQ--IVEEKDDTGFAAFAM-----VIITGSDlHN 5371
Cdd:TIGR00845  449 DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEdgILEANHVSAVAQLASpntatVTILDDD-HA 527

                           90       100
                   ....*....|....*....|....*...
gi 1034646479 5372 GIIGFSE------ESQSGLELRegaVMR 5393
Cdd:TIGR00845  528 GIFTFEEdvfhvsESIGIMEVK---VLR 552
Calx-beta pfam03160
Calx-beta domain;
145-236 3.22e-04

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 43.01  E-value: 3.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  145 GIISFNmLPSIAVSEPKGRNEsmpLTLIREKGTY-GMVMVTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDD 223
Cdd:pfam03160    2 GVIGFE-PPTYQVSENDGVAE---VCVVRMSGTLrRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDD 77

                           90
                   ....*....|...
gi 1034646479  224 EVPENDEIFLIQL 236
Cdd:pfam03160   78 DVYEGDENFFVLL 90
7tmB1_GHRHR cd15270
growth-hormone-releasing hormone receptor, member of the class B family of seven-transmembrane ...
 5916-6035 3.44e-04

growth-hormone-releasing hormone receptor, member of the class B family of seven-transmembrane G protein-coupled receptors; Growth hormone-releasing hormone receptor (GHRHR) is a member of the group of G protein-coupled receptors for structurally similar peptide hormones that also include secretin, pituitary adenylate cyclase activating polypeptide (PACAP), and vasoactive intestinal peptide. These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. GHRHR is a specific receptor for the growth hormone-releasing hormone (GHRH) that controls the synthesis and release of growth hormone (GH) from the anterior pituitary somatotrophs. Mutations in the gene encoding GHRHR have been connected to isolated growth hormone deficiency (IGHD), a short-stature condition caused by deficient production of GH or lack of GH action. GHRH is preferentially coupled to a stimulatory G(s) protein, which leads to the activation of adenylate cyclase and thereby increases in intracellular cAMP level. GHRHR is found in mammals as well as zebrafish and chicken, whereas the GHRHR type 2, an ortholog of the GHRHR, has only been identified in ray-finned fish, chicken and Xenopus. Xenopus laevis GHRHR2 has been shown to interact with both endogenous GHRH and PACAP-related peptide (PRP).


Pssm-ID: 320398 [Multi-domain]  Cd Length: 268  Bit Score: 46.33  E-value: 3.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5916 FTSGF-ICISGLCLAV-----LSHIFCARYSMFAAKLLTHMMAAS---LGTQILFLASAYASPQLAEESCSAMAAVTHYL 5986
Cdd:cd15270      8 YTVGYsISIVSLCVAVailvaFRRLHCPRNYIHIQLFFTFILKAIavfIKDAALFQEDDTDHCSMSTVLCKVSVVFCHYC 87

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1034646479 5987 YLCQFSWMLIQSVNFWYVLVMNDEHTERRYLLFFLLSWGLPAFVVILLI 6035
Cdd:cd15270     88 VMTNFFWLLVEAVYLNCLLASSFPRGKRYFWWLVLLGWGLPTLCTGTWI 136
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 330-487 3.60e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 47.48  E-value: 3.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  330 TVVFPPFIHESHLKFQIVDDTIPEIAESFHI------------MLLKDTLQGDAVLISPSVVQVTIKPNDKPyGVLSFNS 397
Cdd:TIGR00845  456 TLVFKPGETQKEFRIGIIDDDIFEEDEHFYVrlsnlrvgsedgILEANHVSAVAQLASPNTATVTILDDDHA-GIFTFEE 534

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  398 VLFERTVIIDEdrisryEEITVVRNGGTHGNVSANWvLTRNSTdPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDLP 477
Cdd:TIGR00845  535 DVFHVSESIGI------MEVKVLRTSGARGTVIVPY-RTVEGT-ARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEY 606

                          170
                   ....*....|
gi 1034646479  478 EEAEAYLLQI 487
Cdd:TIGR00845  607 EKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 166-244 6.34e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 46.71  E-value: 6.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  166 SMPLTLIREKGTYGM-VMVTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQLKSVEGGAE 244
Cdd:TIGR00845  417 TVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSE 496
7tmB2_CELSR3 cd15993
Cadherin EGF LAG seven-pass G-type receptor 3, member of the class B2 family of ...
 5948-6164 6.72e-04

Cadherin EGF LAG seven-pass G-type receptor 3, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. Celsr3 is expressed in both the developing and adult mouse brain. It has been functionally implicated in proper neuronal migration and axon guidance in the CNS. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320659 [Multi-domain]  Cd Length: 254  Bit Score: 45.22  E-value: 6.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5948 THMMAASLGTQILFLASAYASPQlaEESCSAMAAVTHYLYLCQFSWMLIQSVNFW--YVLVMNDEHTERRYllFFLLSWG 6025
Cdd:cd15993     41 SNIAAALFLSELLFLLGINRTEN--QFLCTVVAILLHYFFLSTFAWLFVQGLHIYrmQTEARNVNFGAMRF--YYAIGWG 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6026 LPAfvvillivILKGIYHQSMSQIYGliHGDLCFIpNVYAALFTAALVPLTCLVV---VFVVFIHAYQVKPQWKAYDDVF 6102
Cdd:cd15993    117 VPA--------IITGLAVGLDPEGYG--NPDFCWI-SIHDKLVWSFAGPIVVVIVmngVMFLLVARMSCSPGQKETKKTS 185

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034646479 6103 RGRTNAAEIPLILylfaLISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQ 6164
Cdd:cd15993    186 VLMTLRSSFLLLL----LISATWLFGLLAVNNSVLAFHYLHAILCCLQGLAVLLLFCVLNEE 243
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 5224-5339 6.76e-04

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 41.86  E-value: 6.76e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  5224 GTFSLGPSIVYIEEEMknGTFntaEVLIRRTGGFTGNVSItvktfgercaqmepnalPFRGIYGIsnltwAVEEEDFEEQ 5303
Cdd:smart00237    2 GSVGFEQPVYTVSESD--GEV---EVCVVRTGGARGPVVV-----------------PYSTEDGT-----ATAGSDYEPV 54

                            90       100       110
                    ....*....|....*....|....*....|....*.
gi 1034646479  5304 TLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLT 5339
Cdd:smart00237   55 PGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRLS 90
7tmB2_GPR124-like_Adhesion_III cd15259
orphan GPR124 and related proteins, group III adhesion GPCRs, member of class B2 family of ...
 5976-6167 9.03e-04

orphan GPR124 and related proteins, group III adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group III adhesion GPCRs include orphan GPR123, GPR124, GPR125, and their closely related proteins. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. GPR123 is predominantly expressed in the CNS including thalamus, brain stem and regions containing large pyramidal cells. GPR124, also known as tumor endothelial marker 5 (TEM5), is highly expressed in tumor vessels and in the vasculature of the developing embryo. GPR124 is essentially required for proper angiogenic sprouting into neural tissue, CNS-specific vascularization, and formation of the blood-brain barrier. GPR124 also interacts with the PDZ domain of DLG1 (discs large homolog 1) through its PDZ-binding motif. Recently, studies of double-knockout mice showed that GPR124 functions as a co-activator of Wnt7a/Wnt7b-dependent beta-catenin signaling in brain endothelium. Furthermore, WNT7-stimulated beta-catenin signaling is regulated by GPR124's intracellular PDZ binding motif and leucine-rich repeats (LRR) in its N-terminal extracellular domain. GPR125 directly interacts with dishevelled (Dvl) via its intracellular C-terminus, and together, GPR125 and Dvl recruit a subset of planar cell polarity (PCP) components into membrane subdomains, a prerequisite for activation of Wnt/PCP signaling. Thus, GPR125 influences the noncanonical WNT/PCP pathway, which does not involve beta-catenin, through interacting with and modulating the distribution of Dvl.


Pssm-ID: 320387 [Multi-domain]  Cd Length: 260  Bit Score: 45.06  E-value: 9.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5976 CSAMAAVTHYLYLCQFSWMLIQSVNFWYVLV--------MNDEHTERRYLL-FFLLSWGLPafVVILLIVILKGIYHQSm 6046
Cdd:cd15259     70 CQAVGILLHYSTLCTLLWVGVTARNMYKQVTktakppqdEDQPPRPPKPMLrFYLIGWGIP--LIICGITAAVNLDNYS- 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 6047 sqiygliHGDLCFI---PNVYAALFTAALVPLTCLvvvfVVFIHAY-QVKPQWKAYDDVFRGrtnaaeIPLILYLFAlis 6122
Cdd:cd15259    147 -------TYDYCWLawdPSLGAFYGPAALIVLVNC----IYFLRIYcQLKGAPVSFQSQLRG------AVITLFLYV--- 206

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034646479 6123 VTWLWGGLHMAYRHFWMLV---LFVIFNSLQGLYVFmVYFILHNQ-------MCC 6167
Cdd:cd15259    207 AMWACGALAVSQRYFLDLVfscLYGATCSSLGLFVL-IHHCLSREdvrqswrQCC 260
PTX smart00159
Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric ...
 1343-1498 1.06e-03

Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric structure. Human serum amyloid P demonstrates calcium-mediated ligand-binding.


Pssm-ID: 128463  Cd Length: 206  Bit Score: 44.18  E-value: 1.06e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  1343 KYHPSRNNTIANFTFSAWVMPNANTNGFIIakddgngsIYYGVKIQTNEshvtLSLHYKTLGSNATYI--AKTTVMKYLE 1420
Cdd:smart00159   21 KLKPELPKPLQAFTVCLWFYSDLSPRGYSL--------FSYATKGQDNE----LLLYKEKQGEYSLYIggKKVQFPVPES 88

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479  1421 ESVWLHLLIILE--DGIIEFYLDGNAMPRgiKSL-KGEAITDGPGIL------RIGAGINGNDRFTGLMQDVRSYERKLT 1491
Cdd:smart00159   89 DGKWHHICTTWEssSGIAELWVDGKPGVR--KGLaKGYTVKPGGSIIlgqeqdSYGGGFDATQSFVGEIGDLNMWDSVLS 166


                    ....*..
gi 1034646479  1492 LEEIYEL 1498
Cdd:smart00159  167 PEEIKSV 173
Calx-beta pfam03160
Calx-beta domain;
3920-4011 1.26e-03

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 41.08  E-value: 1.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3920 MFHVTRGAGEVitayevppplnvlQVPVVRLAGSF-GAVNV-YWKASPDSAGLEDFKPSHGILEFADKQVTAMIEITIID 3997
Cdd:pfam03160   10 TYQVSENDGVA-------------EVCVVRMSGTLrRTVVVpYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID 76

                           90
                   ....*....|....
gi 1034646479 3998 DAEFELTETFNISL 4011
Cdd:pfam03160   77 DDVYEGDENFFVLL 90
Calx-beta pfam03160
Calx-beta domain;
5294-5339 1.55e-03

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 41.08  E-value: 1.55e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1034646479 5294 AVEEEDFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLT 5339
Cdd:pfam03160   46 ATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFVLLS 91
Calx-beta pfam03160
Calx-beta domain;
38-117 2.00e-03

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 40.70  E-value: 2.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479   38 QTEFVVNEtSTTVIRLIIERIGEPANVTAIVSLYGED----AG-DFFDTYAAAFIPAGETNRTVYIAVCDDDLPEPDETF 112
Cdd:pfam03160    8 PPTYQVSE-NDGVAEVCVVRMSGTLRRTVVVPYRTEDgtatAGdDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENF 86


                   ....*
gi 1034646479  113 IFHLT 117
Cdd:pfam03160   87 FVLLS 91
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3090-3254 2.01e-03

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 45.17  E-value: 2.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3090 FFlrEPTALYVQESVAVLY--IVREPAQgLFGTVTVQFiVTEVNSSNESKDLTPSKGYIVLEEGVRFKALQISAILDTEP 3167
Cdd:TIGR00845  403 FF--EPGHYTCLENCGTVAltVVRRGGD-LTNTVYVDY-RTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIF 478

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 3168 EMDEYFVCTLFNPTGG--------------ARLGVHVQTLITVLQNQAPlGLFSIsavENRATSidIEEANRTVYLNVSR 3233
Cdd:TIGR00845  479 EEDEHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDDHA-GIFTF---EEDVFH--VSESIGIMEVKVLR 552

                          170       180
                   ....*....|....*....|.
gi 1034646479 3234 TNGIDLAVSVQWETVSETAFG 3254
Cdd:TIGR00845  553 TSGARGTVIVPYRTVEGTARG 573
Calx-beta pfam03160
Calx-beta domain;
2238-2323 5.57e-03

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 39.54  E-value: 5.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 2238 ITKLIVEEPEFNSVK----VNLPIIRNSGTL-GNVTVQWVaTINGQlATG--DLRVVSGNVTFAPGETIQTLLLEVLADD 2310
Cdd:pfam03160    1 AGVIGFEPPTYQVSEndgvAEVCVVRMSGTLrRTVVVPYR-TEDGT-ATAgdDYEPVEGELVFGPGETEKCINVTIIDDD 78

                           90
                   ....*....|...
gi 1034646479 2311 VPEIEEVIQVQLT 2323
Cdd:pfam03160   79 VYEGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 901-979 5.75e-03

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 39.16  E-value: 5.75e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479   901 INESKGdaiySAVYDVVRNRGNFGDVSVSWVV---SPDFTQDVFPVQGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVI 977
Cdd:smart00237   13 VSESDG----EVEVCVVRTGGARGPVVVPYSTedgTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVR 88


                    ..
gi 1034646479   978 LL 979
Cdd:smart00237   89 LS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 416-488 6.99e-03

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 39.16  E-value: 6.99e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034646479   416 EITVVRNGGTHGNVSANWvltrnSTDPSPVTA--DIRPSSGVLHFAQGQMLATIPLTVVDDDLPEEAEAYLLQIL 488
Cdd:smart00237   21 EVCVVRTGGARGPVVVPY-----STEDGTATAgsDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRLS 90
7tmB1_NPR_B4_insect-like cd15260
insect neuropeptide receptor subgroup B4 and related proteins, member of the class B family of ...
 5926-6086 7.08e-03

insect neuropeptide receptor subgroup B4 and related proteins, member of the class B family of seven-transmembrane G protein-coupled receptors; This subgroup includes a neuropeptide receptor found in Nilaparvata lugens (brown planthopper) and its closely related proteins from mollusks and annelid worms. They belong to the B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, which includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the B1 subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. The class B GPCRs have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi, or prokaryotes.


Pssm-ID: 320388 [Multi-domain]  Cd Length: 267  Bit Score: 42.26  E-value: 7.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5926 LCLAVLSHiF----CARYS----MFAAKLLTHMMAaslgtqILFLASAYASPQLAEES---CSAMAAVTHYLYLCQFSWM 5994
Cdd:cd15260     21 ISLAIFFS-FrslrCTRITihmnLFISFALNNLLW------IVWYKLVVDNPEVLLENpiwCQALHVLLQYFMVCNYFWM 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5995 LIQSVNFWYVLVMNDEHTERRYLLFFLLSWGLPAFVVIllivilkgIYhqSMSQIYGLIHGDLCFIPNVYAALFTAALVP 6074
Cdd:cd15260     94 FCEGLYLHTVLVVAFISEKSLMRWFIAIGWGVPLVITA--------IY--AGVRASLPDDTERCWMEESSYQWILIVPVV 163

                          170
                   ....*....|...
gi 1034646479 6075 LTCLV-VVFVVFI 6086
Cdd:cd15260    164 LSLLInLIFLINI 176
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3592-3635 7.43e-03

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 43.24  E-value: 7.43e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1034646479 3592 DFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPK 3635
Cdd:TIGR00845  577 DFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPR 620
7tmF_FZD3_insect cd15031
class F insect frizzled subfamily 3, member of 7-transmembrane G protein-coupled receptors; ...
 5920-6027 7.58e-03

class F insect frizzled subfamily 3, member of 7-transmembrane G protein-coupled receptors; This group represents subfamily 3 of the frizzled (FZD) family of seven transmembrane-spanning G protein-coupled proteins that is found in insects such as Drosophila melanogaster. This class F protein family consists of 10 isoforms (FZD1-10) in mammals. The FZDs are activated by the wingless/int-1 (WNT) family of secreted lipoglycoproteins and preferentially couple to stimulatory G proteins of the Gs family, which activate adenylate cyclase, but can also couple to G proteins of the Gi/Gq families. In the WNT/beta-catenin signaling pathway, the WNT ligand binds to FZD and a lipoprotein receptor-related protein (LRP) co-receptor. This leads to the stabilization and translocation of beta-catenin to the nucleus, where it induces the activation of TCF/LEF family transcription factors. The conserved cytoplasmic motif of FZD, Lys-Thr-X-X-X-Trp, is required for activation of the WNT/beta-catenin pathway, and for membrane localization and phosphorylation of Dsh (dishevelled) protein, a key component of the WNT pathway that relays the WNT signals from the activated receptor to downstream effector proteins. The WNT pathway plays a critical role in many developmental processes, such as cell-fate determination, cell proliferation, neural patterning, stem cell renewal, tissue homeostasis and repair, and tumorigenesis, among many others.


Pssm-ID: 320159  Cd Length: 311  Bit Score: 42.45  E-value: 7.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 5920 FICisgLCLAVLSHIFCARySMFAAKllTHMMAASLGTQILF---LASAYASPQlaeesCSAMAAVTHYLYLCQFSWMLI 5996
Cdd:cd15031     49 FMA---LCYNLISLCYLER-GILGTF--TNCSARSLAIDCDDrylRQDCLLTPQ-----CLASFIITYYLSLSAASWWLI 117

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1034646479 5997 QSVNfWYV---LVMNDEHTERRYLLFFLLSWGLP 6027
Cdd:cd15031    118 FALC-WYLssaKKWSSEALEKKSGLFHVLAWVPP 150
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4977-5100 7.95e-03

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 42.86  E-value: 7.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646479 4977 EAFVLHLSGVQSSAPGG----------AQLRSGFI----VAEIEPMGVFQFSTSSrnIIVSEDTQMIRLHVQRLFGFHSD 5042
Cdd:TIGR00845  482 EHFYVRLSNLRVGSEDGileanhvsavAQLASPNTatvtILDDDHAGIFTFEEDV--FHVSESIGIMEVKVLRTSGARGT 559

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034646479 5043 LIkVSYQTTAGSAK-PLEDFEPVQnGELFFQKFQTEVDFEITIINDQLSEIEEFFYINL 5100
Cdd:TIGR00845  560 VI-VPYRTVEGTARgGGKDFEDTC-GELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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