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Conserved domains on  [gi|1034639912|ref|XP_016863705|]
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AF4/FMR2 family member 1 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 588-849 1.51e-139

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


:

Pssm-ID: 465894  Cd Length: 262  Bit Score: 414.07  E-value: 1.51e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 588 SKPGKPQVKFDKQQ--ADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIK 665
Cdd:pfam18876   1 SKPRRPQLKFEDRQhsADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 666 FIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSP 745
Cdd:pfam18876  81 YVMKLKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVAKSTGTPSPLSP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 746 MPSPASSVgsQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALN 825
Cdd:pfam18876 161 MPSPASSV--SSQSGSSGSSGSSSSVSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALN 238

                         250       260
                  ....*....|....*....|....
gi 1034639912 826 SSLVDLVHYTRQGFQQLQELTKTP 849
Cdd:pfam18876 239 SSMTELVRYTRQGLHWLRLDAKLP 262
AF-4 super family cl25851
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 1-158 1.14e-37

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


The actual alignment was detected with superfamily member pfam05110:

Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 148.35  E-value: 1.14e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912   1 MTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTsSMLEDDLQLSDSEDSDSEQTPE 80
Cdd:pfam05110 356 MTHSWPPPLTAIHTPSTAEPSKFPFPTKESQHVTSGYQNQKQYDAPSKTLPTSQQGT-SMLEDDLKLSSSEDSDDDQAPE 434

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  81 KPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSD--SESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLT 158
Cdd:pfam05110 435 KPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDSESSSEsdSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 164-431 1.30e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  164 AAPPEGPRSTePPRRHPESKGSSDSATSQEHSESKDP--------------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQ 229
Cdd:PHA03247  2769 PAPPAAPAAG-PPRRLTRPAVASLSESRESLPSPWDPadppaavlapaaalPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  230 ----------------QEPPQRQTVGTkqPKKPVKASARAGSRTSLQGEREPGLLPYGS--RDQTSKDKPKVKTKGRPRA 291
Cdd:PHA03247  2848 pslplggsvapggdvrRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQpeRPPQPQAPPPPQPQPQPPP 2925

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  292 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN----------VEDRTPEHFALVPLTESQGPP-HSGSGSRTS 360
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLgalvpgrvavPRFRVPQPAPSREAPASSTPPlTGHSLSRVS 3005

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034639912  361 GCRQAVVVQEDSrkDRLPLPLRDTKLLSPLRDTPPPQSLMVKIT--LDLLSRIPQPPGKGSRQRKAEDKQPPA 431
Cdd:PHA03247  3006 SWASSLALHEET--DPPPVSLKQTLWPPDDTEDSDADSLFDSDSerSDLEALDPLPPEPHDPFAHEPDPATPE 3076
 
Name Accession Description Interval E-value
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 588-849 1.51e-139

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 414.07  E-value: 1.51e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 588 SKPGKPQVKFDKQQ--ADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIK 665
Cdd:pfam18876   1 SKPRRPQLKFEDRQhsADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 666 FIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSP 745
Cdd:pfam18876  81 YVMKLKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVAKSTGTPSPLSP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 746 MPSPASSVgsQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALN 825
Cdd:pfam18876 161 MPSPASSV--SSQSGSSGSSGSSSSVSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALN 238

                         250       260
                  ....*....|....*....|....
gi 1034639912 826 SSLVDLVHYTRQGFQQLQELTKTP 849
Cdd:pfam18876 239 SSMTELVRYTRQGLHWLRLDAKLP 262
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 1-158 1.14e-37

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 148.35  E-value: 1.14e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912   1 MTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTsSMLEDDLQLSDSEDSDSEQTPE 80
Cdd:pfam05110 356 MTHSWPPPLTAIHTPSTAEPSKFPFPTKESQHVTSGYQNQKQYDAPSKTLPTSQQGT-SMLEDDLKLSSSEDSDDDQAPE 434

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  81 KPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSD--SESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLT 158
Cdd:pfam05110 435 KPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDSESSSEsdSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
PHA03247 PHA03247
large tegument protein UL36; Provisional
 164-431 1.30e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  164 AAPPEGPRSTePPRRHPESKGSSDSATSQEHSESKDP--------------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQ 229
Cdd:PHA03247  2769 PAPPAAPAAG-PPRRLTRPAVASLSESRESLPSPWDPadppaavlapaaalPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  230 ----------------QEPPQRQTVGTkqPKKPVKASARAGSRTSLQGEREPGLLPYGS--RDQTSKDKPKVKTKGRPRA 291
Cdd:PHA03247  2848 pslplggsvapggdvrRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQpeRPPQPQAPPPPQPQPQPPP 2925

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  292 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN----------VEDRTPEHFALVPLTESQGPP-HSGSGSRTS 360
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLgalvpgrvavPRFRVPQPAPSREAPASSTPPlTGHSLSRVS 3005

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034639912  361 GCRQAVVVQEDSrkDRLPLPLRDTKLLSPLRDTPPPQSLMVKIT--LDLLSRIPQPPGKGSRQRKAEDKQPPA 431
Cdd:PHA03247  3006 SWASSLALHEET--DPPPVSLKQTLWPPDDTEDSDADSLFDSDSerSDLEALDPLPPEPHDPFAHEPDPATPE 3076
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
 399-413 1.08e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.08e-03
                          10
                  ....*....|....*
gi 1034639912 399 LMVKITLDLLSRIPQ 413
Cdd:pfam18875   1 LVVKIDLSLLSRVPQ 15
 
Name Accession Description Interval E-value
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 588-849 1.51e-139

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 414.07  E-value: 1.51e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 588 SKPGKPQVKFDKQQ--ADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIK 665
Cdd:pfam18876   1 SKPRRPQLKFEDRQhsADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 666 FIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSP 745
Cdd:pfam18876  81 YVMKLKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVAKSTGTPSPLSP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 746 MPSPASSVgsQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALN 825
Cdd:pfam18876 161 MPSPASSV--SSQSGSSGSSGSSSSVSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALN 238

                         250       260
                  ....*....|....*....|....
gi 1034639912 826 SSLVDLVHYTRQGFQQLQELTKTP 849
Cdd:pfam18876 239 SSMTELVRYTRQGLHWLRLDAKLP 262
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 1-158 1.14e-37

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 148.35  E-value: 1.14e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912   1 MTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTsSMLEDDLQLSDSEDSDSEQTPE 80
Cdd:pfam05110 356 MTHSWPPPLTAIHTPSTAEPSKFPFPTKESQHVTSGYQNQKQYDAPSKTLPTSQQGT-SMLEDDLKLSSSEDSDDDQAPE 434

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  81 KPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSD--SESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLT 158
Cdd:pfam05110 435 KPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDSESSSEsdSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
PHA03247 PHA03247
large tegument protein UL36; Provisional
 164-431 1.30e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  164 AAPPEGPRSTePPRRHPESKGSSDSATSQEHSESKDP--------------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQ 229
Cdd:PHA03247  2769 PAPPAAPAAG-PPRRLTRPAVASLSESRESLPSPWDPadppaavlapaaalPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  230 ----------------QEPPQRQTVGTkqPKKPVKASARAGSRTSLQGEREPGLLPYGS--RDQTSKDKPKVKTKGRPRA 291
Cdd:PHA03247  2848 pslplggsvapggdvrRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQpeRPPQPQAPPPPQPQPQPPP 2925

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  292 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN----------VEDRTPEHFALVPLTESQGPP-HSGSGSRTS 360
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLgalvpgrvavPRFRVPQPAPSREAPASSTPPlTGHSLSRVS 3005

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034639912  361 GCRQAVVVQEDSrkDRLPLPLRDTKLLSPLRDTPPPQSLMVKIT--LDLLSRIPQPPGKGSRQRKAEDKQPPA 431
Cdd:PHA03247  3006 SWASSLALHEET--DPPPVSLKQTLWPPDDTEDSDADSLFDSDSerSDLEALDPLPPEPHDPFAHEPDPATPE 3076
PHA03247 PHA03247
large tegument protein UL36; Provisional
 160-432 9.03e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 9.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  160 VSQPAAPPEGPRSTEPPrrhPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAP-------HPGKRSCQKSPAQQEP 232
Cdd:PHA03247  2695 LTSLADPPPPPPTPEPA---PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPatpggpaRPARPPTTAGPPAPAP 2771

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  233 PqRQTVGTKQPKKPVKASARAG-SRTSLQGEREPGllpygsrdqtskDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHK 311
Cdd:PHA03247  2772 P-AAPAAGPPRRLTRPAVASLSeSRESLPSPWDPA------------DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTA 2838

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  312 SSLP----APSKALSGP-EPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSrkdrlPLPLRDTKL 386
Cdd:PHA03247  2839 PPPPpgppPPSLPLGGSvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQ-----PERPPQPQA 2913

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1034639912  387 LSPLRDTPPPQSLMvkitldllSRIPQPPGKGSRQRKAEDKQPPAG 432
Cdd:PHA03247  2914 PPPPQPQPQPPPPP--------QPQPPPPPPPRPQPPLAPTTDPAG 2951
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
165-329 3.16e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.46  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 165 APPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRScQKSPAQQEPPQRQTVGTKQPK 244
Cdd:PRK07003  366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRA-EAPPAAPAPPATADRGDDAAD 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 245 KPVKASARAGSRTSL-----------QGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSS 313
Cdd:PRK07003  445 GDAPVPAKANARASAdsrcderdaqpPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAA 524

                         170
                  ....*....|....*.
gi 1034639912 314 LPAPSKALSGPEPAKD 329
Cdd:PRK07003  525 AAPPAPEARPPTPAAA 540
PHA03247 PHA03247
large tegument protein UL36; Provisional
 163-430 3.52e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  163 PAAPPEGPRSTEPPRR-------HPESKGSSDSATSQEHSESKDPPPKSS-SKAPRAPPEAPHPGKRSCQKSPAQQEPPQ 234
Cdd:PHA03247  2645 TVPPPERPRDDPAPGRvsrprraRRLGRAAQASSPPQRPRRRAARPTVGSlTSLADPPPPPPTPEPAPHALVSATPLPPG 2724

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  235 RQTVGTKQPKKPVKASARAGSRTSLQ--GEREPGlLPYGSRDQTSKDKPKVKTKGRPRAAasnePKPAVPPSSEKKKHKS 312
Cdd:PHA03247  2725 PAAARQASPALPAAPAPPAVPAGPATpgGPARPA-RPPTTAGPPAPAPPAAPAAGPPRRL----TRPAVASLSESRESLP 2799

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  313 SLPAPSK-ALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSG-SRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPL 390
Cdd:PHA03247  2800 SPWDPADpPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGpPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPA 2879

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 1034639912  391 RdtPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPP 430
Cdd:PHA03247  2880 R--PPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
160-340 7.62e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 7.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 160 VSQPAAPPEGPRSTEPPRRHPE-----SKGSSDSATSQEHSESKDPPPKSSSKAPR-----------APPEAPHPGKRSC 223
Cdd:PRK12323  382 VAQPAPAAAAPAAAAPAPAAPPaapaaAPAAAAAARAVAAAPARRSPAPEALAAARqasargpggapAPAPAPAAAPAAA 461

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 224 QKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPP 303
Cdd:PRK12323  462 ARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETL 541

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1034639912 304 SSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFA 340
Cdd:PRK12323  542 APAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFD 578
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
 399-413 1.08e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.08e-03
                          10
                  ....*....|....*
gi 1034639912 399 LMVKITLDLLSRIPQ 413
Cdd:pfam18875   1 LVVKIDLSLLSRVPQ 15
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 161-341 1.46e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 161 SQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGT 240
Cdd:PRK07764  634 AAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQ 713

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 241 KQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVktKGRPRAAASNEPKPAVPPSSEKKkhksslPAPSKA 320
Cdd:PRK07764  714 ADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPA--QPPPPPAPAPAAAPAAAPPPSPP------SEEEEM 785

                         170       180
                  ....*....|....*....|.
gi 1034639912 321 LSGPEPAKDNVEDRTPEHFAL 341
Cdd:PRK07764  786 AEDDAPSMDDEDRRDAEEVAM 806
dnaA PRK14086
chromosomal replication initiator protein DnaA;
162-327 2.08e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 41.73  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 162 QPAAPPEGPRSTEPPRRHPESKGSSDSATSQEhSESKDPPPKSSSKAPRAPPEAP---HPGKRSCQKSPAQQEPPQRQTV 238
Cdd:PRK14086   94 EPAPPPPHARRTSEPELPRPGRRPYEGYGGPR-ADDRPPGLPRQDQLPTARPAYPayqQRPEPGAWPRAADDYGWQQQRL 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 239 GTKQPKKPvkASARAGSRTSLQGEREPGL----LPYGSRDQT----SKDKPKVKTKGRPRAAASNE------PKPAVPPS 304
Cdd:PRK14086  173 GFPPRAPY--ASPASYAPEQERDREPYDAgrpeYDQRRRDYDhprpDWDRPRRDRTDRPEPPPGAGhvhrggPGPPERDD 250

                         170       180
                  ....*....|....*....|...
gi 1034639912 305 SEKKKHKSSLPAPSKALSGPEPA 327
Cdd:PRK14086  251 APVVPIRPSAPGPLAAQPAPAPG 273
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 163-254 2.62e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.24  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 163 PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSeskdPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQ 242
Cdd:PRK14951  389 PAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAA----PPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPV 464

                          90
                  ....*....|..
gi 1034639912 243 PKKPVKASARAG 254
Cdd:PRK14951  465 RVAPEPAVASAA 476
PHA03325 PHA03325
nuclear-egress-membrane-like protein; Provisional
 163-303 5.34e-03

nuclear-egress-membrane-like protein; Provisional


Pssm-ID: 223044  Cd Length: 418  Bit Score: 40.25  E-value: 5.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 163 PAAPPEGPRSTEPPRRHPESKGSSDSATSQE-------HSESKDPPPKSSSKAPrAPPEAPHPGKRSCQKSP------AQ 229
Cdd:PHA03325  260 SAFMLNSSLPTSAPKRRSRRAGAMRAAAGETadladddGSEHSDPEPLPASLPP-PPVRRPRVKHPEAGKEEpdgarnAE 338

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034639912 230 QEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPP 303
Cdd:PHA03325  339 AKEPAQPATSTSSKGSSSAQNKDSGSTGPGSSLAAASSFLEDDDFGSPPLDLTTSLRHMPSPSVTSAPEPPSIP 412
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
161-351 5.52e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 5.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 161 SQPAAPPEGPRSTEPPRRHPESkgssdsatsqehseSKDPPPKSSSKAPRAPPEAPHPGkrscqkspaqqePPQRQTVGT 240
Cdd:PRK12323  372 AGPATAAAAPVAQPAPAAAAPA--------------AAAPAPAAPPAAPAAAPAAAAAA------------RAVAAAPAR 425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 241 KQPKKPVKASARAGSRTSLQGEREPGLLPygsrdqtskdkPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPskA 320
Cdd:PRK12323  426 RSPAPEALAAARQASARGPGGAPAPAPAP-----------AAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAP--A 492

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1034639912 321 LSGPEPAKDnvedrTPEHFALVPLTESQGPP 351
Cdd:PRK12323  493 DDDPPPWEE-----LPPEFASPAPAQPDAAP 518
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 170-343 6.49e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 6.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 170 PRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKA 249
Cdd:PRK07764  376 ARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPS 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 250 SARAGSrtslqgerepgllpyGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSekkkhksslPAPSKALSGPEPAkD 329
Cdd:PRK07764  456 PPPAAA---------------PSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAA---------PAAPAAPAGADDA-A 510

                         170
                  ....*....|....
gi 1034639912 330 NVEDRTPEHFALVP 343
Cdd:PRK07764  511 TLRERWPEILAAVP 524
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 151-396 6.57e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 6.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  151 WQLDNWLTKVSQPAA-------------PPEGPRSTEPPRRHPESKGSSD---------------SATSQEHSESKDP-- 200
Cdd:PHA03307   170 RQAALPLSSPEETARapssppaepppstPPAAASPRPPRRSSPISASASSpapapgrsaaddagaSSSDSSSSESSGCgw 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  201 --------PPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGS 272
Cdd:PHA03307   250 gpenecplPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSST 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  273 RDQTSKDKPKVKTKGRP--RAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDnvedrtpehfALVPLTESQGP 350
Cdd:PHA03307   330 SSSSESSRGAAVSPGPSpsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRR----------RARAAVAGRAR 399

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1034639912  351 PHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRD-TKLLSPLRDTPPP 396
Cdd:PHA03307   400 RRDATGRFPAGRPRPSPLDAGAASGAFYARYPLlTPSGEPWPGSPPP 446
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 158-258 8.12e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 39.71  E-value: 8.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912 158 TKVSQPAAPPEGPRSTEP-PRRHPESKGSSD----SATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKsPAQQEP 232
Cdd:PHA03269   37 TQKPDPAPAPHQAASRAPdPAVAPTSAASRKpdlaQAPTPAASEKFDPAPAPHQAASRAPDPAVAPQLAAAPK-PDAAEA 115

                          90       100
                  ....*....|....*....|....*.
gi 1034639912 233 PqrqTVGTKQPKKPVKASARAGSRTS 258
Cdd:PHA03269  116 F---TSAAQAHEAPADAGTSAASKKP 138
PHA03247 PHA03247
large tegument protein UL36; Provisional
 206-415 8.16e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 8.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  206 SKAPRAPPEAPHPGKrSCQKSPAQQEPPQRQTvGTKQPKKPVKASARAGSRTSLQGERE----------PGLLPYGSRDQ 275
Cdd:PHA03247  2486 ARFPFAAGAAPDPGG-GGPPDPDAPPAPSRLA-PAILPDEPVGEPVHPRMLTWIRGLEElasddagdppPPLPPAAPPAA 2563

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  276 TSKDKPKVKTKGRPR--AAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHS 353
Cdd:PHA03247  2564 PDRSVPPPRPAPRPSepAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP 2643

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034639912  354 GSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPP 415
Cdd:PHA03247  2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP 2705
PHA03247 PHA03247
large tegument protein UL36; Provisional
 163-537 9.66e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 9.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  163 PAAPPEGPRSTEPPRRhPESKGSSDSATSQEHSES--------------KDPPPKSSSKAPrAPPEAPHPGKRSCQKSPA 228
Cdd:PHA03247  2557 PAAPPAAPDRSVPPPR-PAPRPSEPAVTSRARRPDappqsarprapvddRGDPRGPAPPSP-LPPDTHAPDPPPPSPSPA 2634

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  229 QQEPPQRQTVGTKQPKKPVKASAraGSRTSL-QGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEK 307
Cdd:PHA03247  2635 ANEPDPHPPPTVPPPERPRDDPA--PGRVSRpRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAP 2712

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  308 KKHKSSLPAPSKALSGPEpakdnvedrtpehfALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDtkll 387
Cdd:PHA03247  2713 HALVSATPLPPGPAAARQ--------------ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA---- 2774

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639912  388 splRDTPPPQslmvkitldllsRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGeaerdcdnkkirl 467
Cdd:PHA03247  2775 ---PAAGPPR------------RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG------------- 2826

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034639912  468 ekeiKSQSSSSSSSHKESSKTKPSRPS-----SQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKS 537
Cdd:PHA03247  2827 ----PLPPPTSAQPTAPPPPPGPPPPSlplggSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTES 2897
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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