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Conserved domains on  [gi|767912642|ref|XP_011542573|]
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protein Wnt-9a isoform X1 [Homo sapiens]

Protein Classification

wnt family protein( domain architecture ID 1562737)

wnt family protein may function in development and differentiation

Gene Ontology:  GO:0016055|GO:0005102|GO:0005576
PubMed:  22952392|20477987|8167409
SCOP:  4005649|4007801

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Wnt super family cl38924
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 1-294 0e+00

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


The actual alignment was detected with superfamily member cd19353:

Pssm-ID: 393294  Cd Length: 298  Bit Score: 585.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCT 80
Cdd:cd19353    8 MCRRDPGVAETLMEAISMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHAMAKACSAGRMERCT 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  81 CDEAPDLENREAWQWGGCGDNLKYSSKFVKEFLGRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCW 160
Cdd:cd19353   88 CDEAPDLENREAWQWGGCGDNLKYSNKFVKEFLGRKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHGVSGSCTVRTCW 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 161 RQLAPFHEVGKHLKHKYETALKVGSTTNEAAGEAGAispPRGRASGAGGSDPLPRTPELVHLDDSPSFCLAGRFSPGTAG 240
Cdd:cd19353  168 RQLSPFHEIGKQLKQKYETSLKVGSTTNEATGEGDI---SPPKKSGAGHSDQIPRTTDLVYIDDSPSFCLMSRFSPGTSG 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767912642 241 RRCHREKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19353  245 RRCYKDKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTCK 298
 
Name Accession Description Interval E-value
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 1-294 0e+00

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 585.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCT 80
Cdd:cd19353    8 MCRRDPGVAETLMEAISMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHAMAKACSAGRMERCT 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  81 CDEAPDLENREAWQWGGCGDNLKYSSKFVKEFLGRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCW 160
Cdd:cd19353   88 CDEAPDLENREAWQWGGCGDNLKYSNKFVKEFLGRKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHGVSGSCTVRTCW 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 161 RQLAPFHEVGKHLKHKYETALKVGSTTNEAAGEAGAispPRGRASGAGGSDPLPRTPELVHLDDSPSFCLAGRFSPGTAG 240
Cdd:cd19353  168 RQLSPFHEIGKQLKQKYETSLKVGSTTNEATGEGDI---SPPKKSGAGHSDQIPRTTDLVYIDDSPSFCLMSRFSPGTSG 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767912642 241 RRCHREKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19353  245 RRCYKDKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTCK 298
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 1-294 1.89e-128

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 367.65  E-value: 1.89e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642    1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNC-TLEGR--YRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRME 77
Cdd:pfam00110  12 LCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCsTLENKrpVFGKVLKRGTRETAFVYAISSAGVTHAVTRACSSGELT 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   78 RCTCDEAPDLEN--REAWQWGGCGDNLKYSSKFVKEFL--GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGS 153
Cdd:pfam00110  92 SCGCDRKKRGKSsgEGGWEWGGCSDNIDYGYKFSRKFVdaREKKRRDARALMNLHNNEAGRKAVKSNMRTECKCHGVSGS 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  154 CTVRTCWRQLAPFHEVGKHLKHKYETALKVGSTTNeaagEAGAISPPRGRAsgaggsdPLPRTPELVHLDDSPSFCLAGR 233
Cdd:pfam00110 172 CSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRN----KRGRLVPRNSRF-------KPPTKNDLVYLEKSPDYCERNP 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767912642  234 F--SPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:pfam00110 241 KtgSLGTRGRECNKTSsgpdGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
WNT1 smart00097
found in Wnt-1;
1-294 2.20e-92

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 276.12  E-value: 2.20e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642     1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYRA--SLLKRGFKETAFLYAISSAGLTHALAKACSAGRMER 78
Cdd:smart00097  12 LCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVfgKVLRQGTRETAFVYAISSAGVAHAVTRACSEGELDS 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642    79 CTCDEAP-DLENREAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTV 156
Cdd:smart00097  92 CGCDYRKrGRAGGRGWKWGGCSDNIDFGIRFSREFVdARERGKDARALMNLHNNEAGRLAVKKTMKRECKCHGVSGSCTV 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   157 RTCWRQLAPFHEVGKHLKHKYETALKVgsttneAAGEAGAISPPRGRASgaggSDPLPRTPELVHLDDSPSFCLAGR--F 234
Cdd:smart00097 172 KTCWLQLPDFRKVGDYLKEKYDGASEV------EVDKRGTNKAPVPKNS----TFKPPTETDLVYLESSPDFCEKNPktG 241

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767912642   235 SPGTAGRRCHREKN----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:smart00097 242 SLGTQGRQCNKTSKgldgCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
 
Name Accession Description Interval E-value
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 1-294 0e+00

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 585.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCT 80
Cdd:cd19353    8 MCRRDPGVAETLMEAISMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHAMAKACSAGRMERCT 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  81 CDEAPDLENREAWQWGGCGDNLKYSSKFVKEFLGRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCW 160
Cdd:cd19353   88 CDEAPDLENREAWQWGGCGDNLKYSNKFVKEFLGRKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHGVSGSCTVRTCW 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 161 RQLAPFHEVGKHLKHKYETALKVGSTTNEAAGEAGAispPRGRASGAGGSDPLPRTPELVHLDDSPSFCLAGRFSPGTAG 240
Cdd:cd19353  168 RQLSPFHEIGKQLKQKYETSLKVGSTTNEATGEGDI---SPPKKSGAGHSDQIPRTTDLVYIDDSPSFCLMSRFSPGTSG 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767912642 241 RRCHREKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19353  245 RRCYKDKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTCK 298
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 1-294 3.08e-167

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 465.53  E-value: 3.08e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRyrASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCT 80
Cdd:cd19354    8 LCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGR--GSLLKRGFKETAFLYAVSSAALTHSLAKACSSGRMERCT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  81 CDEAPDLENREAWQWGGCGDNLKYSSKFVKEFLG-RRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTC 159
Cdd:cd19354   86 CDDSPGLENREAWQWGVCGDNLKYSTKFLKNFLGqKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSCAVRTC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 160 WRQLAPFHEVGKHLKHKYETALKVGSTTNEAAGEAGAISPPRGRASGAGGSdplPRTPELVHLDDSPSFCLAGRFSPGTA 239
Cdd:cd19354  166 WKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERHGHTLKGHS---PRSTDLVYLEDSPSFCRPSKYSPGTA 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767912642 240 GRRCHREKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19354  243 GRTCSRETNCDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTCK 297
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 1-294 2.25e-165

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 460.99  E-value: 2.25e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLeGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCT 80
Cdd:cd19341    8 MCRRDPGLAETLLEAIRLSVLECQEQFRYERWNCSL-GKYRINLLKKGYKETAFLYAISSAGLTHSVARACSSGRLDRCT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  81 CDEAPDLE-NREAWQWGGCGDNLKYSSKFVKEFLGRR--SSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVR 157
Cdd:cd19341   87 CDESFSLEeNRQTWLWGGCGDNIKYGKKFTRRFLQLKkkSGKDLRAEIDRHNSEVGIRVVREGVKKTCKCHGVSGSCTVK 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 158 TCWRQLAPFHEVGKHLKHKYETALKVGSTTNEAAGEagaiSPPRGRASGAGGSDPLPRTPELVHLDDSPSFCLAGRFSPG 237
Cdd:cd19341  167 TCWKQLAPFNEIGKILKRKYEKAVKVVSENNAATGG----SQLRKGKSGSVKKKSRPRRKDLVYLEKSPSFCRSTRYSPG 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767912642 238 TAGRRCHREKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19341  243 TKGRRCLKGDNCDTLCCGRGYNTQSEVVVKPCKCRVVWCCQVECKTCTEREEIYTCK 299
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 1-294 1.89e-128

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 367.65  E-value: 1.89e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642    1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNC-TLEGR--YRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRME 77
Cdd:pfam00110  12 LCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCsTLENKrpVFGKVLKRGTRETAFVYAISSAGVTHAVTRACSSGELT 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   78 RCTCDEAPDLEN--REAWQWGGCGDNLKYSSKFVKEFL--GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGS 153
Cdd:pfam00110  92 SCGCDRKKRGKSsgEGGWEWGGCSDNIDYGYKFSRKFVdaREKKRRDARALMNLHNNEAGRKAVKSNMRTECKCHGVSGS 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  154 CTVRTCWRQLAPFHEVGKHLKHKYETALKVGSTTNeaagEAGAISPPRGRAsgaggsdPLPRTPELVHLDDSPSFCLAGR 233
Cdd:pfam00110 172 CSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRN----KRGRLVPRNSRF-------KPPTKNDLVYLEKSPDYCERNP 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767912642  234 F--SPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:pfam00110 241 KtgSLGTRGRECNKTSsgpdGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 8-293 2.00e-113

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 328.87  E-value: 2.00e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   8 VAETLVEAVSMSALECQFQFRFERWNCTL--EGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAP 85
Cdd:cd13113    1 LMESIAEGAQLALKECQRQFANRRWNCSTfnEPLLFGKILKRGTRETAFVHAITSAGVTHAITRACSRGKLKNCGCDRTR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  86 -DLENREAWQWGGCGDNLKYSSKFVKEFLGRRS---SKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWR 161
Cdd:cd13113   81 qGPEGQGDWTWGGCSDNIKFGIKFSRKFLDAREkkkGSDARSLMNLHNNEAGRKAVKKTMKKKCKCHGVSGSCTTKTCWR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 162 QLAPFHEVGKHLKHKYETALKVGSTTNEAageagaisppRGRASGAGGSDPLPRTPELVHLDDSPSFCLAGRF--SPGTA 239
Cdd:cd13113  161 QLPSFREIGDYLKEKYDNAVKVKLNNNGS----------GLRLVPKRSRFRSPTETDLVYLEESPDYCEPNPTlgSLGTA 230

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767912642 240 GRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTC 293
Cdd:cd13113  231 GRECNPTSpgpdSCELLCCGRGYRTETEIVTEKCNCKFVWCCEVKCETCRRTVERYTC 288
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 1-294 1.07e-101

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 299.95  E-value: 1.07e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCT-LEGR----YRASLLKRGFKETAFLYAISSAGLTHALAKACSAGR 75
Cdd:cd19342   17 LCRRYPDVTASAIQGIQLAVHECQRQFRDHRWNCSsLETKnknpHTSPILSRGYRETAFAYAISAAGVAHQVARACSLGK 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  76 MERCTCDE--APDLENREAWQWGGCGDNLKYSSKFVKEFLG-RRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSG 152
Cdd:cd19342   97 LLSCGCDRsrRGKRSSGNDWKWGGCSHNLDFGEKFSRKFLDsREKARDIHSRMNLHNNRAGRLAVSENMERKCKCHGMSG 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 153 SCTVRTCWRQLAPFHEVGKHLKHKYETALKVGsTTNEAAGEAGAISPPRGRASGAGGSDplprtpeLVHLDDSPSFCLAG 232
Cdd:cd19342  177 SCELKTCWKAAPDFREVGDILKEKYDHATLVD-QSNLNNGARRRRLTRRKRRRRPPKTD-------LVYYERSPNFCEAD 248

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767912642 233 RF--SPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19342  249 PSldSPGTRGRVCNKTStgpdSCDSLCCGRGYNTVRQTRTERCNCRFHWCCYVVCEKCTETEWVTVCK 316
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 1-294 4.74e-98

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 290.66  E-value: 4.74e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCT 80
Cdd:cd19338   20 ICRKEPEILEEVAKGAKLGIRECQYQFRNRRWNCSTSRKSFGKILKRDTRETAFVYAITSAGVTYSVTRACSMGELLQCG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  81 CDEA-PDLENREAWQWGGCGDNLKYSSKFVKEFL--GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVR 157
Cdd:cd19338  100 CDKSkRGKSTEGEWEWGGCSDNVRYGYRKSREFMdaKEKNRSDIRTLMNLHNNEAGRLAVKNNMRKECKCHGLSGSCTLK 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 158 TCWRQLAPFHEVGKHLKHKYETALKVgsttnEAAGEAGAISPPRGRASGAGGSDplprtpeLVHLDDSPSFCLAGR--FS 235
Cdd:cd19338  180 TCWRKMPPFREVGDRLKERFDGAIKV-----KGSNDGKSLIPEGKTIKPPTKED-------LVYLEESPDFCEPNKktGS 247

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767912642 236 PGTAGRRCHREKN----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19338  248 LGTRGRECNRTSMgvdgCDLLCCGRGYQTEVRVVEENCNCRFHWCCEVKCETCKVRKEIHTCN 310
WNT1 smart00097
found in Wnt-1;
1-294 2.20e-92

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 276.12  E-value: 2.20e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642     1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYRA--SLLKRGFKETAFLYAISSAGLTHALAKACSAGRMER 78
Cdd:smart00097  12 LCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVfgKVLRQGTRETAFVYAISSAGVAHAVTRACSEGELDS 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642    79 CTCDEAP-DLENREAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTV 156
Cdd:smart00097  92 CGCDYRKrGRAGGRGWKWGGCSDNIDFGIRFSREFVdARERGKDARALMNLHNNEAGRLAVKKTMKRECKCHGVSGSCTV 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   157 RTCWRQLAPFHEVGKHLKHKYETALKVgsttneAAGEAGAISPPRGRASgaggSDPLPRTPELVHLDDSPSFCLAGR--F 234
Cdd:smart00097 172 KTCWLQLPDFRKVGDYLKEKYDGASEV------EVDKRGTNKAPVPKNS----TFKPPTETDLVYLESSPDFCEKNPktG 241

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767912642   235 SPGTAGRRCHREKN----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:smart00097 242 SLGTQGRQCNKTSKgldgCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 1-294 1.43e-91

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 273.75  E-value: 1.43e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCT---LEGRYRASLlKRGFKETAFLYAISSAGLTHALAKACSAGRME 77
Cdd:cd19343    8 LCRRNLELMPSVVEAARLTVDTCQEQFADRRWNCSsieLAPNFTPDL-TRGTREQAFVYALSSAALTHTIARACASGALP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  78 RCTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEFL------GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVS 151
Cdd:cd19343   87 GCGCGRLPREPPDGDFKWGGCGDNVRYGLRFAKRFTdapekkKKKKKRQARALMNLHNNRVGRKAVRDSLETQCKCHGVS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 152 GSCTVRTCWRQLAPFHEVGKHLKHKYETALKVGSTTNEAAGEAGAISPPRGRASGAggsdplprtpELVHLDDSPSFCL- 230
Cdd:cd19343  167 GSCSVKTCWKALPDLSEVASRLKRKYARAVEVVSRKVGSRRKLVPKSLKVRPYTKD----------DLIYLTKSPDYCLp 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767912642 231 -AGRFSPGTAGRRC----HREKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19343  237 dEKLGSLGTRGRECnktsVGSDSCDSMCCGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTVEVHVCK 305
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 1-294 5.65e-89

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 267.18  E-value: 5.65e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYRA--SLLKRGFKETAFLYAISSAGLTHALAKACSAGRMER 78
Cdd:cd19344    8 LCKKKPEAIPSVSEGARLGIYECQHQFRHERWNCSTTNDQNVfgKTLSRGTKETAFIYAITSAGVVHAVTRACSAGNLTD 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  79 CTCD-EAPDLENREAWQWGGCGDNLKYSSKFVKEFL------GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVS 151
Cdd:cd19344   88 CSCDsRRQGQSASEGWKWGGCSDNVDYGIWFARKFVdapeksERKRSRDVRSLMNLHNNEVGRQAIARLMKVKCRCHGVS 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 152 GSCTVRTCWRQLAPFHEVGKHLKHKYETALKVgsttneaageagAISPPRGRASGAGGS---DPLPRTpELVHLDDSPSF 228
Cdd:cd19344  168 GSCEVKTCWKTMPSFEEVGDFLKQKYENSIQI------------ATKKSKRRLRRRERRkrkVPISKD-ELVYIHKSPNY 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767912642 229 CL--AGRFSPGTAGRRCHREKN----CESICCGRGHNTQ-SRVVTRpCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19344  235 CVrdPKKGILGTSGRECNRTSTgpdsCDLLCCGRGYNTQvVRHVER-CNCKFVWCCYVKCKTCETMTDVHTCK 306
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 1-294 3.71e-88

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 265.74  E-value: 3.71e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYRA---SLLKRGFKETAFLYAISSAGLTHALAKACSAGRME 77
Cdd:cd19334   19 LCRKHPDVMVSIGEGAKLGVKECQYQFRNQRWNCSTVDRDATvfgKVLLKGSREAAFVYAISSAGVVHAITRACSKGELL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  78 RCTCDEAPDLENREA---WQWGGCGDNLKYSSKFVKEFLG--RRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSG 152
Cdd:cd19334   99 NCACDPTKRGKGRDSkgeFDWGGCSDNVKYGINFARKFVDarERRVRDARALMNLHNNRAGRKAVKKNLKLQCKCHGVSG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 153 SCTVRTCWRQLAPFHEVGKHLKHKYETALKVgsTTNEAAGEAGAISPPRGRASGAggsdplprtpELVHLDDSPSFCLA- 231
Cdd:cd19334  179 SCTIRTCWRALAEFREVGDYLREKYDGAVQV--TMNQSGTNLLAANKGHKKPTRS----------DLVYFESSPDYCVPn 246

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767912642 232 -GRFSPGTAGRRCHR----EKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19334  247 pETGSLGTAGRVCNKtstgTDGCDIMCCGRGYDTTRVRRTTKCNCKFHWCCQVKCKTCTETVDVHTCK 314
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 1-294 6.71e-86

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 259.91  E-value: 6.71e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYR--ASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMER 78
Cdd:cd19339   15 ICQSRPDAIVAIGEGAQLGIEECQFQFRNHRWNCTLLGERTvfGQELPVGSREAAFTYAITSAGVAYAITQACSQGNLSD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  79 CTCDEAPD--LENREAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCT 155
Cdd:cd19339   95 CGCDKSKKgyGKSDEGWKWGGCSADVKYGLRFSRKFVdAREVKRNARSLMNLHNNEAGRKAVEENLKLECKCHGVSGSCT 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 156 VRTCWRQLAPFHEVGKHLKHKYETALKVgsttneAAGEAGAISPPRGRASGAGGSDPLPRTPELVHLDDSPSFCLAGRF- 234
Cdd:cd19339  175 TKTCWTTLPSFREIGDYLKKKYERARRV------EPVRGRRRRRPTFLKLKISRKYKKPRPRDLVYLEKSPNYCEKDPLt 248

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767912642 235 -SPGTAGRRCHR----EKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19339  249 gSLGTVGRRCNRtstgTDGCDLMCCGRGYNTHQYTKTWQCNCKFHWCCYVKCNTCSERTEEYTCK 313
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 22-294 2.17e-85

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 258.33  E-value: 2.17e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  22 ECQFQFRFERWNCTLEGRYRA--SLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEA--PDLENREaWQWGG 97
Cdd:cd19337   35 ECQYQFRYRRWNCSTPDSSSVfgPVTNIGTREAAFTYAISAAGVVHAIARACREGNLSTCGCSRErrPKDLPRD-WLWGG 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  98 CGDNLKYSSKFVKEFLG---------RRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHE 168
Cdd:cd19337  114 CGDNIEYGYKFAKEFIDareretnypRHSRELARVLMNLHNNEAGRRAVYEKARVACKCHGVSGSCSLKTCWRQLAPFRE 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 169 VGKHLKHKYETALKVgsttneaageagAISPPRGRASGAGGSDPLPRTPELVHLDDSPSFCLAGR--FSPGTAGRRCHRE 246
Cdd:cd19337  194 VGDRLKDKYDGAVKV------------KLNRRGTLLRRRNSRFNKPTKDDLVYLDDSPDYCERNPktGSLGTKGRECNKT 261

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767912642 247 ----KNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19337  262 ssgtDGCELLCCGRGYNTKKVEVVERCHCKFHWCCEVKCKTCEKIVDVHICK 313
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 1-294 5.95e-80

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 244.53  E-value: 5.95e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTL--EGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMER 78
Cdd:cd19336   14 FCKRNLEVMDSVRRGAQLAIEECQFQFRNRRWNCSTldKEPVFGKVLNQGTREAAFVHAISSAGVAHAVTRACSSGELEK 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  79 CTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEF-----LGRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGS 153
Cdd:cd19336   94 CGCDRSVRGRSPEGFQWSGCSDNVAYGVAFSKSFvdareRRKGRASSSRALMNLHNNEAGRKAIEKNMRVECKCHGVSGS 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 154 CTVRTCWRQLAPFHEVGKHLKHKYETALKVGSTTNeaaGEAGAISPPRgrasgaggSDPLPRTPE-LVHLDDSPSFC--- 229
Cdd:cd19336  174 CELKTCWRAMPTFREVGNILKEKFDGATEVQQKRI---GSRPVLVPKN--------PQFKPHTDAdLVYLDSSPDFCepd 242

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 230 -LAGrfSPGTAGRRCHREKN----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19336  243 pKTG--SLGTHGRVCNKTSKaidgCDLLCCGRGYVTRTEEVVERCSCKFHWCCYVKCKTCRREVEVHTCR 310
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 3-293 1.47e-78

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 241.10  E-value: 1.47e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   3 RRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYRAS-----LLKRGFKETAFLYAISSAGLTHALAKACSAGRME 77
Cdd:cd19333   10 RQNPGTLHAIARGARMAIKECKWQFRNRRWNCPTTDSRGGPnvfgkILNRGCRETAFIYAITSAAVTHSVARACSEGSIE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  78 RCTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTV 156
Cdd:cd19333   90 SCSCDYRRRGPGGPDWEWGGCSDNIDFGRKFSREFVdAGEKGRDLRYLMNLHNNEAGRVHVSSEMRQECKCHGMSGSCTV 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 157 RTCWRQLAPFHEVGKHLKHKYETALKVGSTTNEAAGEAGAISPPRGRASGAGGSDPLPRtpELVHLDDSPSFCLAGRF-- 234
Cdd:cd19333  170 KTCWMRLPTFRTVGDRLKDRFDGASRVAYGNNGNNRGSRRAKKFLLEPENPNHKPPTSK--DLVYFEESPNFCEKNPKlg 247

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767912642 235 SPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTC 293
Cdd:cd19333  248 TLGTRGRECNATSigldGCDLMCCGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVHTC 310
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 11-293 4.04e-77

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 236.81  E-value: 4.04e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  11 TLVEAVSMSAL----ECQFQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDE-AP 85
Cdd:cd19340    8 SLSDSVAAGAQlameECQYQFKWDRWNCPESAFFSQKNNPSATRETAFVHAISSAGVMYTLTRNCSLGHFEGCGCDDsKK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  86 DLENREAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLA 164
Cdd:cd19340   88 GSKGGEGWTWGGCSDNVKFGERVSKKFLdSLETGQDAQALMNLHNNRAGRKAVRKTMKKTCKCHGVSGSCSTQTCWMQLA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 165 PFHEVGKHLKHKYETALKVGSTTNEAAgeagaisppRGRASGAGGSDPLPRTpELVHLDDSPSFCLA----GrfSPGTAG 240
Cdd:cd19340  168 PFREIGTDLKRKYDRAVRVDYENGGLR---------ETNGSRAIKLLNIKKN-DLVYLEKSPNYCRAnvtlG--WPGTLG 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767912642 241 RRCHREKN----------CESICCGRGHNTQSRVV--TRPCQCQVRWCCYVECRQCTQREEVYTC 293
Cdd:cd19340  236 RQCSRDKKesvsrwerksCRRLCRACGLKVRKKVVevTSSCNCKFHWCCEVKCETCVELVIEYTC 300
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 2-294 3.92e-76

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 234.98  E-value: 3.92e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   2 CRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYRA---SLLKRGFKETAFLYAISSAGLTHALAKACSAGRMER 78
Cdd:cd19335   18 CRNYTELMPSVAEGAKLGIQECQHQFRGRRWNCTTIEGDLSvfgPVLDKASRESAFVHAIASAGVAHAVTRACAEGDSTS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  79 CTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVR 157
Cdd:cd19335   98 CGCDSRHKGPPGEGWRWGGCSEDVEFGVRFSREFAdARENRPDARSAMNRHNNEAGRQAILDNMELKCKCHGLSGSCELK 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 158 TCWRQLAPFHEVGKHLKHKYETAlkvgsttNEAAGEAGAISPPRGRASGAGGSDPLPRTP-ELVHLDDSPSFClagRFSP 236
Cdd:cd19335  178 TCWWAQPDFRKIGDYLKDKYDSA-------SEMVVERHRESRGWVETLRPKYKLFKPPTErDLIYYEESPNFC---EPNP 247

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767912642 237 -----GTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19335  248 etgsfGTRGRECNVTShgidGCDLLCCGRGYNTRTEKRTEKCHCIFVWCCYVSCQECIRVYDVHTCK 314
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 1-294 2.04e-71

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 222.55  E-value: 2.04e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCT-LEGR----YRASLLKRGFKETAFLYAISSAGLTHALAKACSAGR 75
Cdd:cd19355   17 VCMRHPDVTASAIQGIQIAIHECQHQFRDHRWNCSsLETRnkipYESVVFSRGFRESAFAYAIAAAGVVHAVSNACAMGK 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  76 MERCTCDeapdlenreaWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSC 154
Cdd:cd19355   97 LKACGCD----------WEWGGCSPDVEYGERFSKDFLdSRETYRDIHARMRLHNNRVGRQVVMDNMRRKCKCHGTSGSC 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 155 TVRTCWRQLAPFHEVGKHLKHKYETALKVGSTTNEAAGEAGAISPPRGRASGAggsdplprtpELVHLDDSPSFCLAGRF 234
Cdd:cd19355  167 QLKTCWQVTPEFRTVGSLLKDRFYVATLIKPHNRNTGQLEPGHAPHRRRASIN----------DLVYFEKSPDFCEREPR 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767912642 235 --SPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19355  237 ldSAGTQGRICNKTSpgmdNCESLCCGRGHNILRQTRSERCNCKFHWCCYVVCEECRITEWVSVCK 302
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 1-294 5.50e-70

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 219.04  E-value: 5.50e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYRA---SLLKRGFKETAFLYAISSAGLTHALAKACSAGRME 77
Cdd:cd19345   19 LCHRHPEVMQAIGSGVKEWIAECQHQFRNHRWNCNTLDRDHSlfgRLLLRSSRESAFVYAISSAGVVFAITRACSQGELK 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  78 RCTCDEAPDLENREA---WQWGGCGDNLKYSSKFVKEFLG--RRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSG 152
Cdd:cd19345   99 SCSCDPKKKGSSKDSkgsFDWGGCSDNIDYGIRFARAFVDakERKGKDARALMNLHNNRAGRKAVKRFMTLECKCHGVSG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 153 SCTVRTCWRQLAPFHEVGKHLKHKYETALKVGSTTNeaaGEAGAISPPRGRAsgaggsdplPRTPELVHLDDSPSFCLAG 232
Cdd:cd19345  179 SCTVRTCWLAMADFRKTGDYLRKKYNGAIQVVMNQD---GTGFTVANKHFKK---------PTKNDLVYFENSPDYCVRD 246

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767912642 233 R--FSPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19345  247 RdaGSLGTAGRVCNRTSrgmdGCEVMCCGRGYDTSRVGRMTKCECKFHWCCAVRCKDCHQQVDVHTCK 314
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 1-294 1.43e-66

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 210.68  E-value: 1.43e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYR--ASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMER 78
Cdd:cd19349   20 ICQSRPDAIIVIGEGAQMGINECQFQFRNGRWNCSALGERTvfGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  79 CTCDEAPD--LENREAWQWGGCGDNLKYSSKFVKEFLGRRSSK-DLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCT 155
Cdd:cd19349  100 CGCDKEKQgqYNQEEGWKWGGCSADIRYGIGFSKVFVDAREIKqNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCT 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 156 VRTCWRQLAPFHEVGKHLKHKYETALKVG---STTNEAAGEAGAISPPRGRAsgaggsdplPRTPELVHLDDSPSFCLAG 232
Cdd:cd19349  180 TKTCWTTLPKFRELGYILKDKYNEAVHVEpvrASRNKRPTFLKIKKPLSYRK---------PMDTDLVYIEKSPNYCEED 250

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767912642 233 RF--SPGTAGRRCHR----EKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19349  251 PVtgSVGTQGRMCNKtaqqNNGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTCK 318
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 22-294 1.52e-65

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 207.61  E-value: 1.52e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  22 ECQFQFRFERWNCTL--EGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAPDLEN-REAWQWGGC 98
Cdd:cd19347   35 ECQYQFRHRRWNCSTvdNTSVFGRVMQIGSRETAFTYAISAAGVVNAVSRACREGELSTCGCSRAARPKDlPRDWLWGGC 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  99 GDNLKYSSKFVKEFLGRR---------SSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHEV 169
Cdd:cd19347  115 GDNLEYGYRFAKEFVDARerekiyqkgSYESARTLMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKV 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 170 GKHLKHKYETAlkvgsttneAAGEAGAisppRGRASGAGGSDPLPRTPELVHLDDSPSFCLAGRF--SPGTAGRRCHREK 247
Cdd:cd19347  195 GDALKEKYDSA---------AAMKLNS----RGKLVQVNSRFNPPTTLDLVYIDPSPDYCVRNEStgSLGTQGRLCNKTS 261

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767912642 248 N----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19347  262 EgmdgCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK 312
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 1-294 2.00e-65

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 207.47  E-value: 2.00e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYR---ASLLKRGFKETAFLYAISSAGLTHALAKACSAGRME 77
Cdd:cd19346   19 LCQRHPDIMQSIGEGAKEWIRECQHQFRHHRWNCSTLDRDHtvfGRVMLRSSREAAFVYAISSAGVVYAITRACSQGELK 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  78 RCTCD---EAPDLENREAWQWGGCGDNLKYSSKFVKEFLGRRSS--KDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSG 152
Cdd:cd19346   99 SCSCDphkRGRSHDERGEFDWGGCSDNINYGIKFAKAFVDAKEKkeKDARALMNLHNNRCGRMAVKRFMKLECKCHGVSG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 153 SCTVRTCWRQLAPFHEVGKHLKHKYETALKVgSTTNEAAGEAGAISPPRGrasgaggsdplPRTPELVHLDDSPSFCLAG 232
Cdd:cd19346  179 SCTLRTCWLAMSDFRKTGDYLRKRYNGAVQV-TMNQDGTGFTVANKNFRK-----------ATKTDLVYFENSPDYCVMD 246

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767912642 233 RF--SPGTAGRRCHREKN----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19346  247 KSagSLGTAGRVCNKSSRgtdgCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTCK 314
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 1-294 2.09e-64

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 204.86  E-value: 2.09e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYR--ASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMER 78
Cdd:cd19350   20 ICQSRPDAIIVIGEGAQMGINECQYQFRYGRWNCSALGERTvfGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSN 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  79 CTCDEAPD--LENREAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCT 155
Cdd:cd19350  100 CGCDREKQgyYNQEEGWKWGGCSADIKYGIDFSRKFVdAREIKKNARRLMNLHNNEAGRKVLEERMKLECKCHGVSGSCT 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 156 VRTCWRQLAPFHEVGKHLKHKYETALKVGSTtneaagEAGAISPPRGRASGAGGSDPLPRTPELVHLDDSPSFCL--AGR 233
Cdd:cd19350  180 TKTCWTTLPKFREIGYVLKEKYNAAVQVEVV------RASRLRQPTFLKIKKRRSYQKPMETDLVYIERSPNYCEedAAT 253

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767912642 234 FSPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19350  254 GSVGTQGRLCNRTSphtdGCDLMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 318
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 1-294 3.24e-63

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 201.27  E-value: 3.24e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642   1 MCRRDPGVAETLVEAVSMSALECQFQFRFERWNC-TLEGRYR----ASLLKRGFKETAFLYAISSAGLTHALAKACSAGR 75
Cdd:cd19356   17 LCVRSPDVTASALQGIQIAIHECQHQLRDQRWNCsSLEGGGKlphdSAILKRGFRESAFSFSLLAAGVMHSVATACSLGK 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  76 MERCTCdeapdlenreAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSC 154
Cdd:cd19356   97 LRGCGC----------EWEWGGCSHDIEFGEKFSRDFLdSRESPRDIQARMRIHNNRVGRQVVTENMKRKCKCHGTSGSC 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 155 TVRTCWRQLAPFHEVGKHLKHKYETALKVGSTTNeaagEAGAISPPRGRASGAGgsdplprtpELVHLDDSPSFCL--AG 232
Cdd:cd19356  167 QFKTCWHVTPEFRLVGALLREKFQRAIFINSHNK----NSGVFLPRLRPRRLAR---------ELVYFEKSPDFCErdPA 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767912642 233 RFSPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19356  234 VDSPGTQGRICNKTSpgmdGCGSLCCGRGHNILKQTRSERCHCRFHWCCYVLCEECRVTEWVNVCK 299
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 22-294 1.11e-60

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 195.20  E-value: 1.11e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  22 ECQFQFRFERWNCTL--EGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEA--PDLENREaWQWGG 97
Cdd:cd19348   35 ECQYQFRQRRWNCSTvdNTSVFGRVMQIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCSRAarPKDLPRD-WLWGG 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  98 CGDNLKYSSKFVKEFLGRR---------SSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHE 168
Cdd:cd19348  114 CGDNVEYGYRFAKEFVDARereknypkgSEEHARTLMNLQNNEAGRRAVYNLADVACKCHGVSGSCSLKTCWLQLADFRK 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 169 VGKHLKHKYETALKVGSTTneaageagaisppRGRASGAGGSDPLPRTPELVHLDDSPSFCLAGRF--SPGTAGRRCHRE 246
Cdd:cd19348  194 VGDLLKEKYDSAAAMRINR-------------KGKLELVNSRFNPPTAEDLVYIDPSPDYCLRNETtgSLGTQGRLCNKT 260

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767912642 247 KN----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 294
Cdd:cd19348  261 SEgmdgCELMCCGRGYDQFKTVQVERCHCKFHWCCYVKCKKCTEIVDQFVCK 312
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 22-293 1.01e-58

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 189.85  E-value: 1.01e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  22 ECQFQFRFERWNCTLEGRYRASL--LKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAPDLE-NREAWQWGGC 98
Cdd:cd19352   24 ECKYQFAWDRWNCPERALQLSSHsgLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQlGGQGWLWGGC 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  99 GDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKY 177
Cdd:cd19352  104 SDNVGFGEAISKQFVdALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFREVGNYLKEKY 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 178 ETALKVG---STTNEAAGEaGAISPPRGRASgaggsdplprTPELVHLDDSPSFCLAGRF--SPGTAGRRCHR------- 245
Cdd:cd19352  184 HRALKVDllqGAGNSAASR-GAIAETFRSIS----------KKELVHLEDSPDYCLENKTlgLLGTEGRECLKrgkalsk 252

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767912642 246 --EKNCESIC--CGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTC 293
Cdd:cd19352  253 weKRSCRRLCgdCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFC 304
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 22-293 5.45e-54

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 177.79  E-value: 5.45e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  22 ECQFQFRFERWNCTlEGRYRASL---LKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAPDLE-NREAWQWGG 97
Cdd:cd19351   23 ECKHQFAWERWNCP-ESALQLSThngLRSATRETSFVHAISSAGVMYTLTRNCSLGDFENCGCDDSRNGRtGGRGWIWGG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642  98 CGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHK 176
Cdd:cd19351  102 CSDNVEFGERISKQFVdALETGQDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGSCSIQTCWLQLADFREIGNYLKVK 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912642 177 YETALKVGSTTNEAAGEAGAisppRGRASGAGGSDPLPRTpELVHLDDSPSFCL--AGRFSPGTAGRRCHR--------- 245
Cdd:cd19351  182 HDQALKLEMDKRRMRAGNSA----DNRGAIAEAFGSVAET-ELIYLEDSPDYCTknASLGLQGTEGRECLQsgknlsqwe 256

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 767912642 246 EKNCESIC--CGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTC 293
Cdd:cd19351  257 RRSCRRLCteCGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYC 306
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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