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Conserved domains on  [gi|767936380|ref|XP_011541891|]
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solute carrier family 22 member 4 isoform X2 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 1000272)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates; similar to Drosophila melanogaster organic cation transporter protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A0119 super family cl36765
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 12-426 3.61e-148

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00898:

Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 431.75  E-value: 3.61e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380   12 GEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPLRLRDGRevPHSCSRYRLATIAN 91
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRLPDAANLSSRCELNLTLPRLPDGR--PESCLRFMVDQWAN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380   92 FSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTE-------VWQEE--RSLRNHGC------------------ 144
Cdd:TIGR00898  79 PSLLGCEPLKLSDLGLAATEPCLDGWEYSYDTFSSTIVTEwdlvcedAWKVDltQSCFFVGVllgsfvfgylsdrfgrkk 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  145 -----------TDWLQ-----------------------------LPADFL--HQLGDVHCVICH--------------- 167
Cdd:TIGR00898 159 vlllstlvtavSGVLTafspnytvflvfrllvgmgiggiwvqavvLNTEFLpkKQRAIVGTLIQVffslglvllplvayf 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  168 ----RGhgpdLQL-------CGSLHTRFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSV--EELNPLKQQk 234
Cdd:TIGR00898 239 ipdwRW----LQLavslptfLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLSLSleKDLSSSKKQ- 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  235 AFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLF 314
Cdd:TIGR00898 314 YSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLL 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  315 WGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNR 394
Cdd:TIGR00898 394 LAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWL 473

                         490       500       510
                  ....*....|....*....|....*....|..
gi 767936380  395 MLPYIVMGSLTVLIGILTLFFPESLGMTLPET 426
Cdd:TIGR00898 474 FLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 12-426 3.61e-148

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 431.75  E-value: 3.61e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380   12 GEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPLRLRDGRevPHSCSRYRLATIAN 91
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRLPDAANLSSRCELNLTLPRLPDGR--PESCLRFMVDQWAN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380   92 FSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTE-------VWQEE--RSLRNHGC------------------ 144
Cdd:TIGR00898  79 PSLLGCEPLKLSDLGLAATEPCLDGWEYSYDTFSSTIVTEwdlvcedAWKVDltQSCFFVGVllgsfvfgylsdrfgrkk 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  145 -----------TDWLQ-----------------------------LPADFL--HQLGDVHCVICH--------------- 167
Cdd:TIGR00898 159 vlllstlvtavSGVLTafspnytvflvfrllvgmgiggiwvqavvLNTEFLpkKQRAIVGTLIQVffslglvllplvayf 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  168 ----RGhgpdLQL-------CGSLHTRFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSV--EELNPLKQQk 234
Cdd:TIGR00898 239 ipdwRW----LQLavslptfLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLSLSleKDLSSSKKQ- 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  235 AFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLF 314
Cdd:TIGR00898 314 YSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLL 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  315 WGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNR 394
Cdd:TIGR00898 394 LAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWL 473

                         490       500       510
                  ....*....|....*....|....*....|..
gi 767936380  395 MLPYIVMGSLTVLIGILTLFFPESLGMTLPET 426
Cdd:TIGR00898 474 FLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 106-416 1.57e-108

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 324.80  E-value: 1.57e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 106 GQLEQESCLDGWEFSQDVYLSTVVTEvWqeerslrNHGCTDWLQLP------------ADFLH-QLGDvhcvicHRGHGP 172
Cdd:cd17376    1 TQIEQEPCLDGWEYSQDVYLSTIVTE-W-------NLVCEDDWKVPlttslffvgvllGSFISgQLSD------RFGRKK 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 173 DLQLCGSLHTRFI---PESPRWLI----------SQ-----RRFREAEDIIQKAAKMNNIAVPAVIFDSV-EELNPLKQQ 233
Cdd:cd17376   67 VLFATMAVQTGFSflqIFSPSWEMftvlfvivgmGQisnyvVAFVLGTEILGKSVRILFSTLGVCIFYAIgYMLLPLFAY 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 234 kaFILD---LFRTRN------------IAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWL 298
Cdd:cd17376  147 --FIRDwrmLLLALTlpgvlcvplwwfIPITTIMSLLLWMAISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWL 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 299 LLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRV 378
Cdd:cd17376  225 LLRSLPRRYSIAATLVLGGGVLLFIQLVPTDLQVLATALVMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRI 304

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 767936380 379 GSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFP 416
Cdd:cd17376  305 GSIISPYFVYLGAYDRYLPYILMGSLTVLIGILTLFLP 342
Sugar_tr pfam00083
Sugar (and other) transporter;
184-425 1.56e-11

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 66.14  E-value: 1.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  184 FIPESPRWLISQRRFREAEDIIQKAAKmnniaVPAVIFDSVEELNPLKQ----QKAFILDLFRTRNIAIMTIMSLLLWML 259
Cdd:pfam00083 190 FLPESPRWLVEKGRLEEAREVLAKLRG-----VPDVDRELDEIKDSLEAgqeaEKASWKELFSTKTRRQRLLIGVMLQIF 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  260 T-SVGYFALSLDAPNLHGDAYLNCflSALIEIPAYIT-------AWLLLRTLPRRYI------IAAVLFW--GGGVLLFI 323
Cdd:pfam00083 265 QqLTGINAIFYYSTTIFENLGLSD--SFLVTIIVGVVnfvftfiAIFLVDRFGRRPLlllgaaGMAICFVilGIVALLGV 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  324 QLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYF--VYLGAYNRMLPYIVM 401
Cdd:pfam00083 343 SKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLfpIITDAIGLGYTFFIF 422

                         250       260
                  ....*....|....*....|....*
gi 767936380  402 GSLTVLIGILTLFF-PESLGMTLPE 425
Cdd:pfam00083 423 AGLLVLFIIFVFFFvPETKGRTLEE 447
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
246-416 4.18e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 57.96  E-value: 4.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 246 IAIMTIMSLLLWMLTSVGYFALSLDAP-----NLHGDAYLNCFLSALIEIPA----YITAWLLLRTLPRRYIIAAVLFWG 316
Cdd:COG2271  178 ALLRFWLLALAYFLVYFALYGFLTWLPtylveVRGLSLAQAGLLLSLPFLAGivgsLLGGWLSDRLGRRRKLVLAIGLLL 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 317 GGVLLFIQLVPVDYYFLSIGLVMLGkFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFV--YLGAYNR 394
Cdd:COG2271  258 AALALLLLALLPSPALAIALLFLAG-FGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgyLLDATGY 336

                        170       180
                 ....*....|....*....|..
gi 767936380 395 MLPYIVMGSLTVLIGILTLFFP 416
Cdd:COG2271  337 QAAFLLLAALALLAALLALLLL 358
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 275-415 1.04e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 41.45  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 275 HGDAYLNCFLSALIEIPAYITAWLLLRTLPRR---YIIAAVLFWGGgVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSM 351
Cdd:PRK05771 474 YKDAFLAQLGWLLILLGILLIVLGGFGLVVGLgplGLIGKYLIIGG-VVLIILGEGIDGKSLGGALGGLGLYEITGYLGD 552

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767936380 352 LYVFTaelyptlvRNMAVGVtSTASrvgsiIAPYFVYLGayNRMLPyiVMGSLTVLIGILTLFF 415
Cdd:PRK05771 553 VLSYA--------RLMALGL-AGAG-----IAMAFNLMA--GLLPP--SIGVIGIIVGIIIFIF 598
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 12-426 3.61e-148

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 431.75  E-value: 3.61e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380   12 GEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPLRLRDGRevPHSCSRYRLATIAN 91
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRLPDAANLSSRCELNLTLPRLPDGR--PESCLRFMVDQWAN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380   92 FSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTE-------VWQEE--RSLRNHGC------------------ 144
Cdd:TIGR00898  79 PSLLGCEPLKLSDLGLAATEPCLDGWEYSYDTFSSTIVTEwdlvcedAWKVDltQSCFFVGVllgsfvfgylsdrfgrkk 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  145 -----------TDWLQ-----------------------------LPADFL--HQLGDVHCVICH--------------- 167
Cdd:TIGR00898 159 vlllstlvtavSGVLTafspnytvflvfrllvgmgiggiwvqavvLNTEFLpkKQRAIVGTLIQVffslglvllplvayf 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  168 ----RGhgpdLQL-------CGSLHTRFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSV--EELNPLKQQk 234
Cdd:TIGR00898 239 ipdwRW----LQLavslptfLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLSLSleKDLSSSKKQ- 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  235 AFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLF 314
Cdd:TIGR00898 314 YSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLL 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  315 WGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNR 394
Cdd:TIGR00898 394 LAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWL 473

                         490       500       510
                  ....*....|....*....|....*....|..
gi 767936380  395 MLPYIVMGSLTVLIGILTLFFPESLGMTLPET 426
Cdd:TIGR00898 474 FLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 106-416 1.57e-108

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 324.80  E-value: 1.57e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 106 GQLEQESCLDGWEFSQDVYLSTVVTEvWqeerslrNHGCTDWLQLP------------ADFLH-QLGDvhcvicHRGHGP 172
Cdd:cd17376    1 TQIEQEPCLDGWEYSQDVYLSTIVTE-W-------NLVCEDDWKVPlttslffvgvllGSFISgQLSD------RFGRKK 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 173 DLQLCGSLHTRFI---PESPRWLI----------SQ-----RRFREAEDIIQKAAKMNNIAVPAVIFDSV-EELNPLKQQ 233
Cdd:cd17376   67 VLFATMAVQTGFSflqIFSPSWEMftvlfvivgmGQisnyvVAFVLGTEILGKSVRILFSTLGVCIFYAIgYMLLPLFAY 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 234 kaFILD---LFRTRN------------IAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWL 298
Cdd:cd17376  147 --FIRDwrmLLLALTlpgvlcvplwwfIPITTIMSLLLWMAISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWL 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 299 LLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRV 378
Cdd:cd17376  225 LLRSLPRRYSIAATLVLGGGVLLFIQLVPTDLQVLATALVMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRI 304

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 767936380 379 GSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFP 416
Cdd:cd17376  305 GSIISPYFVYLGAYDRYLPYILMGSLTVLIGILTLFLP 342
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 246-416 1.96e-60

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 200.50  E-value: 1.96e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 246 IAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQL 325
Cdd:cd17317  161 LPRRTIIVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTAL 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 326 VPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLT 405
Cdd:cd17317  241 LPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLA 320

                        170
                 ....*....|.
gi 767936380 406 VLIGILTLFFP 416
Cdd:cd17317  321 LLGGLLTLLLP 331
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 249-416 4.68e-41

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 149.52  E-value: 4.68e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 249 MTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPV 328
Cdd:cd17375  174 RTITVWLIWFTGSLGYYVFSLGSVNLGGNEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQ 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 329 DYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLI 408
Cdd:cd17375  254 DYEVLTIVLSMTGKFAIAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLVGIMAFLS 333


                 ....*...
gi 767936380 409 GILTLFFP 416
Cdd:cd17375  334 GILTLMLP 341
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 236-416 9.27e-35

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 132.41  E-value: 9.27e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 236 FILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFW 315
Cdd:cd17374  161 FFLFFLYSWWLPKRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLL 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 316 GGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRM 395
Cdd:cd17374  241 AGLCILANIFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPL 320

                        170       180
                 ....*....|....*....|.
gi 767936380 396 LPYIVMGSLTVLIGILTLFFP 416
Cdd:cd17374  321 LPMIIYGVLPILAGLLALLLP 341
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 236-416 2.12e-33

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 129.13  E-value: 2.12e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 236 FILDLFrtrnIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLL--RTLPRRYIIAAVL 313
Cdd:cd17377  169 FLLSLF----IPGRTLILMYVWFVCSLVYYGLTLNAGDLGGNIYLNLALSGLVELPAYPLCIYLInqKWSGRRRTLAGFL 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 314 FWGGGVLLFIQLVPV---DYYFLSIG---LVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFV 387
Cdd:cd17377  245 FLGGIACLLVMFVPEkkdSGVFAVVNstsLSLLGKLTISAAFNIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIP 324

                        170       180
                 ....*....|....*....|....*....
gi 767936380 388 YLGAYNRMLPYIVMGSLTVLIGILTLFFP 416
Cdd:cd17377  325 SLKSVQWSLPFIVFGASGLSAGLLSLLLP 353
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 237-416 1.14e-27

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 112.84  E-value: 1.14e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 237 ILDLFRTRNIAIMTImslllWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAY-ITAWLLLRTLPRRYIIAAVLFW 315
Cdd:cd17378  167 LVYLFARRLLAVMVI-----GFGIGMVYYGIPLAVGNLKFNIYLSVALNALSELPAFvITAFLLDRFGRRPSLLGFTLLS 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 316 GGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRM 395
Cdd:cd17378  242 GASCLLCFVLSIGGTTSLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAA 321

                        170       180
                 ....*....|....*....|.
gi 767936380 396 LPYIVMGSLTVLIGILTLFFP 416
Cdd:cd17378  322 LSFGVFGVAILLLGLFALGLP 342
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 249-416 7.64e-26

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 107.50  E-value: 7.64e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 249 MTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPV 328
Cdd:cd17446  172 ITFCLSLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALILAGIMILANIFVPQ 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 329 DYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLI 408
Cdd:cd17446  252 DLQTVRTALAVFGKGCLAASFNCVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAPLVKMLGEYYPFLPLIIYGAAPILS 331


                 ....*...
gi 767936380 409 GILTLFFP 416
Cdd:cd17446  332 GIAACFLP 339
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 250-416 3.09e-25

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 105.90  E-value: 3.09e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 250 TIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVD 329
Cdd:cd17379  173 TFILMYAWFTSAVVYQGLIMRLGITGGNLYLDFFISALVELPAAFIILLTIDRIGRRLPFAASNIVAGAACLITAFIPPD 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 330 YYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVY-LGAYNRMLPYIVMGSLTVLI 408
Cdd:cd17379  253 LHWLKTTIACVGRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPFLLYrLAEIWLELPLIVFGVLALVA 332


                 ....*...
gi 767936380 409 GILTLFFP 416
Cdd:cd17379  333 GGLVLLLP 340
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 249-416 1.44e-18

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 86.71  E-value: 1.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 249 MTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPV 328
Cdd:cd17447  174 ISLCTGIVWFGVAFTYYGISFNISGFGLNVYLTQFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILIPS 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 329 DYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLI 408
Cdd:cd17447  254 EFTVVRTVIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPLVILLDDVWLSLPQVIFCGVALLA 333


                 ....*...
gi 767936380 409 GILTLFFP 416
Cdd:cd17447  334 GGVAFLLP 341
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 246-414 3.61e-14

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 73.40  E-value: 3.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 246 IAIMTIMSLLLWMLTSVGYFALSLDAPNL--------HGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGG 317
Cdd:cd17316  175 LRRRTLLLILLWFFISFGYYGLTTFLPTYlqtvlglsPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 318 GVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFV--YLGAYNRM 395
Cdd:cd17316  255 ILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIalLLASTGGT 334

                        170
                 ....*....|....*....
gi 767936380 396 LPYIVMGSLTVLIGILTLF 414
Cdd:cd17316  335 GVPALILALLAIVALIVAL 353
Sugar_tr pfam00083
Sugar (and other) transporter;
184-425 1.56e-11

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 66.14  E-value: 1.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  184 FIPESPRWLISQRRFREAEDIIQKAAKmnniaVPAVIFDSVEELNPLKQ----QKAFILDLFRTRNIAIMTIMSLLLWML 259
Cdd:pfam00083 190 FLPESPRWLVEKGRLEEAREVLAKLRG-----VPDVDRELDEIKDSLEAgqeaEKASWKELFSTKTRRQRLLIGVMLQIF 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  260 T-SVGYFALSLDAPNLHGDAYLNCflSALIEIPAYIT-------AWLLLRTLPRRYI------IAAVLFW--GGGVLLFI 323
Cdd:pfam00083 265 QqLTGINAIFYYSTTIFENLGLSD--SFLVTIIVGVVnfvftfiAIFLVDRFGRRPLlllgaaGMAICFVilGIVALLGV 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  324 QLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYF--VYLGAYNRMLPYIVM 401
Cdd:pfam00083 343 SKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLfpIITDAIGLGYTFFIF 422

                         250       260
                  ....*....|....*....|....*
gi 767936380  402 GSLTVLIGILTLFF-PESLGMTLPE 425
Cdd:pfam00083 423 AGLLVLFIIFVFFFvPETKGRTLEE 447
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 171-426 4.03e-11

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 64.67  E-value: 4.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  171 GPDLQLCGSLhtrFIPESPRWLISQRRFREAEDIIQKAAKMNNIA------VPAVIFDSVEELNPLKQQKAFILDLFRTR 244
Cdd:TIGR00879 205 PAGLLFLGLF---FLPESPRWLVGKGRVEEARKSLARLRGTSGEDkelldeLELIDIKRSIEKRSVQPSWGSLFSSTRRI 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  245 NIAIMTIMsLLLWMLTSVG-----YFAL----SLDAPNLHgdAYLNCFLSALIEIPAYITAWLLLRTLPRR------YII 309
Cdd:TIGR00879 282 RRRLFLGV-VLQWFQQFTGinaimYYSPtifeNAGVSTDH--AFLVSIIVGAVNFAFTFVAIFLVDRFGRRpllligAAG 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  310 AAVLFWGGGVLLFIQLVPVDYY--FLSIGLVMLGKFGI-TSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGS-IIAPY 385
Cdd:TIGR00879 359 MAICLFVLGILGASFVTGSSKSsgNVAIVFILLFIAFFaMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANfIVGFL 438

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 767936380  386 FVY-LGAYNRMLPYIVMGSLTVLIGILTLFF-PESLGMTLPET 426
Cdd:TIGR00879 439 FPTmLESIGVGGVFIFFGGLNVLGLIFVYFFlPETKGRTLEEI 481
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 183-384 3.20e-09

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 58.52  E-value: 3.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  183 RFIPESPRWLISQRRfreaediiQKAAKMNNIAVPAVIFDSVEELNPLKQQ----KAFILDLFRTRNIAIMtimsLLLWM 258
Cdd:TIGR00895 190 RFLPESIDFLVSKRP--------ETVRRIVNAIAPQMQAEAQSALPEQKSTqgtkRSVFKALFQGKTARIT----VLLWL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  259 LTS---VGYFALSLDAPNLHGDAYLNCFLSALI--------EIPAYITAWLLLRTLPRRYiiaAVLFWGGGVLLFI--QL 325
Cdd:TIGR00895 258 LYFmllVGVYFLTNWLPKLMVELGFSLSLAATGgalfnfggVIGSIIFGWLADRLGPRVT---ALLLLLGAVFAVLvgST 334

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767936380  326 VPVDYYFLSIGLVmLGKFgITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAP 384
Cdd:TIGR00895 335 LFSPTLLLLLGAI-AGFF-VNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGP 391
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
246-416 4.18e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 57.96  E-value: 4.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 246 IAIMTIMSLLLWMLTSVGYFALSLDAP-----NLHGDAYLNCFLSALIEIPA----YITAWLLLRTLPRRYIIAAVLFWG 316
Cdd:COG2271  178 ALLRFWLLALAYFLVYFALYGFLTWLPtylveVRGLSLAQAGLLLSLPFLAGivgsLLGGWLSDRLGRRRKLVLAIGLLL 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 317 GGVLLFIQLVPVDYYFLSIGLVMLGkFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFV--YLGAYNR 394
Cdd:COG2271  258 AALALLLLALLPSPALAIALLFLAG-FGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgyLLDATGY 336

                        170       180
                 ....*....|....*....|..
gi 767936380 395 MLPYIVMGSLTVLIGILTLFFP 416
Cdd:COG2271  337 QAAFLLLAALALLAALLALLLL 358
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 279-385 4.57e-09

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 57.93  E-value: 4.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 279 YLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGG--GVLLFIQLVPvdyyFLSIGLVMLGKFGITSAFSMLYVFT 356
Cdd:cd17372  232 YRDVFIATFAEFPGLLISAAMIDRLGRKASMASMLFTCCifLLLLLICQSP----FILTVLLFGGRACISAAFTVVYIYT 307

                         90       100
                 ....*....|....*....|....*....
gi 767936380 357 AELYPTLVRNMAVGVTSTASRVGSIIAPY 385
Cdd:cd17372  308 PEVYPTAVRALGVGTGSSVGRIGAILCPF 336
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 294-419 1.14e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.50  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 294 ITAWLLLRTLPRRYIIAAVLFWGGGVLLFIqlVPVDYYFLSIGLVMLGkFGITSAFSMLYVFTAELYPTLVRNMAVGVTS 373
Cdd:cd06174   50 LAGLLADRFGRRPVLLLGLLLFALGALLFA--FAPSFWLLLLGRFLLG-LGSGLIDPAVLALIADLFPERERGRALGLLQ 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767936380 374 TASRVGSIIAP----YFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESL 419
Cdd:cd06174  127 AFGSVGGILGPllggILASSLGFGWRAVFLIAAALALLAAILLLLVVPDP 176
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 236-418 1.66e-06

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 49.97  E-value: 1.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 236 FILDL-FRTRNIAIMTImslllwmLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLF 314
Cdd:cd17364  206 FLLDIaFYGQNLFQSTI-------ISAIGFSKTMNAYQELFNIAVGQLIIALAGTVPGYWFTVFLIDRIGRKKIQMMGFF 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 315 wGGGVLLFIQLVPVDYYFLS-IGLVMLgkFGITSAFS------MLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPY-F 386
Cdd:cd17364  279 -GMTIFLLILAGPYDHWKIStIGFFVL--YGLTFFFSnfgpntTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFlF 355

                        170       180       190
                 ....*....|....*....|....*....|...
gi 767936380 387 VYLGAYNRMLPYIVMGSLTVLIG-ILTLFFPES 418
Cdd:cd17364  356 LSLTQNIGVRNVLIILAGVALLGiILTLLFPEE 388
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 183-417 2.07e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 49.61  E-value: 2.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 183 RFIPESPRWLISQRRFREaediiqkaakmnniavpavifdsveelnplKQQKAFILDLFRTRNIAIMtimslLLWMLTSV 262
Cdd:cd17371  175 RFVKEPPQWQAARAARRH------------------------------FADRPSLRELFSPPLLRTT-----LLASLLAT 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 263 ----GYFALSLDAPNL---------HGDA-YLNCFLSALIeIPAYITAWLLLRtLPRRYIIAAvLFWGGG--VLLFIQLv 326
Cdd:cd17371  220 galgGYYGITTWLPSYltgerglsfEGSAgYLVVTILGGF-LGYLAGGFLADR-IGRRNNFAL-FALGSAisILLYFFL- 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 327 PVDYYFLSIGLVMLGkFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFV-YLGAYNRMLPYIVMGSLT 405
Cdd:cd17371  296 PLSPTLILILGFPLG-FFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVgFLATSGSLGTAIAVFAAV 374

                        250
                 ....*....|...
gi 767936380 406 -VLIGILTLFFPE 417
Cdd:cd17371  375 yYIAGLVLALLLP 387
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 292-384 2.11e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 49.51  E-value: 2.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 292 AYITAWLLLRTLPRRyiIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGV 371
Cdd:cd17365  223 SLLLGWLADRFGPKR--VLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGW 300

                         90
                 ....*....|...
gi 767936380 372 TSTASRVGSIIAP 384
Cdd:cd17365  301 ALGVGRLGAILGP 313
MFS_1 pfam07690
Major Facilitator Superfamily;
240-384 3.19e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.95  E-value: 3.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  240 LFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEI----PAYITAWLLLRTLPRRYIIAAVLFW 315
Cdd:pfam07690 196 ALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLlgaiGRLLLGRLSDRLGRRRRLLLALLLL 275

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767936380  316 GGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAP 384
Cdd:pfam07690 276 ILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 226-415 3.31e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.96  E-value: 3.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 226 ELNPLKQQKAFILDLFRTRNIAIMTIMSLLLW-----MLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLL 300
Cdd:cd06174  185 EEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNlayysFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 301 RTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLgkFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGS 380
Cdd:cd06174  265 RLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG--FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGG 342

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767936380 381 IIAPYFV-YLGAYNRMLPYIVMGSLTVLIGILTLFF 415
Cdd:cd06174  343 AIGPLLAgFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 277-385 3.50e-06

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 49.03  E-value: 3.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 277 DAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGgvlLFIQLVPVDYYFLSIGLVMLGKFGITSA-FSMLYVF 355
Cdd:cd17442  237 SDYQTMIISTLGEIALNPLNILGINFLGRRLSLVITMGLTA---IFFLLLNICTSSAGLTIFLFMLRALVSAnFNTVYIY 313

                         90       100       110
                 ....*....|....*....|....*....|
gi 767936380 356 TAELYPTLVRNMAVGVTSTASRVGSIIAPY 385
Cdd:cd17442  314 TAEVYPTTMRALGMGTSGSLCRIGAMVAPF 343
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 184-426 8.16e-06

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 48.03  E-value: 8.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 184 FIPESPRWLISQRRFR-EAEDIIQKaAKMNNIAVPAVIFDSVEELNPLKQQKAF-ILDLFR--TRNIAIMTIMSLLLWML 259
Cdd:cd17357  192 FFPESPKFLLISKGDEeEAEKSLKF-LRGIEDDVDQELEEIKKESEQMGDQKQVsLMQLLRdpSLRLPLLLVLVVSASQQ 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 260 TS----VGYFALSL--DAPNLHGDA-YLNCFLSALIEIPAyITAWLLLRTLPRR--------YIIAAVLFWGGGVLLFIQ 324
Cdd:cd17357  271 FSginaIFFYSTFIfeNAGFSPQLAeWANLGIGIVNVLST-IVGPFLIEKVGRRplllislsVCAVALLLMSVFLFLSEQ 349

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 325 LVPVDYYFlsIGLVMLgkFGITSAFSM---LYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVY----LGAYNRMLP 397
Cdd:cd17357  350 NSWMSYGC--IVAIFL--FIFFFAIGLgpiPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPplqsIGGGFVFII 425

                        250       260
                 ....*....|....*....|....*....
gi 767936380 398 YIVMGSLTVLIgiltlffpesLGMTLPET 426
Cdd:cd17357  426 FAIPCALFLLY----------LYRYLPET 444
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 268-416 9.98e-06

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 47.50  E-value: 9.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 268 SLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAA--VLFWGGGVLLFIqlvPVDYYFLSIGLVMLGKFgI 345
Cdd:cd17441  225 SLECEYLTTSDYMDLLWTTLSEFPGLLVTLWIIDRFGRKKTMALcfFVFSFCTLLLFS---CVGRFSLTVLLFIARAF-I 300

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767936380 346 TSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFV-YLGAYNRMLPYIVMGSLTVLIGILTLFFP 416
Cdd:cd17441  301 SGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAqVMLESSVYLTLSVYSGCCLLAAIASCFLP 372
MFS_1 pfam07690
Major Facilitator Superfamily;
292-417 3.69e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.49  E-value: 3.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380  292 AYITAWLLLRTLPRRYIIAAVLFWGGGVLLFiqLVPVDYYFLSIGLVMLGkFGITSAFSMLYVFTAELYPTLVRNMAVGV 371
Cdd:pfam07690  49 QPLAGRLSDRFGRRRVLLIGLLLFALGLLLL--LFASSLWLLLVLRVLQG-LGAGALFPAALALIADWFPPEERGRALGL 125

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 767936380  372 TSTASRVGSIIAPYFVYLGAYNRM--LPYIVMGSLTVLIGILTLFFPE 417
Cdd:pfam07690 126 VSAGFGLGAALGPLLGGLLASLFGwrAAFLILAILSLLAAVLLLLPRP 173
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 184-425 1.09e-04

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 44.49  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 184 FIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWML---- 259
Cdd:cd17358  175 FIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAELEKEAKESSFSDLFQRKYLKPLVIGLGLMLFqqls 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 260 --TSVGYFALS-LDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRR-------------YIIAAVLFWGGGVLLFI 323
Cdd:cd17358  255 giNAVIFYASSiFDEAGSGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRplllvsaigmgigLLALGLYFYLQEHGALL 334

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 324 QLVPVdyyfLSIGLVMLGKFGITSAF-SMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYF-----VYLGAYNRMLP 397
Cdd:cd17358  335 SSVSW----LPLVGLVIYIISFSIGLgPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTfpfltLAWGASGTFWI 410

                        250       260
                 ....*....|....*....|....*...
gi 767936380 398 YIVMGSLTVLigILTLFFPESLGMTLPE 425
Cdd:cd17358  411 FAGICGLALV--FVLLFVPETKGKSLEE 436
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
241-438 1.31e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.81  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 241 FRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWL---LLRTLPRRYIIAAVLFWGG 317
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLagrLADRFGRRRVLLLGLLLFA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 318 GVLLFIQLVPvDYYFLSIGLVMLGkFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYL--GAYNRM 395
Cdd:COG2814   87 LGSLLCALAP-SLWLLLAARFLQG-LGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLlaDLFGWR 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767936380 396 LPYIVMGSLTVLIGILTLFF-PESLGMTLPETLEQMQKVKWFRS 438
Cdd:COG2814  165 WVFLVNAVLALLALLLLLRLlPESRPAARARLRGSLRELLRRPR 208
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 282-415 1.64e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 43.71  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 282 CFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPvDYYFLSIGLVMLGkFGITSAFSMLYVFTAELYP 361
Cdd:cd17474  241 AGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVP-SLALLLIAIVLFG-LGLGLNLPLLTTLVTELAP 318

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767936380 362 TLVRNMAVGVTSTASRVGSIIAPYF--VYLGAYNRMLPYIVMGSLTVLIGILTLFF 415
Cdd:cd17474  319 EEERGTASSLYNFVRFLGQAVGPLLfgLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
231-383 1.64e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.81  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 231 KQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHG----DAYLNCFLSALIEIPAYITAWLLLRTLPRR 306
Cdd:COG2814  194 ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlsasAAGLLLALFGLGGVLGALLAGRLADRFGRR 273

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767936380 307 YIIAAVLFWGGGVLLFIQLVPvDYYFLSIGLVMLGkFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIA 383
Cdd:COG2814  274 RLLLIGLLLLALGLLLLALAG-SLWLLLLALFLLG-FGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
304-413 6.46e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.78  E-value: 6.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 304 PRRYIIAAVLFWGGGVLLFIqLVPvDYYFLSIGLVMLGkFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIA 383
Cdd:COG2271   74 RRRVLAIGLLLWGLATLLFG-FAT-SFWQLLLLRFLLG-LGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALA 150

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767936380 384 PYFVYLGAYN---RMLpYIVMGSLTVLIGILTL 413
Cdd:COG2271  151 PPLLGWLLAAfgwRAA-FLILGLPGLLLALLRF 182
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 275-415 1.04e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 41.45  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 275 HGDAYLNCFLSALIEIPAYITAWLLLRTLPRR---YIIAAVLFWGGgVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSM 351
Cdd:PRK05771 474 YKDAFLAQLGWLLILLGILLIVLGGFGLVVGLgplGLIGKYLIIGG-VVLIILGEGIDGKSLGGALGGLGLYEITGYLGD 552

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767936380 352 LYVFTaelyptlvRNMAVGVtSTASrvgsiIAPYFVYLGayNRMLPyiVMGSLTVLIGILTLFF 415
Cdd:PRK05771 553 VLSYA--------RLMALGL-AGAG-----IAMAFNLMA--GLLPP--SIGVIGIIVGIIIFIF 598
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
242-415 1.42e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.63  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 242 RTRNIAIMTIMSLLLWML-TSVGYFALSL-DAPNLHGDAY-----LNCFLSALIEIPAyitAWLLLRTLPRRYIIAAVLF 314
Cdd:COG2223    3 RWRVLLLATLAFFLAFGVwYLWSVLAPPLaEEFGLSAAQLgllfaIPVLVGALLRIPL---GFLVDRFGPRRVLLIGLLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 315 WGGGVLLFIQLVPvdYYFLSIGLVMLGkFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFV--YLGAY 392
Cdd:COG2223   80 LGIGLLLLALAVS--YWLLLLLGLLLG-IGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAplLIAAF 156

                        170       180
                 ....*....|....*....|...
gi 767936380 393 NRMLPYIVMGSLTVLIGILTLFF 415
Cdd:COG2223  157 GWRNAFLILGILLLVVAVLAWLF 179
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 307-415 1.89e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 40.29  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 307 YIIAAVLFWGggvLLFIQLVPVdYYFLSIGLVMlgkFGITSAFSMLYVFTAELYPT--LVRNMAVGVTS--TASRVGSII 382
Cdd:cd17353  286 FLIQGVAMFL---LPFIGSVAV-LFVLGVALIG---FCYGGGFALFPALTADFFGTknAGTNYGLLYTAkgVGGLIGPII 358

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767936380 383 APYFVYLGAYNRMlpYIVMGSLTVLIGILTLFF 415
Cdd:cd17353  359 AAYVLYTGGYNAA--FIIAAALSLVALALALLL 389
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 234-415 2.07e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 40.25  E-value: 2.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 234 KAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHG-DAYLNCFLSALIEIPAYITAWL---LLRTLPRRYII 309
Cdd:cd17325  189 RSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGAQGLASALSQPPagkLSDRIGRKPLI 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 310 AAVLFWGGGVLLFIQLVPvDYYFLSIGLVMLGkFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAP----Y 385
Cdd:cd17325  269 LIGLLLSAVALLLLPLAT-SFWLLLLLLALLG-LGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPllggF 346

                        170       180       190
                 ....*....|....*....|....*....|
gi 767936380 386 FVYLGAYNrmLPYIVMGSLTVLIGILTLFF 415
Cdd:cd17325  347 LYDAFGFA--TPFLAAAALLLLAAVLFLLL 374
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
292-416 2.09e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.22  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 292 AYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVpvDYYFLSIGLVMLGkFGITSAFSMLYVFTAELYPTLVR---NMA 368
Cdd:COG0738   60 SLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAP--SYPLLLLALFLLG-LGLGLLDVAANPYVAALGPETAAsrlNLL 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767936380 369 VGVTSTASRVGSIIAPYFVYLGAYNR-MLPYIVMGSLTVLIGILTLFFP 416
Cdd:COG0738  137 HAFFSLGALLGPLLGGLLILLGLSLSwHLPYLILAVLLLLLALLFLRSK 185
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 286-415 6.70e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 38.71  E-value: 6.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 286 ALIEIPAYitaWLLLRTLPRRYIIAAVLFWGggVLLFIQLVPVDYYFLSIGLVMLGkFGITSAFSMLYVFTAELYPTLVR 365
Cdd:cd17319   52 ALFQVPGG---WLLDRFGARKVLAVSMLLWS--LFTALTGFATSLTSLYVLRFLLG-VAEAGFFPGAIKALAEWFPARER 125

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767936380 366 NMAVGVTSTASRVGSIIAPYFV--YLGAYN-RMLpYIVMGSLTVLIGILTLFF 415
Cdd:cd17319  126 GRATGLFNSGAPLGAAIGPPLSgwLLLLFGwRWA-FIIEGLLGLLLAVLWWFY 177
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 290-416 9.16e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.32  E-value: 9.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936380 290 IPAYITAWLLLRTLPRRYIIAAVLFWGGGvLLFIQLVPvDYYFLSIGLVMLGkFGITSAFSMLYVFTAELYPTLVRNMAV 369
Cdd:cd17473  248 IGALLFGRLKRRLGKRRLLAIGFALMALG-FLLLALAS-GLWVVLLGAILAG-LGFGLLLPTLNSWAMSLVPPELRGRAM 324

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767936380 370 GVTSTASRVGSIIAPY---FVYLGAYNRMLPYIVMGSLTVLIGILTLFFP 416
Cdd:cd17473  325 GIVTSAFFLGQFLSPLvlgPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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