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Conserved domains on  [gi|767906369|ref|XP_011540585|]
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volume-regulated anion channel subunit LRRC8C isoform X3 [Homo sapiens]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 6-313 2.04e-173

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 501.76  E-value: 2.04e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369    6 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSLSNVSQAVASTTP 85
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369   86 LPPPKPSPANPITvEMKGLKTDLDLQQYSFINQMCYERALH------------------------------CSKIEHFIS 135
Cdd:pfam12534  81 APTVSSPSASMIP-EPKGRKTNLDRQQYVFINQVCYEKALHwyskyfpylvlihtlifmvssnfwfkfpgtSSKIEHFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369  136 ILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSNTIQSGPEDSLVNSQSLKSIPEKFVVD-KSTAGALDK 207
Cdd:pfam12534 160 ILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369  208 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTM 287
Cdd:pfam12534 240 KEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNL 319

                         330       340
                  ....*....|....*....|....*.
gi 767906369  288 AHLFSKLSFCYLCFVSIYGLTCLYTL 313
Cdd:pfam12534 320 AFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
557-747 1.97e-35

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 139.30  E-value: 1.97e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 557 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWHNSITYIPEHIKKLTS 636
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 637 LERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 716
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180       190
                 ....*....|....*....|....*....|.
gi 767906369 717 SVLsPKIGNLLFLSYLDVKGNHFEILPPELG 747
Cdd:COG4886  241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 487-597 3.71e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 3.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 487 GLRNLEELYLVGSLshdISRNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCIHNDgtKLVMLNNLKK 562
Cdd:cd21340   66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767906369 563 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 597
Cdd:cd21340  141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 6-313 2.04e-173

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 501.76  E-value: 2.04e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369    6 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSLSNVSQAVASTTP 85
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369   86 LPPPKPSPANPITvEMKGLKTDLDLQQYSFINQMCYERALH------------------------------CSKIEHFIS 135
Cdd:pfam12534  81 APTVSSPSASMIP-EPKGRKTNLDRQQYVFINQVCYEKALHwyskyfpylvlihtlifmvssnfwfkfpgtSSKIEHFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369  136 ILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSNTIQSGPEDSLVNSQSLKSIPEKFVVD-KSTAGALDK 207
Cdd:pfam12534 160 ILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369  208 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTM 287
Cdd:pfam12534 240 KEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNL 319

                         330       340
                  ....*....|....*....|....*.
gi 767906369  288 AHLFSKLSFCYLCFVSIYGLTCLYTL 313
Cdd:pfam12534 320 AFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
557-747 1.97e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 139.30  E-value: 1.97e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 557 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWHNSITYIPEHIKKLTS 636
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 637 LERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 716
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180       190
                 ....*....|....*....|....*....|.
gi 767906369 717 SVLsPKIGNLLFLSYLDVKGNHFEILPPELG 747
Cdd:COG4886  241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 560-739 3.15e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 3.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 560 LKKMTNLTeleLVHCDLERIPhaVFSLL-SLQELDLKENNLKSIEeivSFQHLRKLTVLKLWHNSITYIpEHIKKLTSLE 638
Cdd:cd21340    1 LKRITHLY---LNDKNITKID--NLSLCkNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 639 RLSFSHNKIEVLpSHLFLCNKIRYLDLSYNDIrfiPPE----------IGVLQSLQYFSITCNKVESLpDELYFCKKLKT 708
Cdd:cd21340   72 KLYLGGNRISVV-EGLENLTNLEELHIENQRL---PPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQ 146

                        170       180       190
                 ....*....|....*....|....*....|....
gi 767906369 709 LKIGKN---SLSVLSPKIGNLLFLSYLDVKGNHF 739
Cdd:cd21340  147 LDASNNqisDLEELLDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 416-752 2.48e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.65  E-value: 2.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 416 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELSLHQ--CSVKIHSAALSFLKenlkVLSVKFDDMR---ELPPWMY 486
Cdd:PLN00113 230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYLFLYQnkLSGPIPPSIFSLQK----LISLDLSDNSlsgEIPELVI 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 487 GLRNLEELYLvgsLSHDISRNVTlESLRDLKSLKILSIKSN--VSKIPQavvdvssHLQKmciHNDGTKLVMLNN----- 559
Cdd:PLN00113 306 QLQNLEILHL---FSNNFTGKIP-VALTSLPRLQVLQLWSNkfSGEIPK-------NLGK---HNNLTVLDLSTNnltge 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 560 ----LKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDLKENNLkSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEHIKK 633
Cdd:PLN00113 372 ipegLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD 450

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 634 LTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELYFCKKLKTLKI 711
Cdd:PLN00113 451 MPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDL 530

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 767906369 712 GKNSLSVLSP-KIGNLLFLSYLDVKGNHFE-ILPPELGDCRAL 752
Cdd:PLN00113 531 SHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
LRR_8 pfam13855
Leucine rich repeat;
612-670 1.51e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.51e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767906369  612 RKLTVLKLWHNSITYI-PEHIKKLTSLERLSFSHNKIEVLPSHLFLC-NKIRYLDLSYNDI 670
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 487-597 3.71e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 3.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 487 GLRNLEELYLVGSLshdISRNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCIHNDgtKLVMLNNLKK 562
Cdd:cd21340   66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767906369 563 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 597
Cdd:cd21340  141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 400-708 8.17e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 8.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369  400 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSvkihsaalsflkenlkvlsvkfdDMR 479
Cdd:PLN03210  615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCS-----------------------SLV 671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369  480 ELPPWMYGLRNLEELylvgslshDISRNVTLESLR---DLKSLKILSIkSNVSKIpQAVVDVSSHLQKMCIhnDGTKLVM 556
Cdd:PLN03210  672 ELPSSIQYLNKLEDL--------DMSRCENLEILPtgiNLKSLYRLNL-SGCSRL-KSFPDISTNISWLDL--DETAIEE 739

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369  557 LNNLKKMTNLTELELVHCDLERIPHAVFSLL--------SLQELDLkeNNLKSIEEI-VSFQHLRKLTVLKLWH-NSITY 626
Cdd:PLN03210  740 FPSNLRLENLDELILCEMKSEKLWERVQPLTplmtmlspSLTRLFL--SDIPSLVELpSSIQNLHKLEHLEIENcINLET 817

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369  627 IPEHIkKLTSLERLSFSH-NKIEVLPShlfLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFS-ITCNKVESLPDELYFCK 704
Cdd:PLN03210  818 LPTGI-NLESLESLDLSGcSRLRTFPD---ISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDmNGCNNLQRVSLNISKLK 893


                  ....
gi 767906369  705 KLKT 708
Cdd:PLN03210  894 HLET 897
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 6-313 2.04e-173

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 501.76  E-value: 2.04e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369    6 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSLSNVSQAVASTTP 85
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369   86 LPPPKPSPANPITvEMKGLKTDLDLQQYSFINQMCYERALH------------------------------CSKIEHFIS 135
Cdd:pfam12534  81 APTVSSPSASMIP-EPKGRKTNLDRQQYVFINQVCYEKALHwyskyfpylvlihtlifmvssnfwfkfpgtSSKIEHFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369  136 ILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSNTIQSGPEDSLVNSQSLKSIPEKFVVD-KSTAGALDK 207
Cdd:pfam12534 160 ILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369  208 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTM 287
Cdd:pfam12534 240 KEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNL 319

                         330       340
                  ....*....|....*....|....*.
gi 767906369  288 AHLFSKLSFCYLCFVSIYGLTCLYTL 313
Cdd:pfam12534 320 AFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
557-747 1.97e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 139.30  E-value: 1.97e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 557 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWHNSITYIPEHIKKLTS 636
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 637 LERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 716
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180       190
                 ....*....|....*....|....*....|.
gi 767906369 717 SVLsPKIGNLLFLSYLDVKGNHFEILPPELG 747
Cdd:COG4886  241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
490-754 4.97e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 126.59  E-value: 4.97e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 490 NLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTEL 569
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 570 ELVHCDLerIPHAVFSLLSLQELDLKENNlksieeivSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEV 649
Cdd:COG4886   81 LLSLLLL--GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 650 LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFL 729
Cdd:COG4886  151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                        250       260
                 ....*....|....*....|....*
gi 767906369 730 SYLDVKGNHFEILpPELGDCRALKR 754
Cdd:COG4886  231 ETLDLSNNQLTDL-PELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
373-746 2.83e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 112.33  E-value: 2.83e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 373 NKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQC 452
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 453 SVKIHSAALSFLKENLKVLSVKFDDMRELppwmYGLRNLEELYLVGSLSHDISrnvtlESLRDLKSLKILSIKSN-VSKI 531
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEEL----SNLTNLESLDLSGNQLTDLP-----EELANLTNLKELDLSNNqLTDL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 532 PqavvdvsshlqkmcihndgtklvmlNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEivSFQHL 611
Cdd:COG4886  152 P-------------------------EPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE--PLGNL 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 612 RKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPShLFLCNKIRYLDLSYNDIRFIPPEIGvLQSLQYFSITCN 691
Cdd:COG4886  205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNN 282

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767906369 692 KVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPEL 746
Cdd:COG4886  283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
331-733 3.33e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 3.33e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 331 QETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSG 410
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 411 LPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKeNLKVLSVKFDDMRELPPWMYGLRN 490
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLPEPLGNLTN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 491 LEELYLVGSLSHDISrnvtlESLRDLKSLKILSIKSN-VSKIPQAvvdvsshlqkmcihndgtklvmlnnLKKMTNLTEL 569
Cdd:COG4886  161 LKSLDLSNNQLTDLP-----EELGNLTNLKELDLSNNqITDLPEP-------------------------LGNLTNLEEL 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 570 ELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIvsfQHLRKLTVLKLWHNSITYIPEhIKKLTSLERLSFSHNKIEV 649
Cdd:COG4886  211 DLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTD 286

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 650 LP-SHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLF 728
Cdd:COG4886  287 LKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366


                 ....*
gi 767906369 729 LSYLD 733
Cdd:COG4886  367 LTLGL 371
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 560-739 3.15e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 3.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 560 LKKMTNLTeleLVHCDLERIPhaVFSLL-SLQELDLKENNLKSIEeivSFQHLRKLTVLKLWHNSITYIpEHIKKLTSLE 638
Cdd:cd21340    1 LKRITHLY---LNDKNITKID--NLSLCkNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 639 RLSFSHNKIEVLpSHLFLCNKIRYLDLSYNDIrfiPPE----------IGVLQSLQYFSITCNKVESLpDELYFCKKLKT 708
Cdd:cd21340   72 KLYLGGNRISVV-EGLENLTNLEELHIENQRL---PPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQ 146

                        170       180       190
                 ....*....|....*....|....*....|....
gi 767906369 709 LKIGKN---SLSVLSPKIGNLLFLSYLDVKGNHF 739
Cdd:cd21340  147 LDASNNqisDLEELLDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 416-752 2.48e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.65  E-value: 2.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 416 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELSLHQ--CSVKIHSAALSFLKenlkVLSVKFDDMR---ELPPWMY 486
Cdd:PLN00113 230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYLFLYQnkLSGPIPPSIFSLQK----LISLDLSDNSlsgEIPELVI 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 487 GLRNLEELYLvgsLSHDISRNVTlESLRDLKSLKILSIKSN--VSKIPQavvdvssHLQKmciHNDGTKLVMLNN----- 559
Cdd:PLN00113 306 QLQNLEILHL---FSNNFTGKIP-VALTSLPRLQVLQLWSNkfSGEIPK-------NLGK---HNNLTVLDLSTNnltge 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 560 ----LKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDLKENNLkSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEHIKK 633
Cdd:PLN00113 372 ipegLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD 450

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 634 LTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELYFCKKLKTLKI 711
Cdd:PLN00113 451 MPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDL 530

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 767906369 712 GKNSLSVLSP-KIGNLLFLSYLDVKGNHFE-ILPPELGDCRAL 752
Cdd:PLN00113 531 SHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 518-770 1.31e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.79  E-value: 1.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 518 SLKILSIKSNV--SKIPQAVVDVSShLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDL 594
Cdd:PLN00113 165 SLKVLDLGGNVlvGKIPNSLTNLTS-LEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 595 KENNLkSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEHIKKLTSLERLSFSHNKIE-VLPSHLFLCNKIRYLDLSYNDIR- 671
Cdd:PLN00113 244 VYNNL-TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTg 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 672 FIPPEIGVLQSLQYFSITCNKVE-SLPDELYFCKKLKTLKIGKNSLSVLSPKI----GNL----LFLSYLDVKgnhfeiL 742
Cdd:PLN00113 323 KIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEGlcssGNLfkliLFSNSLEGE------I 396

                        250       260
                 ....*....|....*....|....*...
gi 767906369 743 PPELGDCRALKRAGLvVEDALFETLPSD 770
Cdd:PLN00113 397 PKSLGACRSLRRVRL-QDNSFSGELPSE 423
LRR_8 pfam13855
Leucine rich repeat;
612-670 1.51e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.51e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767906369  612 RKLTVLKLWHNSITYI-PEHIKKLTSLERLSFSHNKIEVLPSHLFLC-NKIRYLDLSYNDI 670
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 578-753 3.63e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.17  E-value: 3.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 578 RIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEhiKKLTSLERLSFSHNKIE-VLPSHLF 655
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 656 LCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNK-VESLPDELYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYL 732
Cdd:PLN00113 162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSGEIPYeIGGLTSLNHL 241

                        170       180
                 ....*....|....*....|..
gi 767906369 733 D-VKGNHFEILPPELGDCRALK 753
Cdd:PLN00113 242 DlVYNNLTGPIPSSLGNLKNLQ 263
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
556-776 5.04e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.63  E-value: 5.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 556 MLNNLKKmtNLTELELVHCDLERIPHAVFSllSLQELDLKENNLKSIEEIVSfQHLRKLTVLKlwhNSITYIPEHIKKlt 635
Cdd:PRK15370 172 MRDCLKN--NKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQ-GNIKTLYANS---NQLTSIPATLPD-- 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 636 SLERLSFSHNKIEVLPSHLflcnkiryldlsyndirfipPeigvlQSLQYFSITCNKVESLPDELyfCKKLKTLKIGKNS 715
Cdd:PRK15370 242 TIQEMELSINRITELPERL--------------------P-----SALQSLDLFHNKISCLPENL--PEELRYLSVYDNS 294

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767906369 716 LSVLSPKIGNllFLSYLDVKGNHFEILPPELgdcrALKRAGLVVEDALFETLPSDVREQMK 776
Cdd:PRK15370 295 IRTLPAHLPS--GITHLNVQSNSLTALPETL----PPGLKTLEAGENALTSLPASLPPELQ 349
LRR_8 pfam13855
Leucine rich repeat;
564-624 8.55e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 8.55e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767906369  564 TNLTELELVHCDLERIPHAVFS-LLSLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWHNSI 624
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
588-647 3.47e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 3.47e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767906369  588 SLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWHNSITYI-PEHIKKLTSLERLSFSHNKI 647
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 488-662 6.69e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 6.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 488 LRNLEELYLvgslSH-DISRnvtLESLRDLKSLKILsiksnvskipqavvdvssHLQKMCIhndgtklVMLNNLKKMTNL 566
Cdd:cd21340   45 LTNLTHLYL----QNnQIEK---IENLENLVNLKKL------------------YLGGNRI-------SVVEGLENLTNL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 567 TELelvHCDLERI---------PHAVFSLL-SLQELDLKENNLKSIEEivsFQHLRKLTVLKLWHNSITYIPE---HIKK 633
Cdd:cd21340   93 EEL---HIENQRLppgekltfdPRSLAALSnSLRVLNISGNNIDSLEP---LAPLRNLEQLDASNNQISDLEElldLLSS 166

                        170       180
                 ....*....|....*....|....*....
gi 767906369 634 LTSLERLSFSHNKIevlpshlflCNKIRY 662
Cdd:cd21340  167 WPSLRELDLTGNPV---------CKKPKY 186
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
424-700 1.53e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 424 LKLEIIKNVMIPATIAQ------LDNLQELSLHQCsvkihsaalsfLKENLKVLSVKFDDMRELPPWMYGlrNLEELylv 497
Cdd:PRK15370 183 LRLKILGLTTIPACIPEqittliLDNNELKSLPEN-----------LQGNIKTLYANSNQLTSIPATLPD--TIQEM--- 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 498 gslshDISRNVTLESLRDLKS-LKILSIKSN-VSKIPQAVVDvssHLQKMCIHNdgtklvmlNNLKKMTnltelelvhcd 575
Cdd:PRK15370 247 -----ELSINRITELPERLPSaLQSLDLFHNkISCLPENLPE---ELRYLSVYD--------NSIRTLP----------- 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 576 lERIPHavfsllSLQELDLKENNLKSIEEIVSFQhlrkLTVLKLWHNSITYIPEHIKKltSLERLSFSHNKIEVLPSHlf 655
Cdd:PRK15370 300 -AHLPS------GITHLNVQSNSLTALPETLPPG----LKTLEAGENALTSLPASLPP--ELQVLDVSKNQITVLPET-- 364

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 767906369 656 LCNKIRYLDLSYNDIRFIPPEIGVlqSLQYFSITCNKVESLPDEL 700
Cdd:PRK15370 365 LPPTITTLDVSRNALTNLPENLPA--ALQIMQASRNNLVRLPESL 407
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 557-718 3.36e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.17  E-value: 3.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 557 LNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNL--KSIEEIVS-FQHLRKLTVLKLWHNSIT-----YIP 628
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIGdegviALA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 629 EHIKKLTSLERLSFSHNKIEV-----LPSHLFLCNKIRYLDLSYNDIRFiPPEIGVLQSLQ-----------YFSITCNK 692
Cdd:COG5238  258 EALKNNTTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIGD-EGAIALAEGLQgnktlhtlnlaYNGIGAQG 336

                        170       180
                 ....*....|....*....|....*.
gi 767906369 693 VESLPDELYFCKKLKTLKIGKNSLSV 718
Cdd:COG5238  337 AIALAKALQENTTLHSLDLSDNQIGD 362
PLN03150 PLN03150
hypothetical protein; Provisional
 579-645 4.87e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 4.87e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767906369 579 IPHAVFSLLSLQELDLKENNLKSieEI-VSFQHLRKLTVLKLWHNSIT-YIPEHIKKLTSLERLSFSHN 645
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRG--NIpPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
681-739 1.80e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.80e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767906369  681 QSLQYFSITCNKVESLPDE-LYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYLDVKGNHF 739
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 487-597 3.71e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 3.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369 487 GLRNLEELYLVGSLshdISRNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCIHNDgtKLVMLNNLKK 562
Cdd:cd21340   66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767906369 563 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 597
Cdd:cd21340  141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 400-708 8.17e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 8.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369  400 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSvkihsaalsflkenlkvlsvkfdDMR 479
Cdd:PLN03210  615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCS-----------------------SLV 671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369  480 ELPPWMYGLRNLEELylvgslshDISRNVTLESLR---DLKSLKILSIkSNVSKIpQAVVDVSSHLQKMCIhnDGTKLVM 556
Cdd:PLN03210  672 ELPSSIQYLNKLEDL--------DMSRCENLEILPtgiNLKSLYRLNL-SGCSRL-KSFPDISTNISWLDL--DETAIEE 739

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369  557 LNNLKKMTNLTELELVHCDLERIPHAVFSLL--------SLQELDLkeNNLKSIEEI-VSFQHLRKLTVLKLWH-NSITY 626
Cdd:PLN03210  740 FPSNLRLENLDELILCEMKSEKLWERVQPLTplmtmlspSLTRLFL--SDIPSLVELpSSIQNLHKLEHLEIENcINLET 817

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906369  627 IPEHIkKLTSLERLSFSH-NKIEVLPShlfLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFS-ITCNKVESLPDELYFCK 704
Cdd:PLN03210  818 LPTGI-NLESLESLDLSGcSRLRTFPD---ISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDmNGCNNLQRVSLNISKLK 893


                  ....
gi 767906369  705 KLKT 708
Cdd:PLN03210  894 HLET 897
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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