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Conserved domains on  [gi|767972770|ref|XP_011536033|]
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plexin-C1 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sema_plexin_C1 cd11246
The Sema domain, a protein interacting module, of Plexin C1; Plexins serve as semaphorin ...
 44-453 0e+00

The Sema domain, a protein interacting module, of Plexin C1; Plexins serve as semaphorin receptors. Plexin C1 has been identified as the receptor of semaphorin 7A, which plays regulation roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A-Plexin C1 signaling. Cofilin is not phosphorylated when Plexin C1 expression is silenced. Thus, melanoma invasion and metastasis may be promoted through the loss of Plexin C1 inhibitory signaling on cofilin activation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


:

Pssm-ID: 200507  Cd Length: 401  Bit Score: 656.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770   44 QAIGAIAASQEDGVFVASGSCLDQLDYSLEHSLSRLYRDQAGNCTEPVSLAPPARPRPGSSFSKLLLPY-REGAAGLGGL 122
Cdd:cd11246     1 SAIGAIAASLADSSFVASGSCLDQLDYSLELALARLYRDQAGNCTEPVSLAPPARPRPGSQFSRLLLPYlREGAGGLSGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  123 LLTGWTF--DRGACEVRPLGNLSRNSLRNGTEVVSCHPQGSTAGVVYRAGRNNRWYLAVAATYVLPEPETASRCNPAASD 200
Cdd:cd11246    81 LLTGWTFpgDRGACEVRPLGNLPGASQRNGTEVVSCHPQGSTAGVVYRANRSGGWYLAVAATYVLPEDETASRCNPSASD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  201 HDTAIALKDTEGRSLATQELGRLKLCegaGSLHFVDAFLWNGSIYFPYYPYNYTSGAATGWPSMARIAQSTEVLFQGQAS 280
Cdd:cd11246   161 LDTAIALKATEGRSLATQELGRLKLL---GSLHFVDAFLWNGSLYFPYYPYNYTSGAATGEPSMARVAHSLEVLFQGQAG 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  281 LDCGHGHPDGRRLLLSSSLVEALDVWAGVFSAaaGEGQERRSPTTTALCLFRMSEIQARAKRVSwdfktaeshckeGDQP 360
Cdd:cd11246   238 LDCLHGHPRGRRLLLSSSLVRALDVGAGVFSA--GEGQERRAPCTTALCLFRMEEIQARANGES------------GDFP 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  361 ERVQ-PIASS----TLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIKEETPVFYKLVPDPVK 435
Cdd:cd11246   304 ERVQvPIAPSnnltTLIHSDLVSVYGTVVLNRTVLFLGTGDGQLLKVILGENMTSNCPEVLYEIKEETPVFYKLVPDPVN 383

                         410
                  ....*....|....*...
gi 767972770  436 NIYIYLTAGKEVRRIRVA 453
Cdd:cd11246   384 NIYIYLTSGNKVRRIPVA 401
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 454-507 3.57e-14

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 67.73  E-value: 3.57e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767972770   454 NCNKHKSCSECLTATDPHCGWCHSLQRCTFQGDCVHSE-NLENWLDISSgakKCP 507
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPEgNCEEWEQASS---KCP 52
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 754-840 1.65e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 58.23  E-value: 1.65e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770   754 PHCSLIFPATTWISGGQNITMMGRNFDVID---NLIISHELKGNINVSEYCVAtycgFLAPSLKSSKVRTNVTVKLrvQD 830
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVISVSSTTIV----CTTPPGTSGLVNVSVTVGG--GG 74

                           90
                   ....*....|
gi 767972770   831 TYLDCGTLQY 840
Cdd:pfam01833   75 ISSSPLTFTY 84
RasGAP super family cl02569
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
 1010-1029 2.03e-07

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


The actual alignment was detected with superfamily member cd12789:

Pssm-ID: 470620 [Multi-domain]  Cd Length: 393  Bit Score: 54.48  E-value: 2.03e-07
                          10        20
                  ....*....|....*....|
gi 767972770 1010 FGTVPFLDYKHFALRTFFPE 1029
Cdd:cd12789     1 FGTVPFLDYKHFALRTFFPE 20
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
591-635 7.31e-05

domain found in Plexins, Semaphorins and Integrins;


:

Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 40.99  E-value: 7.31e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 767972770    591 NCSSLKECPACVETG---CAWCKSARRCIHPfTACDPSDYERNQEQCP 635
Cdd:smart00423    1 RCSKYTSCSECLLARdpyCAWCSSQGRCTSG-ERCDSRRQNWLSGGCP 47
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 664-750 9.13e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 42.05  E-value: 9.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770   664 IKSIEPQKVSTLGKSNVIVTGANFTRASNITMILKGTSTCdkdviqVSHVLNDTHMKFSLPSSRKEMKDVCIQFDGGN-C 742
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPC------TVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGiS 76


                   ....*...
gi 767972770   743 SSVGSLSY 750
Cdd:pfam01833   77 SSPLTFTY 84
 
Name Accession Description Interval E-value
Sema_plexin_C1 cd11246
The Sema domain, a protein interacting module, of Plexin C1; Plexins serve as semaphorin ...
 44-453 0e+00

The Sema domain, a protein interacting module, of Plexin C1; Plexins serve as semaphorin receptors. Plexin C1 has been identified as the receptor of semaphorin 7A, which plays regulation roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A-Plexin C1 signaling. Cofilin is not phosphorylated when Plexin C1 expression is silenced. Thus, melanoma invasion and metastasis may be promoted through the loss of Plexin C1 inhibitory signaling on cofilin activation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200507  Cd Length: 401  Bit Score: 656.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770   44 QAIGAIAASQEDGVFVASGSCLDQLDYSLEHSLSRLYRDQAGNCTEPVSLAPPARPRPGSSFSKLLLPY-REGAAGLGGL 122
Cdd:cd11246     1 SAIGAIAASLADSSFVASGSCLDQLDYSLELALARLYRDQAGNCTEPVSLAPPARPRPGSQFSRLLLPYlREGAGGLSGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  123 LLTGWTF--DRGACEVRPLGNLSRNSLRNGTEVVSCHPQGSTAGVVYRAGRNNRWYLAVAATYVLPEPETASRCNPAASD 200
Cdd:cd11246    81 LLTGWTFpgDRGACEVRPLGNLPGASQRNGTEVVSCHPQGSTAGVVYRANRSGGWYLAVAATYVLPEDETASRCNPSASD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  201 HDTAIALKDTEGRSLATQELGRLKLCegaGSLHFVDAFLWNGSIYFPYYPYNYTSGAATGWPSMARIAQSTEVLFQGQAS 280
Cdd:cd11246   161 LDTAIALKATEGRSLATQELGRLKLL---GSLHFVDAFLWNGSLYFPYYPYNYTSGAATGEPSMARVAHSLEVLFQGQAG 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  281 LDCGHGHPDGRRLLLSSSLVEALDVWAGVFSAaaGEGQERRSPTTTALCLFRMSEIQARAKRVSwdfktaeshckeGDQP 360
Cdd:cd11246   238 LDCLHGHPRGRRLLLSSSLVRALDVGAGVFSA--GEGQERRAPCTTALCLFRMEEIQARANGES------------GDFP 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  361 ERVQ-PIASS----TLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIKEETPVFYKLVPDPVK 435
Cdd:cd11246   304 ERVQvPIAPSnnltTLIHSDLVSVYGTVVLNRTVLFLGTGDGQLLKVILGENMTSNCPEVLYEIKEETPVFYKLVPDPVN 383

                         410
                  ....*....|....*...
gi 767972770  436 NIYIYLTAGKEVRRIRVA 453
Cdd:cd11246   384 NIYIYLTSGNKVRRIPVA 401
Sema smart00630
semaphorin domain;
49-435 1.14e-50

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 184.11  E-value: 1.14e-50
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770     49 IAASQEDGVFVASGSCLDQLDYSL--EHSLSRLYRDQAGNCTEPVSlAPPARPRPGSSFSKLLLPYREGAAGLgglllTG 126
Cdd:smart00630    5 LLDEDNGTLYVGARNRLYQLSLNLilEAELKTGPVLSSPDCEECVS-KGKDPPTDCVNYIRLLLDYNEDRLLV-----CG 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770    127 WTFDRGACEVRPLGNLsrnslrngtevvschpqgstagvvyragrnnrwYLAVAATYvLPEPETASRCNPAASdhdtaia 206
Cdd:smart00630   79 TNAFQPVCRLRNLGEL---------------------------------YVGTVADF-SGSDPAIPRSLSVRR------- 117

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770    207 LKDTEGRSLATQELGRLKLCEgagsLHFVDAFLWNGSIYFPYYPYNyTSGAATGWPSMARIAQSTEVLFQGQ-------- 278
Cdd:smart00630  118 LKGTSGVSLRTVLYDSKWLNE----PNFVYAFESGDFVYFFFRETA-VEDDNCGKAVHSRVARVCKNDVGGPrsldkkwt 192

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770    279 ----ASLDCGHGHPDGR--RLL----LSSSLVEALDVWAGVFSAAAGegqerrSPTTTALCLFRMSEIQA---------- 338
Cdd:smart00630  193 sflkARLECSVPGEDPFyfNELqaafLLPPGSESDDVLYGVFSTSSN------PIPGSAVCAFSLSDINAvfngpfkece 266

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770    339 ----RAKRVSWD--FKTAESHCK------------------------EGDQPERVQPIASSTLIHSDLTSVYGTVVM--- 385
Cdd:smart00630  267 tstsQWLPYSRGkvPYPRPGTCPnkppsskdlpdetlnfikshplmdEVVQPLTGRPLFVKTDSNYLLTSIAVDRVAtdg 346

                           410       420       430       440       450
                    ....*....|....*....|....*....|....*....|....*....|
gi 767972770    386 NRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIKeetpVFYKlvPDPVK 435
Cdd:smart00630  347 NYTVLFLGTSDGRILKVVLSESSSSSESVVLEEIS----VFPD--GSPIS 390
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 454-507 3.57e-14

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 67.73  E-value: 3.57e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767972770   454 NCNKHKSCSECLTATDPHCGWCHSLQRCTFQGDCVHSE-NLENWLDISSgakKCP 507
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPEgNCEEWEQASS---KCP 52
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
454-507 2.24e-12

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 62.56  E-value: 2.24e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 767972770    454 NCNKHKSCSECLTATDPHCGWCHSLQRCTFQGDCvhSENLENWLDISsgakkCP 507
Cdd:smart00423    1 RCSKYTSCSECLLARDPYCAWCSSQGRCTSGERC--DSRRQNWLSGG-----CP 47
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 754-840 1.65e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 58.23  E-value: 1.65e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770   754 PHCSLIFPATTWISGGQNITMMGRNFDVID---NLIISHELKGNINVSEYCVAtycgFLAPSLKSSKVRTNVTVKLrvQD 830
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVISVSSTTIV----CTTPPGTSGLVNVSVTVGG--GG 74

                           90
                   ....*....|
gi 767972770   831 TYLDCGTLQY 840
Cdd:pfam01833   75 ISSSPLTFTY 84
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 308-437 2.11e-08

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 54.97  E-value: 2.11e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770   308 GVFSAaagegQERRSPTTTALCLFRMSEIQARAKRVswdFKTAESHC-------------KEG----------------- 357
Cdd:pfam01403   21 GVFTT-----QWSNSIGGSAVCAFSLSDINAVFEGP---FKEQEKSDskwlpytgkvpypRPGtcindplrldlpdsvln 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770   358 ---DQPERVQPIASST----LIHSD--LTSVYGTVVM----NRTVLFLGTGDGQLLKVIlgeNLTSNCPEVIyeikEETP 424
Cdd:pfam01403   93 fvkDHPLMDEAVQPVGgrplLVRTGvrLTSIAVDRVQaldgNYTVLFLGTDDGRLHKVV---LVGSEESHII----EEIQ 165

                          170
                   ....*....|...
gi 767972770   425 VFykLVPDPVKNI 437
Cdd:pfam01403  166 VF--PEPQPVLNL 176
IPT smart00429
ig-like, plexins, transcription factors;
753-841 3.45e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 52.04  E-value: 3.45e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770    753 LPHCSLIFPATTWISGGQNITMMGRNFDVIDNLIISHELKGN----INVSEycVATYCgfLAPSLKSSKVRTNV-TVKLR 827
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEApctfSPSSS--TAIVC--KTPPYHNIPGSVPVrTVGLR 76

                            90
                    ....*....|....
gi 767972770    828 VQDTYLDCGTLQYR 841
Cdd:smart00429   77 NGGVPSSPQPFTYV 90
RasGAP_plexin_C1 cd12789
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ...
 1010-1029 2.03e-07

Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213349 [Multi-domain]  Cd Length: 393  Bit Score: 54.48  E-value: 2.03e-07
                          10        20
                  ....*....|....*....|
gi 767972770 1010 FGTVPFLDYKHFALRTFFPE 1029
Cdd:cd12789     1 FGTVPFLDYKHFALRTFFPE 20
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 754-842 7.57e-07

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 48.23  E-value: 7.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  754 PHCSLIFPATTWISGGQNITMMGRNFDVIDNLIISHelKGNINVS-EYCVATYCGFLAPSLKSS-KVRTNVTVKLRVQDT 831
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTF--GGGVPCSvLSVSSTAIVCTTPPYANPgPGPVEVTVDRGNGGI 78

                          90
                  ....*....|.
gi 767972770  832 YLDCGTLQYRE 842
Cdd:cd00102    79 TSSPLTFTYVP 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
591-635 7.31e-05

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 40.99  E-value: 7.31e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 767972770    591 NCSSLKECPACVETG---CAWCKSARRCIHPfTACDPSDYERNQEQCP 635
Cdd:smart00423    1 RCSKYTSCSECLLARdpyCAWCSSQGRCTSG-ERCDSRRQNWLSGGCP 47
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 591-635 8.65e-05

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 41.15  E-value: 8.65e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767972770   591 NCSSLKECPACVE---TGCAWCKSARRCIHP----FTACDPSDYERNQEQCP 635
Cdd:pfam01437    1 RCSQYTSCSSCLAardPYCGWCSSEGRCVRRsacgAPEGNCEEWEQASSKCP 52
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 664-750 9.13e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 42.05  E-value: 9.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770   664 IKSIEPQKVSTLGKSNVIVTGANFTRASNITMILKGTSTCdkdviqVSHVLNDTHMKFSLPSSRKEMKDVCIQFDGGN-C 742
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPC------TVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGiS 76


                   ....*...
gi 767972770   743 SSVGSLSY 750
Cdd:pfam01833   77 SSPLTFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 664-747 5.63e-03

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 37.06  E-value: 5.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  664 IKSIEPQKVSTLGKSNVIVTGANFTRASNITMILKGTSTCdkdviqVSHVLNDTHMKFSLPSSRKEMK-DVCIQFDGGNC 742
Cdd:cd00102     3 ITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPC------SVLSVSSTAIVCTTPPYANPGPgPVEVTVDRGNG 76


                  ....*
gi 767972770  743 SSVGS 747
Cdd:cd00102    77 GITSS 81
 
Name Accession Description Interval E-value
Sema_plexin_C1 cd11246
The Sema domain, a protein interacting module, of Plexin C1; Plexins serve as semaphorin ...
 44-453 0e+00

The Sema domain, a protein interacting module, of Plexin C1; Plexins serve as semaphorin receptors. Plexin C1 has been identified as the receptor of semaphorin 7A, which plays regulation roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A-Plexin C1 signaling. Cofilin is not phosphorylated when Plexin C1 expression is silenced. Thus, melanoma invasion and metastasis may be promoted through the loss of Plexin C1 inhibitory signaling on cofilin activation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200507  Cd Length: 401  Bit Score: 656.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770   44 QAIGAIAASQEDGVFVASGSCLDQLDYSLEHSLSRLYRDQAGNCTEPVSLAPPARPRPGSSFSKLLLPY-REGAAGLGGL 122
Cdd:cd11246     1 SAIGAIAASLADSSFVASGSCLDQLDYSLELALARLYRDQAGNCTEPVSLAPPARPRPGSQFSRLLLPYlREGAGGLSGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  123 LLTGWTF--DRGACEVRPLGNLSRNSLRNGTEVVSCHPQGSTAGVVYRAGRNNRWYLAVAATYVLPEPETASRCNPAASD 200
Cdd:cd11246    81 LLTGWTFpgDRGACEVRPLGNLPGASQRNGTEVVSCHPQGSTAGVVYRANRSGGWYLAVAATYVLPEDETASRCNPSASD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  201 HDTAIALKDTEGRSLATQELGRLKLCegaGSLHFVDAFLWNGSIYFPYYPYNYTSGAATGWPSMARIAQSTEVLFQGQAS 280
Cdd:cd11246   161 LDTAIALKATEGRSLATQELGRLKLL---GSLHFVDAFLWNGSLYFPYYPYNYTSGAATGEPSMARVAHSLEVLFQGQAG 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  281 LDCGHGHPDGRRLLLSSSLVEALDVWAGVFSAaaGEGQERRSPTTTALCLFRMSEIQARAKRVSwdfktaeshckeGDQP 360
Cdd:cd11246   238 LDCLHGHPRGRRLLLSSSLVRALDVGAGVFSA--GEGQERRAPCTTALCLFRMEEIQARANGES------------GDFP 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  361 ERVQ-PIASS----TLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIKEETPVFYKLVPDPVK 435
Cdd:cd11246   304 ERVQvPIAPSnnltTLIHSDLVSVYGTVVLNRTVLFLGTGDGQLLKVILGENMTSNCPEVLYEIKEETPVFYKLVPDPVN 383

                         410
                  ....*....|....*...
gi 767972770  436 NIYIYLTAGKEVRRIRVA 453
Cdd:cd11246   384 NIYIYLTSGNKVRRIPVA 401
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
 46-453 2.11e-75

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 254.18  E-value: 2.11e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770   46 IGAIAASQEDG-VFVASGSCLDQLDYSL--EHSLSRLYRDQAGNCTEPVSLAPPARPRPGSSFSKLLLPYREGAAGLggl 122
Cdd:cd11236     2 FNHLAVDNSTGrVYVGAVNRLYQLDSSLllEAEVSTGPVLDSPLCLPPGCCSCDHPRSPTDNYNKILLIDYSSGRLI--- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  123 llTGWTFDRGACEVRPLGNLSRNSLRNGTEVVSCHPQGSTAGVVYRAGRNNRWYLAVAATYV-----LPEPETASRCNPA 197
Cdd:cd11236    79 --TCGSLYQGVCQLRNLSNISVVVERSSTPVAANDPNASTVGFVGPGPYNNENVLYVGATYTnngyrDYRPAVSSRSLPP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  198 ASD-------HDTAIALKDTEGrslatqelgrlklceGAGSLHFVDAFLWNGSIYFPYYPYNYTSGAATGWPSMARIAQS 270
Cdd:cd11236   157 DDDfnagsltGGSAISIDDEYR---------------DRYSIKYVYGFSSGGFSYFVTVQRKSVDDESPYISRLVRVCQS 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  271 -TEVLFQGQASLDCGHGHPDGRRLLLSSSLVEA-------------LDVWAGVFSaaAGEGQERRSPTTTALCLFRMSEI 336
Cdd:cd11236   222 dSNYYSYTEVPLQCTGGDGTNYNLLQAAYVGKAgsdlarslgistdDDVLFGVFS--KSKGPSAEPSSKSALCVFSMKDI 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  337 QARAKRvswdfktaesHCKEGdqpeRVQPIASSTLIH-SDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGenltSNCPEV 415
Cdd:cd11236   300 EAAFND----------NCPLG----GGVPITTSAVLSdSLLTSVAVTTTRNHTVAFLGTSDGQLKKVVLE----SSSSAT 361

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 767972770  416 IYEIKEET---PVFYKLVPDPvKNIYIYLTAGKEVRRIRVA 453
Cdd:cd11236   362 QYETLLVDsgsPILPDMVFDP-DGEHLYVMTPKKVTKVPVE 401
Sema smart00630
semaphorin domain;
49-435 1.14e-50

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 184.11  E-value: 1.14e-50
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770     49 IAASQEDGVFVASGSCLDQLDYSL--EHSLSRLYRDQAGNCTEPVSlAPPARPRPGSSFSKLLLPYREGAAGLgglllTG 126
Cdd:smart00630    5 LLDEDNGTLYVGARNRLYQLSLNLilEAELKTGPVLSSPDCEECVS-KGKDPPTDCVNYIRLLLDYNEDRLLV-----CG 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770    127 WTFDRGACEVRPLGNLsrnslrngtevvschpqgstagvvyragrnnrwYLAVAATYvLPEPETASRCNPAASdhdtaia 206
Cdd:smart00630   79 TNAFQPVCRLRNLGEL---------------------------------YVGTVADF-SGSDPAIPRSLSVRR------- 117

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770    207 LKDTEGRSLATQELGRLKLCEgagsLHFVDAFLWNGSIYFPYYPYNyTSGAATGWPSMARIAQSTEVLFQGQ-------- 278
Cdd:smart00630  118 LKGTSGVSLRTVLYDSKWLNE----PNFVYAFESGDFVYFFFRETA-VEDDNCGKAVHSRVARVCKNDVGGPrsldkkwt 192

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770    279 ----ASLDCGHGHPDGR--RLL----LSSSLVEALDVWAGVFSAAAGegqerrSPTTTALCLFRMSEIQA---------- 338
Cdd:smart00630  193 sflkARLECSVPGEDPFyfNELqaafLLPPGSESDDVLYGVFSTSSN------PIPGSAVCAFSLSDINAvfngpfkece 266

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770    339 ----RAKRVSWD--FKTAESHCK------------------------EGDQPERVQPIASSTLIHSDLTSVYGTVVM--- 385
Cdd:smart00630  267 tstsQWLPYSRGkvPYPRPGTCPnkppsskdlpdetlnfikshplmdEVVQPLTGRPLFVKTDSNYLLTSIAVDRVAtdg 346

                           410       420       430       440       450
                    ....*....|....*....|....*....|....*....|....*....|
gi 767972770    386 NRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIKeetpVFYKlvPDPVK 435
Cdd:smart00630  347 NYTVLFLGTSDGRILKVVLSESSSSSESVVLEEIS----VFPD--GSPIS 390
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
 290-491 5.52e-17

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 85.37  E-value: 5.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  290 GRRLLLSSSLVEALDVWAGVFSAaaGEGQERRSPTTTALCLFRMSEIQARAKRVSWDFKTAESH------------CKEG 357
Cdd:cd11272   282 GEVLARSLNITAQEDVLFAIFSK--GQKQYHHPPDDSALCAFPIRAINAQIKERLQSCYQGEGNlelnwllgkdvqCTKA 359

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  358 DQP--------ERVQPIASSTLI---------HSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCP-EVIYEI 419
Cdd:cd11272   360 PVPiddnfcglDINQPLGGSTPVegvtlytssRDRLTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQyEMVSVF 439

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767972770  420 KEETPVFYKLVPDpVKNIYIYLTAGKEVRRIRVANCNKHKSCSECLTATDPHCGWCHSLQRCTFQGDCVHSE 491
Cdd:cd11272   440 KDGSPILRDMAFS-IDHKYLYVMSERQVSRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRAW 510
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 454-507 3.57e-14

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 67.73  E-value: 3.57e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767972770   454 NCNKHKSCSECLTATDPHCGWCHSLQRCTFQGDCVHSE-NLENWLDISSgakKCP 507
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPEgNCEEWEQASS---KCP 52
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
 70-453 2.34e-13

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 73.43  E-value: 2.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770   70 YSLEHSLSRLYRDQAG------NCTEPVSLAPPARPRPGSSFSKLLLpyreGAAGLGGLLLTGWTFdRGACEVRPLGNLS 143
Cdd:cd11245    23 FQLSPNLQLESRADTGpkkdspQCLPPITAAECPQAKETDNFNKLLL----VNSANGTLVVCGSLF-QGVCELRNLNSVN 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  144 RNSLR-----NGTEVVSCHPQGSTAGVVYRaGRNNRWYLAVAATYVLPE----PETASRcnpAASDHDTAIALKDTEGRS 214
Cdd:cd11245    98 KPLYRpetpgDKQYVAANEPSVSTVGLISY-FKDGLSLLFVGRGYTSSLsggiPPITTR---LLQEHGEMDAFSNEVEAK 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  215 LATQELGRLklcegagSLHFVDAFLWNGSIYFPYYPYNYTSgaatgwpSMARIAQSTEVLFQGQ-------ASLDCGHGH 287
Cdd:cd11245   174 LVVGSASRY-------HHDFVYAFADNGYIYFLFSRRPGTA-------DSTKRTYISRLCENDHhyysyveLPLNCTVNQ 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  288 PDGRRLLLSSSLVEALDVWAG--VFSA-AAGEGQERRSPTTTALCLFRMSEIQARAKRVSWDFKTAEShcKEGDQPERV- 363
Cdd:cd11245   240 ENTYNLVQAAYLAKPGKVLNGkvLFGVfSADEASTAAPDGRSALCMYPLSSVDARFERTRESCYTGEG--LEDDKPETAy 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  364 ----------------------------QPIASSTLIHSD--------LTSVYGTVVMNRTVLFLGTGDGQLLKVILGEN 407
Cdd:cd11245   318 ieynvksicktlpdknvkaypcgaehtpSPLASRYPLAAKpiltrndmLTAVAVAVENGHTIAFLGDSGGQLHKVYLDPN 397

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 767972770  408 LTSncPEVIYEIKEETPVFYKLVPDPVKNiYIYLTAGKEVRRIRVA 453
Cdd:cd11245   398 HTD--FYSTIPGDQDSAVNKDLLFDSTLN-HLYVMTGKKISKVPVQ 440
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
454-507 2.24e-12

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 62.56  E-value: 2.24e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 767972770    454 NCNKHKSCSECLTATDPHCGWCHSLQRCTFQGDCvhSENLENWLDISsgakkCP 507
Cdd:smart00423    1 RCSKYTSCSECLLARDPYCAWCSSQGRCTSGERC--DSRRQNWLSGG-----CP 47
Sema_plexin_D1 cd11247
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ...
 131-453 2.36e-12

The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200508 [Multi-domain]  Cd Length: 483  Bit Score: 70.65  E-value: 2.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  131 RGACEVRPLGNLSRNSLR---NGTEVV-------SCHPQGSTAGVVYR-AGRNNRWYLAVAATYVLPEPETASRcNPAAS 199
Cdd:cd11247    97 QGLCQLRRLYNISAVAVRfpvDGDTVFpsmlnvaANHPNASTVGLVLWpRGGGGGLRLLVGATYTGYGSGFFPR-NRSLE 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  200 DH----DTAIALKDTEGR-SLAT--------QELGRLKLCEGAGSLH---FVDAFLWNGSIYFPYYPYNYTSGAA---TG 260
Cdd:cd11247   176 DHrfenTPEIAIRALNTRgDLAKlftfdinpSDDNIFKIKQGAKARHklsFVRAFLQHFLQPYAYLAMNGEANAAgkeSQ 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  261 WPS-MARI----------AQSTEVLFQG-QASLDCGHghPDGRRLLLSSSLVEAlDVWAGVFsaaagegqERRSPTTTAL 328
Cdd:cd11247   256 PPSlLARIclpgrappppGEAKKLTESYiQLGLRCEG--AYTRLVSVFPARVEE-EQLFAVF--------ERAGGAPAAL 324

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  329 CLFRMSEIQA--RAKRVSWDFKTAESHCKEGD------------------QPER--------------VQPI-ASSTLIH 373
Cdd:cd11247   325 CAFRFAEVEEpiRAARTACFVSPAAGVVTVLDsvvqgtgpacerklniqlQPEQldcgaahlqhplaiLQPLkATPVFRA 404

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  374 SDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCPEVIyEIKEETPVFYKLVPDPVKNIYIYLTAGKEVRRIRVA 453
Cdd:cd11247   405 PGLTSVAVASVNNYTVVFLGTVSGRLLKINLDESMQVVSRRSV-TVAYGEPVHHVMQFDPSDSTYLYLMTSHQMTRVKVA 483
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 754-840 1.65e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 58.23  E-value: 1.65e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770   754 PHCSLIFPATTWISGGQNITMMGRNFDVID---NLIISHELKGNINVSEYCVAtycgFLAPSLKSSKVRTNVTVKLrvQD 830
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVISVSSTTIV----CTTPPGTSGLVNVSVTVGG--GG 74

                           90
                   ....*....|
gi 767972770   831 TYLDCGTLQY 840
Cdd:pfam01833   75 ISSSPLTFTY 84
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 308-437 2.11e-08

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 54.97  E-value: 2.11e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770   308 GVFSAaagegQERRSPTTTALCLFRMSEIQARAKRVswdFKTAESHC-------------KEG----------------- 357
Cdd:pfam01403   21 GVFTT-----QWSNSIGGSAVCAFSLSDINAVFEGP---FKEQEKSDskwlpytgkvpypRPGtcindplrldlpdsvln 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770   358 ---DQPERVQPIASST----LIHSD--LTSVYGTVVM----NRTVLFLGTGDGQLLKVIlgeNLTSNCPEVIyeikEETP 424
Cdd:pfam01403   93 fvkDHPLMDEAVQPVGgrplLVRTGvrLTSIAVDRVQaldgNYTVLFLGTDDGRLHKVV---LVGSEESHII----EEIQ 165

                          170
                   ....*....|...
gi 767972770   425 VFykLVPDPVKNI 437
Cdd:pfam01403  166 VF--PEPQPVLNL 176
IPT smart00429
ig-like, plexins, transcription factors;
753-841 3.45e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 52.04  E-value: 3.45e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770    753 LPHCSLIFPATTWISGGQNITMMGRNFDVIDNLIISHELKGN----INVSEycVATYCgfLAPSLKSSKVRTNV-TVKLR 827
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEApctfSPSSS--TAIVC--KTPPYHNIPGSVPVrTVGLR 76

                            90
                    ....*....|....
gi 767972770    828 VQDTYLDCGTLQYR 841
Cdd:smart00429   77 NGGVPSSPQPFTYV 90
RasGAP_plexin_C1 cd12789
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ...
 1010-1029 2.03e-07

Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213349 [Multi-domain]  Cd Length: 393  Bit Score: 54.48  E-value: 2.03e-07
                          10        20
                  ....*....|....*....|
gi 767972770 1010 FGTVPFLDYKHFALRTFFPE 1029
Cdd:cd12789     1 FGTVPFLDYKHFALRTFFPE 20
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 754-842 7.57e-07

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 48.23  E-value: 7.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  754 PHCSLIFPATTWISGGQNITMMGRNFDVIDNLIISHelKGNINVS-EYCVATYCGFLAPSLKSS-KVRTNVTVKLRVQDT 831
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTF--GGGVPCSvLSVSSTAIVCTTPPYANPgPGPVEVTVDRGNGGI 78

                          90
                  ....*....|.
gi 767972770  832 YLDCGTLQYRE 842
Cdd:cd00102    79 TSSPLTFTYVP 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 754-842 6.19e-06

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 45.52  E-value: 6.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  754 PHCSLIFPATTWISGGQNITMMGRNFDVID-NLIISHelkGNIN-VSEYCVATYCGFLAPSLKS-SKVRTNVTVKLR-VQ 829
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSpRVRVTV---GGVPcKVLNVSSTEIVCRTPAAATpGEGPVEVTVDGAnVS 77

                          90
                  ....*....|...
gi 767972770  830 DTYLDCGTLQYRE 842
Cdd:cd00603    78 ARVLSNTTFTYVE 90
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
591-635 7.31e-05

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 40.99  E-value: 7.31e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 767972770    591 NCSSLKECPACVETG---CAWCKSARRCIHPfTACDPSDYERNQEQCP 635
Cdd:smart00423    1 RCSKYTSCSECLLARdpyCAWCSSQGRCTSG-ERCDSRRQNWLSGGCP 47
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
 376-452 7.52e-05

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 46.31  E-value: 7.52e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767972770  376 LTSVYGTVVMNRTVLFLGTGDGQLLKVILgenltSNCPEVIYEIKEET--PVFYKLVPDPVKNiYIYLTAGKEVRRIRV 452
Cdd:cd11276   376 LTAVTVAVENGHTVAFLGTSDGRILKVHL-----SPDPEEYNSILIEKnkPVNKDLVLDKTLE-HLYIMTEDKVFRLPV 448
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 591-635 8.65e-05

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 41.15  E-value: 8.65e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767972770   591 NCSSLKECPACVE---TGCAWCKSARRCIHP----FTACDPSDYERNQEQCP 635
Cdd:pfam01437    1 RCSQYTSCSSCLAardPYCGWCSSEGRCVRRsacgAPEGNCEEWEQASSKCP 52
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 664-750 9.13e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 42.05  E-value: 9.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770   664 IKSIEPQKVSTLGKSNVIVTGANFTRASNITMILKGTSTCdkdviqVSHVLNDTHMKFSLPSSRKEMKDVCIQFDGGN-C 742
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPC------TVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGiS 76


                   ....*...
gi 767972770   743 SSVGSLSY 750
Cdd:pfam01833   77 SSPLTFTY 84
Sema_RON cd11279
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor ...
 281-408 4.82e-03

The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a wide range of effects, including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. RON has been implicated in cancers of the breast, colon, pancreas and ovaries because both splice variants and receptor overexpression have been identified in these tumors. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as ligand recognition and binding model. RON is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain of RON may be necessary for receptor dimerization and activation.


Pssm-ID: 200540 [Multi-domain]  Cd Length: 493  Bit Score: 40.53  E-value: 4.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  281 LDCGHGHPDGRRLLLSSSLVEALDVWAGVFsaAAGEGQERRSPTTTALCLFRMSEI----------------QARAKRvS 344
Cdd:cd11279   292 LQAAHAAPVGSKLAVELGISEGQEVLFGVF--AESQPGSPVPQKNSAVCAFPISLLneaidegmekccsssnSDRLFR-G 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  345 WDFKTAESHCKEGDQPERVQPIAS----STLIHSD---------------LTSVYGTVVMNRTVLFLGTGDGQLLKVILG 405
Cdd:cd11279   369 LDFFQPQSYCPHPPNLSAAVSNTScwnfPTLVSTSsfrvdlfnghlsgvlLTSIYVTVLDNVTVAHLGTSDGRILQVVLQ 448


                  ...
gi 767972770  406 ENL 408
Cdd:cd11279   449 RSL 451
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 664-747 5.63e-03

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 37.06  E-value: 5.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972770  664 IKSIEPQKVSTLGKSNVIVTGANFTRASNITMILKGTSTCdkdviqVSHVLNDTHMKFSLPSSRKEMK-DVCIQFDGGNC 742
Cdd:cd00102     3 ITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPC------SVLSVSSTAIVCTTPPYANPGPgPVEVTVDRGNG 76


                  ....*
gi 767972770  743 SSVGS 747
Cdd:cd00102    77 GITSS 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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