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Conserved domains on  [gi|767938228|ref|XP_011532796|]
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zinc finger protein 346 isoform X2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10648429)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0003676|GO:0008270
PubMed:  11179890|12665246|11361095|10940247|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 223-257 6.67e-07

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 44.94  E-value: 6.67e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767938228   223 DPDKFCSLCHATFNDPVMAQQHYVGKKHRKQETKL 257
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 160-189 1.10e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.77  E-value: 1.10e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 767938228   160 CCPICNMTFSSPVVAQSHYLGKTHAKNLKL 189
Cdd:smart00451   5 YCKLCNVTFTDEISVEAHLKGKKHKKNVKK 34
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 96-129 3.65e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 37.23  E-value: 3.65e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767938228    96 TNTQCKVCCALLISESQKLAHYQSKKHANKVKRY 129
Cdd:smart00451   2 GGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
 
Name Accession Description Interval E-value
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 223-257 6.67e-07

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 44.94  E-value: 6.67e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767938228   223 DPDKFCSLCHATFNDPVMAQQHYVGKKHRKQETKL 257
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 160-189 1.10e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.77  E-value: 1.10e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 767938228   160 CCPICNMTFSSPVVAQSHYLGKTHAKNLKL 189
Cdd:smart00451   5 YCKLCNVTFTDEISVEAHLKGKKHKKNVKK 34
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 226-250 1.11e-04

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 38.63  E-value: 1.11e-04
                          10        20
                  ....*....|....*....|....*
gi 767938228  226 KFCSLCHATFNDPVMAQQHYVGKKH 250
Cdd:pfam12874   1 FYCELCNVTFNSESQLKSHLQGKKH 25
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 161-183 2.31e-04

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 37.86  E-value: 2.31e-04
                          10        20
                  ....*....|....*....|...
gi 767938228  161 CPICNMTFSSPVVAQSHYLGKTH 183
Cdd:pfam12874   3 CELCNVTFNSESQLKSHLQGKKH 25
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 96-129 3.65e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 37.23  E-value: 3.65e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767938228    96 TNTQCKVCCALLISESQKLAHYQSKKHANKVKRY 129
Cdd:smart00451   2 GGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 100-122 1.06e-03

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 35.93  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|...
gi 767938228  100 CKVCCALLISESQKLAHYQSKKH 122
Cdd:pfam12874   3 CELCNVTFNSESQLKSHLQGKKH 25
 
Name Accession Description Interval E-value
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 223-257 6.67e-07

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 44.94  E-value: 6.67e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767938228   223 DPDKFCSLCHATFNDPVMAQQHYVGKKHRKQETKL 257
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 160-189 1.10e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.77  E-value: 1.10e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 767938228   160 CCPICNMTFSSPVVAQSHYLGKTHAKNLKL 189
Cdd:smart00451   5 YCKLCNVTFTDEISVEAHLKGKKHKKNVKK 34
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 226-250 1.11e-04

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 38.63  E-value: 1.11e-04
                          10        20
                  ....*....|....*....|....*
gi 767938228  226 KFCSLCHATFNDPVMAQQHYVGKKH 250
Cdd:pfam12874   1 FYCELCNVTFNSESQLKSHLQGKKH 25
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 161-183 2.31e-04

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 37.86  E-value: 2.31e-04
                          10        20
                  ....*....|....*....|...
gi 767938228  161 CPICNMTFSSPVVAQSHYLGKTH 183
Cdd:pfam12874   3 CELCNVTFNSESQLKSHLQGKKH 25
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 96-129 3.65e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 37.23  E-value: 3.65e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767938228    96 TNTQCKVCCALLISESQKLAHYQSKKHANKVKRY 129
Cdd:smart00451   2 GGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 100-122 1.06e-03

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 35.93  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|...
gi 767938228  100 CKVCCALLISESQKLAHYQSKKH 122
Cdd:pfam12874   3 CELCNVTFNSESQLKSHLQGKKH 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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