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Conserved domains on  [gi|767924418|ref|XP_011532465|]
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protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 isoform X1 [Homo sapiens]

Protein Classification

DUF563 and FN3 domain-containing protein( domain architecture ID 10519000)

DUF563 and FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_transf_61 super family cl15705
Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in ...
 319-391 5.63e-12

Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in this family are further processed into a mature form. It includes O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2, also known as AGO61 or EOGLT) and EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT). This family also includes plant beta-1,2-xylosyltransferases.


The actual alignment was detected with superfamily member COG4421:

Pssm-ID: 472831  Cd Length: 258  Bit Score: 66.14  E-value: 5.63e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767924418 319 VTVSLEDHTFADVVRLVSNASMLVSMHGAQLVTTLFLPRGATVVELFpyavnPDHYTP--YKTLAMLPGMDLQYV 391
Cdd:COG4421  155 EIVDPEELSFAEQIALFAEAEVIVGPHGAGLTNLVFCRPGTKVIELF-----PPGYVNpyFWLLAALLGLRYYYL 224
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 493-580 6.39e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.32  E-value: 6.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924418 493 SVHGASEARLTVSWQIPwnlKYLKVREVKYEVWLQEQGENTYVPYILALQNHT-FT-ENIKPFTTYLVWVRCIfNKILLG 570
Cdd:cd00063    8 RVTDVTSTSVTLSWTPP---EDDGGPITGYVVEYREKGSGDWKEVEVTPGSETsYTlTGLKPGTEYEFRVRAV-NGGGES 83

                         90
                 ....*....|
gi 767924418 571 PFADVLVCNT 580
Cdd:cd00063   84 PPSESVTVTT 93
 
Name Accession Description Interval E-value
COG4421 COG4421
Capsular polysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];
319-391 5.63e-12

Capsular polysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443536  Cd Length: 258  Bit Score: 66.14  E-value: 5.63e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767924418 319 VTVSLEDHTFADVVRLVSNASMLVSMHGAQLVTTLFLPRGATVVELFpyavnPDHYTP--YKTLAMLPGMDLQYV 391
Cdd:COG4421  155 EIVDPEELSFAEQIALFAEAEVIVGPHGAGLTNLVFCRPGTKVIELF-----PPGYVNpyFWLLAALLGLRYYYL 224
Glyco_transf_61 pfam04577
Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in ...
 319-362 7.86e-09

Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in this family are further processed into a mature form. It includes O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2, also known as AGO61 or EOGLT) and EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT). This family also includes plant beta-1,2-xylosyltransferases.


Pssm-ID: 428020  Cd Length: 124  Bit Score: 53.85  E-value: 7.86e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767924418  319 VTVSLEDHTFADVVRLVSNASMLVSMHGAQLVTTLFLPRGATVV 362
Cdd:pfam04577  81 EIVDPEKLSLEEQVKLFSSAKVIVGPHGSGLTNSIFMPPGTVVV 124
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 493-580 6.39e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.32  E-value: 6.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924418 493 SVHGASEARLTVSWQIPwnlKYLKVREVKYEVWLQEQGENTYVPYILALQNHT-FT-ENIKPFTTYLVWVRCIfNKILLG 570
Cdd:cd00063    8 RVTDVTSTSVTLSWTPP---EDDGGPITGYVVEYREKGSGDWKEVEVTPGSETsYTlTGLKPGTEYEFRVRAV-NGGGES 83

                         90
                 ....*....|
gi 767924418 571 PFADVLVCNT 580
Cdd:cd00063   84 PPSESVTVTT 93
 
Name Accession Description Interval E-value
COG4421 COG4421
Capsular polysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];
319-391 5.63e-12

Capsular polysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443536  Cd Length: 258  Bit Score: 66.14  E-value: 5.63e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767924418 319 VTVSLEDHTFADVVRLVSNASMLVSMHGAQLVTTLFLPRGATVVELFpyavnPDHYTP--YKTLAMLPGMDLQYV 391
Cdd:COG4421  155 EIVDPEELSFAEQIALFAEAEVIVGPHGAGLTNLVFCRPGTKVIELF-----PPGYVNpyFWLLAALLGLRYYYL 224
Glyco_transf_61 pfam04577
Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in ...
 319-362 7.86e-09

Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in this family are further processed into a mature form. It includes O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2, also known as AGO61 or EOGLT) and EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT). This family also includes plant beta-1,2-xylosyltransferases.


Pssm-ID: 428020  Cd Length: 124  Bit Score: 53.85  E-value: 7.86e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767924418  319 VTVSLEDHTFADVVRLVSNASMLVSMHGAQLVTTLFLPRGATVV 362
Cdd:pfam04577  81 EIVDPEKLSLEEQVKLFSSAKVIVGPHGSGLTNSIFMPPGTVVV 124
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 493-580 6.39e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.32  E-value: 6.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924418 493 SVHGASEARLTVSWQIPwnlKYLKVREVKYEVWLQEQGENTYVPYILALQNHT-FT-ENIKPFTTYLVWVRCIfNKILLG 570
Cdd:cd00063    8 RVTDVTSTSVTLSWTPP---EDDGGPITGYVVEYREKGSGDWKEVEVTPGSETsYTlTGLKPGTEYEFRVRAV-NGGGES 83

                         90
                 ....*....|
gi 767924418 571 PFADVLVCNT 580
Cdd:cd00063   84 PPSESVTVTT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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