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Conserved domains on  [gi|767923077|ref|XP_011531944|]
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metabotropic glutamate receptor 2 isoform X5 [Homo sapiens]

Protein Classification

PBP1_mGluR_groupII domain-containing protein( domain architecture ID 10157206)

PBP1_mGluR_groupII domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PBP1_mGluR_groupII cd06375
ligand binding domain of the group II metabotropic glutamate receptor; Ligand binding domain ...
 26-470 0e+00

ligand binding domain of the group II metabotropic glutamate receptor; Ligand binding domain of the group II metabotropic glutamate receptor, a family that contains mGlu2R and mGlu3R, all of which inhibit adenylyl cyclase. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes


:

Pssm-ID: 380598 [Multi-domain]  Cd Length: 462  Bit Score: 873.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  26 LTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDF 105
Cdd:cd06375    1 IKLEGDLVLGGLFPVHEKGEGMEECGRINEDRGIQRLEAMLFAIDRINRDPHLLPGVRLGVHILDTCSRDTYALEQSLEF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 106 VRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTV 185
Cdd:cd06375   81 VRASLTKVDDSEYMCPDDGSYAIQEDSPLPIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 186 PPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARV 265
Cdd:cd06375  161 PPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSADRKSFDGVIRELLQKPNARV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 266 AVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWF 345
Cdd:cd06375  241 VVLFTRSDDARELLAAAKRLNASFTWVASDGWGAQESIVKGSEDVAEGAITLELASHPIPDFDRYFQSLTPYNNHRNPWF 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 346 REFWEQRFRCSFRQRDCAA------HSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLY 419
Cdd:cd06375  321 RDFWEQKFQCSLQNKSQAAsvsdkhLSIDSSNYEQESKIMFVVNAVYAMAHALHNMQRTLCPNTTRLCDAMRSLDGKKLY 400

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767923077 420 KDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRA-GSGRYRYQK 470
Cdd:cd06375  401 KDYLLNVSFTAPFPPADAGSEVKFDAFGDGLGRYNIFNYQRAgGSYGYRYKG 452
 
Name Accession Description Interval E-value
PBP1_mGluR_groupII cd06375
ligand binding domain of the group II metabotropic glutamate receptor; Ligand binding domain ...
 26-470 0e+00

ligand binding domain of the group II metabotropic glutamate receptor; Ligand binding domain of the group II metabotropic glutamate receptor, a family that contains mGlu2R and mGlu3R, all of which inhibit adenylyl cyclase. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes


Pssm-ID: 380598 [Multi-domain]  Cd Length: 462  Bit Score: 873.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  26 LTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDF 105
Cdd:cd06375    1 IKLEGDLVLGGLFPVHEKGEGMEECGRINEDRGIQRLEAMLFAIDRINRDPHLLPGVRLGVHILDTCSRDTYALEQSLEF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 106 VRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTV 185
Cdd:cd06375   81 VRASLTKVDDSEYMCPDDGSYAIQEDSPLPIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 186 PPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARV 265
Cdd:cd06375  161 PPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSADRKSFDGVIRELLQKPNARV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 266 AVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWF 345
Cdd:cd06375  241 VVLFTRSDDARELLAAAKRLNASFTWVASDGWGAQESIVKGSEDVAEGAITLELASHPIPDFDRYFQSLTPYNNHRNPWF 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 346 REFWEQRFRCSFRQRDCAA------HSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLY 419
Cdd:cd06375  321 RDFWEQKFQCSLQNKSQAAsvsdkhLSIDSSNYEQESKIMFVVNAVYAMAHALHNMQRTLCPNTTRLCDAMRSLDGKKLY 400

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767923077 420 KDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRA-GSGRYRYQK 470
Cdd:cd06375  401 KDYLLNVSFTAPFPPADAGSEVKFDAFGDGLGRYNIFNYQRAgGSYGYRYKG 452
ANF_receptor pfam01094
Receptor family ligand binding region; This family includes extracellular ligand binding ...
 60-458 2.78e-91

Receptor family ligand binding region; This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.


Pssm-ID: 460062 [Multi-domain]  Cd Length: 347  Bit Score: 281.20  E-value: 2.78e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077   60 QRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRaslsrgadgsrhicpdgsyathgdapTAITGV 139
Cdd:pfam01094   1 LVLLAVRLAVEDINADPGLLPGTKLEYIILDTCCDPSLALAAALDLLK--------------------------GEVVAI 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  140 IGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGET 219
Cdd:pfam01094  55 IGPSCSSVASAVASLANEWKVPLISYGSTSPALSDLNRYPTFLRTTPSDTSQADAIVDILKHFGWKRVALIYSDDDYGES 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  220 GIEAFELEARARNICVATSEKVGRAMSraaFEGVVRALLQ--KPSARVAVLFTRSEDARELLAASQRLN---ASFTWVAS 294
Cdd:pfam01094 135 GLQALEDALRERGIRVAYKAVIPPAQD---DDEIARKLLKevKSRARVIVVCCSSETARRLLKAARELGmmgEGYVWIAT 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  295 DGWG-ALESVVAGSEGAAEGAITIELAsypisdfasyfqsldpwnNSRNPWFREFWEQRFRcsfrqrdcaahsLRAVPFE 373
Cdd:pfam01094 212 DGLTtSLVILNPSTLEAAGGVLGFRLH------------------PPDSPEFSEFFWEKLS------------DEKELYE 261

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  374 QESKIMFV-----VNAVYAMAHALHNMHRALCPNttRLCDAMRPVNGRRLYKDFVLNVKFDapfrpaDTHNEVRFDRFGD 448
Cdd:pfam01094 262 NLGGLPVSygalaYDAVYLLAHALHNLLRDDKPG--RACGALGPWNGGQKLLRYLKNVNFT------GLTGNVQFDENGD 333

                         410
                  ....*....|.
gi 767923077  449 GI-GRYNIFTY 458
Cdd:pfam01094 334 RInPDYDILNL 344
LivK COG0683
ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid ...
 58-293 6.32e-14

ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid transport and metabolism];


Pssm-ID: 440447 [Multi-domain]  Cd Length: 314  Bit Score: 72.27  E-value: 6.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  58 GIQRLEAMLFALDRINRDPHLLpGVRLGAHILDSCSKDTHALEQALDFVraslsrGADGsrhicpdgsyathgdaptaIT 137
Cdd:COG0683   20 GQPIKNGAELAVEEINAAGGVL-GRKIELVVEDDASDPDTAVAAARKLI------DQDK-------------------VD 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 138 GVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAE-ILRFFNWTYVSTVASEGDY 216
Cdd:COG0683   74 AIVGPLSSGVALAVAPVAEEAGVPLISPSATAPALTGPECSPYVFRTAPSDAQQAEALADyLAKKLGAKKVALLYDDYAY 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767923077 217 GETGIEAFELEARARNICVATSEKVGRamSRAAFEGVVRALLQKpSARVAVLFTRSEDARELLAASQRLNASFTWVA 293
Cdd:COG0683  154 GQGLAAAFKAALKAAGGEVVGEEYYPP--GTTDFSAQLTKIKAA-GPDAVFLAGYGGDAALFIKQAREAGLKGPLNK 227
 
Name Accession Description Interval E-value
PBP1_mGluR_groupII cd06375
ligand binding domain of the group II metabotropic glutamate receptor; Ligand binding domain ...
 26-470 0e+00

ligand binding domain of the group II metabotropic glutamate receptor; Ligand binding domain of the group II metabotropic glutamate receptor, a family that contains mGlu2R and mGlu3R, all of which inhibit adenylyl cyclase. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes


Pssm-ID: 380598 [Multi-domain]  Cd Length: 462  Bit Score: 873.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  26 LTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDF 105
Cdd:cd06375    1 IKLEGDLVLGGLFPVHEKGEGMEECGRINEDRGIQRLEAMLFAIDRINRDPHLLPGVRLGVHILDTCSRDTYALEQSLEF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 106 VRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTV 185
Cdd:cd06375   81 VRASLTKVDDSEYMCPDDGSYAIQEDSPLPIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 186 PPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARV 265
Cdd:cd06375  161 PPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSADRKSFDGVIRELLQKPNARV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 266 AVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWF 345
Cdd:cd06375  241 VVLFTRSDDARELLAAAKRLNASFTWVASDGWGAQESIVKGSEDVAEGAITLELASHPIPDFDRYFQSLTPYNNHRNPWF 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 346 REFWEQRFRCSFRQRDCAA------HSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLY 419
Cdd:cd06375  321 RDFWEQKFQCSLQNKSQAAsvsdkhLSIDSSNYEQESKIMFVVNAVYAMAHALHNMQRTLCPNTTRLCDAMRSLDGKKLY 400

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767923077 420 KDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRA-GSGRYRYQK 470
Cdd:cd06375  401 KDYLLNVSFTAPFPPADAGSEVKFDAFGDGLGRYNIFNYQRAgGSYGYRYKG 452
PBP1_mGluR cd06362
ligand binding domain of metabotropic glutamate receptors (mGluR); Ligand binding domain of ...
 30-470 0e+00

ligand binding domain of metabotropic glutamate receptors (mGluR); Ligand binding domain of the metabotropic glutamate receptors (mGluR), which are members of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses. mGluRs bind to glutamate and function as an excitatory neurotransmitter; they are involved in learning, memory, anxiety, and the perception of pain. Eight subtypes of mGluRs have been cloned so far, and are classified into three groups according to their sequence similarities, transduction mechanisms, and pharmacological profiles. Group I is composed of mGlu1R and mGlu5R that both stimulate PLC hydrolysis. Group II includes mGlu2R and mGlu3R, which inhibit adenylyl cyclase, as do mGlu4R, mGlu6R, mGlu7R, and mGlu8R, which form group III.


Pssm-ID: 380585 [Multi-domain]  Cd Length: 460  Bit Score: 606.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  30 GDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRAS 109
Cdd:cd06362    1 GDINLGGLFPVHERSSSGECCGEIREERGIQRLEAMLFAIDEINSRPDLLPNITLGFVILDDCSSDTTALEQALHFIRDS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 110 LSRG-ADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPD 188
Cdd:cd06362   81 LLSQeSAGFCQCSDDPPNLDESFQFYDVVGVIGAESSSVSIQVANLLRLFKIPQISYASTSDELSDKERYPYFLRTVPSD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 189 FFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVL 268
Cdd:cd06362  161 SFQAKAIVDILLHFNWTYVSVVYSEGSYGEEGYKAFKKLARKAGICIAESERISQDSDEKDYDDVIQKLLQKKNARVVVL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 269 FTRSEDARELLAASQRLNAS--FTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFR 346
Cdd:cd06362  241 FADQEDIRGLLRAAKRLGASgrFIWLGSDGWGTNIDDLKGNEDVALGALTVQPYSEEVPRFDDYFKSLTPSNNTRNPWFR 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 347 EFWEQRFRCSFR------QRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLC-DAMRPVNGRRLy 419
Cdd:cd06362  321 EFWQELFQCSFRpsrensCNDDKLLINKSEGYKQESKVSFVIDAVYAFAHALHKMHKDLCPGDTGLCqDLMKCIDGSEL- 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767923077 420 KDFVLNVKFdapfrPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQK 470
Cdd:cd06362  400 LEYLLNVSF-----TGEAGGEIRFDENGDGPGRYDIMNFQRNNDGSYEYVR 445
PBP1_mGluR_groupIII cd06376
ligand-binding domain of the group III metabotropic glutamate receptor; Ligand-binding domain ...
 28-469 0e+00

ligand-binding domain of the group III metabotropic glutamate receptor; Ligand-binding domain of the group III metabotropic glutamate receptor, a family which contains mGlu4R, mGluR6R, mGluR7, and mGluR8; all of which inhibit adenylyl cyclase. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes.


Pssm-ID: 380599 [Multi-domain]  Cd Length: 467  Bit Score: 530.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  28 LEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVR 107
Cdd:cd06376    3 VEGDITLGGLFPVHARGLAGVPCGEIKKEKGIHRLEAMLYALDQINSDPDLLPNVTLGARILDTCSRDTYALEQSLTFVQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 108 ASLSRgaDGSRHICPDGSYATHgDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPP 187
Cdd:cd06376   83 ALIQK--DTSDVRCTNGDPPVF-VKPEKVVGVIGASASSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 188 DFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEAR-ARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVA 266
Cdd:cd06376  160 DSFQAQAMVDIVKALGWNYVSTLASEGNYGEKGVESFVQISReAGGVCIAQSEKIPRERRTGDFDKIIKRLLETPNARAV 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 267 VLFTRSEDARELLAASQRLNAS--FTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPW 344
Cdd:cd06376  240 VIFADEDDIRRVLAAAKRANKTghFLWVGSDSWGAKISPVLQQEDVAEGAITILPKRASIEGFDAYFTSRTLENNRRNVW 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 345 FREFWEQRFRCSFRQ---------RDCAAHSL--RAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPV 413
Cdd:cd06376  320 FAEFWEENFNCKLTSsgskkedtlRKCTGQERigRDSGYEQEGKVQFVVDAVYAMAHALHNMNKDLCPGYRGLCPEMEPA 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767923077 414 NGRRLYKdFVLNVKFDApfrPADThnEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQ 469
Cdd:cd06376  400 GGKKLLK-YIRNVNFNG---SAGT--PVMFNKNGDAPGRYDIFQYQTTNGSNYGYR 449
PBP1_mGluR_groupI cd06374
ligand binding domain of the group I metabotropic glutamate receptor; Ligand binding domain of ...
 23-468 8.96e-171

ligand binding domain of the group I metabotropic glutamate receptor; Ligand binding domain of the group I metabotropic glutamate receptor, a family containing mGlu1R and mGlu5R, all of which stimulate phospholipase C (PLC) hydrolysis. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes.


Pssm-ID: 380597 [Multi-domain]  Cd Length: 474  Bit Score: 488.78  E-value: 8.96e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  23 KKVLTLEGDLVLGGLFPVH----QKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHA 98
Cdd:cd06374    1 RLVARMPGDIIIGALFPVHhqppLKKVFSRKCGEIREQYGIQRVEAMFRTLDKINKDPNLLPNITLGIEIRDSCWYSPVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  99 LEQALDFVRASL-SRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSR 177
Cdd:cd06374   81 LEQSIEFIRDSVaSVEDEKDTQNTPDPTPLSPPENRKPIVGVIGPGSSSVTIQVQNLLQLFHIPQIGYSATSIDLSDKSL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 178 YDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRAL 257
Cdd:cd06374  161 YKYFLRVVPSDYLQARAMLDIVKRYNWTYVSTVHTEGNYGESGIEAFKELAAEEGICIAHSDKIYSNAGEEEFDRLLRKL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 258 LQKPS-ARVAVLFTRSEDARELLAASQRLNAS--FTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSL 334
Cdd:cd06374  241 MNTPNkARVVVCFCEGETVRGLLKAMRRLNATghFLLIGSDGWADRKDVVEGYEDEAAGGITIKIHSPEVESFDEYYFNL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 335 DPWNNSRNPWFREFWEQRFRCSF---------RQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTR 405
Cdd:cd06374  321 KPETNSRNPWFREFWQHRFDCRLpghpdenpyFKKCCTGEESLLGNYVQDSKLGFVINAIYAMAHALHRMQEDLCGGYSV 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767923077 406 -LCDAMRPVNGrRLYKDFVLNVKFDAPFrpadtHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRY 468
Cdd:cd06374  401 gLCPAMLPING-SLLLDYLLNVSFVGVS-----GDTIMFDENGDPPGRYDIMNFQKTGEGSYDY 458
PBP1_GPCR_family_C-like cd06350
ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory ...
 33-468 6.02e-124

ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate; categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (m; Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The metabotropic glutamate receptors (mGluR) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. The mGluRs are coupled to G proteins and are thus distinct from the iGluRs which internally contain ligand-gated ion channels. The mGluR structure is divided into three regions: the extracellular region, the seven-spanning transmembrane region and the cytoplasmic region. The extracellular region is further divided into the ligand-binding domain (LBD) and the cysteine-rich domain. The LBD has sequence similarity to the LIVBP, which is a bacterial periplasmic protein (PBP), as well as to the extracellular region of both iGluR and the gamma-aminobutyric acid (GABA)b receptor. iGluRs are divided into three main subtypes based on pharmacological profile: NMDA, AMPA, and kainate receptors. All family C GPCRs have a large extracellular N terminus that contain a domain with homology to bacterial periplasmic amino acid-binding proteins.


Pssm-ID: 380573  Cd Length: 350  Bit Score: 364.69  E-value: 6.02e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  33 VLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRaslsr 112
Cdd:cd06350    1 IIGGLFPVHYRDDADFCCCGILNPRGVQLVEAMIYAIEEINNDSSLLPNVTLGYDIRDTCSSSSVALESSLEFLL----- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 113 gaDGSRHICPDGSYATHGDAPTAitGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQA 192
Cdd:cd06350   76 --DNGIKLLANSNGQNIGPPNIV--AVIGAASSSVSIAVANLLGLFKIPQISYASTSPELSDKIRYPYFLRTVPSDTLQA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 193 KAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRS 272
Cdd:cd06350  152 KAIADLLKHFNWNYVSTVYSDDDYGRSGIEAFEREAKERGICIAQTIVIPENSTEDEIKRIIDKLKSSPNAKVVVLFLTE 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 273 EDARELLAASQRLNA-SFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQsldpwnnsrnpwfrefweq 351
Cdd:cd06350  232 SDARELLKEAKRRNLtGFTWIGSDGWGDSLVILEGYEDVLGGAIGVVPRSKEIPGFDDYLK------------------- 292

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 352 rfrcsfrqrdcaahslravpfeqeSKIMFVVNAVYAmahalhnmhralcpnttrlcdamrpvngrrlykdfvlnvkfdap 431
Cdd:cd06350  293 ------------------------SYAPYVIDAVYA-------------------------------------------- 304

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 767923077 432 frpadthnEVRFDRFGDGIGRYNIFTYLRAGSGRYRY 468
Cdd:cd06350  305 --------TVKFDENGDGNGGYDIVNLQRTGTGNYEY 333
PBP1_ABC_transporter_GPCR_C-like cd04509
Family C of G-protein coupled receptors and their close homologs, the type 1 ...
 33-319 3.24e-95

Family C of G-protein coupled receptors and their close homologs, the type 1 periplasmic-binding proteins of ATP-binding cassette transporter-like systems; This CD includes members of the family C of G-protein coupled receptors and their close homologs, the type 1 periplasmic-binding proteins of ATP-binding cassette transporter-like systems. The family C GPCR includes glutamate/glycine-gated ion channels such as the NMDA receptor, G-protein-coupled receptors, metabotropic glutamate, GABA-B, calcium sensing, pheromone receptors, and atrial natriuretic peptide-guanylate cyclase receptors. The glutamate receptors that form cation-selective ion channels, iGluR, can be classified into three different subgroups according to their binding-affinity for the agonists NMDA (N-methyl-D-asparate), AMPA (alpha-amino-3-dihydro-5-methyl-3-oxo-4-isoxazolepropionic acid), and kainate. L-glutamate is a major neurotransmitter in the brain of vertebrates and acts through either mGluRs or iGluRs. mGluRs subunits possess seven transmembrane segments and a large N-terminal extracellular domain. ABC-type leucine-isoleucine-valine binding protein (LIVBP) is a bacterial periplasmic binding protein that has homology with the amino-terminal domain of the glutamate-receptor ion channels (iGluRs). The extracellular regions of iGluRs are made of two PBP-like domains in tandem, a LIVBP-like domain that constitutes the N terminus (included in this model) followed by a domain related to lysine-arginine-ornithine-binding protein (LAOBP) that belongs to the type 2 periplasmic binding fold protein superfamily. The uncharacterized periplasmic components of various ABC-type transport systems are also included in this family.


Pssm-ID: 380490  Cd Length: 306  Bit Score: 289.98  E-value: 3.24e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  33 VLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSR 112
Cdd:cd04509    1 KVGVLFAVHGKGPSGVPCGDIVAQYGIQRFEAMEQALDDINADPNLLPNNTLGIVIYDDCCDPKQALEQSNKFVNDLIQK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 113 GADGSRHIcpdGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQA 192
Cdd:cd04509   81 DTSDVRCT---NGEPPVFVKPEGIKGVIGHLCSSVTIPVSNILELFGIPQITYAATAPELSDDRGYQLFLRVVPLDSDQA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 193 KAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRS 272
Cdd:cd04509  158 PAMADIVKEKVWQYVSIVHDEGQYGEGGARAFQDGLKKGGLCIAFSDGITAGEKTKDFDRLVARLKKENNIRFVVYFGYH 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 767923077 273 EDARELLAASQRLN--ASFTWVASDGWGALESVVAGSEGAAEGAITIEL 319
Cdd:cd04509  238 PEMGQILRAARRAGlvGKFQFMGSDGWANVSLSLNIAEESAEGLITIKP 286
ANF_receptor pfam01094
Receptor family ligand binding region; This family includes extracellular ligand binding ...
 60-458 2.78e-91

Receptor family ligand binding region; This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.


Pssm-ID: 460062 [Multi-domain]  Cd Length: 347  Bit Score: 281.20  E-value: 2.78e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077   60 QRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRaslsrgadgsrhicpdgsyathgdapTAITGV 139
Cdd:pfam01094   1 LVLLAVRLAVEDINADPGLLPGTKLEYIILDTCCDPSLALAAALDLLK--------------------------GEVVAI 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  140 IGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGET 219
Cdd:pfam01094  55 IGPSCSSVASAVASLANEWKVPLISYGSTSPALSDLNRYPTFLRTTPSDTSQADAIVDILKHFGWKRVALIYSDDDYGES 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  220 GIEAFELEARARNICVATSEKVGRAMSraaFEGVVRALLQ--KPSARVAVLFTRSEDARELLAASQRLN---ASFTWVAS 294
Cdd:pfam01094 135 GLQALEDALRERGIRVAYKAVIPPAQD---DDEIARKLLKevKSRARVIVVCCSSETARRLLKAARELGmmgEGYVWIAT 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  295 DGWG-ALESVVAGSEGAAEGAITIELAsypisdfasyfqsldpwnNSRNPWFREFWEQRFRcsfrqrdcaahsLRAVPFE 373
Cdd:pfam01094 212 DGLTtSLVILNPSTLEAAGGVLGFRLH------------------PPDSPEFSEFFWEKLS------------DEKELYE 261

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  374 QESKIMFV-----VNAVYAMAHALHNMHRALCPNttRLCDAMRPVNGRRLYKDFVLNVKFDapfrpaDTHNEVRFDRFGD 448
Cdd:pfam01094 262 NLGGLPVSygalaYDAVYLLAHALHNLLRDDKPG--RACGALGPWNGGQKLLRYLKNVNFT------GLTGNVQFDENGD 333

                         410
                  ....*....|.
gi 767923077  449 GI-GRYNIFTY 458
Cdd:pfam01094 334 RInPDYDILNL 344
PBP1_CaSR cd06364
ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors ...
 33-470 1.39e-90

ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily. CaSR provides feedback control of extracellular calcium homeostasis by responding sensitively to acute fluctuations in extracellular ionized Ca2+ concentration. This ligand-binding domain has homology to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). CaSR is widely expressed in mammalian tissues and is active in tissues that are not directly involved in extracellular calcium homeostasis. Moreover, CaSR responds to aromatic, aliphatic, and polar amino acids, but not to positively charged or branched chain amino acids, which suggests that changes in plasma amino acid levels are likely to modulate whole body calcium metabolism. Additionally, the family C GPCRs includes at least two receptors with broad-spectrum amino acid-sensing properties: GPRC6A which recognizes basic and various aliphatic amino acids, its gold-fish homolog the 5.24 chemoreceptor, and a specific taste receptor (T1R) which responds to aliphatic, polar, charged, and branched amino acids, but not to aromatic amino acids.


Pssm-ID: 380587 [Multi-domain]  Cd Length: 473  Bit Score: 283.38  E-value: 1.39e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  33 VLGGLFPVHQK-GGPAEDCGPVNEH--------RGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQAL 103
Cdd:cd06364    1 IIGGLFPIHFRpVSPDPDFTTEPHSpecegfnfRGFRWAQTMIFAIEEINNSPDLLPNITLGYRIYDSCATISKALRAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 104 DFVRASLSRGADGSrhiCPdgsyathGDAPTAitGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFAR 183
Cdd:cd06364   81 ALVNGQEETNLDER---CS-------GGPPVA--AVIGESGSTLSIAVARTLGLFYIPQVSYFASCACLSDKKQFPSFLR 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 184 TVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRAlLQKPSA 263
Cdd:cd06364  149 TIPSDYYQSRALAQLVKHFGWTWVGAIASDDDYGRNGIKAFLEEAEKLGICIAFSETIPRTYSQEKILRIVEV-IKKSTA 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 264 RVAVLFTRSEDARELLAASQRLNAS-FTWVASDGWgALESVVAGSE--GAAEGAITIELASYPISDFASYFQSLDPWNNS 340
Cdd:cd06364  228 KVIVVFSSEGDLEPLIKELVRQNITgRQWIASEAW-ITSSLLATPEyfPVLGGTIGFAIRRGEIPGLKEFLLRVHPSKSP 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 341 RNPWFREFWEQRFRCSF------RQRD-----CAAH-SLRAV--PFEQESKIMF---VVNAVYAMAHALHNMHRalC--- 400
Cdd:cd06364  307 SNPFVKEFWEETFNCSLssssksNSSSssrppCTGSeNLENVqnPYTDVSQLRIsynVYKAVYAIAHALHDLLQ--Cepg 384

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767923077 401 --PNTTRLCDAMRPVNGRRLYKdFVLNVKFDAPFrpadtHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQK 470
Cdd:cd06364  385 kgPFSNGSCADIKKVEPWQLLY-YLKHVNFTTKF-----GEEVYFDENGDPVASYDIINWQLSDDGTIQFVT 450
PBP1_pheromone_receptor cd06365
Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within ...
 33-458 6.86e-67

Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors.


Pssm-ID: 380588 [Multi-domain]  Cd Length: 464  Bit Score: 221.75  E-value: 6.86e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  33 VLGGLFPVHQKGGPAED---------CGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQAL 103
Cdd:cd06365    1 IIGGVFPIHTFSEGKKKdfkeppsplLCFRFSIKYYQHLLAFLFAIEEINKNPDLLPNITLGFHIYDSCSSERLALESSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 104 DFvrasLSrgadGSRHICPDgsYATHGDapTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFAR 183
Cdd:cd06365   81 SI----LS----GNSEPIPN--YSCREQ--RKLVAFIGDLSSSTSVAMARILGLYKYPQISYGAFDPLLSDKVQFPSFYR 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 184 TVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKpSA 263
Cdd:cd06365  149 TVPSDTSQSLAIVQLLKHFGWTWVGLIISDDDYGEQFSQDLKKEMEKNGICVAFVEKIPTNSSLKRIIKYINQIIKS-SA 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 264 RVAVLFTRSEDareLLAASQRLNASF----TWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNN 339
Cdd:cd06365  228 NVIIIYGDTDS---LLELLFRLWEQLvtgkVWITTSQWDISTLPFEFYLNLFNGTLGFSQHSGEIPGFKEFLQSVHPSKY 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 340 SRNPWFREFWEQRFRCSFR-------QRDCAAHSLRAVPFEQESKIMF-----VVNAVYAMAHALHNMHRALCPNTTRLC 407
Cdd:cd06365  305 PEDIFLKTLWESYFNCKWPdqnckslQNCCGNESLETLDVHSFDMTMSrlsynVYNAVYAVAHALHEMLLCQPKTGPGNC 384

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767923077 408 DAMRPVNGRRLYkDFVLNVKFDAPFRpadthNEVRFDRFGDGIGRYNIFTY 458
Cdd:cd06365  385 SDRRNFQPWQLH-HYLKKVQFTNPAG-----DEVNFDEKGDLPTKYDILNW 429
PBP1_glutamate_receptors-like cd06269
ligand-binding domain of family C G-protein couples receptors (GPCRs), membrane bound guanylyl ...
 34-387 1.00e-60

ligand-binding domain of family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as natriuretic peptide receptors (NPRs), and N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of ionotropic glutamate rece; This CD represents the ligand-binding domain of the family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs), and the N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the ionotropic glutamate receptors, all of which are structurally similar and related to the periplasmic-binding fold type 1 family. The family C GPCRs consists of metabotropic glutamate receptor (mGluR), a calcium-sensing receptor (CaSR), gamma-aminobutyric acid receptor (GABAbR), the promiscuous L-alpha-amino acid receptor GPR6A, families of taste and pheromone receptors, and orphan receptors. Truncated splicing variants of the orphan receptors are not included in this CD. The family C GPCRs are activated by endogenous agonists such as amino acids, ions, and sugar based molecules. Their amino terminal ligand-binding region is homologous to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). The ionotropic glutamate receptors (iGluRs) have an integral ion channel and are subdivided into three major groups based on their pharmacology and structural similarities: NMDA receptors, AMPA receptors, and kainate receptors. The family of membrane bound guanylyl cyclases is further divided into three subfamilies: the ANP receptor (GC-A)/C-type natriuretic peptide receptor (GC-B), the heat-stable enterotoxin receptor (GC-C)/sensory organ specific membrane GCs such as retinal receptors (GC-E, GC-F), and olfactory receptors (GC-D and GC-G).


Pssm-ID: 380493 [Multi-domain]  Cd Length: 332  Bit Score: 201.49  E-value: 1.00e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  34 LGGLFPVHQKggpaedcgpvnEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASlsrg 113
Cdd:cd06269    2 IGALLPVHDY-----------LESGAKVLPAFELALSDVNSRPDLLPKTTLGLAIRDSECNPTQALLSACDLLAAA---- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 114 adgsrhicpdgsyathgdaptAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAK 193
Cdd:cd06269   67 ---------------------KVVAILGPGCSASAAPVANLARHWDIPVLSYGATAPGLSDKSRYAYFLRTVPPDSKQAD 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 194 AMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKV--GRAMSraaFEGVVRALLQKPsARVAVLFTR 271
Cdd:cd06269  126 AMLALVRRLGWNKVVLIYSDDEYGEFGLEGLEELFQEKGGLITSRQSFdeNKDDD---LTKLLRNLRDTE-ARVIILLAS 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 272 SEDARELLAASQRLN---ASFTWVASDGWGALES-VVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPwfRE 347
Cdd:cd06269  202 PDTARSLMLEAKRLDmtsKDYVWFVIDGEASSSDeHGDEARQAAEGAITVTLIFPVVKEFLKFSMELKLKSSKRKQ--GL 279

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 767923077 348 FWEQrfrcsfrqrdcaahslravpfEQESKIMFVVNAVYA 387
Cdd:cd06269  280 NEEY---------------------ELNNFAAFFYDAVLA 298
PBP1_taste_receptor cd06363
ligand-binding domain of the T1R taste receptor; Ligand-binding domain of the T1R taste ...
 26-455 2.20e-59

ligand-binding domain of the T1R taste receptor; Ligand-binding domain of the T1R taste receptor. The T1R is a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptors, GABAb receptors, the calcium-sensing receptor (CaSR), the V2R pheromone receptors, and a small group of uncharacterized orphan receptors.


Pssm-ID: 380586 [Multi-domain]  Cd Length: 418  Bit Score: 200.61  E-value: 2.20e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  26 LTLEGDLVLGGLFPVHQ--KGGPAE-------DCGPVNEHrGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSkDT 96
Cdd:cd06363    1 FRLPGDYLLGGLFPLHEltSTLPHRppeptdcSCDRFNLH-GYHLAQAMRFAVEEINNSSDLLPGVTLGYEIFDTCS-DA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  97 HALEQALDFvrasLSRgaDGSRHICPDGSYathGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKS 176
Cdd:cd06363   79 VNFRPTLSF----LSQ--NGSHDIEVQCNY---TNYQPRVVAVIGPDSSELALTTAKLLGFFLMPQISYGASSEELSNKL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 177 RYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKV-GRAMSRAAFEGVVR 255
Cdd:cd06363  150 LYPSFLRTVPSDKYQVEAMVQLLQEFGWNWVAFLGSDDEYGQDGLQLFSEKAANTGICVAYQGLIpTDTDPKPKYQDILK 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 256 AlLQKPSARVAVLFTRSEDARELLAASQRLNAS-FTWVASDGWgALESVVAGSEGAAEG----AITIELASYPisdfasy 330
Cdd:cd06363  230 K-INQTKVNVVVVFAPKQAAKAFFEEVIRQNLTgKVWIASEAW-SLNDTVTSLPGIQSIgtvlGFAIQTGTLP------- 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 331 fqsldpwnnsrnpwfrefweqRFRcsfrqrdcaahslravPFEqESKIMFVVNAVYAMAHALHNmhrALCPNTTRlCDAM 410
Cdd:cd06363  301 ---------------------GFQ----------------EFI-YAFAFSVYAAVYAVAHALHN---LLGCNSGA-CPKG 338

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 767923077 411 RPVNGRRLYKDfVLNVKFdapfrpaDTHNE-VRFDRFGDGIGRYNI 455
Cdd:cd06363  339 RVVYPWQLLEE-LKKVNF-------TLLNQtIRFDENGDPNFGYDI 376
PBP1_GPC6A-like cd06361
ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a ...
 33-297 4.53e-59

ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor; This family includes the ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor, and its fish homolog, the 5.24 chemoreceptor. GPRC6A is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses.


Pssm-ID: 380584 [Multi-domain]  Cd Length: 401  Bit Score: 199.13  E-value: 4.53e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  33 VLGGLFPVHQKGGPAEDCGPVNEH--------RGIQRLEAMLFALDRINRDPhLLPGVRLGAHILDSCSKDTHALEQALD 104
Cdd:cd06361    1 IIGGLFPIHEKVLDLHDRPTKPQIfictgfdlRGFLQSLAMIHAIEMINNST-LLPGIKLGYEIYDTCSDVTKALQATLR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 105 FVRASLSrgadgsrhiCPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFART 184
Cdd:cd06361   80 LLSKFNS---------SNELLECDYTDYVPPVKAVIGASYSEISIAVARLLNLQLIPQISYESSAPILSDKLRFPSFLRT 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 185 VPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQK---- 260
Cdd:cd06361  151 VPSDFHQTKAMAKLISHFGWNWVGIIYTDDDYGRSALESFIIQAEAENVCIAFKEVLPAYLSDPTMNVRINDTIQTiqss 230

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767923077 261 PSARVAVLFTRSEDARELLAASQRLNASFTWVASDGW 297
Cdd:cd06361  231 SQVNVVVLFLKPSLVKKLFKEVIERNISKIWIASDNW 267
PBP1_GABAb_receptor cd06366
ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for ...
 34-455 8.69e-34

ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA); Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and, like glutamate and other transmitters, acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb receptor or GABAbR). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha-i proteins, and activation causes a decrease in calcium, an increase in potassium membrane conductance, and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release, for example.


Pssm-ID: 380589 [Multi-domain]  Cd Length: 404  Bit Score: 131.21  E-value: 8.69e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  34 LGGLFPVHQKGGpaeDCGpvnehrGIQRLEAMLFALDRINRDPHLLPGVRLGAHIldscsKDTHaleqaldfvraslsrg 113
Cdd:cd06366    2 IGGLFPLSGSKG---WWG------GAGILPAAEMALEHINNRSDILPGYNLELIW-----NDTQ---------------- 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 114 adgsrhiCpDGSYATHG-----DAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPD 188
Cdd:cd06366   52 -------C-DPGLGLKAlydllYTPPPKVMLLGPGCSSVTEPVAEASKYWNLVQLSYAATSPALSDRKRYPYFFRTVPSD 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 189 FFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRamsraafEGVVRAL--LQKPSARVA 266
Cdd:cd06366  124 TAFNPARIALLKHFGWKRVATIYQNDEVFSSTAEDLEELLEEANITIVATESFSS-------EDPTDQLenLKEKDARII 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 267 VLFTRSEDARELLAASQRLN---ASFTWVA----SDGW-----GALESVVAGSEGAAEGAITIelasypisDFASYFQSL 334
Cdd:cd06366  197 IGLFYEDAARKVFCEAYKLGmygPKYVWILpgwyDDNWwdvpdNDVNCTPEQMLEALEGHFST--------ELLPLNPDN 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 335 DPWNNSRNPwfREFWEQrfrcsfrqrdcaahsLRAVPFEQESKIM----FVVNAVYAMAHALHNMHRALCPNTTRLCDA- 409
Cdd:cd06366  269 TKTISGLTA--QEFLKE---------------YLERLSNSNYTGSpyapFAYDAVWAIALALNKTIEKLAEYNKTLEDFt 331

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767923077 410 -----MrpvngRRLYKDFVLNVKFDAPfrpadtHNEVRFDRFGDGIGRYNI 455
Cdd:cd06366  332 yndkeM-----ADLFLEAMNSTSFEGV------SGPVSFDSKGDRLGTVDI 371
Periplasmic_Binding_Protein_type1 cd01391
Type 1 periplasmic binding fold superfamily; Type 1 periplasmic binding fold superfamily. This ...
 55-347 2.23e-24

Type 1 periplasmic binding fold superfamily; Type 1 periplasmic binding fold superfamily. This model and hierarchy represent the ligand binding domains of the LacI family of transcriptional regulators, periplasmic binding proteins of the ABC-type transport systems, the family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases including the family of natriuretic peptide receptors (NPRs), and the N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domains of the ionotropic glutamate receptors (iGluRs). In LacI-like transcriptional regulator and the bacterial periplasmic binding proteins, the ligands are monosaccharides, including lactose, ribose, fructose, xylose, arabinose, galactose/glucose and other sugars, with a few exceptions. Periplasmic sugar binding proteins are one of the components of ABC transporters and are involved in the active transport of water-soluble ligands. The LacI family of proteins consists of transcriptional regulators related to the lac repressor. In this case, the sugar binding domain binds a sugar which changes the DNA binding activity of the repressor domain. The periplasmic binding proteins are the primary receptors for chemotaxis and transport of many sugar based solutes. The core structures of periplasmic binding proteins are classified into two types, and they differ in number and order of beta strands: type 1 has six beta strands while type 2 has five beta strands per sub-domain. These two structural folds are thought to be distantly related via a common ancestor. Notably, while the N-terminal LIVBP-like domain of iGluRs belongs to the type 1 periplasmic-binding fold protein superfamily, the glutamate-binding domain of the iGluR is structurally similar to the type 2 periplasmic-binding fold.


Pssm-ID: 380477 [Multi-domain]  Cd Length: 280  Bit Score: 102.35  E-value: 2.23e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  55 EHRGIQRLEAMLFALDRINrdphllpgvrLGAHILDSCSKDTHALEQALDFVRASLSrgadgsrhicpdgsyathgdapt 134
Cdd:cd01391   14 EQFGIQRVEAIFHTADKLG----------ASVEIRDSCWHGSVALEQSIEFIRDNIA----------------------- 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 135 aitGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEG 214
Cdd:cd01391   61 ---GVIGPGSSSVAIVIQNLAQLFDIPQLALDATSQDLSDKTLYKYFLSVVFSDTLGARLGLDIVKRKNWTYVAAIHGEG 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 215 D-YGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTrSEDARELL--AASQRLNASFTW 291
Cdd:cd01391  138 LnSGELRMAGFKELAKQEGICIVASDKADWNAGEKGFDRALRKLREGLKARVIVCAN-DMTARGVLsaMRRLGLVGDVSV 216

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767923077 292 VASDGWGALESVVAGSEGaaEGAITIELASYPISDFASYFQSLDPWNNSRNPWFRE 347
Cdd:cd01391  217 IGSDGWADRDEVGYEVEA--NGLTTIKQQKMGFGITAIKAMADGSQNMHEEVWFDE 270
PBP1_SAP_GC-like cd06370
Ligand-binding domain of membrane bound guanylyl cyclases; Ligand-binding domain of membrane ...
 64-351 1.86e-20

Ligand-binding domain of membrane bound guanylyl cyclases; Ligand-binding domain of membrane bound guanylyl cyclases (GCs), which are known to be activated by sperm-activating peptides (SAPs), such as speract or resact. These ligand peptides are released by a range of invertebrates to stimulate the metabolism and motility of spermatozoa and are also potent chemoattractants. These GCs contain a single transmembrane segment, an extracellular ligand binding domain, and intracellular protein kinase-like and cyclase catalytic domains. GCs of insect and nematodes, which exhibit high sequence similarity to the speract receptor are also included in this model.


Pssm-ID: 380593 [Multi-domain]  Cd Length: 400  Bit Score: 93.08  E-value: 1.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  64 AMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDfvraslsrgadgsrHICPDgsyathgdaptaITGVIG-G 142
Cdd:cd06370   25 AITLAVDDVNNDPNLLPGHTLSFVWNDTRCDELLSIRAMTE--------------LWKRG------------VSAFIGpG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 143 SYSDVSIQVANLLRLfqiPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIE 222
Cdd:cd06370   79 CTCATEARLAAAFNL---PMISYKCADPEVSDKSLYPTFARTIPPDSQISKSVIALLKHFNWNKVSIVYENETKWSKIAD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 223 AFELEARARNICVATSEKV-GRAMSRAA----FEGVVRALLQKpsARVAVLFTRSEDARELL--AASQRLNAS----FTW 291
Cdd:cd06370  156 TIKELLELNNIEINHEEYFpDPYPYTTShgnpFDKIVEETKEK--TRIYVFLGDYSLLREFMyyAEDLGLLDNgdyvVIG 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767923077 292 VasdgwgALESVVAGSEGAAEGAITIELASYPISDFASYFQSL--DPWNNSRNPWFREFWEQ 351
Cdd:cd06370  234 V------ELDQYDVDDPAKYPNFLSGDYTKNDTKEALEAFRSVliVTPSPPTNPEYEKFTKK 289
PBP1_ABC_ligand_binding-like cd06346
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ...
 136-332 1.73e-19

type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.


Pssm-ID: 380569 [Multi-domain]  Cd Length: 314  Bit Score: 88.77  E-value: 1.73e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 136 ITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGD 215
Cdd:cd06346   68 VPAIVGAASSGVTLAVASVAVPNGVVQISPSSTSPALTTLEDKGYVFRTAPSDALQGVVLAQLAAERGFKKVAVIYVNND 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 216 YGETGIEAFE--LEARARNIcvatSEKVGRAMSRAAFEGVVRALLQ-KPSARVAVLFTrsEDARELLAASQRLNASFT-W 291
Cdd:cd06346  148 YGQGLADAFKkaFEALGGTV----TASVPYEPGQTSYRAELAQAAAgGPDALVLIGYP--EDGATILREALELGLDFTpW 221

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767923077 292 VASDGWGALESVVAGSEGAAEGAITIELASYPISD---FASYFQ 332
Cdd:cd06346  222 IGTDGLKSDDLVEAAGAEALEGMLGTAPGSPGSPAyeaFAAAYK 265
PBP1_NPR_GC-like cd06352
ligand-binding domain of membrane guanylyl-cyclase receptors; Ligand-binding domain of ...
 68-411 4.51e-15

ligand-binding domain of membrane guanylyl-cyclase receptors; Ligand-binding domain of membrane guanylyl-cyclase receptors. Membrane guanylyl cyclases (GC) have a single membrane-spanning region and are activated by endogenous and exogenous peptides. This family can be divided into three major subfamilies: the natriuretic peptide receptors (NPRs), sensory organ-specific membrane GCs, and the enterotoxin/guanylin receptors. The binding of peptide ligands to the receptor results in the activation of the cytosolic catalytic domain. Three types of NPRs have been cloned from mammalian tissues: NPR-A/GC-A, NPR-B/ GC-B, and NPR-C. In addition, two of the GCs, GC-D and GC-G, appear to be pseudogenes in humans. Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are produced in the heart, and both bind to the NPR-A. NPR-C, also termed the clearance receptor, binds each of the natriuretic peptides and can alter circulating levels of these peptides. The ligand binding domain of the NPRs exhibits strong structural similarity to the type 1 periplasmic binding fold protein family.


Pssm-ID: 380575 [Multi-domain]  Cd Length: 391  Bit Score: 76.63  E-value: 4.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  68 ALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVraslsrgadgsrhicpdgsYATHGDAptaitgVIGGSYSDV 147
Cdd:cd06352   27 AIERINSEGLLLPGFNFEFTYRDSCCDESEAVGAAADLI-------------------YKRNVDV------FIGPACSAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 148 SIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVAS-EGDYGETGIEAFEL 226
Cdd:cd06352   82 ADAVGRLATYWNIPIITWGAVSASFLDKSRYPTLTRTSPNSLSLAEALLALLKQFNWKRAAIIYSdDDSKCFSIANDLED 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 227 EARARNIC---------VATSEKVGRAMSRAafegvvrallqKPSARVAVLFTRSEDARE-LLAASQR--LNASFTWVA- 293
Cdd:cd06352  162 ALNQEDNLtisyyefveVNSDSDYSSILQEA-----------KKRARIIVLCFDSETVRQfMLAAHDLgmTNGEYVFIFi 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 294 ----SDGWGALESVVAGSEG-------AAEGAITIelasypisdfasyfqSLDPWNNSRNPWFREFWEQRFRCSFRQRDC 362
Cdd:cd06352  231 elfkDGFGGNSTDGWERNDGrdedakqAYESLLVI---------------SLSRPSNPEYDNFSKEVKARAKEPPFYCYD 295

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767923077 363 AAhslravpFEQESKimFVV---NAVYAMAHALHNMHRALC--PNTTRLCDAMR 411
Cdd:cd06352  296 AS-------EEEVSP--YAAalyDAVYLYALALNETLAEGGnyRNGTAIAQRMW 340
PBP1_ABC_transporter_LIVBP-like cd06268
periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the ...
 136-354 6.28e-15

periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily; Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily. They are mostly present in archaea and eubacteria, and are primarily involved in scavenging solutes from the environment. ABC-type transporters couple ATP hydrolysis with the uptake and efflux of a wide range of substrates across bacterial membranes, including amino acids, peptides, lipids and sterols, and various drugs. These systems are comprised of transmembrane domains, nucleotide binding domains, and in most bacterial uptake systems, periplasmic binding proteins (PBPs) which transfer the ligand to the extracellular gate of the transmembrane domains. These PBPs bind their substrates selectively and with high affinity. Members of this group include ABC-type Leucine-Isoleucine-Valine-Binding Proteins (LIVBP), which are homologous to the aliphatic amidase transcriptional repressor, AmiC, of Pseudomonas aeruginosa. The uncharacterized periplasmic components of various ABC-type transport systems are included in this group.


Pssm-ID: 380492 [Multi-domain]  Cd Length: 298  Bit Score: 75.06  E-value: 6.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 136 ITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSrYDYFARTVPPDFFQAKAMAE-ILRFFNWTYVSTVASEG 214
Cdd:cd06268   68 VLAVVGHYSSSVTLAAAPIYQEAGIPLISPGSTAPELTEGG-GPYVFRTVPSDAMQAAALADyLAKKLKGKKVAILYDDY 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 215 DYGETGIEAFELEARARNICVATSEKVgramSRAAFEgvVRALLQK-PSARVAVLFTR--SEDARELLAASQRLNASFTW 291
Cdd:cd06268  147 DYGKSLADAFKKALKALGGEIVAEEDF----PLGTTD--FSAQLTKiKAAGPDVLFLAgyGADAANALKQARELGLKLPI 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767923077 292 VASDGWGALESVVAGSEgAAEGAItielasypisdFASYFqsldPWNNSRNPWFREFWEQRFR 354
Cdd:cd06268  221 LGGDGLYSPELLKLGGE-AAEGVV-----------VAVPW----HPDSPDPPKQAFVKAYKKK 267
PBP1_GABAb_receptor_plant cd19990
periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close ...
 64-393 8.42e-15

periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants; This group includes the ligand-binding domain of Arabidopsis thaliana glutamate receptors, which have sequence similarity with animal ionotropic glutamate receptor and its close homologs in other plants. The ligand-binding domain of GABAb receptors are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and, like glutamate and other transmitters, acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb receptor or GABAbR). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha-i proteins, and activation causes a decrease in calcium, an increase in potassium membrane conductance, and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release, for example.


Pssm-ID: 380645 [Multi-domain]  Cd Length: 373  Bit Score: 75.73  E-value: 8.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  64 AMLFALDRINRDpHLLPGVRLGAHILDSCSKDTHALEQALDF-----VRAslsrgadgsrhicpdgsyathgdaptaitg 138
Cdd:cd19990   19 AIEMAVSDFNSD-SSSYGTKLVLHVRDSKGDPLQAASAALDLiknkkVEA------------------------------ 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 139 VIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSdKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGE 218
Cdd:cd19990   68 IIGPQTSEEASFVAELGNKAQVPIISFSATSPTLS-SLRWPFFIRMTHNDSSQMKAIAAIVQSYGWRRVVLIYEDDDYGS 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 219 TGIEAFELEARARNICVatSEKVgrAMSRAAFEGVVRALLQK---PSARVAVLFTRSEDARELLAASQRLN---ASFTWV 292
Cdd:cd19990  147 GIIPYLSDALQEVGSRI--EYRV--ALPPSSPEDSIEEELIKlksMQSRVFVVHMSSLLASRLFQEAKKLGmmeKGYVWI 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 293 ASDGWG-ALESVVAGSEGAAEGAITIElasypisdfaSYFqsldpwnnSRNPWFREF---WEQRFRCSFRQRDCAA---H 365
Cdd:cd19990  223 VTDGITnLLDSLDSSTISSMQGVIGIK----------TYI--------PESSEFQDFkarFRKKFRSEYPEEENAEpniY 284

                        330       340
                 ....*....|....*....|....*...
gi 767923077 366 SLRAvpfeqeskimfvVNAVYAMAHALH 393
Cdd:cd19990  285 ALRA------------YDAIWALAHAVE 300
LivK COG0683
ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid ...
 58-293 6.32e-14

ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid transport and metabolism];


Pssm-ID: 440447 [Multi-domain]  Cd Length: 314  Bit Score: 72.27  E-value: 6.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  58 GIQRLEAMLFALDRINRDPHLLpGVRLGAHILDSCSKDTHALEQALDFVraslsrGADGsrhicpdgsyathgdaptaIT 137
Cdd:COG0683   20 GQPIKNGAELAVEEINAAGGVL-GRKIELVVEDDASDPDTAVAAARKLI------DQDK-------------------VD 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 138 GVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAE-ILRFFNWTYVSTVASEGDY 216
Cdd:COG0683   74 AIVGPLSSGVALAVAPVAEEAGVPLISPSATAPALTGPECSPYVFRTAPSDAQQAEALADyLAKKLGAKKVALLYDDYAY 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767923077 217 GETGIEAFELEARARNICVATSEKVGRamSRAAFEGVVRALLQKpSARVAVLFTRSEDARELLAASQRLNASFTWVA 293
Cdd:COG0683  154 GQGLAAAFKAALKAAGGEVVGEEYYPP--GTTDFSAQLTKIKAA-GPDAVFLAGYGGDAALFIKQAREAGLKGPLNK 227
PBP1_iGluR_NMDA_NR1 cd06379
N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an ...
 157-294 4.85e-12

N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor. The ionotropic N-methyl-D-asparate (NMDA) subtype of glutamate receptor serves critical functions in neuronal development, functioning, and degeneration in the mammalian central nervous system. The functional NMDA receptor is a heterotetramer ccomposed of two NR1 and two NR2 (A, B, C, and D) or of NR3 (A and B) subunits. The receptor controls a cation channel that is highly permeable to monovalent ions and calcium and exhibits voltage-dependent inhibition by magnesium. Dual agonists, glutamate and glycine, are required for efficient activation of the NMDA receptor. When co-expressed with NR1, the NR3 subunits form receptors that are activated by glycine alone and therefore can be classified as excitatory glycine receptors. NR1/NR3 receptors are calcium-impermeable and unaffected by ligands acting at the NR2 glutamate-binding site


Pssm-ID: 380602  Cd Length: 364  Bit Score: 67.36  E-value: 4.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 157 LFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFE--LEAR----A 230
Cdd:cd06379   89 FYRIPVIGISARDSAFSDKNIHVSFLRTVPPYSHQADVWAEMLRHFEWKQVIVIHSDDQDGRALLGRLEtlAETKdikiE 168

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767923077 231 RNICVATSEK--VGRAMSraafegvvralLQKPSARVAVLFTRSEDARELLAASQRLN---ASFTWVAS 294
Cdd:cd06379  169 KVIEFEPGEKnfTSLLEE-----------MKELQSRVILLYASEDDAEIIFRDAAMLNmtgAGYVWIVT 226
PBP1_ABC_ligand_binding-like cd19984
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ...
 139-331 5.48e-12

type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.


Pssm-ID: 380639 [Multi-domain]  Cd Length: 296  Bit Score: 66.47  E-value: 5.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 139 VIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSryDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGE 218
Cdd:cd19984   71 IIGGVCSSETLAIAPIAEQNKVVLISPGASSPEITKAG--DYIFRNYPSDAYQGKVLAEFAYNKLYKKVAILYENNDYGV 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 219 TGIEAFELEARARNICVATSEKVGRAmsraafEGVVRALLQK-PSARVAVLF--TRSEDARELLAASQRLNASFTWVASD 295
Cdd:cd19984  149 GLKDVFKKEFEELGGKIVASESFEQG------ETDFRTQLTKiKAANPDAIFlpGYPKEGGLILKQAKELGIKAPILGSD 222

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767923077 296 GWGAlESVVAGSEGAAEGAITIELASYPISDFASYF 331
Cdd:cd19984  223 GFED-PELLEIAGEAAEGVIFTYPAFDDSSEKKQKF 257
PBP1_ABC_LIVBP-like cd06342
type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active ...
 136-315 1.10e-10

type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); This subgroup includes the type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine). This subgroup also includes a leucine-specific binding protein (or LivK), which is very similar in sequence and structure to leucine-isoleucine-valine binding protein (LIVBP). ABC-type active transport systems are transmembrane proteins that function in the transport of diverse sets of substrates across extra- and intracellular membranes, including carbohydrates, amino acids, inorganic ions, dipeptides and oligopeptides, metabolic products, lipids and sterols, and heme, to name a few.


Pssm-ID: 380565 [Multi-domain]  Cd Length: 334  Bit Score: 62.93  E-value: 1.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 136 ITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKsRYDYFARTVPPDFFQAKAMAEILrfFNWTYVSTVA--SE 213
Cdd:cd06342   67 VVAVIGHYNSGAAIAAAPIYAEAGIPMISPSATNPKLTEQ-GYKNFFRVVGTDDQQGPAAADYA--AKTLKAKRVAviHD 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 214 G-DYGETGIEAFELEARARNICVATSEKVGRAMSraAFEGVVRALLQ-KPSarvAVLFT-RSEDARELLAASQRLNASFT 290
Cdd:cd06342  144 GtAYGKGLADAFKKALKALGGTVVGREGITPGTT--DFSALLTKIKAaNPD---AVYFGgYYPEAGLLLRQLREAGLKAP 218

                        170       180
                 ....*....|....*....|....*
gi 767923077 291 WVASDGwGALESVVAGSEGAAEGAI 315
Cdd:cd06342  219 FMGGDG-IVSPDFIKAAGDAAEGVY 242
PBP1_ABC_ligand_binding-like cd19980
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ...
 139-329 2.82e-09

type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.


Pssm-ID: 380635 [Multi-domain]  Cd Length: 334  Bit Score: 58.39  E-value: 2.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 139 VIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSdKSRYDYFARTVPPDFFQAKAMAE-ILRFFNWTYVSTVASEGDYG 217
Cdd:cd19980   71 IIGAWCSSVTLAVMPVAERAKVPLVVEISSAPKIT-EGGNPYVFRLNPTNSMLAKAFAKyLADKGKPKKVAFLAENDDYG 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 218 ETGIEAFELEARARNICVATSEKVGR-------AMSRaafegvVRALlqkpSARVAVLFTRSEDARELLAASQRLNASFT 290
Cdd:cd19980  150 RGAAEAFKKALKAKGVKVVATEYFDQgqtdfttQLTK------LKAA----NPDAIFVVAETEDGALILKQARELGLKQQ 219

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767923077 291 WVASDGWGALESVVAGSEgAAEGAITIELASYPISDFAS 329
Cdd:cd19980  220 LVGTGGTTSPDLIKLAGD-AAEGVYGASIYAPTADNPAN 257
PBP1_ABC_RPA1789-like cd06333
type 1 periplasmic binding-protein component (CouP) of an ABC system (CouPSTU; RPA1789, ...
 58-244 3.53e-08

type 1 periplasmic binding-protein component (CouP) of an ABC system (CouPSTU; RPA1789, RPA1791-1793), involved in active transport of lignin-derived aromatic substrates, and its close homologs; This group includes RPA1789 (CouP) from Rhodopseudomonas palustris and its close homologs in other bacteria. RPA1789 (CouP) is the periplasmic binding-protein component of an ABC system (CouPSTU; RPA1789, RPA1791-1793) that is involved in the active transport of lignin-derived aromatic substrates. Members of this group has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP).


Pssm-ID: 380556 [Multi-domain]  Cd Length: 342  Bit Score: 55.25  E-value: 3.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  58 GIQRLEAMLFALDRINRDPHLLpGVRLGAHILDSCSKDTHALEQAldfvraslsrgadgSRHICPDGsyathgdaptaIT 137
Cdd:cd06333   16 GIPERNAVELLVEQINAAGGIN-GRKLELIVYDDESDPTKAVTNA--------------RKLIEEDK-----------VD 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 138 GVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYfaRTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYG 217
Cdd:cd06333   70 AIIGPSTTGESLAVAPIAEEAKVPLISLAGAAAIVEPVRKWVF--KTPQSDSLVAEAILDYMKKKGIKKVALLGDSDAYG 147

                        170       180
                 ....*....|....*....|....*..
gi 767923077 218 ETGIEAFELEARARNICVATSEKVGRA 244
Cdd:cd06333  148 QSGRAALKKLAPEYGIEIVADERFART 174
PBP1_ABC_HAAT-like cd19985
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ...
 138-298 1.34e-07

type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of hydrophobic amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of hydrophobic amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.


Pssm-ID: 380640 [Multi-domain]  Cd Length: 321  Bit Score: 53.05  E-value: 1.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 138 GVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYdYFaRTVPPDFFQAKAMAEILR-FFNWTYVSTVASEGDY 216
Cdd:cd19985   69 AVIGHYYSSASIAAGKIYKKAGIPAITPSATADAVTRDNPW-YF-RVIFNDSLQGRFLANYAKkVLKKDKVSIIYEEDSY 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 217 GETGIEAFELEARARNICVATSEKVGRAMS--RAAFEGVVRALLQKPS-ARVAVLFTRSEDARELLAASQRLNASFTWVA 293
Cdd:cd19985  147 GKSLASVFEATARALGLKVLKKWSFDTDSSqlDQNLDQIVDELKKAPDePGVIFLATHADEGAKLIKKLRDAGLKAPIIG 226


                 ....*
gi 767923077 294 SDGWG 298
Cdd:cd19985  227 PDSLA 231
PBP1_iGluR_NMDA cd06367
N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the ionotropic ...
 160-323 2.15e-07

N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the ionotropic N-methyl-D-asparate (NMDA) subtype of glutamate receptors; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the ionotropic N-methyl-D-asparate (NMDA) subtype of glutamate receptors. While this N-terminal domain belongs to the periplasmic-binding fold type 1 superfamily, the glutamate-binding domain of the iGluR is structurally homologous to the periplasmic-binding fold type 2. The LIVBP-like domain of iGluRs is thought to play a role in the initial assembly of iGluR subunits, but it is not well understood how this domain is arranged and functions in intact iGluR. The function of the NMDA subtype receptor serves critical functions in neuronal development, functioning, and degeneration in the mammalian central nervous system. The functional NMDA receptor is a heterotetramer comprising two NR1 and two NR2 (A, B, C, and D) or NR3 (A and B) subunits. The receptor controls a cation channel that is highly permeable to monovalent ions and calcium and exhibits voltage-dependent inhibition by magnesium. Dual agonists, glutamate and glycine, are required for efficient activation of the NMDA receptor. Among NMDA receptor subtypes, the NR2B subunit containing receptors appear particularly important for pain perception; thus NR2B-selective antagonists may be useful in the treatment of chronic pain.


Pssm-ID: 380590 [Multi-domain]  Cd Length: 357  Bit Score: 52.63  E-value: 2.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 160 IPQISYASTSAK-LSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEgDYGETGIEAfELEARARNICVATS 238
Cdd:cd06367   91 TPVLGLHGRSSMiMADKSEHSMFLQFGPPIEQQASVMLNIMEEYDWYIVSLVTTY-FPGYQDFVN-KLRSTIENSGWELE 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 239 EKVGRAMSRAAFEGVVRALL---QKPSARVAVLFTRSEDARELLAASQRLN---ASFTWVasdgwgaLESVVAGSE---- 308
Cdd:cd06367  169 EVLQLDMSLDDGDSKLQAQLkklQSPEARVILLYCTKEEATYVFEVAASVGltgYGYTWL-------VGSLVAGTDtvpa 241

                        170
                 ....*....|....*
gi 767923077 309 GAAEGAITIELASYP 323
Cdd:cd06367  242 EFPTGLISLSYDEWY 256
PBP1_GC_G-like cd06372
Ligand-binding domain of membrane guanylyl cyclase G; This group includes the ligand-binding ...
 60-286 2.69e-07

Ligand-binding domain of membrane guanylyl cyclase G; This group includes the ligand-binding domain of membrane guanylyl cyclase G (GC-G) which is a sperm surface receptor and might function, similar to its sea urchin counterpart, in the early signaling event that regulates the Ca2+ influx/efflux and subsequent motility response in sperm. GC-G appears to be a pseudogene in human. Furthermore, in contrast to the other orphan receptor GCs, GC-G has a broad tissue distribution in rat, including lung, intestine, kidney, and skeletal muscle.


Pssm-ID: 380595 [Multi-domain]  Cd Length: 390  Bit Score: 52.49  E-value: 2.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077  60 QRLEAML-FALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRaslsrgadgSRHI-------CPDGSyathgd 131
Cdd:cd06372   17 QRLGSAIqLAVDKVNSEPSLLGNYSLDFVYTDCGCNAKESLGAFIDQVQ---------KENIsalfgpaCPEAA------ 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 132 aptAITGVIGGSYSdvsiqvanllrlfqIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYV---- 207
Cdd:cd06372   82 ---EVTGLLASEWN--------------IPMFGFVGQSPKLDDRDVYDTYVKLVPPLQRIGEVLVKTLQFFGWTHVamfg 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 208 -STVASEGDYGETGIEAFELEARAR-NIcvatsekvgraMSRAAFEGVVRALLQK------PSARVAVLFTRSEDARELL 279
Cdd:cd06372  145 gSSATSTWDKVDELWKSVENQLKFNfNV-----------TAKVKYDTSNPDLLQEnlryisSVARVIVLICSSEDARSIL 213


                 ....*..
gi 767923077 280 AASQRLN 286
Cdd:cd06372  214 LEAEKLG 220
PBP1_ABC_HAAT-like cd06344
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ...
 136-239 3.25e-07

type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of hydrophobic amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of hydrophobic amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.


Pssm-ID: 380567 [Multi-domain]  Cd Length: 332  Bit Score: 52.23  E-value: 3.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 136 ITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKsRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGD 215
Cdd:cd06344   66 VVAVIGHRSSYVAIPASIIYERAGLLMLSPGATAPKLTQH-GFKYIFRNIPSDEDIARQLARYAARQGYKRIVIYYDDDS 144

                         90       100
                 ....*....|....*....|....
gi 767923077 216 YGETGIEAFELEARARNICVATSE 239
Cdd:cd06344  145 YGKGLANAFEEEARELGITIVDRR 168
PBP1_ABC_ligand_binding-like cd06343
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ...
 135-353 4.40e-07

type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however its ligand specificity has not been determined experimentally.


Pssm-ID: 380566 [Multi-domain]  Cd Length: 355  Bit Score: 51.80  E-value: 4.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 135 AITGVIGGSysdVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFArTVPPDFFQAKAMAE-ILRFFNWTYVSTVASE 213
Cdd:cd06343   77 AIVGGLGTP---TNLAVRPYLNEAGVPQLFPATGASALSPPPKPYTFG-VQPSYEDEGRILADyIVETLPAAKVAVLYQN 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 214 GDYGETGIEAFELEARARNICVATSEKVGRAMsrAAFEGVVRALLQKpSARVAVLFTRSEDARELLAASQRLNASFTWVA 293
Cdd:cd06343  153 DDFGKDGLEGLKEALKAYGLEVVAEETYEPGD--TDFSSQVLKLKAA-GADVVVLGTLPKEAAAALKEAAKLGWKPTFLG 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767923077 294 SDGWGALESVVAGSEGAAEGAITielasypisdfasyFQSLDPWNNSRNPW---FREFWEQRF 353
Cdd:cd06343  230 SSVSADPTTLAKAGGDAAEGVYS--------------ASYLKDPTDADDPAvkeFREAYKKYF 278
PBP1_ABC_LivK_ligand_binding-like cd06347
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ...
 136-197 5.11e-06

type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.


Pssm-ID: 380570 [Multi-domain]  Cd Length: 334  Bit Score: 48.31  E-value: 5.11e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767923077 136 ITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYdYFaRTVPPDFFQAKAMAE 197
Cdd:cd06347   68 VVAIIGPVTSSIALAAAPIAQKAKIPMITPSATNPLVTKGGDY-IF-RACFTDPFQGAALAK 127
PBP1_ABC_ligand_binding-like cd06335
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ...
 136-317 5.81e-05

type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.


Pssm-ID: 380558 [Multi-domain]  Cd Length: 348  Bit Score: 44.91  E-value: 5.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 136 ITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYD--YFARTVPPDFFQAKAMAEILRFFNWTYVSTVASE 213
Cdd:cd06335   68 VVAIIGPTNSGVALATIPILQEAKIPLIIPVATGTAITKPPAKPrnYIFRVAASDTLQADFLVDYAVKKGFKKIAILHDT 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 214 GDYGETGIEAFELEARARNICVATSEKVGR-------AMSRAafegvvrallQKPSARVAVLFTRSEDARELLAASQRLN 286
Cdd:cd06335  148 TGYGQGGLKDVEAALKKRGITPVATESFKIgdtdmtpQLLKA----------KDAGADVILVYGLGPDLAQILKAMEKLG 217

                        170       180       190
                 ....*....|....*....|....*....|....
gi 767923077 287 ASFTWVASdgWGALESVV---AGSegAAEGAITI 317
Cdd:cd06335  218 WKVPLVGS--WGLSMPNFielAGP--LAEGTIMT 247
PBP1_ABC_HAAT-like cd19988
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ...
 136-240 2.61e-04

type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.


Pssm-ID: 380643 [Multi-domain]  Cd Length: 302  Bit Score: 43.03  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 136 ITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDkSRYDYFARTVPPDFFQAKAMAE-ILRFFNWTYVSTVASEG 214
Cdd:cd19988   68 VWAIIGSINSSCTLAAIRVALKAGVPQINPGSSAPTITE-SGNPWVFRCTPDDRQQAYALVDyAFEKLKVTKIAVLYVND 146

                         90       100
                 ....*....|....*....|....*.
gi 767923077 215 DYGETGIEAFELEARARNICVATSEK 240
Cdd:cd19988  147 DYGRGGIDAFKDAAKKYGIEVVVEES 172
PBP1_ABC_HAAT-like cd19986
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ...
 139-197 2.38e-03

type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.


Pssm-ID: 380641 [Multi-domain]  Cd Length: 297  Bit Score: 39.92  E-value: 2.38e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767923077 139 VIGGSYSDVSIQVANLLRLFQIPQIsYASTSAKLSDKsRYDYFARTVPPDFFQAKAMAE 197
Cdd:cd19986   71 VIGPHYSTQVLAVSPLVKEAKIPVI-TGGTSPKLTEQ-GNPYMFRIRPSDSVSAKALAK 127
PBP1_ABC_HAAT-like cd19981
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ...
 138-228 7.08e-03

type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.


Pssm-ID: 380636 [Multi-domain]  Cd Length: 297  Bit Score: 38.43  E-value: 7.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767923077 138 GVIGGSYSDVSIQVANLLRLFQIPQIS-YASTSAKLSDKsryDYFARTVPPDFFQAKAMAEIL-RFFNWTYVSTVASEGD 215
Cdd:cd19981   70 AVVSGSYSGPTRAAAPIFQEAKVPMVSaYAVHPDITKAG---DYVFRVAFLGPVQGRAGAEYAvKDLGAKKVAILTIDND 146

                         90
                 ....*....|...
gi 767923077 216 YGETGIEAFELEA 228
Cdd:cd19981  147 FGKSLAAGFKEEA 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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