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Conserved domains on  [gi|767915136|ref|XP_011531371|]
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3-oxo-5-alpha-steroid 4-dehydrogenase 2 isoform X1 [Homo sapiens]

Protein Classification

3-oxo-5-alpha-steroid 4-dehydrogenase( domain architecture ID 10495092)

3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)) converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 31-180 6.27e-74

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


:

Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 218.81  E-value: 6.27e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915136   31 RPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGG 110
Cdd:pfam02544   1 ATMPLTIVAKAFAFCTLNGLIQGRYNSYYQPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPRGG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915136  111 LFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF 180
Cdd:pfam02544  81 LFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKFEKYPKSRKALIPFVF 150
 
Name Accession Description Interval E-value
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 31-180 6.27e-74

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 218.81  E-value: 6.27e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915136   31 RPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGG 110
Cdd:pfam02544   1 ATMPLTIVAKAFAFCTLNGLIQGRYNSYYQPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPRGG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915136  111 LFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF 180
Cdd:pfam02544  81 LFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKFEKYPKSRKALIPFVF 150
PLN02392 PLN02392
probable steroid reductase DET2
 19-180 4.23e-30

probable steroid reductase DET2


Pssm-ID: 178015  Cd Length: 260  Bit Score: 110.67  E-value: 4.23e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915136  19 LKTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLI-YCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLR 97
Cdd:PLN02392  98 LRLYRSTSQQNTKGFPVSMALLAFGFNLLNAYLQARWVShYKDDYEDGGWFWWRFFGGLVVFLWGMRINVWSDRVLVGLK 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915136  98 KPGEiSYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMF-EDYPKSRKALI 176
Cdd:PLN02392 178 REGG-GYKVPRGGWFELVSCPNYFGEIVEWLGWAVMTWSWAGFGFFLYTCSNLVPRACANHKWYLEKFgEDYPKGRKAVI 256


                 ....
gi 767915136 177 PFIF 180
Cdd:PLN02392 257 PFLY 260
 
Name Accession Description Interval E-value
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 31-180 6.27e-74

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 218.81  E-value: 6.27e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915136   31 RPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGG 110
Cdd:pfam02544   1 ATMPLTIVAKAFAFCTLNGLIQGRYNSYYQPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPRGG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915136  111 LFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF 180
Cdd:pfam02544  81 LFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKFEKYPKSRKALIPFVF 150
PLN02392 PLN02392
probable steroid reductase DET2
 19-180 4.23e-30

probable steroid reductase DET2


Pssm-ID: 178015  Cd Length: 260  Bit Score: 110.67  E-value: 4.23e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915136  19 LKTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLI-YCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLR 97
Cdd:PLN02392  98 LRLYRSTSQQNTKGFPVSMALLAFGFNLLNAYLQARWVShYKDDYEDGGWFWWRFFGGLVVFLWGMRINVWSDRVLVGLK 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915136  98 KPGEiSYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMF-EDYPKSRKALI 176
Cdd:PLN02392 178 REGG-GYKVPRGGWFELVSCPNYFGEIVEWLGWAVMTWSWAGFGFFLYTCSNLVPRACANHKWYLEKFgEDYPKGRKAVI 256


                 ....
gi 767915136 177 PFIF 180
Cdd:PLN02392 257 PFLY 260
PLN02560 PLN02560
enoyl-CoA reductase
 86-179 4.77e-13

enoyl-CoA reductase


Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 65.51  E-value: 4.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915136  86 NIHSDYILRQLRKP-GEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKM 164
Cdd:PLN02560 208 NFYCHIILRNLRKPdGKGGYQIPRGFLFNYVTCANYTTEIYQWLGFNIATQTVAGYLFLAVAAAIMTNWALAKHRRLKKL 287

                         90       100
                 ....*....|....*....|.
gi 767915136 165 FE------DYPKSRKALIPFI 179
Cdd:PLN02560 288 FDgkdgrpKYPRRWVILPPFL 308
PLN03164 PLN03164
3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal domain containing protein; Provisional
 65-180 1.10e-11

3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal domain containing protein; Provisional


Pssm-ID: 215610 [Multi-domain]  Cd Length: 323  Bit Score: 61.75  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915136  65 GWYTDIrfslGVFLFILGMGINIHSDYILRQLRKPGEIS--YRIPQGGLFTYVSGANFLGEIIEWIGYALAT-------W 135
Cdd:PLN03164 208 GWFQWI----GAAIFLWGWIHQYRCHAILGSLREHKKQAdeYVIPYGDWFEMVSCPHYLAEIVIYAGLLIASggtdltiW 283

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767915136 136 SLpaLAFAFFSLCFlglRAFHHHRFYLKMFEDYPKSRKALIPFIF 180
Cdd:PLN03164 284 LL--FGFVVANLTF---AAAETHRWYLQKFENYPRNRYAIIPFVY 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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