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Conserved domains on  [gi|768024557|ref|XP_011528423|]
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sulfotransferase 4A1 isoform X2 [Homo sapiens]

Protein Classification

sulfotransferase family protein( domain architecture ID 229543)

sulfotransferase family protein may utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to its substrate(s)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 super family cl21551
Sulfotransferase domain;
59-164 8.39e-28

Sulfotransferase domain;


The actual alignment was detected with superfamily member pfam00685:

Pssm-ID: 473908 [Multi-domain]  Cd Length: 253  Bit Score: 103.96  E-value: 8.39e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024557   59 YGSWFEHVQEFWEHRMDSNVLFLKYEDMHRDLVTMVEQLARFLGVSCDKAQLEALTEHCHQLV---DQCCNAEALPVG-- 133
Cdd:pfam00685 139 CGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENmkgNPCLNYSKLPKEvs 218

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 768024557  134 ----RGRVGLWKDIFTVSMNEKFDLVYKQKMGKCD 164
Cdd:pfam00685 219 pffrKGLVGDWKNYFTPEQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
59-164 8.39e-28

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 103.96  E-value: 8.39e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024557   59 YGSWFEHVQEFWEHRMDSNVLFLKYEDMHRDLVTMVEQLARFLGVSCDKAQLEALTEHCHQLV---DQCCNAEALPVG-- 133
Cdd:pfam00685 139 CGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENmkgNPCLNYSKLPKEvs 218

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 768024557  134 ----RGRVGLWKDIFTVSMNEKFDLVYKQKMGKCD 164
Cdd:pfam00685 219 pffrKGLVGDWKNYFTPEQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 58-102 3.17e-04

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 39.90  E-value: 3.17e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 768024557  58 GYGSWFEHVQEFWEHRMDS--NVLFLKYEDMHRDLVTMVEQLARFLG 102
Cdd:PLN02164 212 VYGPYLDHVLGYWKAYQENpdRILFLKYETMRADPLPYVKRLAEFMG 258
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
62-115 5.11e-03

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 36.14  E-value: 5.11e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024557  62 WFEHVQEF---WEHRMDSN---VLFLKYEDMHRDLVTMVEQLARFLGVSCDKAQLEALTE 115
Cdd:COG4424  154 LLEALQDFearWEAWFARTgitPLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK 213
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
59-164 8.39e-28

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 103.96  E-value: 8.39e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024557   59 YGSWFEHVQEFWEHRMDSNVLFLKYEDMHRDLVTMVEQLARFLGVSCDKAQLEALTEHCHQLV---DQCCNAEALPVG-- 133
Cdd:pfam00685 139 CGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENmkgNPCLNYSKLPKEvs 218

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 768024557  134 ----RGRVGLWKDIFTVSMNEKFDLVYKQKMGKCD 164
Cdd:pfam00685 219 pffrKGLVGDWKNYFTPEQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 58-102 3.17e-04

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 39.90  E-value: 3.17e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 768024557  58 GYGSWFEHVQEFWEHRMDS--NVLFLKYEDMHRDLVTMVEQLARFLG 102
Cdd:PLN02164 212 VYGPYLDHVLGYWKAYQENpdRILFLKYETMRADPLPYVKRLAEFMG 258
Sulfotransfer_3 pfam13469
Sulfotransferase family;
62-103 2.95e-03

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 36.50  E-value: 2.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 768024557   62 WFEHVQEFWEHRM---DSNVLFLKYEDMHRDLVTMVEQLARFLGV 103
Cdd:pfam13469 125 WSRAYERLMAARArvpPGRFLDVRYEDLVADPEGTLRRILEFLGL 169
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
62-115 5.11e-03

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 36.14  E-value: 5.11e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024557  62 WFEHVQEF---WEHRMDSN---VLFLKYEDMHRDLVTMVEQLARFLGVSCDKAQLEALTE 115
Cdd:COG4424  154 LLEALQDFearWEAWFARTgitPLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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