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Conserved domains on  [gi|767995738|ref|XP_011523480|]
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protein Wnt-9b isoform X1 [Homo sapiens]

Protein Classification

wnt family protein( domain architecture ID 14443642)

wnt family protein function in both normal development and differentiation as well as in mammary tumorigenesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 66-362 0e+00

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


:

Pssm-ID: 381728  Cd Length: 297  Bit Score: 591.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKRGFKETAFLYAVSSAALTHTLARACSAGR 145
Cdd:cd19354    1 LSRRQKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGRGSLLKRGFKETAFLYAVSSAALTHSLAKACSSGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 146 MERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 225
Cdd:cd19354   81 MERCTCDDSPGLENREAWQWGVCGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSC 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 226 AVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYSPG 305
Cdd:cd19354  161 AVRTCWKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERHGHTLKGHSPRSTDLVYLEDSPSFCRPSKYSPG 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767995738 306 TAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19354  241 TAGRTCSRETNCDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTCK 297
 
Name Accession Description Interval E-value
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 66-362 0e+00

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 591.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKRGFKETAFLYAVSSAALTHTLARACSAGR 145
Cdd:cd19354    1 LSRRQKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGRGSLLKRGFKETAFLYAVSSAALTHSLAKACSSGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 146 MERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 225
Cdd:cd19354   81 MERCTCDDSPGLENREAWQWGVCGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSC 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 226 AVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYSPG 305
Cdd:cd19354  161 AVRTCWKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERHGHTLKGHSPRSTDLVYLEDSPSFCRPSKYSPG 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767995738 306 TAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19354  241 TAGRTCSRETNCDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTCK 297
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 63-362 2.68e-136

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 390.37  E-value: 2.68e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738   63 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGR----MGLLKRGFKETAFLYAVSSAALTHTL 137
Cdd:pfam00110   2 LPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCStLENKrpvfGKVLKRGTRETAFVYAISSAGVTHAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  138 ARACSAGRMERCTCDDSPGLES--RQAWQWGVCGDNLKYSTKFLSNFLGSK-RGNKDLRARADAHNTHVGIKAVKSGLRT 214
Cdd:pfam00110  82 TRACSSGELTSCGCDRKKRGKSsgEGGWEWGGCSDNIDYGYKFSRKFVDAReKKRRDARALMNLHNNEAGRKAVKSNMRT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  215 TCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEAlGRLELWAPARQgsltkglAPRSGDLVYMEDSP 294
Cdd:pfam00110 162 ECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRNKR-GRLVPRNSRFK-------PPTKNDLVYLEKSP 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767995738  295 SFCRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:pfam00110 234 DYCERNPKtgSLGTRGRECNKTSsgpdGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
WNT1 smart00097
found in Wnt-1;
63-362 3.13e-100

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 298.46  E-value: 3.13e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738    63 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGRM---GLLKRGFKETAFLYAVSSAALTHTLA 138
Cdd:smart00097   2 LPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCStLDNASvfgKVLRQGTRETAFVYAISSAGVAHAVT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738   139 RACSAGRMERCTCDDSP-GLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCK 217
Cdd:smart00097  82 RACSEGELDSCGCDYRKrGRAGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKRECK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738   218 CHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVssatnEALGRLELWAPARQGSLTKglAPRSGDLVYMEDSPSFC 297
Cdd:smart00097 162 CHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEV-----EVDKRGTNKAPVPKNSTFK--PPTETDLVYLESSPDFC 234

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767995738   298 R--PSKYSPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:smart00097 235 EknPKTGSLGTQGRQCNKTSkgldGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
 
Name Accession Description Interval E-value
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 66-362 0e+00

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 591.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKRGFKETAFLYAVSSAALTHTLARACSAGR 145
Cdd:cd19354    1 LSRRQKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGRGSLLKRGFKETAFLYAVSSAALTHSLAKACSSGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 146 MERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 225
Cdd:cd19354   81 MERCTCDDSPGLENREAWQWGVCGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSC 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 226 AVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYSPG 305
Cdd:cd19354  161 AVRTCWKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERHGHTLKGHSPRSTDLVYLEDSPSFCRPSKYSPG 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767995738 306 TAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19354  241 TAGRTCSRETNCDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTCK 297
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 66-362 1.99e-164

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 461.37  E-value: 1.99e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLE-GRMGLLKRGFKETAFLYAVSSAALTHTLARACSAG 144
Cdd:cd19341    1 LSRRQRRMCRRDPGLAETLLEAIRLSVLECQEQFRYERWNCSLGkYRINLLKKGYKETAFLYAISSAGLTHSVARACSSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 145 RMERCTCDDSPGLE-SRQAWQWGVCGDNLKYSTKFLSNFLGSKRGN-KDLRARADAHNTHVGIKAVKSGLRTTCKCHGVS 222
Cdd:cd19341   81 RLDRCTCDESFSLEeNRQTWLWGGCGDNIKYGKKFTRRFLQLKKKSgKDLRAEIDRHNSEVGIRVVREGVKKTCKCHGVS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 223 GSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELwAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKY 302
Cdd:cd19341  161 GSCTVKTCWKQLAPFNEIGKILKRKYEKAVKVVSENNAATGGSQL-RKGKSGSVKKKSRPRRKDLVYLEKSPSFCRSTRY 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 303 SPGTAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19341  240 SPGTKGRRCLKGDNCDTLCCGRGYNTQSEVVVKPCKCRVVWCCQVECKTCTEREEIYTCK 299
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 66-362 1.40e-151

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 429.07  E-value: 1.40e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGR--MGLLKRGFKETAFLYAVSSAALTHTLARACSA 143
Cdd:cd19353    1 LERKQRRMCRRDPGVAETLMEAISMSALECQYQFRFERWNCTLEGRyrASLLKRGFKETAFLYAISSAGLTHAMAKACSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 144 GRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGsKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSG 223
Cdd:cd19353   81 GRMERCTCDEAPDLENREAWQWGGCGDNLKYSNKFVKEFLG-RKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHGVSG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 224 SCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYS 303
Cdd:cd19353  160 SCTVRTCWRQLSPFHEIGKQLKQKYETSLKVGSTTNEATGEGDISPPKKSGAGHSDQIPRTTDLVYIDDSPSFCLMSRFS 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767995738 304 PGTAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19353  240 PGTSGRRCYKDKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTCK 298
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 63-362 2.68e-136

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 390.37  E-value: 2.68e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738   63 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGR----MGLLKRGFKETAFLYAVSSAALTHTL 137
Cdd:pfam00110   2 LPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCStLENKrpvfGKVLKRGTRETAFVYAISSAGVTHAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  138 ARACSAGRMERCTCDDSPGLES--RQAWQWGVCGDNLKYSTKFLSNFLGSK-RGNKDLRARADAHNTHVGIKAVKSGLRT 214
Cdd:pfam00110  82 TRACSSGELTSCGCDRKKRGKSsgEGGWEWGGCSDNIDYGYKFSRKFVDAReKKRRDARALMNLHNNEAGRKAVKSNMRT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  215 TCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEAlGRLELWAPARQgsltkglAPRSGDLVYMEDSP 294
Cdd:pfam00110 162 ECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRNKR-GRLVPRNSRFK-------PPTKNDLVYLEKSP 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767995738  295 SFCRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:pfam00110 234 DYCERNPKtgSLGTRGRECNKTSsgpdGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 80-361 8.06e-109

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 320.01  E-value: 8.06e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  80 LAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGL----LKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDSP 155
Cdd:cd13113    1 LMESIAEGAQLALKECQRQFANRRWNCSTFNEPLLfgkiLKRGTRETAFVHAITSAGVTHAITRACSRGKLKNCGCDRTR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 156 -GLESRQAWQWGVCGDNLKYSTKFLSNFL--GSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWK 232
Cdd:cd13113   81 qGPEGQGDWTWGGCSDNIKFGIKFSRKFLdaREKKKGSDARSLMNLHNNEAGRKAVKKTMKKKCKCHGVSGSCTTKTCWR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 233 QLSPFRETGQVLKLRYDSAVKVSSATNealGRLELWAPARQGSLTkglaPRSGDLVYMEDSPSFCRP--SKYSPGTAGRV 310
Cdd:cd13113  161 QLPSFREIGDYLKEKYDNAVKVKLNNN---GSGLRLVPKRSRFRS----PTETDLVYLEESPDYCEPnpTLGSLGTAGRE 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767995738 311 CSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTC 361
Cdd:cd13113  234 CNPTSpgpdSCELLCCGRGYRTETEIVTEKCNCKFVWCCEVKCETCRRTVERYTC 288
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 66-362 6.37e-107

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 316.13  E-value: 6.37e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGR------MGLLKRGFKETAFLYAVSSAALTHTLA 138
Cdd:cd19342   10 LTREQLELCRRYPDVTASAIQGIQLAVHECQRQFRDHRWNCSsLETKnknphtSPILSRGYRETAFAYAISAAGVAHQVA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 139 RACSAGRMERCTCDDS--PGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTC 216
Cdd:cd19342   90 RACSLGKLLSCGCDRSrrGKRSSGNDWKWGGCSHNLDFGEKFSRKFLDSREKARDIHSRMNLHNNRAGRLAVSENMERKC 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 217 KCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSaTNEALGRLELWAPARQGSLTkglaPRSGDLVYMEDSPSF 296
Cdd:cd19342  170 KCHGMSGSCELKTCWKAAPDFREVGDILKEKYDHATLVDQ-SNLNNGARRRRLTRRKRRRR----PPKTDLVYYERSPNF 244

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767995738 297 CRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19342  245 CEADPSldSPGTRGRVCNKTStgpdSCDSLCCGRGYNTVRQTRTERCNCRFHWCCYVVCEKCTETEWVTVCK 316
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 65-362 3.62e-105

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 311.46  E-value: 3.62e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  65 KLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRM--GLLKRGFKETAFLYAVSSAALTHTLARACS 142
Cdd:cd19338   12 RLKGKQREICRKEPEILEEVAKGAKLGIRECQYQFRNRRWNCSTSRKSfgKILKRDTRETAFVYAITSAGVTYSVTRACS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 143 AGRMERCTCDDSPGLESRQ-AWQWGVCGDNLKYSTKFLSNFL-GSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHG 220
Cdd:cd19338   92 MGELLQCGCDKSKRGKSTEgEWEWGGCSDNVRYGYRKSREFMdAKEKNRSDIRTLMNLHNNEAGRLAVKNNMRKECKCHG 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 221 VSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSsatnealgrlelwaPARQGsltKGLAPRS--------GDLVYMED 292
Cdd:cd19338  172 LSGSCTLKTCWRKMPPFREVGDRLKERFDGAIKVK--------------GSNDG---KSLIPEGktikpptkEDLVYLEE 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767995738 293 SPSFCRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19338  235 SPDFCEPNKKtgSLGTRGRECNRTSmgvdGCDLLCCGRGYQTEVRVVEENCNCRFHWCCEVKCETCKVRKEIHTCN 310
WNT1 smart00097
found in Wnt-1;
63-362 3.13e-100

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 298.46  E-value: 3.13e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738    63 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGRM---GLLKRGFKETAFLYAVSSAALTHTLA 138
Cdd:smart00097   2 LPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCStLDNASvfgKVLRQGTRETAFVYAISSAGVAHAVT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738   139 RACSAGRMERCTCDDSP-GLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCK 217
Cdd:smart00097  82 RACSEGELDSCGCDYRKrGRAGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKRECK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738   218 CHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVssatnEALGRLELWAPARQGSLTKglAPRSGDLVYMEDSPSFC 297
Cdd:smart00097 162 CHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEV-----EVDKRGTNKAPVPKNSTFK--PPTETDLVYLESSPDFC 234

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767995738   298 R--PSKYSPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:smart00097 235 EknPKTGSLGTQGRQCNKTSkgldGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 66-362 8.38e-100

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 297.61  E-value: 8.38e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRM----GLLKRGFKETAFLYAVSSAALTHTLARAC 141
Cdd:cd19344    1 LVSQQRRLCKKKPEAIPSVSEGARLGIYECQHQFRHERWNCSTTNDQnvfgKTLSRGTKETAFIYAITSAGVVHAVTRAC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 142 SAGRMERCTCDDSP-GLESRQAWQWGVCGDNLKYSTKFLSNFL-----GSKRGNKDLRARADAHNTHVGIKAVKSGLRTT 215
Cdd:cd19344   81 SAGNLTDCSCDSRRqGQSASEGWKWGGCSDNVDYGIWFARKFVdapekSERKRSRDVRSLMNLHNNEVGRQAIARLMKVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 216 CKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVssATNEALGRLElwapaRQGSLTKGLAPRSGDLVYMEDSPS 295
Cdd:cd19344  161 CRCHGVSGSCEVKTCWKTMPSFEEVGDFLKQKYENSIQI--ATKKSKRRLR-----RRERRKRKVPISKDELVYIHKSPN 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767995738 296 FCR--PSKYSPGTAGRVCSREA----SCSSLCCGRGYDTQ-SRLVAfSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19344  234 YCVrdPKKGILGTSGRECNRTStgpdSCDLLCCGRGYNTQvVRHVE-RCNCKFVWCCYVKCKTCETMTDVHTCK 306
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 66-362 2.20e-98

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 294.24  E-value: 2.20e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMG-----LLKRGFKETAFLYAVSSAALTHTLARA 140
Cdd:cd19334   12 LVSKQRQLCRKHPDVMVSIGEGAKLGVKECQYQFRNQRWNCSTVDRDAtvfgkVLLKGSREAAFVYAISSAGVVHAITRA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 141 CSAGRMERCTCDDSP---GLESRQAWQWGVCGDNLKYSTKFLSNFLGSK-RGNKDLRARADAHNTHVGIKAVKSGLRTTC 216
Cdd:cd19334   92 CSKGELLNCACDPTKrgkGRDSKGEFDWGGCSDNVKYGINFARKFVDAReRRVRDARALMNLHNNRAGRKAVKKNLKLQC 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 217 KCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNealGRLELWAPARQGSLTKglaprsGDLVYMEDSPSF 296
Cdd:cd19334  172 KCHGVSGSCTIRTCWRALAEFREVGDYLREKYDGAVQVTMNQS---GTNLLAANKGHKKPTR------SDLVYFESSPDY 242

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767995738 297 CRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19334  243 CVPNPEtgSLGTAGRVCNKTStgtdGCDIMCCGRGYDTTRVRRTTKCNCKFHWCCQVKCKTCTETVDVHTCK 314
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 61-362 4.29e-95

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 285.68  E-value: 4.29e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  61 CDLLK-LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKR----GFKETAFLYAVSSAALTH 135
Cdd:cd19337    1 CDQLRgLSPGQRKLCQLYQDHMPSVGRGAKLAIEECQYQFRYRRWNCSTPDSSSVFGPvtniGTREAAFTYAISAAGVVH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 136 TLARACSAGRMERCTCDDSPGLES-RQAWQWGVCGDNLKYSTKFLSNFLGS-------KRGNKDL-RARADAHNTHVGIK 206
Cdd:cd19337   81 AIARACREGNLSTCGCSRERRPKDlPRDWLWGGCGDNIEYGYKFAKEFIDAreretnyPRHSRELaRVLMNLHNNEAGRR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 207 AVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATneaLGRLELwapARQGSLTKglaPRSGD 286
Cdd:cd19337  161 AVYEKARVACKCHGVSGSCSLKTCWRQLAPFREVGDRLKDKYDGAVKVKLNR---RGTLLR---RRNSRFNK---PTKDD 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 287 LVYMEDSPSFCRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYT 360
Cdd:cd19337  232 LVYLDDSPDYCERNPKtgSLGTKGRECNKTSsgtdGCELLCCGRGYNTKKVEVVERCHCKFHWCCEVKCKTCEKIVDVHI 311


                 ..
gi 767995738 361 CK 362
Cdd:cd19337  312 CK 313
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 66-362 1.78e-94

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 283.76  E-value: 1.78e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS---LEGRMGL-LKRGFKETAFLYAVSSAALTHTLARAC 141
Cdd:cd19343    1 LVGDQVKLCRRNLELMPSVVEAARLTVDTCQEQFADRRWNCSsieLAPNFTPdLTRGTREQAFVYALSSAALTHTIARAC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 142 SAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFL-GSKRGNKDLRARADA----HNTHVGIKAVKSGLRTTC 216
Cdd:cd19343   81 ASGALPGCGCGRLPREPPDGDFKWGGCGDNVRYGLRFAKRFTdAPEKKKKKKKRQARAlmnlHNNRVGRKAVRDSLETQC 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 217 KCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEalGRLELWAPARQGSLTkglapRSGDLVYMEDSPSF 296
Cdd:cd19343  161 KCHGVSGSCSVKTCWKALPDLSEVASRLKRKYARAVEVVSRKVG--SRRKLVPKSLKVRPY-----TKDDLIYLTKSPDY 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767995738 297 CRPSKY--SPGTAGRVC----SREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19343  234 CLPDEKlgSLGTRGRECnktsVGSDSCDSMCCGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTVEVHVCK 305
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 61-362 2.37e-92

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 278.82  E-value: 2.37e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  61 CDLLK-LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRM----GLLKRGFKETAFLYAVSSAALTH 135
Cdd:cd19336    1 CESLKgLTKRQVQFCKRNLEVMDSVRRGAQLAIEECQFQFRNRRWNCSTLDKEpvfgKVLNQGTREAAFVHAISSAGVAH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 136 TLARACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGS----KRGNKDLRARADAHNTHVGIKAVKSG 211
Cdd:cd19336   81 AVTRACSSGELEKCGCDRSVRGRSPEGFQWSGCSDNVAYGVAFSKSFVDArerrKGRASSSRALMNLHNNEAGRKAIEKN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 212 LRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVssatnealgrlelwAPARQGSlTKGLAPR-------- 283
Cdd:cd19336  161 MRVECKCHGVSGSCELKTCWRAMPTFREVGNILKEKFDGATEV--------------QQKRIGS-RPVLVPKnpqfkpht 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 284 SGDLVYMEDSPSFCR--PSKYSPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEEL 357
Cdd:cd19336  226 DADLVYLDSSPDFCEpdPKTGSLGTHGRVCNKTSkaidGCDLLCCGRGYVTRTEEVVERCSCKFHWCCYVKCKTCRREVE 305


                 ....*
gi 767995738 358 VYTCK 362
Cdd:cd19336  306 VHTCR 310
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 66-361 2.81e-92

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 278.47  E-value: 2.81e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMG-------LLKRGFKETAFLYAVSSAALTHTLA 138
Cdd:cd19333    1 LTKKQRRLVRQNPGTLHAIARGARMAIKECKWQFRNRRWNCPTTDSRGgpnvfgkILNRGCRETAFIYAITSAAVTHSVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 139 RACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKC 218
Cdd:cd19333   81 RACSEGSIESCSCDYRRRGPGGPDWEWGGCSDNIDFGRKFSREFVDAGEKGRDLRYLMNLHNNEAGRVHVSSEMRQECKC 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 219 HGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATN--------EALGRLELWAPARQgsltkglAPRSGDLVYM 290
Cdd:cd19333  161 HGMSGSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYGNNgnnrgsrrAKKFLLEPENPNHK-------PPTSKDLVYF 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767995738 291 EDSPSFCRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTC 361
Cdd:cd19333  234 EESPNFCEKNPKlgTLGTRGRECNATSigldGCDLMCCGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVHTC 310
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 66-362 2.63e-90

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 273.78  E-value: 2.63e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGR----MGLLKRGFKETAFLYAVSSAALTHTLARAC 141
Cdd:cd19339    8 LTPRQRAICQSRPDAIVAIGEGAQLGIEECQFQFRNHRWNCTLLGErtvfGQELPVGSREAAFTYAITSAGVAYAITQAC 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 142 SAGRMERCTCD--DSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCH 219
Cdd:cd19339   88 SQGNLSDCGCDksKKGYGKSDEGWKWGGCSADVKYGLRFSRKFVDAREVKRNARSLMNLHNNEAGRKAVEENLKLECKCH 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 220 GVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKglaPRSGDLVYMEDSPSFCR- 298
Cdd:cd19339  168 GVSGSCTTKTCWTTLPSFREIGDYLKKKYERARRVEPVRGRRRRRPTFLKLKISRKYKK---PRPRDLVYLEKSPNYCEk 244

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767995738 299 -PSKYSPGTAGRVCSR----EASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19339  245 dPLTGSLGTVGRRCNRtstgTDGCDLMCCGRGYNTHQYTKTWQCNCKFHWCCYVKCNTCSERTEEYTCK 313
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 66-362 1.43e-85

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 261.56  E-value: 1.43e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGRMGL----LKRGFKETAFLYAVSSAALTHTLARA 140
Cdd:cd19335   10 LVPKQLRFCRNYTELMPSVAEGAKLGIQECQHQFRGRRWNCTtIEGDLSVfgpvLDKASRESAFVHAIASAGVAHAVTRA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 141 CSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHG 220
Cdd:cd19335   90 CAEGDSTSCGCDSRHKGPPGEGWRWGGCSEDVEFGVRFSREFADARENRPDARSAMNRHNNEAGRQAILDNMELKCKCHG 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 221 VSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVK-VSSATNEALGRLELWAParqgSLTKGLAPRSGDLVYMEDSPSFCR- 298
Cdd:cd19335  170 LSGSCELKTCWWAQPDFRKIGDYLKDKYDSASEmVVERHRESRGWVETLRP----KYKLFKPPTERDLIYYEESPNFCEp 245

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767995738 299 -PSKYSPGTAGRVCSREAS----CSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19335  246 nPETGSFGTRGRECNVTSHgidgCDLLCCGRGYNTRTEKRTEKCHCIFVWCCYVSCQECIRVYDVHTCK 314
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 80-361 2.78e-81

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 250.29  E-value: 2.78e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  80 LAETLRDAAHLGLLECQFQFRHERWNCSLEGRM--GLLKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDS-PG 156
Cdd:cd19340    9 LSDSVAAGAQLAMEECQYQFKWDRWNCPESAFFsqKNNPSATRETAFVHAISSAGVMYTLTRNCSLGHFEGCGCDDSkKG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 157 LESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSP 236
Cdd:cd19340   89 SKGGEGWTWGGCSDNVKFGERVSKKFLDSLETGQDAQALMNLHNNRAGRKAVRKTMKKTCKCHGVSGSCSTQTCWMQLAP 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 237 FRETGQVLKLRYDSAVKVSSATnealGRLELWAPARQgslTKGLAPRSGDLVYMEDSPSFCRPSKY--SPGTAGRVCSR- 313
Cdd:cd19340  169 FREIGTDLKRKYDRAVRVDYEN----GGLRETNGSRA---IKLLNIKKNDLVYLEKSPNYCRANVTlgWPGTLGRQCSRd 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767995738 314 ---------EASCSSLCCGRGYDTQSR--LVAFSCHCQVQWCCYVECQQCVQEELVYTC 361
Cdd:cd19340  242 kkesvsrweRKSCRRLCRACGLKVRKKvvEVTSSCNCKFHWCCEVKCETCVELVIEYTC 300
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 66-362 6.74e-74

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 231.73  E-value: 6.74e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-------LEGRMGLlkRGFKETAFLYAVSSAALTHTLA 138
Cdd:cd19346   12 LVNKQRQLCQRHPDIMQSIGEGAKEWIRECQHQFRHHRWNCStldrdhtVFGRVML--RSSREAAFVYAISSAGVVYAIT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 139 RACSAGRMERCTCDDSPGLES---RQAWQWGVCGDNLKYSTKFLSNFLGSK-RGNKDLRARADAHNTHVGIKAVKSGLRT 214
Cdd:cd19346   90 RACSQGELKSCSCDPHKRGRShdeRGEFDWGGCSDNINYGIKFAKAFVDAKeKKEKDARALMNLHNNRCGRMAVKRFMKL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 215 TCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVsSATNEALGrlelWAPARQGSltkgLAPRSGDLVYMEDSP 294
Cdd:cd19346  170 ECKCHGVSGSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQV-TMNQDGTG----FTVANKNF----RKATKTDLVYFENSP 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767995738 295 SFCRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19346  241 DYCVMDKSagSLGTAGRVCNKSSrgtdGCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTCK 314
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 66-362 7.33e-74

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 231.86  E-value: 7.33e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGL----LKRGFKETAFLYAVSSAALTHTLARAC 141
Cdd:cd19349   13 LAPRQRAICQSRPDAIIVIGEGAQMGINECQFQFRNGRWNCSALGERTVfgkeLKVGSREAAFTYAIIAAGVAHAITAAC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 142 SAGRMERCTCDDSP--GLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCH 219
Cdd:cd19349   93 TQGNLSDCGCDKEKqgQYNQEEGWKWGGCSADIRYGIGFSKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCH 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 220 GVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKglaPRSGDLVYMEDSPSFCR- 298
Cdd:cd19349  173 GVSGSCTTKTCWTTLPKFRELGYILKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRK---PMDTDLVYIEKSPNYCEe 249

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767995738 299 -PSKYSPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19349  250 dPVTGSVGTQGRMCNKTAqqnnGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTCK 318
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 66-362 2.28e-73

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 230.21  E-value: 2.28e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNC-------SLEGRmgLLKRGFKETAFLYAVSSAALTHTLA 138
Cdd:cd19345   12 LVSRQRQLCHRHPEVMQAIGSGVKEWIAECQHQFRNHRWNCntldrdhSLFGR--LLLRSSRESAFVYAISSAGVVFAIT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 139 RACSAGRMERCTCDDSPGLESRQA---WQWGVCGDNLKYSTKFLSNFLGSK-RGNKDLRARADAHNTHVGIKAVKSGLRT 214
Cdd:cd19345   90 RACSQGELKSCSCDPKKKGSSKDSkgsFDWGGCSDNIDYGIRFARAFVDAKeRKGKDARALMNLHNNRAGRKAVKRFMTL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 215 TCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVsSATNEALGRLELWAPARQgsltkglaPRSGDLVYMEDSP 294
Cdd:cd19345  170 ECKCHGVSGSCTVRTCWLAMADFRKTGDYLRKKYNGAIQV-VMNQDGTGFTVANKHFKK--------PTKNDLVYFENSP 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767995738 295 SFCRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19345  241 DYCVRDRDagSLGTAGRVCNRTSrgmdGCEVMCCGRGYDTSRVGRMTKCECKFHWCCAVRCKDCHQQVDVHTCK 314
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 66-362 9.45e-71

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 223.32  E-value: 9.45e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGRMGL------LKRGFKETAFLYAVSSAALTHTLA 138
Cdd:cd19355   10 LTRRQLEVCMRHPDVTASAIQGIQIAIHECQHQFRDHRWNCSsLETRNKIpyesvvFSRGFRESAFAYAIAAAGVVHAVS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 139 RACSAGRMERCTCDdspglesrqaWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKC 218
Cdd:cd19355   90 NACAMGKLKACGCD----------WEWGGCSPDVEYGERFSKDFLDSRETYRDIHARMRLHNNRVGRQVVMDNMRRKCKC 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 219 HGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVsSATNEALGRLElwaparQGSLTKGLAPRSGDLVYMEDSPSFCR 298
Cdd:cd19355  160 HGTSGSCQLKTCWQVTPEFRTVGSLLKDRFYVATLI-KPHNRNTGQLE------PGHAPHRRRASINDLVYFEKSPDFCE 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 299 --PSKYSPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19355  233 rePRLDSAGTQGRICNKTSpgmdNCESLCCGRGHNILRQTRSERCNCKFHWCCYVVCEECRITEWVSVCK 302
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 66-362 2.01e-68

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 217.95  E-value: 2.01e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGL----LKRGFKETAFLYAVSSAALTHTLARAC 141
Cdd:cd19350   13 LAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRYGRWNCSALGERTVfgqeLRVGSREAAFTYAITAAGVAHAVTAAC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 142 SAGRMERCTCDDSPG--LESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCH 219
Cdd:cd19350   93 SQGNLSNCGCDREKQgyYNQEEGWKWGGCSADIKYGIDFSRKFVDAREIKKNARRLMNLHNNEAGRKVLEERMKLECKCH 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 220 GVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEalgRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRP 299
Cdd:cd19350  173 GVSGSCTTKTCWTTLPKFREIGYVLKEKYNAAVQVEVVRAS---RLRQPTFLKIKKRRSYQKPMETDLVYIERSPNYCEE 249

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767995738 300 SKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19350  250 DAAtgSVGTQGRLCNRTSphtdGCDLMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 318
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 66-362 2.21e-67

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 214.37  E-value: 2.21e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  66 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LE--GRM----GLLKRGFKETAFLYAVSSAALTHTLA 138
Cdd:cd19356   10 LSKRQMGLCVRSPDVTASALQGIQIAIHECQHQLRDQRWNCSsLEggGKLphdsAILKRGFRESAFSFSLLAAGVMHSVA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 139 RACSAGRMERCTCddspglesrqAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKC 218
Cdd:cd19356   90 TACSLGKLRGCGC----------EWEWGGCSHDIEFGEKFSRDFLDSRESPRDIQARMRIHNNRVGRQVVTENMKRKCKC 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 219 HGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEAlgrlelwaparqGSLTKGLAPR--SGDLVYMEDSPSF 296
Cdd:cd19356  160 HGTSGSCQFKTCWHVTPEFRLVGALLREKFQRAIFINSHNKNS------------GVFLPRLRPRrlARELVYFEKSPDF 227

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767995738 297 CR--PSKYSPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19356  228 CErdPAVDSPGTQGRICNKTSpgmdGCGSLCCGRGHNILKQTRSERCHCRFHWCCYVLCEECRVTEWVNVCK 299
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 63-362 8.44e-67

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 213.39  E-value: 8.44e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  63 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKR----GFKETAFLYAVSSAALTHTLA 138
Cdd:cd19347    4 LAGLSQGQKKLCQLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRvmqiGSRETAFTYAISAAGVVNAVS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 139 RACSAGRMERCTCDDSPGLESRQA-WQWGVCGDNLKYSTKFLSNFLGSKRGNK--------DLRARADAHNTHVGIKAVK 209
Cdd:cd19347   84 RACREGELSTCGCSRAARPKDLPRdWLWGGCGDNLEYGYRFAKEFVDAREREKiyqkgsyeSARTLMNLHNNEAGRRTVY 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 210 SGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLElwaparqgslTKGLAPRSGDLVY 289
Cdd:cd19347  164 NLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNSRGKLVQVN----------SRFNPPTTLDLVY 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767995738 290 MEDSPSFC--RPSKYSPGTAGRVCSREAS----CSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19347  234 IDPSPDYCvrNESTGSLGTQGRLCNKTSEgmdgCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK 312
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 63-362 7.35e-61

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 197.90  E-value: 7.35e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  63 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKR----GFKETAFLYAVSSAALTHTLA 138
Cdd:cd19348    4 LTGLSPGQRKLCQLYQDHMVYIGEGAKTGIKECQYQFRQRRWNCSTVDNTSVFGRvmqiGSRETAFTYAVSAAGVVNAIS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 139 RACSAGRMERCTCDDSPGLES-RQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDL--------RARADAHNTHVGIKAVK 209
Cdd:cd19348   84 RACREGELSTCGCSRAARPKDlPRDWLWGGCGDNVEYGYRFAKEFVDAREREKNYpkgseehaRTLMNLQNNEAGRRAVY 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 210 SGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNealGRLELWAparqgslTKGLAPRSGDLVY 289
Cdd:cd19348  164 NLADVACKCHGVSGSCSLKTCWLQLADFRKVGDLLKEKYDSAAAMRINRK---GKLELVN-------SRFNPPTAEDLVY 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767995738 290 MEDSPSFC--RPSKYSPGTAGRVCSREAS----CSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 362
Cdd:cd19348  234 IDPSPDYClrNETTGSLGTQGRLCNKTSEgmdgCELMCCGRGYDQFKTVQVERCHCKFHWCCYVKCKKCTEIVDQFVCK 312
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 81-361 4.26e-57

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 188.19  E-value: 4.26e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  81 AETLRDAAHLGLLECQFQFRHERWNCSlEGRMGL-----LKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDS- 154
Cdd:cd19351   10 SSSVAAGAQSGIEECKHQFAWERWNCP-ESALQLsthngLRSATRETSFVHAISSAGVMYTLTRNCSLGDFENCGCDDSr 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 155 PGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQL 234
Cdd:cd19351   89 NGRTGGRGWIWGGCSDNVEFGERISKQFVDALETGQDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGSCSIQTCWLQL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 235 SPFRETGQVLKLRYDSAVKVS------SATNEALGRlelWAPARQGSltkglAPRSGDLVYMEDSPSFC--RPSKYSPGT 306
Cdd:cd19351  169 ADFREIGNYLKVKHDQALKLEmdkrrmRAGNSADNR---GAIAEAFG-----SVAETELIYLEDSPDYCtkNASLGLQGT 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767995738 307 AGRVCSREA---------SCSSLC--CGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTC 361
Cdd:cd19351  241 EGRECLQSGknlsqwerrSCRRLCteCGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYC 306
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 87-361 6.47e-57

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 187.54  E-value: 6.47e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738  87 AAHLGLLECQFQFRHERWNCSLEG----RMGLLKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDS-PGLESRQ 161
Cdd:cd19352   17 GAQSGIEECKYQFAWDRWNCPERAlqlsSHSGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSrNGQLGGQ 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 162 AWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETG 241
Cdd:cd19352   97 GWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFREVG 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995738 242 QVLKLRYDSAVKVS---SATNEALGRlelwaparqGSLTKGLAPRS-GDLVYMEDSPSFCRPSKY--SPGTAGRVCSREA 315
Cdd:cd19352  177 NYLKEKYHRALKVDllqGAGNSAASR---------GAIAETFRSISkKELVHLEDSPDYCLENKTlgLLGTEGRECLKRG 247

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767995738 316 ---------SCSSLC--CGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTC 361
Cdd:cd19352  248 kalskwekrSCRRLCgdCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFC 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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