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Conserved domains on  [gi|767992243|ref|XP_011522204|]
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platelet-activating factor acetylhydrolase IB subunit beta isoform X1 [Homo sapiens]

Protein Classification

WD40 domain-containing protein( domain architecture ID 10553538)

WD40 domain-containing protein similar to Homo sapiens F-box-like/WD repeat-containing protein TBL1X/TBL1Y/TBL1XR1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-426 5.14e-118

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 345.86  E-value: 5.14e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 122 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE 201
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 202 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV 281
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 282 ATKECKAELREHEHVVECISWAPEssyssiseatgsetkksgkpGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRG 361
Cdd:cd00200  165 RTGKCVATLTGHTGEVNSVAFSPD--------------------GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767992243 362 VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 426
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 30-52 5.08e-05

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


:

Pssm-ID: 462501  Cd Length: 25  Bit Score: 39.99  E-value: 5.08e-05
                          10        20
                  ....*....|....*....|...
gi 767992243   30 NRAIADYLRSNGYEEAYSVFKKE 52
Cdd:pfam08513   3 NRLIYDYLVKEGYEETAEAFEKE 25
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-426 5.14e-118

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 345.86  E-value: 5.14e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 122 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE 201
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 202 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV 281
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 282 ATKECKAELREHEHVVECISWAPEssyssiseatgsetkksgkpGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRG 361
Cdd:cd00200  165 RTGKCVATLTGHTGEVNSVAFSPD--------------------GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767992243 362 VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 426
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
122-425 1.51e-99

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 302.99  E-value: 1.51e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 122 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE 201
Cdd:COG2319  116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 202 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV 281
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 282 ATKECKAELREHEHVVECISWAPEssyssiseatgsetkksgkpGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRG 361
Cdd:COG2319  276 ATGELLRTLTGHSGGVNSVAFSPD--------------------GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767992243 362 VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 425
Cdd:COG2319  336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
PTZ00421 PTZ00421
coronin; Provisional
 114-279 1.26e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 62.99  E-value: 1.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 114 PRPPekyALSGHRSPVTRVIFHPVFSV-MVSASEDATIKVWDYETGDFERT-------LKGHTDSVQDISFDHSGK-LLA 184
Cdd:PTZ00421  66 SNPP---ILLGQEGPIIDVAFNPFDPQkLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMnVLA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 185 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE-------WVRm 257
Cdd:PTZ00421 143 SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaksqrclWAK- 221

                        170       180
                 ....*....|....*....|..
gi 767992243 258 vRPNQDGTLIASCSNDQTVRVW 279
Cdd:PTZ00421 222 -RKDLIITLGCSKSQQRQIMLW 242
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 157-196 4.87e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 4.87e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767992243   157 TGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWD 196
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
158-196 4.22e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 4.22e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767992243  158 GDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWD 196
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 30-52 5.08e-05

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 39.99  E-value: 5.08e-05
                          10        20
                  ....*....|....*....|...
gi 767992243   30 NRAIADYLRSNGYEEAYSVFKKE 52
Cdd:pfam08513   3 NRLIYDYLVKEGYEETAEAFEKE 25
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 30-57 1.66e-04

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 38.57  E-value: 1.66e-04
                           10        20
                   ....*....|....*....|....*...
gi 767992243    30 NRAIADYLRSNGYEEAYSVFKKEAELDV 57
Cdd:smart00667   7 NRLILEYLLRNGYEETAETLQKESGLSL 34
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-426 5.14e-118

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 345.86  E-value: 5.14e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 122 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE 201
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 202 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV 281
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 282 ATKECKAELREHEHVVECISWAPEssyssiseatgsetkksgkpGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRG 361
Cdd:cd00200  165 RTGKCVATLTGHTGEVNSVAFSPD--------------------GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767992243 362 VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 426
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
122-425 1.51e-99

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 302.99  E-value: 1.51e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 122 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE 201
Cdd:COG2319  116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 202 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV 281
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 282 ATKECKAELREHEHVVECISWAPEssyssiseatgsetkksgkpGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRG 361
Cdd:COG2319  276 ATGELLRTLTGHSGGVNSVAFSPD--------------------GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767992243 362 VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 425
Cdd:COG2319  336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
112-426 4.04e-97

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 296.82  E-value: 4.04e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 112 WIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMT 191
Cdd:COG2319   64 DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 192 IKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 271
Cdd:COG2319  144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 272 NDQTVRVWVVATKECKAELREHEHVVECISWAPEssyssiseatgsetkksgkpGPFLLSGSRDKTIKMWDVSTGMCLMT 351
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD--------------------GRLLASGSADGTVRLWDLATGELLRT 283

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767992243 352 LVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 426
Cdd:COG2319  284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
142-425 3.00e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 224.79  E-value: 3.00e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 142 VSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPN 221
Cdd:COG2319   10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 222 GDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECIS 301
Cdd:COG2319   90 GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 302 WAPEssyssiseatgsetkksgkpGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 381
Cdd:COG2319  170 FSPD--------------------GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 767992243 382 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 425
Cdd:COG2319  230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
122-345 1.89e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 220.17  E-value: 1.89e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 122 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE 201
Cdd:COG2319  200 LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 202 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV 281
Cdd:COG2319  280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767992243 282 ATKECKAELREHEHVVECISWAPEssyssiseatgsetkksgkpGPFLLSGSRDKTIKMWDVST 345
Cdd:COG2319  360 ATGELLRTLTGHTGAVTSVAFSPD--------------------GRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 202-428 5.70e-65

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.88  E-value: 5.70e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 202 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV 281
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 282 ATKECKAELREHEHVVECISWAPEssyssiseatgsetkksgkpGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRG 361
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPD--------------------GRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767992243 362 VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 428
Cdd:cd00200  141 VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 110-279 2.16e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 177.14  E-value: 2.16e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 110 KEW-IPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSA 188
Cdd:cd00200  118 KVWdVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 189 DMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 268
Cdd:cd00200  198 DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                        170
                 ....*....|.
gi 767992243 269 SCSNDQTVRVW 279
Cdd:cd00200  278 SGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
175-426 1.89e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.48  E-value: 1.89e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 175 SFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREW 254
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 255 VRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPEssyssiseatgsetkksgkpGPFLLSGSR 334
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD--------------------GKTLASGSA 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 335 DKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVV 414
Cdd:COG2319  141 DGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                        250
                 ....*....|..
gi 767992243 415 TGSVDQTVKVWE 426
Cdd:COG2319  221 SGSADGTVRLWD 232
PTZ00421 PTZ00421
coronin; Provisional
 114-279 1.26e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 62.99  E-value: 1.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 114 PRPPekyALSGHRSPVTRVIFHPVFSV-MVSASEDATIKVWDYETGDFERT-------LKGHTDSVQDISFDHSGK-LLA 184
Cdd:PTZ00421  66 SNPP---ILLGQEGPIIDVAFNPFDPQkLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMnVLA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 185 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE-------WVRm 257
Cdd:PTZ00421 143 SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaksqrclWAK- 221

                        170       180
                 ....*....|....*....|..
gi 767992243 258 vRPNQDGTLIASCSNDQTVRVW 279
Cdd:PTZ00421 222 -RKDLIITLGCSKSQQRQIMLW 242
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 157-196 4.87e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 4.87e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767992243   157 TGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWD 196
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 200-238 3.35e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 3.35e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767992243   200 FECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 238
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
158-196 4.22e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 4.22e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767992243  158 GDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWD 196
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 154-426 4.95e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.56  E-value: 4.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 154 DYETGDfertLKGHTDSVQDISFDHSGKLLASCSADMTIKLwdfqgFECIRTMH-GHDHNVSSVAImpngdhivsASRDK 232
Cdd:PLN00181 473 DLKQGD----LLNSSNLVCAIGFDRDGEFFATAGVNKKIKI-----FECESIIKdGRDIHYPVVEL---------ASRSK 534

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 233 TikmwevqTGYCvktftghreWVRMVRpnqdgTLIASCSNDQTVRVWVVATKECKAELREHEHVVecisWAPESSyssis 312
Cdd:PLN00181 535 L-------SGIC---------WNSYIK-----SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRV----WSIDYS----- 584

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 313 eatgsetkkSGKPgPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNwVRGVLF--HSGGKFILSCADDKtLRVWDYKNKRC 390
Cdd:PLN00181 585 ---------SADP-TLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFpsESGRSLAFGSADHK-VYYYDLRNPKL 652

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767992243 391 -MKTLNAHEHFVTSLDFHKTAPyVVTGSVDQTVKVWE 426
Cdd:PLN00181 653 pLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 345-384 5.10e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 5.10e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767992243   345 TGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWD 384
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
346-384 6.00e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 6.00e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767992243  346 GMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWD 384
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
200-238 1.38e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 1.38e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767992243  200 FECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 238
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 122-240 3.48e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 55.28  E-value: 3.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 122 LSGHRSPVTRVIFHP-VFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 200
Cdd:PTZ00421 121 LQGHTKKVGIVSFHPsAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767992243 201 ECIRTMHGHDHNVSSVAI-MPNGDHIV----SASRDKTIKMWEVQ 240
Cdd:PTZ00421 201 TIVSSVEAHASAKSQRCLwAKRKDLIItlgcSKSQQRQIMLWDTR 245
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 241-279 5.73e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 5.73e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767992243   241 TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 279
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
242-279 8.69e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 8.69e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767992243  242 GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 279
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
388-426 1.12e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 1.12e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767992243  388 KRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 426
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 387-426 1.65e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.65e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767992243   387 NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 426
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
326-427 4.84e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 4.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 326 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLD 405
Cdd:COG2319    6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                         90       100
                 ....*....|....*....|..
gi 767992243 406 FHKTAPYVVTGSVDQTVKVWEC 427
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDL 107
PTZ00420 PTZ00420
coronin; Provisional
 96-198 6.61e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 51.49  E-value: 6.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243  96 EFTSGGPLGQKRDPKEWipRPPEKYALSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWDY--------ETGDFERTLKG 166
Cdd:PTZ00420  46 EVEGGGLIGAIRLENQM--RKPPVIKLKGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIphndesvkEIKDPQCILKG 123

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767992243 167 HTDSVQDISFDHSGK-LLASCSADMTIKLWDFQ 198
Cdd:PTZ00420 124 HKKKISIIDWNPMNYyIMCSSGFDSFVNIWDIE 156
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 122-154 1.54e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.54e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767992243   122 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWD 154
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 139-279 2.52e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 2.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 139 SVMVSASEDATIKVWDYETGDFERTLKGHTDsVQDISF-DHSGKLLASCSADMTIKLWDFQGFEC-IRTMHGHDHNVSSV 216
Cdd:PLN00181 589 TLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFpSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYV 667

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767992243 217 AIMpNGDHIVSASRDKTIKMWEVQTGYC------VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 279
Cdd:PLN00181 668 RFV-DSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVY 735
PTZ00420 PTZ00420
coronin; Provisional
 164-240 2.67e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.56  E-value: 2.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 164 LKGHTDSVQDISFDHS-GKLLASCSADMTIKLWDF----------QGFECIrtMHGHDHNVSSVAIMPNGDHIVSASR-D 231
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIphndesvkeiKDPQCI--LKGHKKKISIIDWNPMNYYIMCSSGfD 147


                 ....*....
gi 767992243 232 KTIKMWEVQ 240
Cdd:PTZ00420 148 SFVNIWDIE 156
WD40 pfam00400
WD domain, G-beta repeat;
122-154 8.63e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 8.63e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767992243  122 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWD 154
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 30-52 5.08e-05

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 39.99  E-value: 5.08e-05
                          10        20
                  ....*....|....*....|...
gi 767992243   30 NRAIADYLRSNGYEEAYSVFKKE 52
Cdd:pfam08513   3 NRLIYDYLVKEGYEETAEAFEKE 25
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 139-279 6.23e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 6.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 139 SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSG-KLLASCSADMTIKLWDFQGFECIRTMHGhDHNVSSVA 217
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQ 624

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767992243 218 I-MPNGDHIVSASRDKTIKMWEVQT---GYCvkTFTGHREWVRMVRPNQDGTLIAScSNDQTVRVW 279
Cdd:PLN00181 625 FpSESGRSLAFGSADHKVYYYDLRNpklPLC--TMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 283-342 1.03e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.03e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243   283 TKECKAELREHEHVVECISWAPEssyssiseatgsetkksgkpGPFLLSGSRDKTIKMWD 342
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--------------------GKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
118-157 1.26e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 1.26e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767992243 118 EKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYET 157
Cdd:COG2319  364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 30-57 1.66e-04

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 38.57  E-value: 1.66e-04
                           10        20
                   ....*....|....*....|....*...
gi 767992243    30 NRAIADYLRSNGYEEAYSVFKKEAELDV 57
Cdd:smart00667   7 NRLILEYLLRNGYEETAETLQKESGLSL 34
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 118-154 2.16e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 2.16e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767992243 118 EKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWD 154
Cdd:cd00200  253 CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PTZ00421 PTZ00421
coronin; Provisional
 327-428 3.79e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 327 PF----LLSGSRDKTIKMWDV-------STGMCLMTLVGHDNWVRGVLFHSGGKFILSCAD-DKTLRVWDYKNKRCMKTL 394
Cdd:PTZ00421  85 PFdpqkLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKAVEVI 164

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767992243 395 NAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 428
Cdd:PTZ00421 165 KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR 198
WD40 pfam00400
WD domain, G-beta repeat;
284-342 4.53e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.53e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767992243  284 KECKAELREHEHVVECISWAPEssyssiseatgsetkksgkpGPFLLSGSRDKTIKMWD 342
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD--------------------GKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 329-398 1.57e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 40.65  E-value: 1.57e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992243 329 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHE 398
Cdd:PTZ00421 141 LASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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