|
Name |
Accession |
Description |
Interval |
E-value |
| ADAMTS_spacer1 |
pfam05986 |
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ... |
117-227 |
4.43e-35 |
|
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.
:
Pssm-ID: 461796 Cd Length: 115 Bit Score: 129.62 E-value: 4.43e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 117 TVSGTFEEAEGLGYVDVGLIPAGAREIRIQEVAEAANFLALRSeDPEKYFLNGGWTIQ-WNGDYQVAGTTFTYARRGN-W 194
Cdd:pfam05986 1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPaL 79
|
90 100 110
....*....|....*....|....*....|....*.
gi 767983147 195 ENLTSPGPTKEPVWIQLLFQ---ESNPGVHYEYTIH 227
Cdd:pfam05986 80 EELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
991-1046 |
1.54e-12 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 63.24 E-value: 1.54e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767983147 991 WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSdQCGHEAWPESSRPCGTEDC 1046
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDS-ECSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
243-297 |
2.44e-12 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 62.47 E-value: 2.44e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767983147 243 WHYGPWTKCTVTCGRGVQRQNVYCL-ERQAGPVDEEHCDPLGRPDDQQRkCSEQPC 297
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQS-CNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
884-939 |
2.10e-11 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 59.77 E-value: 2.10e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767983147 884 WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCqPGPAKPPAHRPCGAQPC 939
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS super family |
cl40597 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
833-881 |
3.02e-09 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
The actual alignment was detected with superfamily member pfam19030:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 54.00 E-value: 3.02e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767983147 833 WQAGNWSECSTTCGLGAVWRPVRCSSG------RDEDCAPAGRPQPARRCHLRPC 881
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKgggsivPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS super family |
cl40597 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
364-412 |
4.55e-09 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
The actual alignment was detected with superfamily member pfam19030:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 53.23 E-value: 4.55e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767983147 364 WAVGNWSQCSVTCGEGTQRRNVLCT---NDTGVP---CDEAQQPASEVTCSLPLC 412
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqkgGGSIVPdseCSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS super family |
cl40597 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
301-360 |
1.67e-08 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
The actual alignment was detected with superfamily member pfam19030:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 51.68 E-value: 1.67e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 301 WWAGEWQLCSSSCGpGGLSRRAVLCIRSVGLDEQSalePPACEHLPRPPTETPCNRHvPC 360
Cdd:pfam19030 1 WVAGPWGECSVTCG-GGVQTRLVQCVQKGGGSIVP---DSECSAQKKPPETQSCNLK-PC 55
|
|
| TSP1_ADAMTS super family |
cl40597 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
942-988 |
1.69e-08 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
The actual alignment was detected with superfamily member pfam19030:
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 51.68 E-value: 1.69e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767983147 942 WYTSSWRECSEACGGGEQQRLVTCPEPG--------LCEEALRPNTTRPCNTHPC 988
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdsECSAQKKPPETQSCNLKPC 55
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
445-886 |
1.70e-06 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 52.63 E-value: 1.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 445 APRPSPASSPKPgtmgNAIEEEAPELDLPGPvfvdDFYYDYNFINFHEDLSYGPSEEPDLDLA-GTGDRTPPPHSHPAAP 523
Cdd:PHA03247 2603 DDRGDPRGPAPP----SPLPPDTHAPDPPPP----SPSPAANEPDPHPPPTVPPPERPRDDPApGRVSRPRRARRLGRAA 2674
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 524 STGSPVPATEPPAAKEegVLGPWSPSPWPSQAGRSP-PPPSEQTPGNPLinflPEEDTPIGAPDLGLPSLSWPRVSTDGL 602
Cdd:PHA03247 2675 QASSPPQRPRRRAARP--TVGSLTSLADPPPPPPTPePAPHALVSATPL----PPGPAAARQASPALPAAPAPPAVPAGP 2748
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 603 QTPATPESQNDFPVGKDSQSQLPPpwrdrtnevfkddeepkgrGAPHLPPRPSSTLPPLSPVG-STHSSPSPDVAELWTG 681
Cdd:PHA03247 2749 ATPGGPARPARPPTTAGPPAPAPP-------------------AAPAAGPPRRLTRPAVASLSeSRESLPSPWDPADPPA 2809
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 682 GTVAWEPALEGGLGPVDSELWPTVGVASLLPPPIAPLPEMKVRDSSLEPGTPSFPTPGPGSWDLQTVA-----VWGTFLP 756
Cdd:PHA03247 2810 AVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAparppVRRLARP 2889
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 757 TTLTGLGHMPEPALNPGPKGQPEslSPEVPLSSRLLSTPAWDSPAnshrvPETQPLAPslAEAGPPADPLVVRNAGWQAG 836
Cdd:PHA03247 2890 AVSRSTESFALPPDQPERPPQPQ--APPPPQPQPQPPPPPQPQPP-----PPPPPRPQ--PPLAPTTDPAGAGEPSGAVP 2960
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 767983147 837 NWSECSTTCGLGAVWRpVRCSSGRDEDCAPAGRPQPARRCHLRPCATWHS 886
Cdd:PHA03247 2961 QPWLGALVPGRVAVPR-FRVPQPAPSREAPASSTPPLTGHSLSRVSSWAS 3009
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ADAMTS_spacer1 |
pfam05986 |
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ... |
117-227 |
4.43e-35 |
|
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.
Pssm-ID: 461796 Cd Length: 115 Bit Score: 129.62 E-value: 4.43e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 117 TVSGTFEEAEGLGYVDVGLIPAGAREIRIQEVAEAANFLALRSeDPEKYFLNGGWTIQ-WNGDYQVAGTTFTYARRGN-W 194
Cdd:pfam05986 1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPaL 79
|
90 100 110
....*....|....*....|....*....|....*.
gi 767983147 195 ENLTSPGPTKEPVWIQLLFQ---ESNPGVHYEYTIH 227
Cdd:pfam05986 80 EELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
991-1046 |
1.54e-12 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 63.24 E-value: 1.54e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767983147 991 WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSdQCGHEAWPESSRPCGTEDC 1046
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDS-ECSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
243-297 |
2.44e-12 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 62.47 E-value: 2.44e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767983147 243 WHYGPWTKCTVTCGRGVQRQNVYCL-ERQAGPVDEEHCDPLGRPDDQQRkCSEQPC 297
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQS-CNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
884-939 |
2.10e-11 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 59.77 E-value: 2.10e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767983147 884 WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCqPGPAKPPAHRPCGAQPC 939
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
833-881 |
3.02e-09 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 54.00 E-value: 3.02e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767983147 833 WQAGNWSECSTTCGLGAVWRPVRCSSG------RDEDCAPAGRPQPARRCHLRPC 881
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKgggsivPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
364-412 |
4.55e-09 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 53.23 E-value: 4.55e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767983147 364 WAVGNWSQCSVTCGEGTQRRNVLCT---NDTGVP---CDEAQQPASEVTCSLPLC 412
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqkgGGSIVPdseCSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
301-360 |
1.67e-08 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 51.68 E-value: 1.67e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 301 WWAGEWQLCSSSCGpGGLSRRAVLCIRSVGLDEQSalePPACEHLPRPPTETPCNRHvPC 360
Cdd:pfam19030 1 WVAGPWGECSVTCG-GGVQTRLVQCVQKGGGSIVP---DSECSAQKKPPETQSCNLK-PC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
942-988 |
1.69e-08 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 51.68 E-value: 1.69e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767983147 942 WYTSSWRECSEACGGGEQQRLVTCPEPG--------LCEEALRPNTTRPCNTHPC 988
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdsECSAQKKPPETQSCNLKPC 55
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
243-298 |
5.66e-07 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 47.20 E-value: 5.66e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767983147 243 WHYGPWTKCTVTCGRGVQRQNVYCLeRQAGPVDEEHCDPlgrPDDQQRKCSEQPCP 298
Cdd:smart00209 2 SEWSEWSPCSVTCGGGVQTRTRSCC-SPPPQNGGGPCTG---EDVETRACNEQPCP 53
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
445-886 |
1.70e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 52.63 E-value: 1.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 445 APRPSPASSPKPgtmgNAIEEEAPELDLPGPvfvdDFYYDYNFINFHEDLSYGPSEEPDLDLA-GTGDRTPPPHSHPAAP 523
Cdd:PHA03247 2603 DDRGDPRGPAPP----SPLPPDTHAPDPPPP----SPSPAANEPDPHPPPTVPPPERPRDDPApGRVSRPRRARRLGRAA 2674
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 524 STGSPVPATEPPAAKEegVLGPWSPSPWPSQAGRSP-PPPSEQTPGNPLinflPEEDTPIGAPDLGLPSLSWPRVSTDGL 602
Cdd:PHA03247 2675 QASSPPQRPRRRAARP--TVGSLTSLADPPPPPPTPePAPHALVSATPL----PPGPAAARQASPALPAAPAPPAVPAGP 2748
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 603 QTPATPESQNDFPVGKDSQSQLPPpwrdrtnevfkddeepkgrGAPHLPPRPSSTLPPLSPVG-STHSSPSPDVAELWTG 681
Cdd:PHA03247 2749 ATPGGPARPARPPTTAGPPAPAPP-------------------AAPAAGPPRRLTRPAVASLSeSRESLPSPWDPADPPA 2809
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 682 GTVAWEPALEGGLGPVDSELWPTVGVASLLPPPIAPLPEMKVRDSSLEPGTPSFPTPGPGSWDLQTVA-----VWGTFLP 756
Cdd:PHA03247 2810 AVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAparppVRRLARP 2889
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 757 TTLTGLGHMPEPALNPGPKGQPEslSPEVPLSSRLLSTPAWDSPAnshrvPETQPLAPslAEAGPPADPLVVRNAGWQAG 836
Cdd:PHA03247 2890 AVSRSTESFALPPDQPERPPQPQ--APPPPQPQPQPPPPPQPQPP-----PPPPPRPQ--PPLAPTTDPAGAGEPSGAVP 2960
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 767983147 837 NWSECSTTCGLGAVWRpVRCSSGRDEDCAPAGRPQPARRCHLRPCATWHS 886
Cdd:PHA03247 2961 QPWLGALVPGRVAVPR-FRVPQPAPSREAPASSTPPLTGHSLSRVSSWAS 3009
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
988-1047 |
2.31e-04 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 39.88 E-value: 2.31e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 988 CTQWvvGPWGQCSGPCGGGVQRRLVKCVNtqtGLPEEDSDQCGHEAwpESSRPCGTEDCE 1047
Cdd:smart00209 1 WSEW--SEWSPCSVTCGGGVQTRTRSCCS---PPPQNGGGPCTGED--VETRACNEQPCP 53
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
364-389 |
5.08e-04 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 39.11 E-value: 5.08e-04
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ADAMTS_spacer1 |
pfam05986 |
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ... |
117-227 |
4.43e-35 |
|
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.
Pssm-ID: 461796 Cd Length: 115 Bit Score: 129.62 E-value: 4.43e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 117 TVSGTFEEAEGLGYVDVGLIPAGAREIRIQEVAEAANFLALRSeDPEKYFLNGGWTIQ-WNGDYQVAGTTFTYARRGN-W 194
Cdd:pfam05986 1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSISlNPTYPSLLGTVLEYRRSLPaL 79
|
90 100 110
....*....|....*....|....*....|....*.
gi 767983147 195 ENLTSPGPTKEPVWIQLLFQ---ESNPGVHYEYTIH 227
Cdd:pfam05986 80 EELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
991-1046 |
1.54e-12 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 63.24 E-value: 1.54e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767983147 991 WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSdQCGHEAWPESSRPCGTEDC 1046
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDS-ECSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
243-297 |
2.44e-12 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 62.47 E-value: 2.44e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767983147 243 WHYGPWTKCTVTCGRGVQRQNVYCL-ERQAGPVDEEHCDPLGRPDDQQRkCSEQPC 297
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQS-CNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
884-939 |
2.10e-11 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 59.77 E-value: 2.10e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767983147 884 WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCqPGPAKPPAHRPCGAQPC 939
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
833-881 |
3.02e-09 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 54.00 E-value: 3.02e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767983147 833 WQAGNWSECSTTCGLGAVWRPVRCSSG------RDEDCAPAGRPQPARRCHLRPC 881
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKgggsivPDSECSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
364-412 |
4.55e-09 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 53.23 E-value: 4.55e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767983147 364 WAVGNWSQCSVTCGEGTQRRNVLCT---NDTGVP---CDEAQQPASEVTCSLPLC 412
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVqkgGGSIVPdseCSAQKKPPETQSCNLKPC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
301-360 |
1.67e-08 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 51.68 E-value: 1.67e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 301 WWAGEWQLCSSSCGpGGLSRRAVLCIRSVGLDEQSalePPACEHLPRPPTETPCNRHvPC 360
Cdd:pfam19030 1 WVAGPWGECSVTCG-GGVQTRLVQCVQKGGGSIVP---DSECSAQKKPPETQSCNLK-PC 55
|
|
| TSP1_ADAMTS |
pfam19030 |
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ... |
942-988 |
1.69e-08 |
|
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.
Pssm-ID: 465950 [Multi-domain] Cd Length: 55 Bit Score: 51.68 E-value: 1.69e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767983147 942 WYTSSWRECSEACGGGEQQRLVTCPEPG--------LCEEALRPNTTRPCNTHPC 988
Cdd:pfam19030 1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsivpdsECSAQKKPPETQSCNLKPC 55
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
243-298 |
5.66e-07 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 47.20 E-value: 5.66e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767983147 243 WHYGPWTKCTVTCGRGVQRQNVYCLeRQAGPVDEEHCDPlgrPDDQQRKCSEQPCP 298
Cdd:smart00209 2 SEWSEWSPCSVTCGGGVQTRTRSCC-SPPPQNGGGPCTG---EDVETRACNEQPCP 53
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
445-886 |
1.70e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 52.63 E-value: 1.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 445 APRPSPASSPKPgtmgNAIEEEAPELDLPGPvfvdDFYYDYNFINFHEDLSYGPSEEPDLDLA-GTGDRTPPPHSHPAAP 523
Cdd:PHA03247 2603 DDRGDPRGPAPP----SPLPPDTHAPDPPPP----SPSPAANEPDPHPPPTVPPPERPRDDPApGRVSRPRRARRLGRAA 2674
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 524 STGSPVPATEPPAAKEegVLGPWSPSPWPSQAGRSP-PPPSEQTPGNPLinflPEEDTPIGAPDLGLPSLSWPRVSTDGL 602
Cdd:PHA03247 2675 QASSPPQRPRRRAARP--TVGSLTSLADPPPPPPTPePAPHALVSATPL----PPGPAAARQASPALPAAPAPPAVPAGP 2748
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 603 QTPATPESQNDFPVGKDSQSQLPPpwrdrtnevfkddeepkgrGAPHLPPRPSSTLPPLSPVG-STHSSPSPDVAELWTG 681
Cdd:PHA03247 2749 ATPGGPARPARPPTTAGPPAPAPP-------------------AAPAAGPPRRLTRPAVASLSeSRESLPSPWDPADPPA 2809
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 682 GTVAWEPALEGGLGPVDSELWPTVGVASLLPPPIAPLPEMKVRDSSLEPGTPSFPTPGPGSWDLQTVA-----VWGTFLP 756
Cdd:PHA03247 2810 AVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAparppVRRLARP 2889
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 757 TTLTGLGHMPEPALNPGPKGQPEslSPEVPLSSRLLSTPAWDSPAnshrvPETQPLAPslAEAGPPADPLVVRNAGWQAG 836
Cdd:PHA03247 2890 AVSRSTESFALPPDQPERPPQPQ--APPPPQPQPQPPPPPQPQPP-----PPPPPRPQ--PPLAPTTDPAGAGEPSGAVP 2960
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 767983147 837 NWSECSTTCGLGAVWRpVRCSSGRDEDCAPAGRPQPARRCHLRPCATWHS 886
Cdd:PHA03247 2961 QPWLGALVPGRVAVPR-FRVPQPAPSREAPASSTPPLTGHSLSRVSSWAS 3009
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
527-823 |
7.24e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 47.24 E-value: 7.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 527 SPVPATEPPAakeegvlGPWSPSPWPSQAGRSPPPPSEQTP-----GNPLINFLPEEDTPIGAPdlglpslSWPRVSTDG 601
Cdd:PHA03247 2600 APVDDRGDPR-------GPAPPSPLPPDTHAPDPPPPSPSPaanepDPHPPPTVPPPERPRDDP-------APGRVSRPR 2665
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 602 LQTPATPESQNDFPVGKDSQSQLPPPWRDRTNEVFKDDEEPKgrgaPHLPPRPSSTLPPLSPVGSTHSSPSPDVAELWTG 681
Cdd:PHA03247 2666 RARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPT----PEPAPHALVSATPLPPGPAAARQASPALPAAPAP 2741
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 682 GTVAWEPALEGGLGPVDSELWPTVGVASLLPPPIAPLPEMKV---RDSSLEPGTPSFPTPGPGSWDLQTVAVWGTFLPTT 758
Cdd:PHA03247 2742 PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLtrpAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767983147 759 LTglghmPEPALNPGPKGQPESLSPEVPLSSRLLSTPAWDSPAN--SHRVPETQPLAPSLAEAGPPA 823
Cdd:PHA03247 2822 AS-----PAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGdvRRRPPSRSPAAKPAAPARPPV 2883
|
|
| PRK08691 |
PRK08691 |
DNA polymerase III subunits gamma and tau; Validated |
531-656 |
1.87e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236333 [Multi-domain] Cd Length: 709 Bit Score: 45.47 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 531 ATEPPAAKEEGVLGPWSPSPWPSQ--AGRSP--------------PPPSEQTPGNPLINFL--PEEDTPIGAPDLGLPSL 592
Cdd:PRK08691 421 TAGPVSNQENNDVPPWEDAPDEAQtaAGTAQtsaksiqtaseaetPPENQVSKNKAADNETdaPLSEVPSENPIQATPND 500
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767983147 593 SWPRVSTDGLQTPATPE-----SQNDFPVgKDSQSQLPPPWR-----DRTNEVFKDDEEPKGRGAPHLPPRPSS 656
Cdd:PRK08691 501 EAVETETFAHEAPAEPFygygfPDNDCPP-EDGAEIPPPDWEhaapaDTAGGGADEEAEAGGIGGNNTPSAPPP 573
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
988-1047 |
2.31e-04 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 39.88 E-value: 2.31e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 988 CTQWvvGPWGQCSGPCGGGVQRRLVKCVNtqtGLPEEDSDQCGHEAwpESSRPCGTEDCE 1047
Cdd:smart00209 1 WSEW--SEWSPCSVTCGGGVQTRTRSCCS---PPPQNGGGPCTGED--VETRACNEQPCP 53
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
534-828 |
3.47e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.93 E-value: 3.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 534 PPAAKEEGVLGPWSPSPWPSQAGRSPPPPSEQTPGNPL----------INFLPEEDTpiGAPDLGLPSLSWPRVSTDGLQ 603
Cdd:PHA03247 2492 AGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPVhprmltwirgLEELASDDA--GDPPPPLPPAAPPAAPDRSVP 2569
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 604 TPATPESQNDFPVGKDSQSQLPPPWRDRTNEVFKDDEEPKGRGAPHLPPRPSSTLPPLSPvgsthsSPSPDVAELWTGGT 683
Cdd:PHA03247 2570 PPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPP------SPSPAANEPDPHPP 2643
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983147 684 VAWEPALEGGLGPVDSELWPTVGVASLLPPPIAPLPEMKVRDSSLEPGTPSF------PTPGPGSWDLQTVAVWGTFLPT 757
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLtsladpPPPPPTPEPAPHALVSATPLPP 2723
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767983147 758 -TLTGLGHMPEPALNPGPKGQPEslSPEVPLSSRLLSTPAWDSPANSHRVPETQPLAPSLAEAGPPADPLVV 828
Cdd:PHA03247 2724 gPAAARQASPALPAAPAPPAVPA--GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSE 2793
|
|
| TSP1 |
smart00209 |
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta. |
364-389 |
5.08e-04 |
|
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
Pssm-ID: 214559 [Multi-domain] Cd Length: 53 Bit Score: 39.11 E-value: 5.08e-04
|
| |
