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Conserved domains on  [gi|767960733|ref|XP_011518060|]
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ankyrin repeat domain-containing protein 30A isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-272 5.18e-42

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 155.88  E-value: 5.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   42 IHKAASRGQVRKLEKMTKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEAC 121
Cdd:COG0666    56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  122 ANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAV 201
Cdd:COG0666   136 VKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767960733  202 NKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHEQIMEYIRKLSKNHQNTN 272
Cdd:COG0666   216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286
PTZ00121 super family cl31754
MAEBL; Provisional
 344-1166 1.92e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.90  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  344 KATSGKFEQSAEETPREiTSPAKETSEKFTWPAKGRPRKIAWEKKEdtpREIMSPAKETSEKFTWAAKGRPRKIAWEKKE 423
Cdd:PTZ00121 1073 KPSYKDFDFDAKEDNRA-DEATEEAFGKAEEAKKTETGKAEEARKA---EEAKKKAEDARKAEEARKAEDARKAEEARKA 1148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  424 TPVKTGCVARVTSNKTKVLEKGRSKmiacPTKESSTKASANDQRFPSESKQEEDEEYSCDSRSlFESSAKIQVCIPESIY 503
Cdd:PTZ00121 1149 EDAKRVEIARKAEDARKAEEARKAE----DAKKAEAARKAEEVRKAEELRKAEDARKAEAARK-AEEERKAEEARKAEDA 1223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  504 QKVMEInREVEEPPKKPSAFKPAIEMQNSVPNKAFE-------LKNEQTLRADPMFPPESKQKDYEENSWDSESLCETVS 576
Cdd:PTZ00121 1224 KKAEAV-KKAEEAKKDAEEAKKAEEERNNEEIRKFEearmahfARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKK 1302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  577 QKDVCLPKATHQKEIDKINGKLEESPNKDGLLKAtcgmKVSIPTKALELKdmqtfKAEPPGKPSAFEPATEMQKSVPNKA 656
Cdd:PTZ00121 1303 KADEAKKKAEEAKKADEAKKKAEEAKKKADAAKK----KAEEAKKAAEAA-----KAEAEAAADEAEAAEEKAEAAEKKK 1373

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  657 LELK---NEQTLRADEILPSESKQKDYEENSWDTESLCETVSQK---DVCLPKAAHQKEIDKINGKLEGRYAAEfrtfsa 730
Cdd:PTZ00121 1374 EEAKkkaDAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKkkaDEAKKKAEEKKKADEAKKKAEEAKKAD------ 1447

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  731 MIRSPVKDGLLKANCGMKVSIPTKALELMDmqtfKAEPPEKPSAFEPAIEMQKsvpNKALELKN--EQTLRADEILPSES 808
Cdd:PTZ00121 1448 EAKKKAEEAKKAEEAKKKAEEAKKADEAKK----KAEEAKKADEAKKKAEEAK---KKADEAKKaaEAKKKADEAKKAEE 1520

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  809 KQKDYEesswdseslcetvsqkdvcLPKAAHQKEIDKINGKLEGRYAAEFRTfsamirspvKDGLLKANCGMKVSIPTKA 888
Cdd:PTZ00121 1521 AKKADE-------------------AKKAEEAKKADEAKKAEEKKKADELKK---------AEELKKAEEKKKAEEAKKA 1572

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  889 LELMDMQTFKAE---PPEKPSAFEPAIEMQKSVPNKALELKN--EQTLRADEILPSESKQKDYEESSWDSESLCETVSQk 963
Cdd:PTZ00121 1573 EEDKNMALRKAEeakKAEEARIEEVMKLYEEEKKMKAEEAKKaeEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEE- 1651

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  964 dvcLPKATHQKEIDKINGKLEESPDNdgflkapcrmkvsipTKALELMdmqtfKAEPPEKPSAfepaiemqksvpnKALE 1043
Cdd:PTZ00121 1652 ---LKKAEEENKIKAAEEAKKAEEDK---------------KKAEEAK-----KAEEDEKKAA-------------EALK 1695

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733 1044 LKNEQTLRADQMfpseskQKKVEENSWDSESLRETVSQKDVCVPKATHQKEMDKisgkledstslSKILDTVHSCERARE 1123
Cdd:PTZ00121 1696 KEAEEAKKAEEL------KKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDK-----------KKAEEAKKDEEEKKK 1758

                         810       820       830       840
                  ....*....|....*....|....*....|....*....|...
gi 767960733 1124 LQKDHCEQRTGKMEQMKKKFCVLKKKLSEAKEIKSQLENQKVK 1166
Cdd:PTZ00121 1759 IAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIK 1801
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-272 5.18e-42

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 155.88  E-value: 5.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   42 IHKAASRGQVRKLEKMTKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEAC 121
Cdd:COG0666    56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  122 ANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAV 201
Cdd:COG0666   136 VKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767960733  202 NKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHEQIMEYIRKLSKNHQNTN 272
Cdd:COG0666   216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286
Ank_2 pfam12796
Ankyrin repeats (3 copies);
77-169 3.49e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 80.55  E-value: 3.49e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733    77 LHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSgADINLVDvYGNTALHYAVYSEILSVVA 156
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 767960733   157 KLLSHGAVIEVHN 169
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 65-213 1.70e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 83.78  E-value: 1.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   65 NLNIQDAQK-RTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTAL 143
Cdd:PHA02878  159 DINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPL 238

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767960733  144 HYAVYSEI-LSVVAKLLSHGAviEVHNKAS---LTPLLLSItkRSEQIVEFLLIKNANANAVNKYKCTALMLAV 213
Cdd:PHA02878  239 HISVGYCKdYDILKLLLEHGV--DVNAKSYilgLTALHSSI--KSERKLKLLLEYGADINSLNSYKLTPLSSAV 308
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 72-194 3.45e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 3.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   72 QKRTALHWACVNGHEEVV-----------------TFLVDRKCQLdVLDGEHrtPLMKALQCHQEACANILIDSGADINL 134
Cdd:cd22192    88 QGETALHIAVVNQNLNLVreliargadvvspratgTFFRPGPKNL-IYYGEH--PLSFAACVGNEEIVRLLIEHGADIRA 164

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767960733  135 VDVYGNTALHYAV-----------YSEILSVVAKLLSHgAVIEVHNKASLTPLLLSITKRSEQIVEFLLIK 194
Cdd:cd22192   165 QDSLGNTVLHILVlqpnktfacqmYDLILSYDKEDDLQ-PLDLVPNNQGLTPFKLAAKEGNIVMFQHLVQK 234
PTZ00121 PTZ00121
MAEBL; Provisional
 344-1166 1.92e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.90  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  344 KATSGKFEQSAEETPREiTSPAKETSEKFTWPAKGRPRKIAWEKKEdtpREIMSPAKETSEKFTWAAKGRPRKIAWEKKE 423
Cdd:PTZ00121 1073 KPSYKDFDFDAKEDNRA-DEATEEAFGKAEEAKKTETGKAEEARKA---EEAKKKAEDARKAEEARKAEDARKAEEARKA 1148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  424 TPVKTGCVARVTSNKTKVLEKGRSKmiacPTKESSTKASANDQRFPSESKQEEDEEYSCDSRSlFESSAKIQVCIPESIY 503
Cdd:PTZ00121 1149 EDAKRVEIARKAEDARKAEEARKAE----DAKKAEAARKAEEVRKAEELRKAEDARKAEAARK-AEEERKAEEARKAEDA 1223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  504 QKVMEInREVEEPPKKPSAFKPAIEMQNSVPNKAFE-------LKNEQTLRADPMFPPESKQKDYEENSWDSESLCETVS 576
Cdd:PTZ00121 1224 KKAEAV-KKAEEAKKDAEEAKKAEEERNNEEIRKFEearmahfARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKK 1302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  577 QKDVCLPKATHQKEIDKINGKLEESPNKDGLLKAtcgmKVSIPTKALELKdmqtfKAEPPGKPSAFEPATEMQKSVPNKA 656
Cdd:PTZ00121 1303 KADEAKKKAEEAKKADEAKKKAEEAKKKADAAKK----KAEEAKKAAEAA-----KAEAEAAADEAEAAEEKAEAAEKKK 1373

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  657 LELK---NEQTLRADEILPSESKQKDYEENSWDTESLCETVSQK---DVCLPKAAHQKEIDKINGKLEGRYAAEfrtfsa 730
Cdd:PTZ00121 1374 EEAKkkaDAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKkkaDEAKKKAEEKKKADEAKKKAEEAKKAD------ 1447

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  731 MIRSPVKDGLLKANCGMKVSIPTKALELMDmqtfKAEPPEKPSAFEPAIEMQKsvpNKALELKN--EQTLRADEILPSES 808
Cdd:PTZ00121 1448 EAKKKAEEAKKAEEAKKKAEEAKKADEAKK----KAEEAKKADEAKKKAEEAK---KKADEAKKaaEAKKKADEAKKAEE 1520

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  809 KQKDYEesswdseslcetvsqkdvcLPKAAHQKEIDKINGKLEGRYAAEFRTfsamirspvKDGLLKANCGMKVSIPTKA 888
Cdd:PTZ00121 1521 AKKADE-------------------AKKAEEAKKADEAKKAEEKKKADELKK---------AEELKKAEEKKKAEEAKKA 1572

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  889 LELMDMQTFKAE---PPEKPSAFEPAIEMQKSVPNKALELKN--EQTLRADEILPSESKQKDYEESSWDSESLCETVSQk 963
Cdd:PTZ00121 1573 EEDKNMALRKAEeakKAEEARIEEVMKLYEEEKKMKAEEAKKaeEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEE- 1651

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  964 dvcLPKATHQKEIDKINGKLEESPDNdgflkapcrmkvsipTKALELMdmqtfKAEPPEKPSAfepaiemqksvpnKALE 1043
Cdd:PTZ00121 1652 ---LKKAEEENKIKAAEEAKKAEEDK---------------KKAEEAK-----KAEEDEKKAA-------------EALK 1695

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733 1044 LKNEQTLRADQMfpseskQKKVEENSWDSESLRETVSQKDVCVPKATHQKEMDKisgkledstslSKILDTVHSCERARE 1123
Cdd:PTZ00121 1696 KEAEEAKKAEEL------KKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDK-----------KKAEEAKKDEEEKKK 1758

                         810       820       830       840
                  ....*....|....*....|....*....|....*....|...
gi 767960733 1124 LQKDHCEQRTGKMEQMKKKFCVLKKKLSEAKEIKSQLENQKVK 1166
Cdd:PTZ00121 1759 IAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIK 1801
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 72-101 1.22e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 1.22e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 767960733     72 QKRTALHWACVNGHEEVVTFLVDRKCQLDV 101
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-272 5.18e-42

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 155.88  E-value: 5.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   42 IHKAASRGQVRKLEKMTKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEAC 121
Cdd:COG0666    56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  122 ANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAV 201
Cdd:COG0666   136 VKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767960733  202 NKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHEQIMEYIRKLSKNHQNTN 272
Cdd:COG0666   216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-272 4.22e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.19  E-value: 4.22e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   29 NDSYIVHSGDLRKIHKAASRGQVRKLEKMTKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRT 108
Cdd:COG0666    10 LLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  109 PLMKALQCHQEACANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIV 188
Cdd:COG0666    90 LLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  189 EFLLIKNANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHEQIMEYIRKLSKNH 268
Cdd:COG0666   170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249


                  ....
gi 767960733  269 QNTN 272
Cdd:COG0666   250 KDGL 253
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
61-333 6.33e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.83  E-value: 6.33e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   61 KKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGN 140
Cdd:COG0666     9 LLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  141 TALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEI 220
Cdd:COG0666    89 TLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  221 VGMLLQQNVDVFAADICGVTAEHYAVTCGfhhiHEQIMEYIRKLSKNHQNTNPEGTSAgtPDEAAplAERTPDTAESLVE 300
Cdd:COG0666   169 VKLLLEAGADVNARDNDGETPLHLAAENG----HLEIVKLLLEAGADVNAKDNDGKTA--LDLAA--ENGNLEIVKLLLE 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 767960733  301 KTPDEAAPLVERTPDTAESLVEKTPDEAASLVE 333
Cdd:COG0666   241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-209 7.30e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.83  E-value: 7.30e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   42 IHKAASRGQVRKLEKMTKRKktINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEAC 121
Cdd:COG0666   124 LHLAAYNGNLEIVKLLLEAG--ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  122 ANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAV 201
Cdd:COG0666   202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281


                  ....*...
gi 767960733  202 NKYKCTAL 209
Cdd:COG0666   282 LLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
77-169 3.49e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 80.55  E-value: 3.49e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733    77 LHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSgADINLVDvYGNTALHYAVYSEILSVVA 156
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 767960733   157 KLLSHGAVIEVHN 169
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
42-136 2.86e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 2.86e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733    42 IHKAASRGQVRKLEKMTKRKktINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGehRTPLMKALQCHQEAC 121
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENG--ADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNG--RTALHYAARSGHLEI 76

                           90
                   ....*....|....*
gi 767960733   122 ANILIDSGADINLVD 136
Cdd:pfam12796   77 VKLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 65-213 1.70e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 83.78  E-value: 1.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   65 NLNIQDAQK-RTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTAL 143
Cdd:PHA02878  159 DINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPL 238

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767960733  144 HYAVYSEI-LSVVAKLLSHGAviEVHNKAS---LTPLLLSItkRSEQIVEFLLIKNANANAVNKYKCTALMLAV 213
Cdd:PHA02878  239 HISVGYCKdYDILKLLLEHGV--DVNAKSYilgLTALHSSI--KSERKLKLLLEYGADINSLNSYKLTPLSSAV 308
PHA03095 PHA03095
ankyrin-like protein; Provisional
 103-292 5.75e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 81.99  E-value: 5.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  103 DGEH-RTPLMKALQCHQEACANI---LIDSGADINLVDVYGNTALH-YAVYSEILSVVAKLLSHGAVIEVHNKASLTPL- 176
Cdd:PHA03095   43 RGEYgKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLh 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  177 -LLSITKRSEQIVEFLLIKNANANAVNKYKCTAL-MLAVCHGSS-EIVGMLLQQNVDVFAADICGVTAehyavtcgFHHI 253
Cdd:PHA03095  123 vYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLaVLLKSRNANvELLRLLIDAGADVYAVDDRFRSL--------LHHH 194

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 767960733  254 HEQIMEYIRKLSKNhqntnpegTSAGTPDEAAPLAERTP 292
Cdd:PHA03095  195 LQSFKPRARIVREL--------IRAGCDPAATDMLGNTP 225
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 92-246 1.06e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 80.86  E-value: 1.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   92 LVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTALHY-----AVYSEILSVVAKLLSHGAVIE 166
Cdd:PHA03100   21 IIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYlsnikYNLTDVKEIVKLLLEYGANVN 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  167 VHNKASLTPLLLSITKRSEQ--IVEFLLIKNANANAVNKYKCTALMLAV--CHGSSEIVGMLLQQNVDVFA--------- 233
Cdd:PHA03100  101 APDNNGITPLLYAISKKSNSysIVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVDINAknrvnylls 180

                         170       180
                  ....*....|....*....|
gi 767960733  234 -------ADICGVTAEHYAV 246
Cdd:PHA03100  181 ygvpiniKDVYGFTPLHYAV 200
Ank_2 pfam12796
Ankyrin repeats (3 copies);
143-235 5.23e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 5.23e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   143 LHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEfLLIKNANANAVNkYKCTALMLAVCHGSSEIVG 222
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVK-LLLEHADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 767960733   223 MLLQQNVDVFAAD 235
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 61-241 3.06e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.52  E-value: 3.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   61 KKTINLNIQDAQKRTALHwACVNG---HEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHqEACA---NILIDSGADINL 134
Cdd:PHA03095  105 KAGADVNAKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPLAVLLKSR-NANVellRLLIDAGADVYA 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  135 VDVYGNTALHY-AVYSEI-LSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQ--IVEFLLIKNANANAVNKYKCTALM 210
Cdd:PHA03095  183 VDDRFRSLLHHhLQSFKPrARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLH 262

                         170       180       190
                  ....*....|....*....|....*....|.
gi 767960733  211 LAVCHGSSEIVGMLLQQNVDVFAADICGVTA 241
Cdd:PHA03095  263 YAAVFNNPRACRRLIALGADINAVSSDGNTP 293
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 64-204 6.91e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 72.01  E-value: 6.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   64 INLNIQDAQKRTALHWACVNGHE--EVVTFLVDRKCQLDVLDGehrtplmkalqchqeacANILIDSGADINLVDVYGNT 141
Cdd:PHA03100  132 ANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDINAKNR-----------------VNYLLSYGVPINIKDVYGFT 194

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767960733  142 ALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAVNKY 204
Cdd:PHA03100  195 PLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIET 257
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 64-235 7.12e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 72.30  E-value: 7.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   64 INLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTAL 143
Cdd:PHA02874  115 IDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  144 HYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITkRSEQIVEfLLIKNANANAVNKYKCTALMLAV---ChgSSEI 220
Cdd:PHA02874  195 HNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII-HNRSAIE-LLINNASINDQDIDGSTPLHHAInppC--DIDI 270

                         170
                  ....*....|....*
gi 767960733  221 VGMLLQQNVDVFAAD 235
Cdd:PHA02874  271 IDILLYHKADISIKD 285
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 86-246 4.11e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.69  E-value: 4.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   86 EEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACAN-----ILIDSGADINLVDVYGNTALHYAVYSEI--LSVVAKL 158
Cdd:PHA03100   48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDVkeivkLLLEYGANVNAPDNNGITPLLYAISKKSnsYSIVEYL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  159 LSHGAVIEVHNKASLTPL--LLSITKRSEQIVEFLLIKNANANAVNKYKC----------------TALMLAVCHGSSEI 220
Cdd:PHA03100  128 LDNGANVNIKNSDGENLLhlYLESNKIDLKILKLLIDKGVDINAKNRVNYllsygvpinikdvygfTPLHYAVYNNNPEF 207

                         170       180
                  ....*....|....*....|....*.
gi 767960733  221 VGMLLQQNVDVFAADICGVTAEHYAV 246
Cdd:PHA03100  208 VKYLLDLGANPNLVNKYGDTPLHIAI 233
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 61-245 6.58e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 70.09  E-value: 6.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   61 KKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDV--LDG--------------------EHRT-------PLM 111
Cdd:PHA02876  166 EGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIiaLDDlsvlecavdsknidtikaiiDNRSninkndlSLL 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  112 KALQCHQEACANILIDSGADINLVDVYGNTALHYAVYSEILS-VVAKLLSHGAVIEVHNKASLTPL-LLSITKRSEQIVE 189
Cdd:PHA02876  246 KAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIR 325

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767960733  190 FLLIKNANANAVNKYKCTALMLA-VCHGSSEIVGMLLQQNVDVFAADICGVTAEHYA 245
Cdd:PHA02876  326 TLIMLGADVNAADRLYITPLHQAsTLDRNKDIVITLLELGANVNARDYCDKTPIHYA 382
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 61-231 3.01e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 67.00  E-value: 3.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   61 KKTINLNIQDAQKRTALHWACVNGHE-----EVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANI--LIDSGADIN 133
Cdd:PHA03100   56 DNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVeyLLDNGANVN 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  134 LVDVYGNTALHYAVYS-----EILSV-------------VAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKN 195
Cdd:PHA03100  136 IKNSDGENLLHLYLESnkidlKILKLlidkgvdinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLG 215

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 767960733  196 ANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDV 231
Cdd:PHA03100  216 ANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSI 251
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 22-260 2.39e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 64.70  E-value: 2.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   22 SQLVYTSNDSyiVHSGDLRK---IHKAASRGQVRKL-EKMTKRKktINLNIQDAQKRTALHWACVNGHE-EVVTFLVDRK 96
Cdd:PHA02876  256 SLLLYDAGFS--VNSIDDCKntpLHHASQAPSLSRLvPKLLERG--ADVNAKNIKGETPLYLMAKNGYDtENIRTLIMLG 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   97 CQLDVLDGEHRTPLMKALQCHQEACANI-LIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTP 175
Cdd:PHA02876  332 ADVNAADRLYITPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTA 411

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  176 LLLSITKRSEQI-VEFLLIKNANANAVNKYKCTALMLAvCHGSS--EIVGMLLQQNVDVFAADIcgvtAEHYA--VTCGF 250
Cdd:PHA02876  412 LHFALCGTNPYMsVKTLIDRGANVNSKNKDLSTPLHYA-CKKNCklDVIEMLLDNGADVNAINI----QNQYPllIALEY 486

                         250
                  ....*....|
gi 767960733  251 HHIHEQIMEY 260
Cdd:PHA02876  487 HGIVNILLHY 496
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 74-230 2.97e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 63.86  E-value: 2.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   74 RTALHWACVNGHEEVVTFLVD-RKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTALHYAVYSEIL 152
Cdd:PHA02875   69 ESELHDAVEEGDVKAVEELLDlGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767960733  153 SVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAVNKYKCTALM-LAVCHGSSEIVGMLLQQNVD 230
Cdd:PHA02875  149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALcYAIENNKIDIVRLFIKRGAD 227
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
122-260 5.01e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 5.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  122 ANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAV 201
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767960733  202 NKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGfhhiHEQIMEY 260
Cdd:COG0666    84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG----NLEIVKL 138
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 49-246 2.08e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.13  E-value: 2.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   49 GQVRKLEKMTKRKKTInLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQ------------- 115
Cdd:PHA02874   12 GDIEAIEKIIKNKGNC-INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKigahdiikllidn 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  116 ----------CHQEACANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSE 185
Cdd:PHA02874   91 gvdtsilpipCIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFF 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767960733  186 QIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAV 246
Cdd:PHA02874  171 DIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAI 231
Ank_2 pfam12796
Ankyrin repeats (3 copies);
176-261 3.53e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 3.53e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   176 LLLSITKRSEQIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEIVgMLLQQNVDVFAADIcGVTAEHYAVTCGfhhiHE 255
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIV-KLLLEHADVNLKDN-GRTALHYAARSG----HL 74


                   ....*.
gi 767960733   256 QIMEYI 261
Cdd:pfam12796   75 EIVKLL 80
PHA03095 PHA03095
ankyrin-like protein; Provisional
 70-201 4.64e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.42  E-value: 4.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   70 DAQKRTALHWACVNGH--EEVVTFLVDRKCQLDVLDGEHRTPL-MKALQChqeACANI----LIDSGADINLVDVYGNTA 142
Cdd:PHA03095  184 DDRFRSLLHHHLQSFKprARIVRELIRAGCDPAATDMLGNTPLhSMATGS---SCKRSlvlpLLIAGISINARNRYGQTP 260

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767960733  143 LHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAV 201
Cdd:PHA03095  261 LHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETV 319
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 88-314 1.15e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 59.31  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   88 VVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIev 167
Cdd:PHA02876  160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNI-- 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  168 hNKASLTpLLLSItkRSEQIVEFLLIKNA--NANAVNKYKCTALMLAVCHGS-SEIVGMLLQQNVDVFAADICGVTAEHY 244
Cdd:PHA02876  238 -NKNDLS-LLKAI--RNEDLETSLLLYDAgfSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYL 313

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767960733  245 AVTCGFHhiheqiMEYIRKLSKNHQNTNPEGTSAGTPDEAAPLAERTPDTAESLVEKTPD-EAAPLVERTP 314
Cdd:PHA02876  314 MAKNGYD------TENIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANvNARDYCDKTP 378
Ank_4 pfam13637
Ankyrin repeats (many copies);
74-126 4.85e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.35  E-value: 4.85e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767960733    74 RTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILI 126
Cdd:pfam13637    2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 64-246 1.58e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 55.27  E-value: 1.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   64 INLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDgehrtplmkALQCHQEACAN--------ILIDSGADINLV 135
Cdd:PHA02878   61 HNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFY---------TLVAIKDAFNNrnveifkiILTNRYKNIQTI 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  136 DVYGNTALHYAVYSEIlSVVAKLLSHGAVIEVHNKASL-TPLLLSITKRSEQIVEFLLIKNANANAVNKYKCTALMLAVC 214
Cdd:PHA02878  132 DLVYIDKKSKDDIIEA-EITKLLLSYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVK 210

                         170       180       190
                  ....*....|....*....|....*....|..
gi 767960733  215 HGSSEIVGMLLQQNVDVFAADICGVTAEHYAV 246
Cdd:PHA02878  211 HYNKPIVHILLENGASTDARDKCGNTPLHISV 242
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 45-204 1.72e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 55.64  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   45 AASRGQVRKLEKMTKRKKtiNLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANI 124
Cdd:PLN03192  532 VASTGNAALLEELLKAKL--DPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRI 609

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  125 LIDSGAdinLVDVY-GNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAVNK 203
Cdd:PLN03192  610 LYHFAS---ISDPHaAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANT 686


                  .
gi 767960733  204 Y 204
Cdd:PLN03192  687 D 687
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 52-163 7.16e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.07  E-value: 7.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   52 RKLEKM-TKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGA 130
Cdd:PHA02875  113 KKLDIMkLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA 192

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767960733  131 DINLVDVYGN-TALHYAVYSEILSVVAKLLSHGA 163
Cdd:PHA02875  193 NIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGA 226
Ank_2 pfam12796
Ankyrin repeats (3 copies);
209-271 8.92e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.19  E-value: 8.92e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767960733   209 LMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHEQIMEYIRKLSKNHQNT 271
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRT 63
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 72-194 3.45e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 3.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   72 QKRTALHWACVNGHEEVV-----------------TFLVDRKCQLdVLDGEHrtPLMKALQCHQEACANILIDSGADINL 134
Cdd:cd22192    88 QGETALHIAVVNQNLNLVreliargadvvspratgTFFRPGPKNL-IYYGEH--PLSFAACVGNEEIVRLLIEHGADIRA 164

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767960733  135 VDVYGNTALHYAV-----------YSEILSVVAKLLSHgAVIEVHNKASLTPLLLSITKRSEQIVEFLLIK 194
Cdd:cd22192   165 QDSLGNTVLHILVlqpnktfacqmYDLILSYDKEDDLQ-PLDLVPNNQGLTPFKLAAKEGNIVMFQHLVQK 234
Ank_4 pfam13637
Ankyrin repeats (many copies);
42-93 4.63e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 4.63e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767960733    42 IHKAASRGQVRKLEkmTKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLV 93
Cdd:pfam13637    5 LHAAAASGHLELLR--LLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
92-146 8.28e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.26  E-value: 8.28e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767960733    92 LVDRK-CQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTALHYA 146
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 152-273 5.10e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 47.35  E-value: 5.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  152 LSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAVNKYKCTALMLAVCHGSS-----EIVGMLLQ 226
Cdd:PHA03100   15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLE 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 767960733  227 QNVDVFAADICGVTAEHYAVTCGFHHIHeqIMEYirkLSKNHQNTNP 273
Cdd:PHA03100   95 YGANVNAPDNNGITPLLYAISKKSNSYS--IVEY---LLDNGANVNI 136
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 45-247 1.34e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.16  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   45 AASRGQVRKLEKMTKrKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDrkcqldvldgehrtplmkalqchqeaCANI 124
Cdd:cd22192    24 AAKENDVQAIKKLLK-CPSCDLFQRGALGETALHVAALYDNLEAAVVLME--------------------------AAPE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  125 LidsgadINLV---DVY-GNTALHYAVYSEILSVVAKLLSHGAVIevhNKASLTPLLLSITKRS-----EQIVEFllikn 195
Cdd:cd22192    77 L------VNEPmtsDLYqGETALHIAVVNQNLNLVRELIARGADV---VSPRATGTFFRPGPKNliyygEHPLSF----- 142

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767960733  196 ananavnkykctalmlAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVT 247
Cdd:cd22192   143 ----------------AACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVL 178
Ank_4 pfam13637
Ankyrin repeats (many copies);
139-192 1.36e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 1.36e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767960733   139 GNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLL 192
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00121 PTZ00121
MAEBL; Provisional
 344-1166 1.92e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.90  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  344 KATSGKFEQSAEETPREiTSPAKETSEKFTWPAKGRPRKIAWEKKEdtpREIMSPAKETSEKFTWAAKGRPRKIAWEKKE 423
Cdd:PTZ00121 1073 KPSYKDFDFDAKEDNRA-DEATEEAFGKAEEAKKTETGKAEEARKA---EEAKKKAEDARKAEEARKAEDARKAEEARKA 1148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  424 TPVKTGCVARVTSNKTKVLEKGRSKmiacPTKESSTKASANDQRFPSESKQEEDEEYSCDSRSlFESSAKIQVCIPESIY 503
Cdd:PTZ00121 1149 EDAKRVEIARKAEDARKAEEARKAE----DAKKAEAARKAEEVRKAEELRKAEDARKAEAARK-AEEERKAEEARKAEDA 1223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  504 QKVMEInREVEEPPKKPSAFKPAIEMQNSVPNKAFE-------LKNEQTLRADPMFPPESKQKDYEENSWDSESLCETVS 576
Cdd:PTZ00121 1224 KKAEAV-KKAEEAKKDAEEAKKAEEERNNEEIRKFEearmahfARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKK 1302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  577 QKDVCLPKATHQKEIDKINGKLEESPNKDGLLKAtcgmKVSIPTKALELKdmqtfKAEPPGKPSAFEPATEMQKSVPNKA 656
Cdd:PTZ00121 1303 KADEAKKKAEEAKKADEAKKKAEEAKKKADAAKK----KAEEAKKAAEAA-----KAEAEAAADEAEAAEEKAEAAEKKK 1373

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  657 LELK---NEQTLRADEILPSESKQKDYEENSWDTESLCETVSQK---DVCLPKAAHQKEIDKINGKLEGRYAAEfrtfsa 730
Cdd:PTZ00121 1374 EEAKkkaDAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKkkaDEAKKKAEEKKKADEAKKKAEEAKKAD------ 1447

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  731 MIRSPVKDGLLKANCGMKVSIPTKALELMDmqtfKAEPPEKPSAFEPAIEMQKsvpNKALELKN--EQTLRADEILPSES 808
Cdd:PTZ00121 1448 EAKKKAEEAKKAEEAKKKAEEAKKADEAKK----KAEEAKKADEAKKKAEEAK---KKADEAKKaaEAKKKADEAKKAEE 1520

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  809 KQKDYEesswdseslcetvsqkdvcLPKAAHQKEIDKINGKLEGRYAAEFRTfsamirspvKDGLLKANCGMKVSIPTKA 888
Cdd:PTZ00121 1521 AKKADE-------------------AKKAEEAKKADEAKKAEEKKKADELKK---------AEELKKAEEKKKAEEAKKA 1572

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  889 LELMDMQTFKAE---PPEKPSAFEPAIEMQKSVPNKALELKN--EQTLRADEILPSESKQKDYEESSWDSESLCETVSQk 963
Cdd:PTZ00121 1573 EEDKNMALRKAEeakKAEEARIEEVMKLYEEEKKMKAEEAKKaeEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEE- 1651

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  964 dvcLPKATHQKEIDKINGKLEESPDNdgflkapcrmkvsipTKALELMdmqtfKAEPPEKPSAfepaiemqksvpnKALE 1043
Cdd:PTZ00121 1652 ---LKKAEEENKIKAAEEAKKAEEDK---------------KKAEEAK-----KAEEDEKKAA-------------EALK 1695

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733 1044 LKNEQTLRADQMfpseskQKKVEENSWDSESLRETVSQKDVCVPKATHQKEMDKisgkledstslSKILDTVHSCERARE 1123
Cdd:PTZ00121 1696 KEAEEAKKAEEL------KKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDK-----------KKAEEAKKDEEEKKK 1758

                         810       820       830       840
                  ....*....|....*....|....*....|....*....|...
gi 767960733 1124 LQKDHCEQRTGKMEQMKKKFCVLKKKLSEAKEIKSQLENQKVK 1166
Cdd:PTZ00121 1759 IAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIK 1801
Ank_4 pfam13637
Ankyrin repeats (many copies);
173-225 1.98e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 1.98e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767960733   173 LTPLLLSITKRSEQIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEIVGMLL 225
Cdd:pfam13637    2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 122-192 2.76e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 2.76e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767960733  122 ANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLL 192
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 119-272 3.08e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.57  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  119 EACANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANA 198
Cdd:PHA02874   15 EAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDT 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  199 -----------------------NAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHE 255
Cdd:PHA02874   95 silpipciekdmiktildcgidvNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIK 174

                         170
                  ....*....|....*..
gi 767960733  256 QIMEYIRKLSKNHQNTN 272
Cdd:PHA02874  175 LLLEKGAYANVKDNNGE 191
PTZ00121 PTZ00121
MAEBL; Provisional
 454-1169 4.67e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 4.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  454 TKESSTKASANDQRFPSESKQEEDEEYSCDSRSLFEssAKIQVCIPESIYQKVMEINREVEEPpKKPSAFKPAIEMQnsv 533
Cdd:PTZ00121 1115 RKAEEAKKKAEDARKAEEARKAEDARKAEEARKAED--AKRVEIARKAEDARKAEEARKAEDA-KKAEAARKAEEVR--- 1188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  534 pnKAFEL-KNEQTLRADPMFPPESKQKDYEENSWDSESLCETVSQKDVCLPKATHQKeidkingKLEESPNKDGLLKATC 612
Cdd:PTZ00121 1189 --KAEELrKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAK-------KAEEERNNEEIRKFEE 1259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  613 GMKVSIPTKALELKDMQTFKAEPPGKPSAFEPATEMQKSVPNKALElknEQTLRADEILPSESKQKDYEENSWDTESLCE 692
Cdd:PTZ00121 1260 ARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKAD---EAKKKAEEAKKADEAKKKAEEAKKKADAAKK 1336

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  693 TV--SQKDVCLPKAAHQKEIDKINGKLEGRYAAEFRTFSAMIRSpvkDGLLKancgmKVSIPTKALELMDmqtfKAEPPE 770
Cdd:PTZ00121 1337 KAeeAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKA---DAAKK-----KAEEKKKADEAKK----KAEEDK 1404

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  771 KPSAfepAIEMQKSVPNKALELKNeqtlRADEILPSESKQKDYEESSWDSESL--CETVSQKDVCLPKAAHQKEIDKING 848
Cdd:PTZ00121 1405 KKAD---ELKKAAAAKKKADEAKK----KAEEKKKADEAKKKAEEAKKADEAKkkAEEAKKAEEAKKKAEEAKKADEAKK 1477

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  849 KLEGRYAAEFRTFSAMIRSPVKDGLLKANCGMKvsiptKALELMdmqtfKAEPPEKPSAFEPAIEMQKSVPNKalelKNE 928
Cdd:PTZ00121 1478 KAEEAKKADEAKKKAEEAKKKADEAKKAAEAKK-----KADEAK-----KAEEAKKADEAKKAEEAKKADEAK----KAE 1543

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  929 QTLRADEILPSESKQKDYEESSWDSESLCEtvSQKDVCLPKATHQKEIDKinGKLEESPDNDGFLKapcRMKVSIPTKAL 1008
Cdd:PTZ00121 1544 EKKKADELKKAEELKKAEEKKKAEEAKKAE--EDKNMALRKAEEAKKAEE--ARIEEVMKLYEEEK---KMKAEEAKKAE 1616

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733 1009 ElmdmQTFKAEPPEKPSAFEPAIEMQKSVP----NKALELKNEQTlraDQMFPSESKQKKVEENSWDSESLRETVSQK-- 1082
Cdd:PTZ00121 1617 E----AKIKAEELKKAEEEKKKVEQLKKKEaeekKKAEELKKAEE---ENKIKAAEEAKKAEEDKKKAEEAKKAEEDEkk 1689

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733 1083 --DVCVPKATHQKEMDKISGKLEDSTSLSKILdtvhscERARELQKDHCEQRTGKMEQMKKKFCVLKKKLSEAKEIKSQL 1160
Cdd:PTZ00121 1690 aaEALKKEAEEAKKAEELKKKEAEEKKKAEEL------KKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLK 1763


                  ....*....
gi 767960733 1161 ENQKVKWEQ 1169
Cdd:PTZ00121 1764 KEEEKKAEE 1772
PHA02798 PHA02798
ankyrin-like protein; Provisional
 65-231 5.74e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 44.06  E-value: 5.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   65 NLNIQDAQKRTALHWACVNGH---EEVVTFLVDRKCQLDVLDGEHRTPLMKALQ--CH-QEACANILIDSGADINLV-DV 137
Cdd:PHA02798  101 DINKKNSDGETPLYCLLSNGYinnLEILLFMIENGADTTLLDKDGFTMLQVYLQsnHHiDIEIIKLLLEKGVDINTHnNK 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  138 YGNTALHYAV---YSEILSVVAKLL-SHGAVIEVHNKAS-------LTPLLLSITKRSEQIVEFLLiKNANANAVNKYKC 206
Cdd:PHA02798  181 EKYDTLHCYFkynIDRIDADILKLFvDNGFIINKENKSHkkkfmeyLNSLLYDNKRFKKNILDFIF-SYIDINQVDELGF 259

                         170       180
                  ....*....|....*....|....*
gi 767960733  207 TALMLAVCHGSSEIVGMLLQQNVDV 231
Cdd:PHA02798  260 NPLYYSVSHNNRKIFEYLLQLGGDI 284
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 108-249 6.20e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.83  E-value: 6.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  108 TPLMKALQCHQEACANILIDSGA--DINLVDVygNTALHYAVYSEILSVVAKLLSHGAVI-EVHNKASLTPLLLSITKRS 184
Cdd:PHA02875   37 SPIKLAMKFRDSEAIKLLMKHGAipDVKYPDI--ESELHDAVEEGDVKAVEELLDLGKFAdDVFYKDGMTPLHLATILKK 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767960733  185 EQIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCG 249
Cdd:PHA02875  115 LDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKG 179
PTZ00121 PTZ00121
MAEBL; Provisional
 255-865 6.54e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 6.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  255 EQIMEYIRKLSKNHQNTNPEGTSAGTPDEAaplaeRTPDTAESLVEKTPDEAAPLVERTPDTAEslVEKTPDEAASLVEG 334
Cdd:PTZ00121 1248 ERNNEEIRKFEEARMAHFARRQAAIKAEEA-----RKADELKKAEEKKKADEAKKAEEKKKADE--AKKKAEEAKKADEA 1320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  335 TSDKIQCLEKATSGKfeQSAEETPREITSPAKETSEKFTWPAKGRPRKIAWEKKEDTPREIMSPAKETSEKFTWAAKGRP 414
Cdd:PTZ00121 1321 KKKAEEAKKKADAAK--KKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKK 1398

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  415 RKIAWEKKETPVKTGCVARVTSNKTKVLEKGRSKMIACPTK-ESSTKASANDQRFPSESKQEEDEEYSCDSRSLFESSAK 493
Cdd:PTZ00121 1399 KAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKaEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKK 1478

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  494 IQVCipesiyQKVMEINREVEEPPKKPSAFKPAIEMQnsvpNKAFELKN-EQTLRADPMFPPESKQKDYEenswdseslc 572
Cdd:PTZ00121 1479 AEEA------KKADEAKKKAEEAKKKADEAKKAAEAK----KKADEAKKaEEAKKADEAKKAEEAKKADE---------- 1538

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  573 etvsqkdvcLPKATHQKEIDKINgKLEEspnkdgLLKATCGMKVSIPTKALELKDMQTFKAEPPGKpsAFEPATEMQKSV 652
Cdd:PTZ00121 1539 ---------AKKAEEKKKADELK-KAEE------LKKAEEKKKAEEAKKAEEDKNMALRKAEEAKK--AEEARIEEVMKL 1600

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  653 PNKALELKNEQTLRADEILPSESKQKDYEENSWDTESLCETVSQKDVCLPKAAHQKEIDKINGKLEGRYAAEFRTFSAMI 732
Cdd:PTZ00121 1601 YEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEA 1680

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733  733 RSPVKDGLLKANCGMKVSIPTKALElmDMQTFKAEPPEKPSAFEPAIEMQKSVPNKALELKNEQTLRADEILPSESKQKD 812
Cdd:PTZ00121 1681 KKAEEDEKKAAEALKKEAEEAKKAE--ELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKK 1758

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767960733  813 YEESSWDSESLCETVSQKDVCLPKAAHQKEIDKINGKLEGRYAAEFRTFSAMI 865
Cdd:PTZ00121 1759 IAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANII 1811
Ank_5 pfam13857
Ankyrin repeats (many copies);
192-245 7.62e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 7.62e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767960733   192 LIKN--ANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYA 245
Cdd:pfam13857    1 LLEHgpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
64-110 8.33e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 8.33e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 767960733    64 INLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPL 110
Cdd:pfam13857    7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 72-101 1.22e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 1.22e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 767960733     72 QKRTALHWACVNGHEEVVTFLVDRKCQLDV 101
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
207-260 1.28e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 1.28e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767960733   207 TALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGfhhiHEQIMEY 260
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNG----NVEVLKL 52
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 74-103 2.44e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.50  E-value: 2.44e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767960733    74 RTALHWACV-NGHEEVVTFLVDRKCQLDVLD 103
Cdd:pfam00023    3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 138-170 2.80e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.50  E-value: 2.80e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767960733   138 YGNTALHYAVYSE-ILSVVAKLLSHGAVIEVHNK 170
Cdd:pfam00023    1 DGNTPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 72-194 3.19e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 41.79  E-value: 3.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960733   72 QKRTALHWACVNGHEEVVTFLVDRKCQLD---------------VLDGEHrtPLMKALQCHQEACANILIDSGADI---N 133
Cdd:cd21882    72 QGQTALHIAIENRNLNLVRLLVENGADVSaratgrffrkspgnlFYFGEL--PLSLAACTNQEEIVRLLLENGAQPaalE 149

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767960733  134 LVDVYGNTALHYAV----------------YSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIK 194
Cdd:cd21882   150 AQDSLGNTVLHALVlqadntpensafvcqmYNLLLSYGAHLDPTQQLEEIPNHQGLTPLKLAAVEGKIVMFQHILQR 226
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 74-101 4.69e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.70  E-value: 4.69e-03
                           10        20
                   ....*....|....*....|....*...
gi 767960733    74 RTALHWACVNGHEEVVTFLVDRKCQLDV 101
Cdd:pfam13606    3 NTPLHLAARNGRLEIVKLLLENGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 67-128 4.90e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.04  E-value: 4.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767960733   67 NIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTP---------------LMKALQCHQEACANILIDS 128
Cdd:PTZ00322  109 NCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPlelaeengfrevvqlLSRHSQCHFELGANAKPDS 185
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 206-235 8.10e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 8.10e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767960733   206 CTALMLAVCH-GSSEIVGMLLQQNVDVFAAD 235
Cdd:pfam00023    3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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