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Conserved domains on  [gi|767957899|ref|XP_011517166|]
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volume-regulated anion channel subunit LRRC8A isoform X1 [Homo sapiens]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-340 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 600.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899    1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCK---WVTKDSCNDSFRGWAAPGP 77
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLespPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899   78 EPTYPNSTILPTPDtgPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFV 157
Cdd:pfam12534  81 APTVSSPSASMIPE--PKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899  158 SILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDK---KSSTVSEDVEATVPMLQRTKSRIEQGIVDR-SETGVLD 233
Cdd:pfam12534 159 SILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEVpSTVSVLD 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899  234 KKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHP 313
Cdd:pfam12534 239 KKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHN 318

                         330       340
                  ....*....|....*....|....*..
gi 767957899  314 LATLFKILASFYISLVIFYGLICMYTL 340
Cdd:pfam12534 319 LAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
491-795 2.45e-41

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 156.63  E-value: 2.45e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 491 LRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQ 570
Cdd:COG4886    8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 571 KLSINNEGTKLIVLN-----SLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEiiSFQHLHRLTCLK 645
Cdd:COG4886   88 GLTDLGDLTNLTELDlsgneELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLD 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 646 LWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPp 725
Cdd:COG4886  166 LSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 726 ELFQCRKLRALHLGNNVLQSLPSrVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795
Cdd:COG4886  245 ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-340 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 600.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899    1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCK---WVTKDSCNDSFRGWAAPGP 77
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLespPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899   78 EPTYPNSTILPTPDtgPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFV 157
Cdd:pfam12534  81 APTVSSPSASMIPE--PKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899  158 SILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDK---KSSTVSEDVEATVPMLQRTKSRIEQGIVDR-SETGVLD 233
Cdd:pfam12534 159 SILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEVpSTVSVLD 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899  234 KKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHP 313
Cdd:pfam12534 239 KKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHN 318

                         330       340
                  ....*....|....*....|....*..
gi 767957899  314 LATLFKILASFYISLVIFYGLICMYTL 340
Cdd:pfam12534 319 LAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
491-795 2.45e-41

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 156.63  E-value: 2.45e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 491 LRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQ 570
Cdd:COG4886    8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 571 KLSINNEGTKLIVLN-----SLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEiiSFQHLHRLTCLK 645
Cdd:COG4886   88 GLTDLGDLTNLTELDlsgneELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLD 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 646 LWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPp 725
Cdd:COG4886  166 LSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 726 ELFQCRKLRALHLGNNVLQSLPSrVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795
Cdd:COG4886  245 ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 435-768 6.04e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 89.14  E-value: 6.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 435 LSG-IPDTVFDLVELEVLKLeLIPDVT--IPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIK-EIPL 510
Cdd:PLN00113 224 LSGeIPYEIGGLTSLNHLDL-VYNNLTgpIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPE 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 511 WIYSLKTLEELHLTGNlsaeNNRYIVIDGLRELKRLKVLRLKSNlsKLP-QVVTDVGVH----LQKLSINNEGTKLIvlN 585
Cdd:PLN00113 303 LVIQLQNLEILHLFSN----NFTGKIPVALTSLPRLQVLQLWSN--KFSgEIPKNLGKHnnltVLDLSTNNLTGEIP--E 374

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 586 SLKKMANLTELELIRCDLE-RIPHSIFSLHNLQEIDLKDNNLK-------------------------TIE----EIISF 635
Cdd:PLN00113 375 GLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgelpseftklplvyfldisnnnlqgRINsrkwDMPSL 454

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 636 QHLH-----------------RLTCLKLWYNHIA-YIPIQIGNLTNLERLYLNRNKIE-KIPTQLFYCRKLRYLDLSHNN 696
Cdd:PLN00113 455 QMLSlarnkffgglpdsfgskRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQ 534

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767957899 697 LT-FLPADIGLLQNLQNLAITANRIE-TLPPELFQCRKLRALHLGNNVLQ-SLPSrVGELTNLTQIELRGNRLEC 768
Cdd:PLN00113 535 LSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPS-TGAFLAINASAVAGNIDLC 608
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 590-764 7.89e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.13  E-value: 7.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 590 MANLTELELIRCDLERIPhSIFSLHNLQEIDLKDNNLKTIEeiiSFQHLHRLTCLKLWYNHIAYIPiQIGNLTNLERLYL 669
Cdd:cd21340    1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 670 NRNKIEKIpTQLFYCRKLRYLDLSHNNL------TFLPADI-GLLQNLQNLAITANRIETLPPeLFQCRKLRALHLGNNV 742
Cdd:cd21340   76 GGNRISVV-EGLENLTNLEELHIENQRLppgeklTFDPRSLaALSNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQ 153

                        170       180
                 ....*....|....*....|....*
gi 767957899 743 LQSLP---SRVGELTNLTQIELRGN 764
Cdd:cd21340  154 ISDLEellDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
640-697 1.70e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.70e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899  640 RLTCLKLWYNHIAYI-PIQIGNLTNLERLYLNRNKIEKIPTQLFYC-RKLRYLDLSHNNL 697
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR smart00370
Leucine-rich repeats, outliers;
661-682 9.85e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 9.85e-03
                           10        20
                   ....*....|....*....|..
gi 767957899   661 LTNLERLYLNRNKIEKIPTQLF 682
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAF 22
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-340 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 600.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899    1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCK---WVTKDSCNDSFRGWAAPGP 77
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLespPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899   78 EPTYPNSTILPTPDtgPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFV 157
Cdd:pfam12534  81 APTVSSPSASMIPE--PKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899  158 SILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDK---KSSTVSEDVEATVPMLQRTKSRIEQGIVDR-SETGVLD 233
Cdd:pfam12534 159 SILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEVpSTVSVLD 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899  234 KKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHP 313
Cdd:pfam12534 239 KKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHN 318

                         330       340
                  ....*....|....*....|....*..
gi 767957899  314 LATLFKILASFYISLVIFYGLICMYTL 340
Cdd:pfam12534 319 LAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
491-795 2.45e-41

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 156.63  E-value: 2.45e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 491 LRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQ 570
Cdd:COG4886    8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 571 KLSINNEGTKLIVLN-----SLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEiiSFQHLHRLTCLK 645
Cdd:COG4886   88 GLTDLGDLTNLTELDlsgneELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLD 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 646 LWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPp 725
Cdd:COG4886  166 LSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 726 ELFQCRKLRALHLGNNVLQSLPSrVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795
Cdd:COG4886  245 ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
517-799 1.59e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 142.77  E-value: 1.59e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 517 TLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTEL 596
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 597 ELIRCDLerIPHSIFSLHNLQEIDLKDNNlktieeiiSFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676
Cdd:COG4886   81 LLSLLLL--GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 677 IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNL 756
Cdd:COG4886  151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 767957899 757 TQIELRGNRLECLPvELGECPLLKRsgLVVEEDLFNTLPPEVK 799
Cdd:COG4886  231 ETLDLSNNQLTDLP-ELGNLTNLEE--LDLSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
435-775 5.39e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 129.28  E-value: 5.39e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYS 514
Cdd:COG4886   15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 515 LKTLEELHLTGNlsaennryiviDGLRELKRLKVLRLKSN-LSKLPQVVTDVgVHLQKLSINNegTKLIVL-NSLKKMAN 592
Cdd:COG4886   95 LTNLTELDLSGN-----------EELSNLTNLESLDLSGNqLTDLPEELANL-TNLKELDLSN--NQLTDLpEPLGNLTN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 593 LTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEiiSFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 673 KIEKIPtQLFYCRKLRYLDLSHNNLTFLPaDIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGE 752
Cdd:COG4886  239 QLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                        330       340
                 ....*....|....*....|...
gi 767957899 753 LTNLTQIELRGNRLECLPVELGE 775
Cdd:COG4886  317 LLLLTTLLLLLLLLKGLLVTLTT 339
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
347-729 5.59e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 5.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 347 SLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQD 426
Cdd:COG4886   15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 427 KLELHLFMLSGIPDtVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLrENLRALHIKFTDIK 506
Cdd:COG4886   95 LTNLTELDLSGNEE-LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNL-TNLKSLDLSNNQLT 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 507 EIPLWIYSLKTLEELHLTGNlsaennryividglrelkrlkvlrlksNLSKLPqvvtdvgvhlqklsinnegtklivlNS 586
Cdd:COG4886  173 DLPEELGNLTNLKELDLSNN---------------------------QITDLP-------------------------EP 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 587 LKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIisfQHLHRLTCLKLWYNHIAYIPiQIGNLTNLER 666
Cdd:COG4886  201 LGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767957899 667 LYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQ 729
Cdd:COG4886  277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 435-768 6.04e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 89.14  E-value: 6.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 435 LSG-IPDTVFDLVELEVLKLeLIPDVT--IPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIK-EIPL 510
Cdd:PLN00113 224 LSGeIPYEIGGLTSLNHLDL-VYNNLTgpIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPE 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 511 WIYSLKTLEELHLTGNlsaeNNRYIVIDGLRELKRLKVLRLKSNlsKLP-QVVTDVGVH----LQKLSINNEGTKLIvlN 585
Cdd:PLN00113 303 LVIQLQNLEILHLFSN----NFTGKIPVALTSLPRLQVLQLWSN--KFSgEIPKNLGKHnnltVLDLSTNNLTGEIP--E 374

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 586 SLKKMANLTELELIRCDLE-RIPHSIFSLHNLQEIDLKDNNLK-------------------------TIE----EIISF 635
Cdd:PLN00113 375 GLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgelpseftklplvyfldisnnnlqgRINsrkwDMPSL 454

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 636 QHLH-----------------RLTCLKLWYNHIA-YIPIQIGNLTNLERLYLNRNKIE-KIPTQLFYCRKLRYLDLSHNN 696
Cdd:PLN00113 455 QMLSlarnkffgglpdsfgskRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQ 534

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767957899 697 LT-FLPADIGLLQNLQNLAITANRIE-TLPPELFQCRKLRALHLGNNVLQ-SLPSrVGELTNLTQIELRGNRLEC 768
Cdd:PLN00113 535 LSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPS-TGAFLAINASAVAGNIDLC 608
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 590-764 7.89e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.13  E-value: 7.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 590 MANLTELELIRCDLERIPhSIFSLHNLQEIDLKDNNLKTIEeiiSFQHLHRLTCLKLWYNHIAYIPiQIGNLTNLERLYL 669
Cdd:cd21340    1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 670 NRNKIEKIpTQLFYCRKLRYLDLSHNNL------TFLPADI-GLLQNLQNLAITANRIETLPPeLFQCRKLRALHLGNNV 742
Cdd:cd21340   76 GGNRISVV-EGLENLTNLEELHIENQRLppgeklTFDPRSLaALSNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQ 153

                        170       180
                 ....*....|....*....|....*
gi 767957899 743 LQSLP---SRVGELTNLTQIELRGN 764
Cdd:cd21340  154 ISDLEellDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 546-802 4.38e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.89  E-value: 4.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 546 LKVLRLKSNL--SKLPQvvtDVGVhLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLER----IPHSIFSLHNLQEI 619
Cdd:PLN00113 142 LETLDLSNNMlsGEIPN---DIGS-FSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQlvgqIPRELGQMKSLKWI 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 620 DLKDNNL-----KTIEEIISFQHLhrltclKLWYNHIA-YIPIQIGNLTNLERLYLNRNKIE-KIPTQLFYCRKLRYLDL 692
Cdd:PLN00113 218 YLGYNNLsgeipYEIGGLTSLNHL------DLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDL 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 693 SHNNLTF-LPADIGLLQNLQNLAITANRIE-TLPPELFQCRKLRALHLGNNVLQ-SLPSRVGELTNLTQIELRGNRLEcl 769
Cdd:PLN00113 292 SDNSLSGeIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLT-- 369

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 767957899 770 pvelGECP-LLKRSGLVVEEDLF-NTLPPEVKERL 802
Cdd:PLN00113 370 ----GEIPeGLCSSGNLFKLILFsNSLEGEIPKSL 400
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 398-766 2.24e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.11  E-value: 2.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 398 SENKLRQLNL-NNEWTLDKLRQRLTknAQDKLELHLFMLSG-IPDTVFDLVELEVLKLE---LIPDvtIPPSIAQLTGLK 472
Cdd:PLN00113 116 TSSSLRYLNLsNNNFTGSIPRGSIP--NLETLDLSNNMLSGeIPNDIGSFSSLKVLDLGgnvLVGK--IPNSLTNLTSLE 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 473 ELWLYHTAAKIEAPALAFLRENLRALHIKFTDIK-EIPLWIYSLKTLEELHLT-GNLSAEnnryiVIDGLRELKRLKVLR 550
Cdd:PLN00113 192 FLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVyNNLTGP-----IPSSLGNLKNLQYLF 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 551 LKSNlsklpqvvtdvgvhlqKLSinnegtklivlnslkkmanltelelircdlERIPHSIFSLHNLQEIDLKDNNLK-TI 629
Cdd:PLN00113 267 LYQN----------------KLS------------------------------GPIPPSIFSLQKLISLDLSDNSLSgEI 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 630 EEIISfqHLHRLTCLKLWYNHI-AYIPIQIGNLTNLERLYLNRNKIE-KIPTQLFYCRKLRYLDLSHNNLT-FLPADIGL 706
Cdd:PLN00113 301 PELVI--QLQNLEILHLFSNNFtGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCS 378

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767957899 707 LQNLQNLAITANRIET-LPPELFQCRKLRALHLGNNVLQ-SLPSRVGELTNLTQIELRGNRL 766
Cdd:PLN00113 379 SGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL 440
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 605-774 2.07e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 2.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 605 RIPHSIFSLHNLQEIDLKDNNLK-TIEEIIsFQHLHRLTCLKLWYNHIAYiPIQIGNLTNLERLYLNRNKIE-KIPTQLF 682
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSgPIPDDI-FTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 683 YCRKLRYLDLSHNNLT-FLPADIGLLQNLQNLAITANR-IETLPPELFQCRKLRALHLG-NNVLQSLPSRVGELTNLTQI 759
Cdd:PLN00113 162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGyNNLSGEIPYEIGGLTSLNHL 241

                        170
                 ....*....|....*.
gi 767957899 760 ELRGNRLE-CLPVELG 774
Cdd:PLN00113 242 DLVYNNLTgPIPSSLG 257
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
585-795 6.58e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.34  E-value: 6.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 585 NSLKKmaNLTELELIRCDLERIPHSIfsLHNLQEIDLKDNNLKTIEEiisfqHLH-RLTCLKLWYNHIAYIPIQIGNltN 663
Cdd:PRK15370 174 DCLKN--NKTELRLKILGLTTIPACI--PEQITTLILDNNELKSLPE-----NLQgNIKTLYANSNQLTSIPATLPD--T 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 664 LERLYLNRNKIEKIPTQL--------FYCRK-----------LRYLDLSHNNLTFLPADI--GLLQ-NLQNLAITAnRIE 721
Cdd:PRK15370 243 IQEMELSINRITELPERLpsalqsldLFHNKisclpenlpeeLRYLSVYDNSIRTLPAHLpsGITHlNVQSNSLTA-LPE 321

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767957899 722 TLPPelfqcrKLRALHLGNNVLQSLPSRV-GELTNLtqiELRGNRLECLPVELGecPLLKRsgLVVEEDLFNTLP 795
Cdd:PRK15370 322 TLPP------GLKTLEAGENALTSLPASLpPELQVL---DVSKNQITVLPETLP--PTITT--LDVSRNALTNLP 383
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 664-780 8.26e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 8.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 664 LERLYLNRNKIE-KIPTQLFY-CRKLRYLDLSHNNLTFlPADIGLLQNLQNLAITANRIE-TLPPELFQCRKLRALHLGN 740
Cdd:PLN00113  95 IQTINLSNNQLSgPIPDDIFTtSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGG 173

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767957899 741 NVLQS-LPSRVGELTNLTQIELRGNRLEC-LPVELGECPLLK 780
Cdd:PLN00113 174 NVLVGkIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLK 215
LRR_8 pfam13855
Leucine rich repeat;
640-697 1.70e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.70e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899  640 RLTCLKLWYNHIAYI-PIQIGNLTNLERLYLNRNKIEKIPTQLFYC-RKLRYLDLSHNNL 697
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
662-720 1.77e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.77e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767957899  662 TNLERLYLNRNKIEKIPTQLFY-CRKLRYLDLSHNNLTFL-PADIGLLQNLQNLAITANRI 720
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
708-766 3.19e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 3.19e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767957899  708 QNLQNLAITANRIETLPPELFQ-CRKLRALHLGNNVLQSLPSRVGE-LTNLTQIELRGNRL 766
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 690-778 4.67e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 53.28  E-value: 4.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 690 LDLSHNNLT-FLPADIGLLQNLQNLAITANRIE-TLPPELFQCRKLRALHLGNNVLQ-SLPSRVGELTNLTQIELRGNRL 766
Cdd:PLN03150 423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502

                         90
                 ....*....|...
gi 767957899 767 EC-LPVELGECPL 778
Cdd:PLN03150 503 SGrVPAALGGRLL 515
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 515-695 6.00e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 6.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 515 LKTLEELHLtgnlsaeNNRYIV-IDGLRELKRLKVLRLKSN-LSKLPQVVTDVG---VHLQklsiNNEGTKLIVLNSLKk 589
Cdd:cd21340    1 LKRITHLYL-------NDKNITkIDNLSLCKNLKVLYLYDNkITKIENLEFLTNlthLYLQ----NNQIEKIENLENLV- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 590 maNLTELEL----IRC--DLEriphsifSLHNLQEIDLKDNNLKTIEEII----SFQHL-HRLTCLKLWYNHIAYIpIQI 658
Cdd:cd21340   69 --NLKKLYLggnrISVveGLE-------NLTNLEELHIENQRLPPGEKLTfdprSLAALsNSLRVLNISGNNIDSL-EPL 138

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767957899 659 GNLTNLERLYLNRNKIEKIP--TQLFY-CRKLRYLDLSHN 695
Cdd:cd21340  139 APLRNLEQLDASNNQISDLEelLDLLSsWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
592-651 1.64e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.64e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767957899  592 NLTELELIRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEiISFQHLHRLTCLKLWYNHI 651
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 444-711 1.74e-06

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 51.80  E-value: 1.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899  444 DLVELEVL--KLELIPDvtippSIAQLTGLKELWLYHTAAKIEAPALAfLRENLRALHI-KFTDIKEIPLWIYSLKTLEE 520
Cdd:PLN03210  612 NLVKLQMQgsKLEKLWD-----GVHSLTGLRNIDLRGSKNLKEIPDLS-MATNLETLKLsDCSSLVELPSSIQYLNKLED 685

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899  521 LHLTGNLSAENnryiVIDGLrELKRLKVLRLK--SNLSKLPQVVTDVG---------------VHLQKL--------SIN 575
Cdd:PLN03210  686 LDMSRCENLEI----LPTGI-NLKSLYRLNLSgcSRLKSFPDISTNISwldldetaieefpsnLRLENLdelilcemKSE 760

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899  576 NEGTKLIVLNSLKKMANLTELELIRCD---LERIPHSIFSLHNLQEIDLKD-NNLKTIEEIISFQHLHRLT---CLKL-W 647
Cdd:PLN03210  761 KLWERVQPLTPLMTMLSPSLTRLFLSDipsLVELPSSIQNLHKLEHLEIENcINLETLPTGINLESLESLDlsgCSRLrT 840

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767957899  648 YNHIAyipiqignlTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSH-NNLTFLPADIGLLQNLQ 711
Cdd:PLN03210  841 FPDIS---------TNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHLE 896
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 512-667 7.17e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 7.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 512 IYSLKTLEEL-HLTgNLSAENNRYIVIDGLRELKRLKVLRLKSN-------LSKLPQvvtdvgvhLQKLSINN----EGT 579
Cdd:cd21340   36 ITKIENLEFLtNLT-HLYLQNNQIEKIENLENLVNLKKLYLGGNrisvvegLENLTN--------LEELHIENqrlpPGE 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 580 KLIV-LNSLKKMAN-LTELELIRCDLERIpHSIFSLHNLQEIDLKDNNLKTIEEII-SFQHLHRLTCLKLWYNHIAYIPI 656
Cdd:cd21340  107 KLTFdPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPK 185

                        170
                 ....*....|....*
gi 767957899 657 ----QIGNLTNLERL 667
Cdd:cd21340  186 yrdkIILASKSLEVL 200
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
435-671 1.11e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.78  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 435 LSGIPDTVFDLVELEVLKL---ELIpdvTIPPSIAQLTGLKELWLYHTAAKiEAPALAFLrENLRALHIKFTDIKEIPLw 511
Cdd:COG4886  194 ITDLPEPLGNLTNLEELDLsgnQLT---DLPEPLANLTNLETLDLSNNQLT-DLPELGNL-TNLEELDLSNNQLTDLPP- 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 512 IYSLKTLEELHLTGNlsaennryividGLRELKrLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMA 591
Cdd:COG4886  268 LANLTNLKTLDLSNN------------QLTDLK-LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 592 NLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 671
Cdd:COG4886  335 VTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PLN03150 PLN03150
hypothetical protein; Provisional
 606-681 2.58e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 2.58e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767957899 606 IPHSIFSLHNLQEIDLKDNNLKTieEI-ISFQHLHRLTCLKLWYNHI-AYIPIQIGNLTNLERLYLNRNKIE-KIPTQL 681
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRG--NIpPSLGSITSLEVLDLSYNSFnGSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 662-697 2.64e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 2.64e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767957899  662 TNLERLYLNRNKIEKIPtQLFYCRKLRYLDLSHNNL 697
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP-PLAKLPNLETLDLSGNNK 35
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 592-770 3.00e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 44.48  E-value: 3.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899  592 NLTELELIRCDLERIPHSIFSLHNLQEIDL-KDNNLKTIEEI---ISFQHLHRLTCLKLwynhiAYIPIQIGNLTNLERL 667
Cdd:PLN03210  612 NLVKLQMQGSKLEKLWDGVHSLTGLRNIDLrGSKNLKEIPDLsmaTNLETLKLSDCSSL-----VELPSSIQYLNKLEDL 686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899  668 YLNR-NKIEKIPT----------QLFYCRKLR----------YLDLSHNNLTFLPADIGlLQNLQNLAITANRIETL--- 723
Cdd:PLN03210  687 DMSRcENLEILPTginlkslyrlNLSGCSRLKsfpdistnisWLDLDETAIEEFPSNLR-LENLDELILCEMKSEKLwer 765

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767957899  724 -----PPELFQCRKLRALHLGNN-VLQSLPSRVGELTNLTQIELRGNR-LECLP 770
Cdd:PLN03210  766 vqpltPLMTMLSPSLTRLFLSDIpSLVELPSSIQNLHKLEHLEIENCInLETLP 819
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
616-766 5.88e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 43.61  E-value: 5.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 616 LQEIDLKDNNLKTIEEIISfqhlhrlTCLKLWY--NHIAYIPI-------------QIGNL----TNLERLYLNRNKIEK 676
Cdd:PRK15387 304 LQELSVSDNQLASLPALPS-------ELCKLWAynNQLTSLPTlpsglqelsvsdnQLASLptlpSELYKLWAYNNRLTS 376

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 677 IPTqlfYCRKLRYLDLSHNNLTFLPAdigLLQNLQNLAITANRIETLPpelFQCRKLRALHLGNNVLQSLPSRVGELTNL 756
Cdd:PRK15387 377 LPA---LPSGLKELIVSGNRLTSLPV---LPSELKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSE 447

                        170
                 ....*....|
gi 767957899 757 TQIELRGNRL 766
Cdd:PRK15387 448 TTVNLEGNPL 457
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
645-783 9.01e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.84  E-value: 9.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 645 KLWY--NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLfyCRKLRYldlsHNNLTFLPAdigLLQNLQNLAITANRIET 722
Cdd:PRK15387 286 KLWIfgNQLTSLPVLPPGLQELSVSDNQLASLPALPSEL--CKLWAY----NNQLTSLPT---LPSGLQELSVSDNQLAS 356

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767957899 723 LPPELFQCRKLRALHLGNNVLQSLPSRVGELTnltqieLRGNRLECLPVELGECPLLKRSG 783
Cdd:PRK15387 357 LPTLPSELYKLWAYNNRLTSLPALPSGLKELI------VSGNRLTSLPVLPSELKELMVSG 411
PLN03150 PLN03150
hypothetical protein; Provisional
 653-720 4.86e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 4.86e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957899 653 YIPIQIGNLTNLERLYLNRNKIE-KIPTQLFYCRKLRYLDLSHNNLT-FLPADIGLLQNLQNLAITANRI 720
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
LRR smart00370
Leucine-rich repeats, outliers;
661-682 9.85e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 9.85e-03
                           10        20
                   ....*....|....*....|..
gi 767957899   661 LTNLERLYLNRNKIEKIPTQLF 682
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAF 22
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
661-682 9.85e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 9.85e-03
                           10        20
                   ....*....|....*....|..
gi 767957899   661 LTNLERLYLNRNKIEKIPTQLF 682
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAF 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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