NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767911099|ref|XP_011508523|]
View 

DENN domain-containing protein 4B isoform X13 [Homo sapiens]

Protein Classification

DENN and dDENN domain-containing protein( domain architecture ID 13671257)

protein containing domains DENN, dDENN, and PPR_2

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 165-295 2.27e-55

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


:

Pssm-ID: 460461  Cd Length: 186  Bit Score: 190.48  E-value: 2.27e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767911099   165 QRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFP 244
Cdd:pfam02141   55 GRTQKLKPLGGTEPILLQRPEDSELPLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYP 134

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767911099   245 LHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDL-HDPPADVICVDLDTN 295
Cdd:pfam02141  135 FVWQHIYIPVLPASLLDVLSAPTPFIIGVHSRYFDLlEDPLDDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 361-434 5.01e-21

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 88.12  E-value: 5.01e-21
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767911099    361 EREVQGAFLRFMACLLKGYRVFLRPLtqapsEGARDVDNLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEEC 434
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLREL-----RKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
PPR_2 super family cl38385
PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is ...
 609-649 2.36e-04

PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is found in up to 18 copies in some proteins. The family appears to be greatly expanded in plants and fungi. The repeat has been called PPR.


The actual alignment was detected with superfamily member pfam13041:

Pssm-ID: 463778 [Multi-domain]  Cd Length: 50  Bit Score: 40.04  E-value: 2.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767911099   609 PDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITY 649
Cdd:pfam13041    1 PDVVTYNTLINGYCKKGKVEEAFKLFNEMKKRGVKPNVYTY 41
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 165-295 2.27e-55

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 190.48  E-value: 2.27e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767911099   165 QRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFP 244
Cdd:pfam02141   55 GRTQKLKPLGGTEPILLQRPEDSELPLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYP 134

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767911099   245 LHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDL-HDPPADVICVDLDTN 295
Cdd:pfam02141  135 FVWQHIYIPVLPASLLDVLSAPTPFIIGVHSRYFDLlEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 163-295 2.05e-47

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 167.76  E-value: 2.05e-47
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767911099    163 TRQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMI 242
Cdd:smart00799   49 PPGGSLVLVSLGPGDLIELQRPLDSSLPLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALL 128

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 767911099    243 FPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPP--ADVICVDLDTN 295
Cdd:smart00799  129 YPFVWQHIYIPILPASLLDVLSAPTPFIIGVHSSYFEEVKELpdEDVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 361-434 5.01e-21

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 88.12  E-value: 5.01e-21
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767911099    361 EREVQGAFLRFMACLLKGYRVFLRPLtqapsEGARDVDNLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEEC 434
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLREL-----RKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 401-450 4.80e-13

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 64.52  E-value: 4.80e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767911099   401 FFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSarHAALEFFDSC 450
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS--DPSIDLFDEE 48
PPR_2 pfam13041
PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is ...
 609-649 2.36e-04

PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is found in up to 18 copies in some proteins. The family appears to be greatly expanded in plants and fungi. The repeat has been called PPR.


Pssm-ID: 463778 [Multi-domain]  Cd Length: 50  Bit Score: 40.04  E-value: 2.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767911099   609 PDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITY 649
Cdd:pfam13041    1 PDVVTYNTLINGYCKKGKVEEAFKLFNEMKKRGVKPNVYTY 41
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 165-295 2.27e-55

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 190.48  E-value: 2.27e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767911099   165 QRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFP 244
Cdd:pfam02141   55 GRTQKLKPLGGTEPILLQRPEDSELPLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYP 134

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767911099   245 LHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDL-HDPPADVICVDLDTN 295
Cdd:pfam02141  135 FVWQHIYIPVLPASLLDVLSAPTPFIIGVHSRYFDLlEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 163-295 2.05e-47

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 167.76  E-value: 2.05e-47
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767911099    163 TRQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMI 242
Cdd:smart00799   49 PPGGSLVLVSLGPGDLIELQRPLDSSLPLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALL 128

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 767911099    243 FPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPP--ADVICVDLDTN 295
Cdd:smart00799  129 YPFVWQHIYIPILPASLLDVLSAPTPFIIGVHSSYFEEVKELpdEDVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 361-434 5.01e-21

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 88.12  E-value: 5.01e-21
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767911099    361 EREVQGAFLRFMACLLKGYRVFLRPLtqapsEGARDVDNLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEEC 434
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLREL-----RKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 401-450 4.80e-13

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 64.52  E-value: 4.80e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767911099   401 FFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSarHAALEFFDSC 450
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS--DPSIDLFDEE 48
SPA pfam08616
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 194-298 2.37e-05

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


Pssm-ID: 400783  Cd Length: 113  Bit Score: 44.97  E-value: 2.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767911099   194 ASFLQLLQSLGPELaITLLLAVLTEHKLLVHSlRPDLLTSVCE------ALVSMIFPLH-WQCPYIPLCPLVLADVLSAP 266
Cdd:pfam08616    2 HSLLKLLGPFTPPI-ILLINALLTSKRIIFLS-YQRSAGEVSEfvlalcNLISGGFVLRgFTNNSFPYVDLSKLDALRKV 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 767911099   267 VPFIVGIHSSYFDLHDPPADVICvDLDTNTLF 298
Cdd:pfam08616   80 PGYIAGVTNPIFENQDQWWDVLC-DLDSGSVK 110
PPR_2 pfam13041
PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is ...
 609-649 2.36e-04

PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is found in up to 18 copies in some proteins. The family appears to be greatly expanded in plants and fungi. The repeat has been called PPR.


Pssm-ID: 463778 [Multi-domain]  Cd Length: 50  Bit Score: 40.04  E-value: 2.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767911099   609 PDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITY 649
Cdd:pfam13041    1 PDVVTYNTLINGYCKKGKVEEAFKLFNEMKKRGVKPNVYTY 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH