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Conserved domains on  [gi|530366583|ref|XP_005273370|]
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dihydroxyacetone phosphate acyltransferase isoform X1 [Homo sapiens]

Protein Classification

glycerol-3-phosphate acyltransferase( domain architecture ID 13250295)

glycerol-3-phosphate acyltransferase catalyzes the incorporation of an acyl group from acylCoA into the acceptor glycerol 3-phosphate

CATH:  3.40.1130.10
EC:  2.3.1.15
Gene Ontology:  GO:0004366|GO:0006072|GO:0016020|GO:0008654
PubMed:  9515909|18931347|18287005
SCOP:  3000661

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 133-338 1.47e-106

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


:

Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 321.83  E-value: 1.47e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 133 FSKVCVNEEGIQKLQRAIQE-HPVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDFLGMkMVGELLRMSGAFFMRRT 211
Cdd:cd07993    1 FDGVQVNEGQLERLRKAAQEgHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIP-ILGTLLRRLGAFFIRRS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 212 FGGNKLYWAVFSEYVKTMLRNGYaPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETL 291
Cdd:cd07993   80 FGKDPLYRAVLQEYVQELLKNGQ-PLEFFIEGTRSRTGKLLPPKLGLLSVVVEAYLKGSVPDVLIVPVSISYDRVLEEEL 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 530366583 292 YVYELLGVPKPKESTTGLLKARKILSENFGSIHVYFGDPVSLRSLAA 338
Cdd:cd07993  159 YAEELLGPPKPKESLSGLLGASKILRENFGRIRVDFGEPISLREYLG 205
PlsB super family cl30506
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
 74-643 9.87e-105

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


The actual alignment was detected with superfamily member COG2937:

Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 334.20  E-value: 9.87e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  74 VLNSEEIHYVIKQLSKESLQSVDVLREEVSEILDEMSHKLRLGAIRFCAFTLSKVFKQIFSKVCVNeeGIQKLQRAIQEH 153
Cdd:COG2937  126 LLRSPAVRKAIEEEAKSKGISEEKARKEARRYLREIAADFSYSAIRFLDRVLRWLWNRLYDGIRVD--NLERLRELAKGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 154 PVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAG--MDFLGmkmVGELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLR 231
Cdd:COG2937  204 EIVYVPCHRSHMDYLLLSYVLYHNGLVPPHIAAGinLNFWP---LGPILRRGGAFFIRRSFKGNKLYSAVFREYLAELFE 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 232 NGYaPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETLYVYELLGVPKPKESTTGLLK 311
Cdd:COG2937  281 RGY-SVEYFIEGGRSRTGRLLPPKTGMLSMTVQAFLRGARRPVVFVPVYIGYERVLEVGSYAKELRGGEKKKESLGGLLR 359

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 312 ARKILSENFGSIHVYFGDPVSLRSLAAgrmsrsSYNLVPRYIPQKQSEDMHAFVTEVAYK-MEllQIEN-MVLSPWTLIV 389
Cdd:COG2937  360 ALRKLRRRFGRVYVNFGEPISLSEYLD------QHVPDWRESEDLRPEWLRPAVDKLAFEiMV--RINRaAAVNPVNLVA 431

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 390 AVLLQNRP-SMDFDALVEKTLWLKGLTQAFGGfliwPDNKPAEEVVPASILLHsniasLVKDQVILKVDSGDSEVVdglM 468
Cdd:COG2937  432 LALLASPKrALTEAELLAQLDLYLDLLRNVPY----SLSVTLPELTPEELLEH-----LLSLGLIEVEKDGLGDVI---S 499

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 469 L---QHITLlmcSAYRNQLLNIFVRPSLVAVALQMTPGFRKEDVYSCFRFLRDVFADEFIFLPGNTLKD-FEEGCYLLCK 544
Cdd:COG2937  500 IddeQAVLL---TYYRNNILHLFALPALIASALLANRRISRAELLELVRLLYPLLKAELFLRWDAEFEEvLDEELDELVR 576

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 545 SEAIQVTTKDILVTEKGNTVLEFLVGLFKPFVESYQIICKYLLSEEEDHFSEEQYLAAVRKFTSQLLDQGTSQCYDVLSS 624
Cdd:COG2937  577 QGLLEREGDTLRRPPARFRQLQLLAHVLRETLERYAIVLSLLAKLGSGTLDRKELEKESLLLAQRLSLLHGINAPEFFDK 656

                        570
                 ....*....|....*....
gi 530366583 625 DVQKNALAACVRLGVVEKK 643
Cdd:COG2937  657 ALFRNFIQTLREQGYLDDD 675
 
Name Accession Description Interval E-value
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 133-338 1.47e-106

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 321.83  E-value: 1.47e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 133 FSKVCVNEEGIQKLQRAIQE-HPVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDFLGMkMVGELLRMSGAFFMRRT 211
Cdd:cd07993    1 FDGVQVNEGQLERLRKAAQEgHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIP-ILGTLLRRLGAFFIRRS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 212 FGGNKLYWAVFSEYVKTMLRNGYaPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETL 291
Cdd:cd07993   80 FGKDPLYRAVLQEYVQELLKNGQ-PLEFFIEGTRSRTGKLLPPKLGLLSVVVEAYLKGSVPDVLIVPVSISYDRVLEEEL 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 530366583 292 YVYELLGVPKPKESTTGLLKARKILSENFGSIHVYFGDPVSLRSLAA 338
Cdd:cd07993  159 YAEELLGPPKPKESLSGLLGASKILRENFGRIRVDFGEPISLREYLG 205
PlsB COG2937
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
 74-643 9.87e-105

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 334.20  E-value: 9.87e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  74 VLNSEEIHYVIKQLSKESLQSVDVLREEVSEILDEMSHKLRLGAIRFCAFTLSKVFKQIFSKVCVNeeGIQKLQRAIQEH 153
Cdd:COG2937  126 LLRSPAVRKAIEEEAKSKGISEEKARKEARRYLREIAADFSYSAIRFLDRVLRWLWNRLYDGIRVD--NLERLRELAKGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 154 PVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAG--MDFLGmkmVGELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLR 231
Cdd:COG2937  204 EIVYVPCHRSHMDYLLLSYVLYHNGLVPPHIAAGinLNFWP---LGPILRRGGAFFIRRSFKGNKLYSAVFREYLAELFE 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 232 NGYaPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETLYVYELLGVPKPKESTTGLLK 311
Cdd:COG2937  281 RGY-SVEYFIEGGRSRTGRLLPPKTGMLSMTVQAFLRGARRPVVFVPVYIGYERVLEVGSYAKELRGGEKKKESLGGLLR 359

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 312 ARKILSENFGSIHVYFGDPVSLRSLAAgrmsrsSYNLVPRYIPQKQSEDMHAFVTEVAYK-MEllQIEN-MVLSPWTLIV 389
Cdd:COG2937  360 ALRKLRRRFGRVYVNFGEPISLSEYLD------QHVPDWRESEDLRPEWLRPAVDKLAFEiMV--RINRaAAVNPVNLVA 431

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 390 AVLLQNRP-SMDFDALVEKTLWLKGLTQAFGGfliwPDNKPAEEVVPASILLHsniasLVKDQVILKVDSGDSEVVdglM 468
Cdd:COG2937  432 LALLASPKrALTEAELLAQLDLYLDLLRNVPY----SLSVTLPELTPEELLEH-----LLSLGLIEVEKDGLGDVI---S 499

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 469 L---QHITLlmcSAYRNQLLNIFVRPSLVAVALQMTPGFRKEDVYSCFRFLRDVFADEFIFLPGNTLKD-FEEGCYLLCK 544
Cdd:COG2937  500 IddeQAVLL---TYYRNNILHLFALPALIASALLANRRISRAELLELVRLLYPLLKAELFLRWDAEFEEvLDEELDELVR 576

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 545 SEAIQVTTKDILVTEKGNTVLEFLVGLFKPFVESYQIICKYLLSEEEDHFSEEQYLAAVRKFTSQLLDQGTSQCYDVLSS 624
Cdd:COG2937  577 QGLLEREGDTLRRPPARFRQLQLLAHVLRETLERYAIVLSLLAKLGSGTLDRKELEKESLLLAQRLSLLHGINAPEFFDK 656

                        570
                 ....*....|....*....
gi 530366583 625 DVQKNALAACVRLGVVEKK 643
Cdd:COG2937  657 ALFRNFIQTLREQGYLDDD 675
PTZ00374 PTZ00374
dihydroxyacetone phosphate acyltransferase; Provisional
 61-607 5.14e-74

dihydroxyacetone phosphate acyltransferase; Provisional


Pssm-ID: 240389 [Multi-domain]  Cd Length: 1108  Bit Score: 258.65  E-value: 5.14e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583   61 GITPckpiDIKCSVLNSEEIHYVIKQLS-KESLQSVDVLREEVSeILDEMSHKLRLGAIRFCAFTLSKVFKQIFSKVCVN 139
Cdd:PTZ00374  539 GLTP----ESLTSILAQPSIQRLMTALAkKEGASEKDVEARAKA-ILRTCGDNLNHVQCRLFGLMVRRILFRLYDRVSLN 613

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  140 EEGIQKLQRAIQEhP---VVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDFLGMKMVGELLRMSGAFFMRRTFGGNK 216
Cdd:PTZ00374  614 SGAFERLHRYVAM-PrvaVVLLPLHRSYIDFIIMTYLLAVMGLPLPHVCAGDDFLRMGPIATLMRGSGAFFMRRSFRDDP 692

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  217 LYWAVFSEYVKTMLRnGYAPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFF--KREVFDTYLVPISISYDKILEETLYVY 294
Cdd:PTZ00374  693 LYAALFKEYVRHLVL-RRRPLEFFIEGTRSRTGKTMAPKLGLLKFICDTFYegQQELDDVLIIPVSLSYDELLETTLYAK 771

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  295 ELLGVPKPKESTTGLLKARKILSENFGSIHVYFGDPVSLRSLA-------------AGRMSRSSYNL--------VPRYI 353
Cdd:PTZ00374  772 EQLGVSKPKENPGNLLRARSLLKRRHGKIHVHIGEPVSLRSFKdhplqcplpfepkGEATTSVCKTLdttpsiarKSSIT 851

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  354 PQKqsedmhaFVTEVAYK-MELLQiENMVLSPWTLIVAVLLQNRPS---MDFDALVEKTLWLKGLTQAFGGFL-IWPDNK 428
Cdd:PTZ00374  852 PPR-------VLTNIAWHlTHKLQ-RNTIITPTALVAAVLECLGPTagaMPLAEVQQGMTWLRTNIRRRGAALsDDCANL 923

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  429 PAEEVVPASIllhSNIASLVKdqvILKVDSGDSEVVDGLMlQHITLLMCSayrNQLLNIFVRPSLVAVALQM-----TPG 503
Cdd:PTZ00374  924 NPETMVRKAL---THLQEFVE---ITDEMSEVIYVRQDVV-TRLGVNICS---NQLIHVFMDEAVVAVVARAfgevtAPH 993

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  504 FR---KEDVYS--CfRFLRDVFADEFiflpgntlKDFEEGC------YLLCKSEAIQVTTKDIL-VTEKGNTVLEFLVGL 571
Cdd:PTZ00374  994 RVrrvEADVLKeqC-QLLRQLLSAEF--------QDYLPACpytfasWHGLELKPVAKEAAYTIpATADRTVLLERLQQL 1064

                         570       580       590
                  ....*....|....*....|....*....|....*....
gi 530366583  572 FKPFVESYQIICKYLLSEEEDHFSE---EQYLAAVRKFT 607
Cdd:PTZ00374 1065 MRHVCEMRSSSPHLLRAEEQKKAREdilKEYVKVLRRMK 1103
PRK04974 PRK04974
glycerol-3-phosphate 1-O-acyltransferase PlsB;
73-495 8.39e-60

glycerol-3-phosphate 1-O-acyltransferase PlsB;


Pssm-ID: 235325 [Multi-domain]  Cd Length: 818  Bit Score: 215.10  E-value: 8.39e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  73 SVLNSEEIHYVIKQLSKESLQSVDVLREEVSEILDEMSHKLRLGAIRFCAFTLSKVFKQIFSKVCV-NEEGIQKLqrAIQ 151
Cdd:PRK04974 223 KLLASPAIKKAIEDEAKSKKISHEKARQNAIAYMDEIAADYSYSAIRLADRFLTWLWNRLYQGINVhNAERVRQL--AQD 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 152 EHPVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDfLGMKMVGELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLR 231
Cdd:PRK04974 301 GHEIVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGIN-LNFWPAGPIFRRGGAFFIRRSFKGNKLYSTVFREYLGELFA 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 232 NGYaPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETLYVYELLGVPKPKESTTGLLK 311
Cdd:PRK04974 380 RGY-SVEYFVEGGRSRTGRLLQPKTGMLAMTLQAMLRGSRRPITLVPVYIGYEHVMEVGTYAKELRGAPKEKESLFQVLR 458

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 312 ARKILSeNFGSIHVYFGDPVSLRSLAAGRM--SRSSYNLVPRYIPQKqsedMHAFVTEVAYKMeLLQIEN-MVLSPWTLI 388
Cdd:PRK04974 459 GIRKLR-NFGQGYVNFGEPIPLNDYLNQHVpeWRESIDPIEEQRPAW----LTPAVNNLANQV-MVRINNaAAANPVNLC 532

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 389 VAVLLQNRP-SMDFDALVEK-TLWLKGLTQA-FGGFLIWPDNKPAEevvpasILLHS---NIASLVKDQV--ILKVDsgD 460
Cdd:PRK04974 533 ALALLASRQrALDREQLIEQlDLYLQLLRNVpYSSDTTVPEGSGEE------LIDHAlslNKFEVEKDTLgdIISLD--R 604

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 530366583 461 SEVVdgLMlqhitllmcSAYRNQLLNIFVRPSLVA 495
Cdd:PRK04974 605 EQAV--LM---------TYYRNNILHLFVLPSLIA 628
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 137-282 1.17e-30

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 116.61  E-value: 1.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  137 CVNEEGIQKLQRaiqEHPVVLLPSHRSYIDFLMLSFLLYNYDLPvPVIAAGMDFLGMKMVGELLRMSGAFFMRRtfgGNK 216
Cdd:pfam01553   1 RIEVHGLENLPR---GGPAIVVANHQSYLDVLLLSLALYKRGRP-LVFVAKKELFDIPLVGWLMRLLGCIFIDR---KNR 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530366583  217 LYWAVFSEYVKTMLRNGYaPVEFFLEGTRSRSAKTLTPKFGLLNIVMEpffkrevFDTYLVPISIS 282
Cdd:pfam01553  74 KDAAGTLEYLVELLREGK-LVVIFPEGTRSREGELLPFKKGAFRLAIE-------AGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 155-284 1.34e-22

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 93.19  E-value: 1.34e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583   155 VVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDFLgMKMVGELLRMSGAFFMRRTFGgnKLYWAVFSEYVKtMLRNGY 234
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFY-VPLLGWLLRLLGAIFIDRSNG--RKARAALREAVE-LLKEGE 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 530366583   235 aPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPffkrevfDTYLVPISISYD 284
Cdd:smart00563  77 -WLLIFPEGTRSRPGKLLPFKKGAARLALEA-------GVPIVPVAIRGT 118
GPAT_C pfam19277
Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal ...
 292-581 5.02e-17

Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal region of Glycerol-3-phosphate acyltransferase.


Pssm-ID: 466024  Cd Length: 370  Bit Score: 83.34  E-value: 5.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  292 YVYELLGVPKPKESTTGLLK-ARKILSENFGSIHVYFGDPVSLRSLAAGRMSRSSYnlvpryipqkQSEDMHAFVTEVAY 370
Cdd:pfam19277   1 YAAELLGGPKKPEGLSWLLSyARSQLSLKLGRVYVRFGEPWSLREFLDEQGDRPAT----------DAARRRLALQKLAF 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  371 KMeLLQI-ENMVLSPWTLIVAVLLQNRP-SMDFDALVEKTLWL------KGLTQAFGGFLiwpdnkPAEEVVPASillhs 442
Cdd:pfam19277  71 EV-LSRInRVTPVMPTALVGTVLLTLRGrALTLSELIRRVEWLldyiraRGGPVAHFGDL------RTEEVVDRA----- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  443 nIASLVKDQVILKVDSGDSEV-----VDGLMLqhitllmcSAYRNQLLNIFVRPSLVAVALQMTP-----GFRKEDVYSC 512
Cdd:pfam19277 139 -LDVLGNAGLVTRVDGGPEPVyyiapEDHFQA--------SFYRNMTIHLFVERAIVELALLTKVkaaqrGDSYEALWDQ 209

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  513 FRFLRDVFADEFIFLPGNTLK-DFEEGCYLLCKSEAIQVTTKDILVTEKGNTVLEFLVGLFKPFVESYQI 581
Cdd:pfam19277 210 VLRLRDLLKFEFFFPPKEGFReNLRAELDLLDPWEDRVITGERDIERLLGRENPDFACFLLWPFIEAYWL 279
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 151-337 3.12e-10

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 60.41  E-value: 3.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 151 QEHPVVLLPSHRSYIDFLMLSFLlynydLPVPV-IAAGMDFLGMKMVGELLRMSGAFFMRRTFGGNKLywAVFsEYVKTM 229
Cdd:COG0204   41 ADGPVLIVANHQSWLDILLLLAA-----LPRPVrFVAKKELFKIPLLGWLLRALGAIPVDRSKRRAAL--RAL-RQAVEA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 230 LRNGYAPVeFFLEGTRSRSAKTLTPKFGLLNIVMEpffkrevFDTYLVPISISYdkileeTLYVYELLGVPKPkesttgl 309
Cdd:COG0204  113 LKAGESLV-IFPEGTRSPDGRLLPFKTGAARLALE-------AGVPIVPVAIDG------TERALPKGFLPRP------- 171

                        170       180
                 ....*....|....*....|....*...
gi 530366583 310 lkarkilsenfGSIHVYFGDPVSLRSLA 337
Cdd:COG0204  172 -----------GKVTVRIGPPIDPSDLE 188
 
Name Accession Description Interval E-value
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 133-338 1.47e-106

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 321.83  E-value: 1.47e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 133 FSKVCVNEEGIQKLQRAIQE-HPVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDFLGMkMVGELLRMSGAFFMRRT 211
Cdd:cd07993    1 FDGVQVNEGQLERLRKAAQEgHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIP-ILGTLLRRLGAFFIRRS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 212 FGGNKLYWAVFSEYVKTMLRNGYaPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETL 291
Cdd:cd07993   80 FGKDPLYRAVLQEYVQELLKNGQ-PLEFFIEGTRSRTGKLLPPKLGLLSVVVEAYLKGSVPDVLIVPVSISYDRVLEEEL 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 530366583 292 YVYELLGVPKPKESTTGLLKARKILSENFGSIHVYFGDPVSLRSLAA 338
Cdd:cd07993  159 YAEELLGPPKPKESLSGLLGASKILRENFGRIRVDFGEPISLREYLG 205
PlsB COG2937
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
 74-643 9.87e-105

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 334.20  E-value: 9.87e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  74 VLNSEEIHYVIKQLSKESLQSVDVLREEVSEILDEMSHKLRLGAIRFCAFTLSKVFKQIFSKVCVNeeGIQKLQRAIQEH 153
Cdd:COG2937  126 LLRSPAVRKAIEEEAKSKGISEEKARKEARRYLREIAADFSYSAIRFLDRVLRWLWNRLYDGIRVD--NLERLRELAKGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 154 PVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAG--MDFLGmkmVGELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLR 231
Cdd:COG2937  204 EIVYVPCHRSHMDYLLLSYVLYHNGLVPPHIAAGinLNFWP---LGPILRRGGAFFIRRSFKGNKLYSAVFREYLAELFE 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 232 NGYaPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETLYVYELLGVPKPKESTTGLLK 311
Cdd:COG2937  281 RGY-SVEYFIEGGRSRTGRLLPPKTGMLSMTVQAFLRGARRPVVFVPVYIGYERVLEVGSYAKELRGGEKKKESLGGLLR 359

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 312 ARKILSENFGSIHVYFGDPVSLRSLAAgrmsrsSYNLVPRYIPQKQSEDMHAFVTEVAYK-MEllQIEN-MVLSPWTLIV 389
Cdd:COG2937  360 ALRKLRRRFGRVYVNFGEPISLSEYLD------QHVPDWRESEDLRPEWLRPAVDKLAFEiMV--RINRaAAVNPVNLVA 431

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 390 AVLLQNRP-SMDFDALVEKTLWLKGLTQAFGGfliwPDNKPAEEVVPASILLHsniasLVKDQVILKVDSGDSEVVdglM 468
Cdd:COG2937  432 LALLASPKrALTEAELLAQLDLYLDLLRNVPY----SLSVTLPELTPEELLEH-----LLSLGLIEVEKDGLGDVI---S 499

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 469 L---QHITLlmcSAYRNQLLNIFVRPSLVAVALQMTPGFRKEDVYSCFRFLRDVFADEFIFLPGNTLKD-FEEGCYLLCK 544
Cdd:COG2937  500 IddeQAVLL---TYYRNNILHLFALPALIASALLANRRISRAELLELVRLLYPLLKAELFLRWDAEFEEvLDEELDELVR 576

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 545 SEAIQVTTKDILVTEKGNTVLEFLVGLFKPFVESYQIICKYLLSEEEDHFSEEQYLAAVRKFTSQLLDQGTSQCYDVLSS 624
Cdd:COG2937  577 QGLLEREGDTLRRPPARFRQLQLLAHVLRETLERYAIVLSLLAKLGSGTLDRKELEKESLLLAQRLSLLHGINAPEFFDK 656

                        570
                 ....*....|....*....
gi 530366583 625 DVQKNALAACVRLGVVEKK 643
Cdd:COG2937  657 ALFRNFIQTLREQGYLDDD 675
PTZ00374 PTZ00374
dihydroxyacetone phosphate acyltransferase; Provisional
 61-607 5.14e-74

dihydroxyacetone phosphate acyltransferase; Provisional


Pssm-ID: 240389 [Multi-domain]  Cd Length: 1108  Bit Score: 258.65  E-value: 5.14e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583   61 GITPckpiDIKCSVLNSEEIHYVIKQLS-KESLQSVDVLREEVSeILDEMSHKLRLGAIRFCAFTLSKVFKQIFSKVCVN 139
Cdd:PTZ00374  539 GLTP----ESLTSILAQPSIQRLMTALAkKEGASEKDVEARAKA-ILRTCGDNLNHVQCRLFGLMVRRILFRLYDRVSLN 613

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  140 EEGIQKLQRAIQEhP---VVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDFLGMKMVGELLRMSGAFFMRRTFGGNK 216
Cdd:PTZ00374  614 SGAFERLHRYVAM-PrvaVVLLPLHRSYIDFIIMTYLLAVMGLPLPHVCAGDDFLRMGPIATLMRGSGAFFMRRSFRDDP 692

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  217 LYWAVFSEYVKTMLRnGYAPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFF--KREVFDTYLVPISISYDKILEETLYVY 294
Cdd:PTZ00374  693 LYAALFKEYVRHLVL-RRRPLEFFIEGTRSRTGKTMAPKLGLLKFICDTFYegQQELDDVLIIPVSLSYDELLETTLYAK 771

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  295 ELLGVPKPKESTTGLLKARKILSENFGSIHVYFGDPVSLRSLA-------------AGRMSRSSYNL--------VPRYI 353
Cdd:PTZ00374  772 EQLGVSKPKENPGNLLRARSLLKRRHGKIHVHIGEPVSLRSFKdhplqcplpfepkGEATTSVCKTLdttpsiarKSSIT 851

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  354 PQKqsedmhaFVTEVAYK-MELLQiENMVLSPWTLIVAVLLQNRPS---MDFDALVEKTLWLKGLTQAFGGFL-IWPDNK 428
Cdd:PTZ00374  852 PPR-------VLTNIAWHlTHKLQ-RNTIITPTALVAAVLECLGPTagaMPLAEVQQGMTWLRTNIRRRGAALsDDCANL 923

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  429 PAEEVVPASIllhSNIASLVKdqvILKVDSGDSEVVDGLMlQHITLLMCSayrNQLLNIFVRPSLVAVALQM-----TPG 503
Cdd:PTZ00374  924 NPETMVRKAL---THLQEFVE---ITDEMSEVIYVRQDVV-TRLGVNICS---NQLIHVFMDEAVVAVVARAfgevtAPH 993

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  504 FR---KEDVYS--CfRFLRDVFADEFiflpgntlKDFEEGC------YLLCKSEAIQVTTKDIL-VTEKGNTVLEFLVGL 571
Cdd:PTZ00374  994 RVrrvEADVLKeqC-QLLRQLLSAEF--------QDYLPACpytfasWHGLELKPVAKEAAYTIpATADRTVLLERLQQL 1064

                         570       580       590
                  ....*....|....*....|....*....|....*....
gi 530366583  572 FKPFVESYQIICKYLLSEEEDHFSE---EQYLAAVRKFT 607
Cdd:PTZ00374 1065 MRHVCEMRSSSPHLLRAEEQKKAREdilKEYVKVLRRMK 1103
PRK04974 PRK04974
glycerol-3-phosphate 1-O-acyltransferase PlsB;
73-495 8.39e-60

glycerol-3-phosphate 1-O-acyltransferase PlsB;


Pssm-ID: 235325 [Multi-domain]  Cd Length: 818  Bit Score: 215.10  E-value: 8.39e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  73 SVLNSEEIHYVIKQLSKESLQSVDVLREEVSEILDEMSHKLRLGAIRFCAFTLSKVFKQIFSKVCV-NEEGIQKLqrAIQ 151
Cdd:PRK04974 223 KLLASPAIKKAIEDEAKSKKISHEKARQNAIAYMDEIAADYSYSAIRLADRFLTWLWNRLYQGINVhNAERVRQL--AQD 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 152 EHPVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDfLGMKMVGELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLR 231
Cdd:PRK04974 301 GHEIVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGIN-LNFWPAGPIFRRGGAFFIRRSFKGNKLYSTVFREYLGELFA 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 232 NGYaPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETLYVYELLGVPKPKESTTGLLK 311
Cdd:PRK04974 380 RGY-SVEYFVEGGRSRTGRLLQPKTGMLAMTLQAMLRGSRRPITLVPVYIGYEHVMEVGTYAKELRGAPKEKESLFQVLR 458

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 312 ARKILSeNFGSIHVYFGDPVSLRSLAAGRM--SRSSYNLVPRYIPQKqsedMHAFVTEVAYKMeLLQIEN-MVLSPWTLI 388
Cdd:PRK04974 459 GIRKLR-NFGQGYVNFGEPIPLNDYLNQHVpeWRESIDPIEEQRPAW----LTPAVNNLANQV-MVRINNaAAANPVNLC 532

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 389 VAVLLQNRP-SMDFDALVEK-TLWLKGLTQA-FGGFLIWPDNKPAEevvpasILLHS---NIASLVKDQV--ILKVDsgD 460
Cdd:PRK04974 533 ALALLASRQrALDREQLIEQlDLYLQLLRNVpYSSDTTVPEGSGEE------LIDHAlslNKFEVEKDTLgdIISLD--R 604

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 530366583 461 SEVVdgLMlqhitllmcSAYRNQLLNIFVRPSLVA 495
Cdd:PRK04974 605 EQAV--LM---------TYYRNNILHLFVLPSLIA 628
PRK03355 PRK03355
glycerol-3-phosphate 1-O-acyltransferase;
70-641 8.16e-46

glycerol-3-phosphate 1-O-acyltransferase;


Pssm-ID: 179567 [Multi-domain]  Cd Length: 783  Bit Score: 174.51  E-value: 8.16e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  70 IKCSVLNSEEIHYVIKQLSKESLQSVDVLREEVSEILDEMShklrLGAIRFcAFTLSKVFKQIFS-----KVCVNEEGIQ 144
Cdd:PRK03355 184 VKPEILASARFRAGLAKIAAKLGRPPGATVREAGKMLDELV----AGWSRV-SVDLVSVLGRLFSrgfdpEIDYDEYELA 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 145 KLQRAIQEHPVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDfLGMKMVGELLRMSGAFFMRRTFGGNKLYWAVFSE 224
Cdd:PRK03355 259 ALRALLEEHPAVLLFSHRSYIDGLVVPVAMQENRLPPVHVFGGIN-LSFGPMGPIMRRSGMIFIRRNIGDDPLYKYVLRE 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 225 YVKTMLRNGYaPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETLYVYELLGVPKPKE 304
Cdd:PRK03355 338 YVGYLVEKRF-NLSWYIEGTRSRTGKLLPPKLGLLSYVADAYLDGRSDDVLLQPVSISFDQLHEIGEYAAEARGGEKTPE 416

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 305 STTGLLKARKILSE-NFGSIHVYFGDPVSLRS-LAAGRMSRSSYNLVPRYIPQKQsedmhAFvtEVAYkmELLQIENMVL 382
Cdd:PRK03355 417 GLRWLYNYIKAQGErNYGKIYVRFGEPVSMRQyLGAPHGPLTQDPDAKRLALQKM-----AF--EVAW--RINQVTPVTA 487

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 383 SpwTLIVAVLLQNRPsmdfdalveKTLWLKGLTQAFGGFLIW------PDNKPA-----EEVVPASILLHSNiaslvkDQ 451
Cdd:PRK03355 488 T--SLVSLLLLGTRG---------RALTLDELHHTLQDSLDYlerrqlPVSTSAlrlrdPEGVRAALDALSN------GG 550

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 452 VILKVDSGDSEVVDGLMLQHitlLMCSAYRNQLLNIFVRPSLVAVALQMTPGFRKEDVYSCF-----RfLRDVFADEFIF 526
Cdd:PRK03355 551 PVTRVDSGREPVWYIAPDDH---LVAAFYRNSVIHAFLERAIVELALAAAAHVDEGDRLAAFwdqamR-LRDLLKFEFFF 626

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 527 LPGNTLK------------DFEEgcyllckSEAIQVTTKDILVTEKGntvleFLVG--LFKPFVESYQIICKYLLSEEED 592
Cdd:PRK03355 627 ADSDAFRanlraemawidpDWED-------RLAAGGDEIDALLRAKR-----PLMAhaMLRPFFEAYEVVADVLRDAPPD 694

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*....
gi 530366583 593 HFSEEQYLAAVRKFTSQLLDQGTSQCYDVLSSDVQKNALAACVRLGVVE 641
Cdd:PRK03355 695 TIDEKELTALALGLGRQYVLQGRVRSSESVSTLLFATARQLARDQGLLE 743
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 137-282 1.17e-30

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 116.61  E-value: 1.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  137 CVNEEGIQKLQRaiqEHPVVLLPSHRSYIDFLMLSFLLYNYDLPvPVIAAGMDFLGMKMVGELLRMSGAFFMRRtfgGNK 216
Cdd:pfam01553   1 RIEVHGLENLPR---GGPAIVVANHQSYLDVLLLSLALYKRGRP-LVFVAKKELFDIPLVGWLMRLLGCIFIDR---KNR 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530366583  217 LYWAVFSEYVKTMLRNGYaPVEFFLEGTRSRSAKTLTPKFGLLNIVMEpffkrevFDTYLVPISIS 282
Cdd:pfam01553  74 KDAAGTLEYLVELLREGK-LVVIFPEGTRSREGELLPFKKGAFRLAIE-------AGVPIVPVAIS 131
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 133-339 3.21e-26

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 105.96  E-value: 3.21e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 133 FSKVCVNEEGIQKLQRAIQEH-----PVVLLPSHRSYIDFLMLSFLLYNYdLPVPVIAAGMDFLGMKmvGELLRMSGAFF 207
Cdd:cd06551    1 FRYLLLNFFGFVRLEVKGPPPppgggPVLFVSNHSSWWDGLILFLLLERG-LRRDVYGLMDEELLER--YPFFTRLGAFS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 208 MRRTFGGnklYWAVFSEYVKTMLRNGYAPVEFFLEGTRSR-SAKTLTPKFGLLNIvmepffkREVFDTYLVPISISYDKI 286
Cdd:cd06551   78 VDRDSPR---SAAKSLKYVARLLSKPGSVVWIFPEGTRTRrDKRPLQFKPGVAHL-------AEKAGVPIVPVALRYTFE 147

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530366583 287 LEetlyvyellgvpkpkesttgllkarkilsENFGSIHVYFGDPVSLRSLAAG 339
Cdd:cd06551  148 LF-----------------------------EQFPEIFVRIGPPIPYAETALG 171
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 155-284 1.34e-22

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 93.19  E-value: 1.34e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583   155 VVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDFLgMKMVGELLRMSGAFFMRRTFGgnKLYWAVFSEYVKtMLRNGY 234
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFY-VPLLGWLLRLLGAIFIDRSNG--RKARAALREAVE-LLKEGE 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 530366583   235 aPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPffkrevfDTYLVPISISYD 284
Cdd:smart00563  77 -WLLIFPEGTRSRPGKLLPFKKGAARLALEA-------GVPIVPVAIRGT 118
PRK11915 PRK11915
lysophospholipid acyltransferase;
84-601 2.51e-20

lysophospholipid acyltransferase;


Pssm-ID: 237022 [Multi-domain]  Cd Length: 621  Bit Score: 95.40  E-value: 2.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  84 IKQLSKESLQSVDVLREEVSEILDEMSHKLRLGAIR-FCAFtlSKVFKQIFSkVCVNEEGIQKLQRAIQEHPVVLLPSHR 162
Cdd:PRK11915  48 LRALADELGRDPDSVRAEAAGYLREMAASLDERAVQaWRGF--SRWLMRAYD-VLVDEDQITQLRKLDRKATLAFAFSHR 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 163 SYID-FLMLSFLLYNYDLPVPVIA-AGMDFLGMkmvGELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRNgYAPVEFF 240
Cdd:PRK11915 125 SYLDgMLLPEVILANRLSPALTFGgANLNFFPM---GAWAKRTGAIFIRRQTKDIPVYRFVLRAYAAQLVQN-HVNLTWS 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 241 LEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETLYVYELLGVPKPKESTTGLLKARKILSENF 320
Cdd:PRK11915 201 IEGGRTRTGKLRPPVFGILRYITDAVDEIDGPEVYLVPTSIVYDQLHEVEAMTTEAYGAVKRPEDLRFLVRLARQQGERL 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 321 GSIHVYFGDPVSLRS-LAAGRMSRSSynlvpryipqKQSEdmhafVTEVAYKMELLQIENMVLSPWTLIVAVLLQNRPSM 399
Cdd:PRK11915 281 GRAYLDFGEPLPLRKrLQELRADKSG----------TGSE-----IERIALDVEHRINRATPVTPTAVVSLALLGADRSL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 400 DFDALVEKTLWLKGLTQAFGgfliWPDNKPAEEVVPASI--LLHSNIASlvkdQVILKVDSGdSEVVDGLML-QHitlLM 476
Cdd:PRK11915 346 SISEVLATVRPLASYIAARN----WAVAGAADLTNRSTIrwTLHQMVAS----GVVSVYDAG-TEAVWGIGEdQH---LV 413

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 477 CSAYRNQLLNIFVRPSLVAVALQMTPGFRKE------DVYSCFRFLRDVFADEFIFlPGNTL--KDFEEGCYLLCKSEAI 548
Cdd:PRK11915 414 AAFYRNTAIHILVDRAIAELALLAAAETTTNgsvspaTVRDEALSLRELLKFEFLF-SGRAQfeKDLANEVRLIGSVVDT 492

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530366583 549 Q--VTTKDIL-VTEKGNTVLEFLVglFKPFVESYQIICKYLLSEEEDHFSEEQYLA 601
Cdd:PRK11915 493 SkaAAAADVWrLLESADLLLAHLV--LRPFLDAYHIVADRLAAHEDDSFDEEGFLA 546
GPAT_C pfam19277
Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal ...
 292-581 5.02e-17

Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal region of Glycerol-3-phosphate acyltransferase.


Pssm-ID: 466024  Cd Length: 370  Bit Score: 83.34  E-value: 5.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  292 YVYELLGVPKPKESTTGLLK-ARKILSENFGSIHVYFGDPVSLRSLAAGRMSRSSYnlvpryipqkQSEDMHAFVTEVAY 370
Cdd:pfam19277   1 YAAELLGGPKKPEGLSWLLSyARSQLSLKLGRVYVRFGEPWSLREFLDEQGDRPAT----------DAARRRLALQKLAF 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  371 KMeLLQI-ENMVLSPWTLIVAVLLQNRP-SMDFDALVEKTLWL------KGLTQAFGGFLiwpdnkPAEEVVPASillhs 442
Cdd:pfam19277  71 EV-LSRInRVTPVMPTALVGTVLLTLRGrALTLSELIRRVEWLldyiraRGGPVAHFGDL------RTEEVVDRA----- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  443 nIASLVKDQVILKVDSGDSEV-----VDGLMLqhitllmcSAYRNQLLNIFVRPSLVAVALQMTP-----GFRKEDVYSC 512
Cdd:pfam19277 139 -LDVLGNAGLVTRVDGGPEPVyyiapEDHFQA--------SFYRNMTIHLFVERAIVELALLTKVkaaqrGDSYEALWDQ 209

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583  513 FRFLRDVFADEFIFLPGNTLK-DFEEGCYLLCKSEAIQVTTKDILVTEKGNTVLEFLVGLFKPFVESYQI 581
Cdd:pfam19277 210 VLRLRDLLKFEFFFPPKEGFReNLRAELDLLDPWEDRVITGERDIERLLGRENPDFACFLLWPFIEAYWL 279
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 151-337 3.12e-10

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 60.41  E-value: 3.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 151 QEHPVVLLPSHRSYIDFLMLSFLlynydLPVPV-IAAGMDFLGMKMVGELLRMSGAFFMRRTFGGNKLywAVFsEYVKTM 229
Cdd:COG0204   41 ADGPVLIVANHQSWLDILLLLAA-----LPRPVrFVAKKELFKIPLLGWLLRALGAIPVDRSKRRAAL--RAL-RQAVEA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 230 LRNGYAPVeFFLEGTRSRSAKTLTPKFGLLNIVMEpffkrevFDTYLVPISISYdkileeTLYVYELLGVPKPkesttgl 309
Cdd:COG0204  113 LKAGESLV-IFPEGTRSPDGRLLPFKTGAARLALE-------AGVPIVPVAIDG------TERALPKGFLPRP------- 171

                        170       180
                 ....*....|....*....|....*...
gi 530366583 310 lkarkilsenfGSIHVYFGDPVSLRSLA 337
Cdd:COG0204  172 -----------GKVTVRIGPPIDPSDLE 188
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 154-343 4.17e-10

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 59.59  E-value: 4.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 154 PVVLLPSHRSYIDFLMLSFLLYNYdlPVPVIAAgmDFLGMKMVGELLRMSGAFFMRRtfGGNKLYWAVFsEYVKTMLRNG 233
Cdd:cd07989   25 PVIIVANHQSYLDPLVLGAALPRP--IRFVAKK--ELFKIPFLGWLLRLLGAIPIDR--GNGRSAREAL-REAIEALKEG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366583 234 YAPVeFFLEGTRSRSAKTLTPKFGLLNIVMEpffkrevFDTYLVPISISYdkileeTLYVYELLGVPKPkesttgllkar 313
Cdd:cd07989   98 ESVV-IFPEGTRSRDGELLPFKSGAFRLAKE-------AGVPIVPVAISG------TWGSLPKGKKLPR----------- 152

                        170       180       190
                 ....*....|....*....|....*....|
gi 530366583 314 kilsenFGSIHVYFGDPVSLRSLAAGRMSR 343
Cdd:cd07989  153 ------PGRVTVRIGEPIPPEGLELAEEDR 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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