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Conserved domains on  [gi|530400177|ref|XP_005268895|]
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aquaporin-5 isoform X1 [Homo sapiens]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 239)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  8849412|11473620|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 4-204 7.14e-66

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member pfam00230:

Pssm-ID: 444743 [Multi-domain]  Cd Length: 223  Bit Score: 202.55  E-value: 7.14e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177    4 EVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALP-----TILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLV 78
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSslavsGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177   79 GNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPV 158
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 530400177  159 GS-PALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFsPAHW 204
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKW-DDHW 206
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-204 7.14e-66

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 202.55  E-value: 7.14e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177    4 EVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALP-----TILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLV 78
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSslavsGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177   79 GNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPV 158
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 530400177  159 GS-PALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFsPAHW 204
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKW-DDHW 206
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-204 1.22e-55

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 176.68  E-value: 1.22e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  12 KAVFAEFLATLIFVFFGLGSALKW---PSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAF 88
Cdd:cd00333    1 RKYLAEFLGTFLLVFFGCGSVLAVklaGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  89 FYVAAQLVGAIAGAGILYGV---------APLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTD-SRRTSPV 158
Cdd:cd00333   81 PYIIAQLLGAILGAALLYGLyyglyleflGANNIVAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDdPNGPPPG 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 530400177 159 GSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHW 204
Cdd:cd00333  161 GLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHY 206
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 16-204 7.43e-51

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 164.39  E-value: 7.43e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177   16 AEFLATLIFVFFGLGSAL-------KWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAF 88
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177   89 FYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNN-TTQGQAMVVELILTFQLALCIFASTDSRRTSPVG-SPALSIG 166
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGgFAPLAIG 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 530400177  167 LSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFS-PAHW 204
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGwGNHW 199
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 10-195 5.15e-42

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 142.19  E-value: 5.15e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  10 FLKAVFAEFLATLIFVFFGLGSA--LKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRA 87
Cdd:COG0580    2 LMKRLLAEFLGTFILVLLGCGVVavLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  88 FFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALN--------NNTTQGQAMVVELILTFQLALCIFASTDSRRTsPVG 159
Cdd:COG0580   82 LPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLgvfatspaIGYSLGAAFLTEIIGTFVLVFVILGITDKRAA-PGG 160

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 530400177 160 SPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVV 195
Cdd:COG0580  161 LAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLF 196
PRK05420 PRK05420
aquaporin Z; Provisional
 11-194 5.37e-30

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 110.83  E-value: 5.37e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  11 LKAVFAEFLATLIFVFFGLGSALkWPSALPTI----LQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLR 86
Cdd:PRK05420   2 FKKLAAEFFGTFWLVFGGCGSAV-LAAAFPELgigfLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  87 AFFYVAAQLVGAIAGAGILY----GVAPLNARGNLAVNALNNNTTQGQ-----AMVVELILTFQLALCIFASTDSRrtSP 157
Cdd:PRK05420  81 LVPYIIAQVVGGIAAAAVLYliasGKAGFDLAGSGFASNGYGEHSPGGysllaALVCEVVLTAFFLLVILGATDKR--AP 158

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 530400177 158 VGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAV 194
Cdd:PRK05420 159 AGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVAL 195
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-204 7.14e-66

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 202.55  E-value: 7.14e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177    4 EVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALP-----TILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLV 78
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSslavsGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177   79 GNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPV 158
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 530400177  159 GS-PALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFsPAHW 204
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKW-DDHW 206
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-204 1.22e-55

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 176.68  E-value: 1.22e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  12 KAVFAEFLATLIFVFFGLGSALKW---PSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAF 88
Cdd:cd00333    1 RKYLAEFLGTFLLVFFGCGSVLAVklaGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  89 FYVAAQLVGAIAGAGILYGV---------APLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTD-SRRTSPV 158
Cdd:cd00333   81 PYIIAQLLGAILGAALLYGLyyglyleflGANNIVAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDdPNGPPPG 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 530400177 159 GSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHW 204
Cdd:cd00333  161 GLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHY 206
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 16-204 7.43e-51

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 164.39  E-value: 7.43e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177   16 AEFLATLIFVFFGLGSAL-------KWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAF 88
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177   89 FYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNN-TTQGQAMVVELILTFQLALCIFASTDSRRTSPVG-SPALSIG 166
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGgFAPLAIG 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 530400177  167 LSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFS-PAHW 204
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGwGNHW 199
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 10-195 5.15e-42

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 142.19  E-value: 5.15e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  10 FLKAVFAEFLATLIFVFFGLGSA--LKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRA 87
Cdd:COG0580    2 LMKRLLAEFLGTFILVLLGCGVVavLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  88 FFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALN--------NNTTQGQAMVVELILTFQLALCIFASTDSRRTsPVG 159
Cdd:COG0580   82 LPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLgvfatspaIGYSLGAAFLTEIIGTFVLVFVILGITDKRAA-PGG 160

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 530400177 160 SPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVV 195
Cdd:COG0580  161 LAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLF 196
PRK05420 PRK05420
aquaporin Z; Provisional
 11-194 5.37e-30

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 110.83  E-value: 5.37e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  11 LKAVFAEFLATLIFVFFGLGSALkWPSALPTI----LQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLR 86
Cdd:PRK05420   2 FKKLAAEFFGTFWLVFGGCGSAV-LAAAFPELgigfLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  87 AFFYVAAQLVGAIAGAGILY----GVAPLNARGNLAVNALNNNTTQGQ-----AMVVELILTFQLALCIFASTDSRrtSP 157
Cdd:PRK05420  81 LVPYIIAQVVGGIAAAAVLYliasGKAGFDLAGSGFASNGYGEHSPGGysllaALVCEVVLTAFFLLVILGATDKR--AP 158

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 530400177 158 VGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAV 194
Cdd:PRK05420 159 AGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVAL 195
PLN00166 PLN00166
aquaporin TIP2; Provisional
 7-200 5.01e-26

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 101.17  E-value: 5.01e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177   7 SVAFLKAVFAEFLATLIFVFFGLGSALKWP-----SAL--PTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVG 79
Cdd:PLN00166  14 SVASLKAYLSEFIATLLFVFAGVGSAIAFAkltsdAALdpAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  80 NQISLLRAFFYVAAQLVGAIAGAGILYGVAplNARGNLAVNALNNNTTQgQAMVVELILTFQLALCIFASTDSRRTSPVG 159
Cdd:PLN00166  94 GNITIITGFFYWIAQCLGSIVACLLLVFVT--NGESVPTHGVAAGLGAI-EGVVMEIVVTFALVYTVYATAADPKKGSLG 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 530400177 160 SPA-LSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFS 200
Cdd:PLN00166 171 TIApIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFS 212
PLN00027 PLN00027
aquaporin TIP; Provisional
 11-195 1.30e-22

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 92.16  E-value: 1.30e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  11 LKAVFAEFLATLIFVFFGLGSALKW-------PSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQIS 83
Cdd:PLN00027  20 LKAALAEFISTLIFVFAGEGSGMAFnkltdngSTTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNIT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  84 LLRAFFYVAAQLVGAIAGAGIL---YGVAPLNARGnlavnaLNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGS 160
Cdd:PLN00027 100 LLRGILYWIAQLLGSVVACLLLkfsTGGLETSAFS------LSSGVGVWNAFVFEIVMTFGLVYTVYATAVDPKKGDLGI 173

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 530400177 161 PA-LSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVV 195
Cdd:PLN00027 174 IApIAIGFIVGANILAGGAFDGASMNPAVSFGPAVV 209
PLN00167 PLN00167
aquaporin TIP5; Provisional
 3-199 4.14e-22

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 90.73  E-value: 4.14e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177   3 KEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALP-------TILQIALAFGLAIGTLAQALGPVSGGHINPAITLA 75
Cdd:PLN00167  14 QQSVTRNALRSYLAEFISTFFFVFAAVGSAMSSRKLMPdaasdpsSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  76 LLVGNQISLLRAFFYVAAQLVGAIAgAGILYGVAPLNARgnLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRT 155
Cdd:PLN00167  94 MAVGGHISVPTAMFYWISQMLASVM-ACLFLKVTTVGQH--VPTYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGDPRRG 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 530400177 156 SPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRF 199
Cdd:PLN00167 171 LLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSF 214
PLN00184 PLN00184
aquaporin NIP1; Provisional
 7-195 2.11e-19

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 84.30  E-value: 2.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177   7 SVAFLKAVFAEFLATLIFVFFGLGSAL--KWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISL 84
Cdd:PLN00184  50 SVPFLQKLIAEVLGTYFLVFTGCASVVvnMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPL 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  85 LRAFFYVAAQLVGAIAGAG---ILYGVAPLNARGNLAVNALNNNT-TQGQAMVVELILTFQLALCIFA-STDSRRTSPVG 159
Cdd:PLN00184 130 KQVPAYVISQVIGSTLAAAtlrLLFGLDHDVCSGKHDVFIGSSPVgSDLQAFVMEFIVTFYLMFIISGvATDNRAIGELA 209

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 530400177 160 spALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVV 195
Cdd:PLN00184 210 --GLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMV 243
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 16-205 6.29e-19

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 82.87  E-value: 6.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  16 AEFLATLIFVFFGLG---------SALKWPSalptiLQIALAFGLAIGTLAQAlgPVSGGHINPAITLALLVGNQISLLR 86
Cdd:PTZ00016  55 AEFLGTFVLLFFGEGvvatthtvgNNGDYLA-----ITIGWGLGVTFGLLVSA--GISGGHLNPAVTLGNAVFGKFPWKK 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  87 AFFYVAAQLVGAIAGAGILYGV----------APLNARGNLAVNALNNNTTQGQ----AMVVELILTFQLALCIFASTDS 152
Cdd:PTZ00016 128 LPGYFVAQLLGAFVGAACVYGLyygffkdhgiPELPWETMANGFAGVFATYPREgnfyAIFSELILTAILLLVILAITDP 207

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530400177 153 RRTSPVGSPALSIGLSVTlghLVGIYF---TGCSMNPARSFGPAVvmnrFSPAHWG 205
Cdd:PTZ00016 208 NNCPAFNYLPVAVGLLVF---VIGISFggnTGYALNPARDLGPRL----FSAILWG 256
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 1-199 4.06e-18

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 80.72  E-value: 4.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177   1 MKKEVCS----VAFLKAVFAEFLATLIFVFFGLGSAL--KWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITL 74
Cdd:PLN00182  28 IETAICTspsiVCLTQKLIAEMIGTYFIIFSGCGVVVvnVLYGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTV 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  75 ALLVGNQISLLRAFFYVAAQLVGAIAGAGIL---YGVAPLNARGNLAVnalnnnTTQGQAMVVELILTFQLALCIFA-ST 150
Cdd:PLN00182 108 TFAIFRRFPWYQVPLYIGAQLTGSLLASLTLrlmFNVTPEAFFGTTPT------DSSGQALVAEIIISFLLMFVISGvAT 181

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 530400177 151 DSRRTSPVGspALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRF 199
Cdd:PLN00182 182 DSRAVGELA--GIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRY 228
PLN00026 PLN00026
aquaporin NIP; Provisional
 8-199 6.69e-17

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 77.59  E-value: 6.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177   8 VAFLKAVFAEFLATLIFVFFGLGSAL--KWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLL 85
Cdd:PLN00026  68 VSLTRKLGAEFVGTFILIFAATAGPIvnQKYDGAETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWK 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  86 RAFFYVAAQLVGAIAGAGILYGV-APLNARGNLAVNALNnnttqGQAMVVELILTFQLALCIFA-STDSRrtsPVGSPA- 162
Cdd:PLN00026 148 HVPAYIAAQVSASICASFALKGVfHPFMSGGVTVPSVST-----GQAFALEFIITFNLLFVVTAvATDTR---AVGELAg 219

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 530400177 163 LSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRF 199
Cdd:PLN00026 220 IAVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNY 256
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 11-199 6.72e-15

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 71.43  E-value: 6.72e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  11 LKAVFAEFLATLIFVF--FGLGSALKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAF 88
Cdd:PLN00183  45 ARMVLAEMVGTFILMFcvCGIIASTQLSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVP 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177  89 FYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTtqgqAMVVELILTFqLALCIFASTDSRRTSPVGSPALSIGLS 168
Cdd:PLN00183 125 LYITAQTVGSVLATYVGVSVYGVKADLMTTKPAQGCSS----AFWVEFIATF-IVMFLAASLTSQPQSLGHLSGFVIGIA 199

                        170       180       190
                 ....*....|....*....|....*....|.
gi 530400177 169 VTLGHLVGIYFTGCSMNPARSFGPAVVMNRF 199
Cdd:PLN00183 200 IGLAVLITGPVSGGSMNPARSLGPAIVSWDF 230
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 8-102 1.70e-06

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 47.25  E-value: 1.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177   8 VAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQiALAFGLAIGTLAQALGPVSGGHINPAITLA-LLVGNQISLLR 86
Cdd:cd00333  127 VSNGNAFFVEFIGTFILVLVVFATTDDPNGPPPGGLA-PLAIGLLVAAIGLAGGPITGASMNPARSLGpALFTGLARHWH 205

                         90
                 ....*....|....*..
gi 530400177  87 AF-FYVAAQLVGAIAGA 102
Cdd:cd00333  206 YFwVYWVGPLIGAIAGA 222
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 8-102 1.97e-03

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 38.05  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177    8 VAFLKAVFAEFLATLIFVFFGLGSALKwPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLA-LLVGNQISLLR 86
Cdd:TIGR00861 119 VSSGQAFFVEFIGTAILVLVIFATTDD-RNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGpALFAGLAGWGN 197

                          90
                  ....*....|....*.
gi 530400177   87 AFFYVAAQLVGAIAGA 102
Cdd:TIGR00861 198 HWVYWVGPIIGAILGA 213
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 6-102 3.99e-03

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 37.53  E-value: 3.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530400177   6 CSVAFlkavFAEFLATLIFVFfgLGSALKWPSALPTILQiALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQiSLL 85
Cdd:PLN00183 160 CSSAF----WVEFIATFIVMF--LAASLTSQPQSLGHLS-GFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSW-DFK 231

                         90
                 ....*....|....*..
gi 530400177  86 RAFFYVAAQLVGAIAGA 102
Cdd:PLN00183 232 DIWIYITAPTIGAVAGA 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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