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Conserved domains on  [gi|530412108|ref|XP_005257366|]
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integrin beta-4 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 37-453 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


:

Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 616.64  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108     37 SCTECVRVDKDCAYCTDEMFRDR---RCNTQAELLAAGCQRESIVVMESSFQITEETQID---TTLRRSQMSPQGLRVRL 110
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108    111 RPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 190
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108    191 KEPWPN----SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 266
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108    267 FHYEADGAnvLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLG 346
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108    347 VLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSkMFQKTRTGSFHirRGEVGIYQVQLRALEHVDGTHVCQl 426
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394

                           410       420
                    ....*....|....*....|....*...
gi 530412108    427 PEDQKGNIHLKP-SFSDGLKMDAGIICD 453
Cdd:smart00187  395 PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 626-709 1.97e-27

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


:

Pssm-ID: 462325  Cd Length: 84  Bit Score: 107.36  E-value: 1.97e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   626 CEDLRSCVQCQAWGTGEKKGRTC-EECNFKVKMVDELKRAEE-VVVRCSFRDEdDDCTYSYTMEGDgaPGPNSTVLVHKK 703
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77


                   ....*.
gi 530412108   704 KDCPPG 709
Cdd:pfam07965   78 RECPPG 83
Calx-beta pfam03160
Calx-beta domain;
990-1084 3.64e-25

Calx-beta domain;


:

Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 101.17  E-value: 3.64e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   990 DVVSFEQPEFSVSRGDQVARIPVIRRVLD-GGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLElqevD 1068
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77

                           90
                   ....*....|....*.
gi 530412108  1069 SLLRGRqvRRFHVQLS 1084
Cdd:pfam03160   78 DVYEGD--ENFFVLLS 91
fn3 pfam00041
Fibronectin type III domain;
1695-1780 2.74e-21

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 89.78  E-value: 2.74e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108  1695 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQARTT 1774
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 530412108  1775 EGFGPE 1780
Cdd:pfam00041   79 GGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1582-1664 2.10e-19

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.39  E-value: 2.10e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108  1582 DTPTRLVFSALGPTSLRVSWQEPR-CERPLQGYSVEYQLLNGGE-LHRLNIPNPaQTSVVVEDLLPNHSYVFRVRAQSQE 1659
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdGNGPITGYEVEYRPKNSGEpWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 530412108  1660 GWGRE 1664
Cdd:pfam00041   80 GEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1128-1208 6.61e-16

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 6.61e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108  1128 GAPQNPNAKAAGSRKIHFNWLPP---SGKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 530412108  1204 EGPYS 1208
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1221-1309 3.59e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 3.59e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108  1221 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1300
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75


                   ....*....
gi 530412108  1301 RNGAGWGPE 1309
Cdd:pfam00041   76 VNGGGEGPP 84
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 457-485 1.60e-10

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


:

Pssm-ID: 465729  Cd Length: 29  Bit Score: 57.50  E-value: 1.60e-10
                           10        20
                   ....*....|....*....|....*....
gi 530412108   457 CELQKEVRSARCSFNGDFVCGQCVCSEGW 485
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 550-573 1.16e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 1.16e-03
                           10        20
                   ....*....|....*....|....*.
gi 530412108   550 LCNDRGRCSM--GQCVCEPGWTGPSC 573
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 37-453 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 616.64  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108     37 SCTECVRVDKDCAYCTDEMFRDR---RCNTQAELLAAGCQRESIVVMESSFQITEETQID---TTLRRSQMSPQGLRVRL 110
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108    111 RPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 190
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108    191 KEPWPN----SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 266
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108    267 FHYEADGAnvLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLG 346
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108    347 VLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSkMFQKTRTGSFHirRGEVGIYQVQLRALEHVDGTHVCQl 426
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394

                           410       420
                    ....*....|....*....|....*...
gi 530412108    427 PEDQKGNIHLKP-SFSDGLKMDAGIICD 453
Cdd:smart00187  395 PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 125-370 3.19e-149

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 459.27  E-value: 3.19e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   125 PLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 200
Cdd:pfam00362    1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   201 FSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGAnvLAGI 280
Cdd:pfam00362   81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   281 MSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE 360
Cdd:pfam00362  159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238

                          250
                   ....*....|
gi 530412108   361 EAFNRIRSNL 370
Cdd:pfam00362  239 EAYEKIRSKV 248
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 626-709 1.97e-27

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 107.36  E-value: 1.97e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   626 CEDLRSCVQCQAWGTGEKKGRTC-EECNFKVKMVDELKRAEE-VVVRCSFRDEdDDCTYSYTMEGDgaPGPNSTVLVHKK 703
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77


                   ....*.
gi 530412108   704 KDCPPG 709
Cdd:pfam07965   78 RECPPG 83
Calx-beta pfam03160
Calx-beta domain;
990-1084 3.64e-25

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 101.17  E-value: 3.64e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   990 DVVSFEQPEFSVSRGDQVARIPVIRRVLD-GGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLElqevD 1068
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77

                           90
                   ....*....|....*.
gi 530412108  1069 SLLRGRqvRRFHVQLS 1084
Cdd:pfam03160   78 DVYEGD--ENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 991-1084 2.91e-23

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 95.40  E-value: 2.91e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108    991 VVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLelqeVDSL 1070
Cdd:smart00237    3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDDI 78

                            90
                    ....*....|....
gi 530412108   1071 LRGrqVRRFHVQLS 1084
Cdd:smart00237   79 YEK--DETFYVRLS 90
fn3 pfam00041
Fibronectin type III domain;
1695-1780 2.74e-21

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 89.78  E-value: 2.74e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108  1695 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQARTT 1774
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 530412108  1775 EGFGPE 1780
Cdd:pfam00041   79 GGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1582-1664 2.10e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.39  E-value: 2.10e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108  1582 DTPTRLVFSALGPTSLRVSWQEPR-CERPLQGYSVEYQLLNGGE-LHRLNIPNPaQTSVVVEDLLPNHSYVFRVRAQSQE 1659
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdGNGPITGYEVEYRPKNSGEpWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 530412108  1660 GWGRE 1664
Cdd:pfam00041   80 GEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1581-1662 2.30e-19

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 84.47  E-value: 2.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1581 PDTPTRLVFSALGPTSLRVSWQEPRCE-RPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQE 1659
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80


                  ...
gi 530412108 1660 GWG 1662
Cdd:cd00063    81 GES 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1694-1779 4.54e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.92  E-value: 4.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1694 PSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAfrVDGDSPESRLTVPGLSENVPYKFKVQART 1773
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEV--EVTPGSETSYTLTGLKPGTEYEFRVRAVN 78


                  ....*.
gi 530412108 1774 TEGFGP 1779
Cdd:cd00063    79 GGGESP 84
fn3 pfam00041
Fibronectin type III domain;
1128-1208 6.61e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 6.61e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108  1128 GAPQNPNAKAAGSRKIHFNWLPP---SGKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 530412108  1204 EGPYS 1208
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1581-1662 2.21e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 73.03  E-value: 2.21e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   1581 PDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRLN--IPNPAQTSVVVEDLLPNHSYVFRVRAQSQ 1658
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 530412108   1659 EGWG 1662
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1694-1778 1.14e-14

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 70.72  E-value: 1.14e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   1694 PSAPGPLVFTALSPDSLQLSWERPRRPNGDivGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQART 1773
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 530412108   1774 TEGFG 1778
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1221-1309 3.59e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 3.59e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108  1221 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1300
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75


                   ....*....
gi 530412108  1301 RNGAGWGPE 1309
Cdd:pfam00041   76 VNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1220-1313 4.43e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 4.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1220 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1299
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....
gi 530412108 1300 ARNGAGWGPEREAI 1313
Cdd:cd00063    76 AVNGGGESPPSESV 89
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1580-1799 5.97e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 5.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1580 VPDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRlnIPNPAQTSVVVEDLLPNHSYVFRVRAQSQE 1659
Cdd:COG3401   232 PPSAPTGLTATADTPGSVTLSWDPVT-ESDATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1660 GwgreregvitIESqvhPQSPlcplPGSAFT-LSTPSAPGPLVFTALSPDSLQLSWERPrrPNGDIVGYLVTcemaQGGG 1738
Cdd:COG3401   309 G----------NES---APSN----VVSVTTdLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVY----RSTS 365

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530412108 1739 PATAFRVDGDSP-ESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLG 1799
Cdd:COG3401   366 GGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLT 427
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1128-1215 3.23e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 3.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1128 GAPQNPNAKAAGSRKIHFNWLPPS---GKPMGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 530412108 1204 EGPYSSLVSCRT 1215
Cdd:cd00063    82 ESPPSESVTVTT 93
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 457-485 1.60e-10

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 57.50  E-value: 1.60e-10
                           10        20
                   ....*....|....*....|....*....
gi 530412108   457 CELQKEVRSARCSFNGDFVCGQCVCSEGW 485
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 992-1106 6.00e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 64.43  E-value: 6.00e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   992 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKS-QVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLL--ELQEVD 1068
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIddDIFEED 481

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530412108  1069 sllrgrqvRRFHVQLSNPKFG--------------AHLGQPHSTTIIIRDPD 1106
Cdd:TIGR00845  482 --------EHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDD 525
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1128-1205 1.98e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 1.98e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   1128 GAPQNPNAKAAGSRKIHFNWLPP-SGKPMGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 530412108   1204 EG 1205
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1220-1307 2.60e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 2.60e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   1220 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNddnRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1299
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*...
gi 530412108   1300 ARNGAGWG 1307
Cdd:smart00060   76 AVNGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1632-1776 3.69e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 3.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1632 NPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1710
Cdd:COG3401   188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530412108 1711 QLSWERPrrPNGDIVGYLVtcemAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEG 1776
Cdd:COG3401   250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1146-1305 2.16e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.70  E-value: 2.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1146 NWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGR 1225
Cdd:COG3401   159 TASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1226 LAFNVVSSTVTQLSWAEPAETNgeITAYEVCYGLVNDdnrpiGPMKKvlVDNPKNRMLLIENLRESQPYRYTVKARNGAG 1305
Cdd:COG3401   239 LTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGD-----GPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 550-573 1.16e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 1.16e-03
                           10        20
                   ....*....|....*....|....*.
gi 530412108   550 LCNDRGRCSM--GQCVCEPGWTGPSC 573
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 37-453 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 616.64  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108     37 SCTECVRVDKDCAYCTDEMFRDR---RCNTQAELLAAGCQRESIVVMESSFQITEETQID---TTLRRSQMSPQGLRVRL 110
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108    111 RPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 190
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108    191 KEPWPN----SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 266
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108    267 FHYEADGAnvLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLG 346
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108    347 VLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSkMFQKTRTGSFHirRGEVGIYQVQLRALEHVDGTHVCQl 426
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394

                           410       420
                    ....*....|....*....|....*...
gi 530412108    427 PEDQKGNIHLKP-SFSDGLKMDAGIICD 453
Cdd:smart00187  395 PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 125-370 3.19e-149

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 459.27  E-value: 3.19e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   125 PLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 200
Cdd:pfam00362    1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   201 FSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGAnvLAGI 280
Cdd:pfam00362   81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   281 MSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE 360
Cdd:pfam00362  159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238

                          250
                   ....*....|
gi 530412108   361 EAFNRIRSNL 370
Cdd:pfam00362  239 EAYEKIRSKV 248
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 626-709 1.97e-27

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 107.36  E-value: 1.97e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   626 CEDLRSCVQCQAWGTGEKKGRTC-EECNFKVKMVDELKRAEE-VVVRCSFRDEdDDCTYSYTMEGDgaPGPNSTVLVHKK 703
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77


                   ....*.
gi 530412108   704 KDCPPG 709
Cdd:pfam07965   78 RECPPG 83
Calx-beta pfam03160
Calx-beta domain;
990-1084 3.64e-25

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 101.17  E-value: 3.64e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   990 DVVSFEQPEFSVSRGDQVARIPVIRRVLD-GGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLElqevD 1068
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77

                           90
                   ....*....|....*.
gi 530412108  1069 SLLRGRqvRRFHVQLS 1084
Cdd:pfam03160   78 DVYEGD--ENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 991-1084 2.91e-23

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 95.40  E-value: 2.91e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108    991 VVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLelqeVDSL 1070
Cdd:smart00237    3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDDI 78

                            90
                    ....*....|....
gi 530412108   1071 LRGrqVRRFHVQLS 1084
Cdd:smart00237   79 YEK--DETFYVRLS 90
fn3 pfam00041
Fibronectin type III domain;
1695-1780 2.74e-21

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 89.78  E-value: 2.74e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108  1695 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQARTT 1774
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 530412108  1775 EGFGPE 1780
Cdd:pfam00041   79 GGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1582-1664 2.10e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.39  E-value: 2.10e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108  1582 DTPTRLVFSALGPTSLRVSWQEPR-CERPLQGYSVEYQLLNGGE-LHRLNIPNPaQTSVVVEDLLPNHSYVFRVRAQSQE 1659
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdGNGPITGYEVEYRPKNSGEpWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 530412108  1660 GWGRE 1664
Cdd:pfam00041   80 GEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1581-1662 2.30e-19

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 84.47  E-value: 2.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1581 PDTPTRLVFSALGPTSLRVSWQEPRCE-RPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQE 1659
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80


                  ...
gi 530412108 1660 GWG 1662
Cdd:cd00063    81 GES 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1694-1779 4.54e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.92  E-value: 4.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1694 PSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAfrVDGDSPESRLTVPGLSENVPYKFKVQART 1773
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEV--EVTPGSETSYTLTGLKPGTEYEFRVRAVN 78


                  ....*.
gi 530412108 1774 TEGFGP 1779
Cdd:cd00063    79 GGGESP 84
fn3 pfam00041
Fibronectin type III domain;
1128-1208 6.61e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 6.61e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108  1128 GAPQNPNAKAAGSRKIHFNWLPP---SGKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 530412108  1204 EGPYS 1208
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1581-1662 2.21e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 73.03  E-value: 2.21e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   1581 PDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRLN--IPNPAQTSVVVEDLLPNHSYVFRVRAQSQ 1658
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 530412108   1659 EGWG 1662
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1694-1778 1.14e-14

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 70.72  E-value: 1.14e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   1694 PSAPGPLVFTALSPDSLQLSWERPRRPNGDivGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQART 1773
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 530412108   1774 TEGFG 1778
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1221-1309 3.59e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 3.59e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108  1221 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1300
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75


                   ....*....
gi 530412108  1301 RNGAGWGPE 1309
Cdd:pfam00041   76 VNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1220-1313 4.43e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 4.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1220 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1299
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....
gi 530412108 1300 ARNGAGWGPEREAI 1313
Cdd:cd00063    76 AVNGGGESPPSESV 89
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1580-1799 5.97e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 5.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1580 VPDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRlnIPNPAQTSVVVEDLLPNHSYVFRVRAQSQE 1659
Cdd:COG3401   232 PPSAPTGLTATADTPGSVTLSWDPVT-ESDATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1660 GwgreregvitIESqvhPQSPlcplPGSAFT-LSTPSAPGPLVFTALSPDSLQLSWERPrrPNGDIVGYLVTcemaQGGG 1738
Cdd:COG3401   309 G----------NES---APSN----VVSVTTdLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVY----RSTS 365

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530412108 1739 PATAFRVDGDSP-ESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLG 1799
Cdd:COG3401   366 GGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLT 427
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1128-1215 3.23e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 3.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1128 GAPQNPNAKAAGSRKIHFNWLPPS---GKPMGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 530412108 1204 EGPYSSLVSCRT 1215
Cdd:cd00063    82 ESPPSESVTVTT 93
PSI_integrin pfam17205
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of ...
 28-73 7.98e-11

Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of integrin beta chains.


Pssm-ID: 465380  Cd Length: 47  Bit Score: 58.71  E-value: 7.98e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 530412108    28 NRCKKApVKSCTECVRVDKDCAYCTDEMF--RDRRCNTQAELLAAGCQ 73
Cdd:pfam17205    1 NRCTSA-STSCEECIQSGPDCAWCTDENFtsGSPRCDTRENLLARGCS 47
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 457-485 1.60e-10

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 57.50  E-value: 1.60e-10
                           10        20
                   ....*....|....*....|....*....
gi 530412108   457 CELQKEVRSARCSFNGDFVCGQCVCSEGW 485
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1129-1305 1.99e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 65.79  E-value: 1.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1129 APQNPNAKAAGSRKIHFNWLPPSGKP-MGYRVKYWIQGDSESEahlldsKVPSVELTNlypYCD--------YEMKVCAY 1199
Cdd:COG3401   235 APTGLTATADTPGSVTLSWDPVTESDaTGYRVYRSNSGDGPFT------KVATVTTTS---YTDtgltngttYYYRVTAV 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1200 GAQG-EGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPaeTNGEITAYEVCYglvndDNRPIGPMKKVlVDNP 1278
Cdd:COG3401   306 DAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVYR-----STSGGGTYTKI-AETV 377

                         170       180
                  ....*....|....*....|....*..
gi 530412108 1279 KNRMLLIENLRESQPYRYTVKARNGAG 1305
Cdd:COG3401   378 TTTSYTDTGLTPGTTYYYKVTAVDAAG 404
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 992-1106 6.00e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 64.43  E-value: 6.00e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   992 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKS-QVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLL--ELQEVD 1068
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIddDIFEED 481

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530412108  1069 sllrgrqvRRFHVQLSNPKFG--------------AHLGQPHSTTIIIRDPD 1106
Cdd:TIGR00845  482 --------EHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDD 525
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1128-1205 1.98e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 1.98e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   1128 GAPQNPNAKAAGSRKIHFNWLPP-SGKPMGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 530412108   1204 EG 1205
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1220-1307 2.60e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 2.60e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   1220 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNddnRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1299
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*...
gi 530412108   1300 ARNGAGWG 1307
Cdd:smart00060   76 AVNGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1632-1776 3.69e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 3.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1632 NPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1710
Cdd:COG3401   188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530412108 1711 QLSWERPrrPNGDIVGYLVtcemAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEG 1776
Cdd:COG3401   250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1146-1305 2.16e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.70  E-value: 2.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1146 NWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGR 1225
Cdd:COG3401   159 TASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108 1226 LAFNVVSSTVTQLSWAEPAETNgeITAYEVCYGLVNDdnrpiGPMKKvlVDNPKNRMLLIENLRESQPYRYTVKARNGAG 1305
Cdd:COG3401   239 LTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGD-----GPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 978-1087 2.21e-06

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 52.87  E-value: 2.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412108   978 LVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKE 1056
Cdd:TIGR00845  516 TATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARgGGKDFEDTCGELEFENDETEKT 595

                           90       100       110
                   ....*....|....*....|....*....|.
gi 530412108  1057 LQVKLLELQEVDsllrgRQVrRFHVQLSNPK 1087
Cdd:TIGR00845  596 IRVKIVDDEEYE-----KND-TFFIELGEPR 620
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 550-573 1.16e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 1.16e-03
                           10        20
                   ....*....|....*....|....*.
gi 530412108   550 LCNDRGRCSM--GQCVCEPGWTGPSC 573
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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