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Conserved domains on  [gi|530389279|ref|XP_005251099|]
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thyroglobulin isoform X11 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 95-160 4.13e-21

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


:

Pssm-ID: 238114  Cd Length: 66  Bit Score: 88.67  E-value: 4.13e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279   95 FCQLQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRC 160
Cdd:cd00191     1 PCERERASALESLAGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 300-358 3.81e-18

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


:

Pssm-ID: 238114  Cd Length: 66  Bit Score: 80.20  E-value: 3.81e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279  300 KCEVERFTATS------FGHPYVPSCRRNGDYQAVQCQTE-GPCWCVDAQGKEMHGTRQQGEPPSC 358
Cdd:cd00191     1 PCERERASALEslagpkLSGLYVPQCDEDGNYEPVQCHGStGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 662-724 6.17e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 79.65  E-value: 6.17e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530389279   662 CEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTRSAIGKPK 724
Cdd:pfam00086    1 CERERARALEQAASGRPASGLYIPNCDEDGFYKPVQCHGStgYCWCVDPEGQEIPGTRTRGGDPD 65
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1149-1210 1.49e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


:

Pssm-ID: 238114  Cd Length: 66  Bit Score: 78.66  E-value: 1.49e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279 1149 CNVLKSGVLSRRVSPG----YVPACRaEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPAC 1210
Cdd:cd00191     2 CERERASALESLAGPKlsglYVPQCD-EDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 599-658 2.37e-17

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 78.11  E-value: 2.37e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530389279   599 METVLSSQTCEQTPERLFVPSCTTEGSYEDVQCFS--GECWCVNSWGKELPGSRVRGGQPRC 658
Cdd:pfam00086    5 RARALEQAASGRPASGLYIPNCDEDGFYKPVQCHGstGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 33-92 7.45e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


:

Pssm-ID: 238114  Cd Length: 66  Bit Score: 76.73  E-value: 7.45e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279   33 PCELQRETAFLKQA------DYVPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPVAC 92
Cdd:cd00191     1 PCERERASALESLAgpklsgLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1018-1073 2.14e-16

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


:

Pssm-ID: 238114  Cd Length: 66  Bit Score: 75.19  E-value: 2.14e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279 1018 ASALLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARslQIPQC 1073
Cdd:cd00191    13 LAGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRG--GPPNC 66
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
 1465-1510 2.51e-14

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


:

Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 68.91  E-value: 2.51e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 530389279  1465 GSYSQDE--ECIPCPVGFYQEQAGSLACVPCPVGRTTISAGAFSQTHC 1510
Cdd:pfam07699    1 GTYSNTGlePCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1520-1567 7.27e-08

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


:

Pssm-ID: 214561  Cd Length: 46  Bit Score: 50.45  E-value: 7.27e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 530389279   1520 GLQCDQNGQYRASQKDRGSGKAFCVDGEGRRLPWweTEAPLEDSQCLM 1567
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPG--TRTEGGDPDCPS 46
TY super family cl00150
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1077-1145 1.34e-04

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


The actual alignment was detected with superfamily member cd00191:

Pssm-ID: 469630  Cd Length: 66  Bit Score: 41.68  E-value: 1.34e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530389279 1077 CEKSRTSGLLSSwkqarsqENPSPKDLFVPACLETGEYARLQ--ASGAGTWCVDPAsGEELrPGSSS---SAQC 1145
Cdd:cd00191     2 CERERASALESL-------AGPKLSGLYVPQCDEDGNYEPVQchGSTGYCWCVDPD-GEEI-PGTRTrggPPNC 66
TY super family cl00150
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 892-922 2.00e-03

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


The actual alignment was detected with superfamily member smart00211:

Pssm-ID: 469630  Cd Length: 46  Bit Score: 37.74  E-value: 2.00e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 530389279    892 HFDLRNCWCVDEAGQELEGMRSEPSKlPTCP 922
Cdd:smart00211   16 DGSSGQCWCVDATGREIPGTRTEGGD-PDCP 45
TY super family cl00150
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 743-776 6.60e-03

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


The actual alignment was detected with superfamily member pfam00086:

Pssm-ID: 469630  Cd Length: 66  Bit Score: 36.90  E-value: 6.60e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 530389279   743 QALLSNSSMLPtLSDTYIPQCSTDGQWRQVQCNG 776
Cdd:pfam00086    7 RALEQAASGRP-ASGLYIPNCDEDGFYKPVQCHG 39
 
Name Accession Description Interval E-value
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 95-160 4.13e-21

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 88.67  E-value: 4.13e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279   95 FCQLQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRC 160
Cdd:cd00191     1 PCERERASALESLAGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 96-160 2.62e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 80.81  E-value: 2.62e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279    96 CQLQKQQILLS-GYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRC 160
Cdd:pfam00086    1 CERERARALEQaASGRPASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 300-358 3.81e-18

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 80.20  E-value: 3.81e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279  300 KCEVERFTATS------FGHPYVPSCRRNGDYQAVQCQTE-GPCWCVDAQGKEMHGTRQQGEPPSC 358
Cdd:cd00191     1 PCERERASALEslagpkLSGLYVPQCDEDGNYEPVQCHGStGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 662-724 6.17e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 79.65  E-value: 6.17e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530389279   662 CEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTRSAIGKPK 724
Cdd:pfam00086    1 CERERARALEQAASGRPASGLYIPNCDEDGFYKPVQCHGStgYCWCVDPEGQEIPGTRTRGGDPD 65
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1149-1210 1.49e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 78.66  E-value: 1.49e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279 1149 CNVLKSGVLSRRVSPG----YVPACRaEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPAC 1210
Cdd:cd00191     2 CERERASALESLAGPKlsglYVPQCD-EDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 599-658 2.37e-17

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 78.11  E-value: 2.37e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530389279   599 METVLSSQTCEQTPERLFVPSCTTEGSYEDVQCFS--GECWCVNSWGKELPGSRVRGGQPRC 658
Cdd:pfam00086    5 RARALEQAASGRPASGLYIPNCDEDGFYKPVQCHGstGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 33-92 7.45e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 76.73  E-value: 7.45e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279   33 PCELQRETAFLKQA------DYVPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPVAC 92
Cdd:cd00191     1 PCERERASALESLAgpklsgLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 612-658 7.98e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 76.35  E-value: 7.98e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 530389279  612 PERLFVPSCTTEGSYEDVQCFS--GECWCVNSWGKELPGSRVRGGQPRC 658
Cdd:cd00191    18 LSGLYVPQCDEDGNYEPVQCHGstGYCWCVDPDGEEIPGTRTRGGPPNC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 662-724 1.69e-16

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 75.58  E-value: 1.69e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530389279  662 CEKQRARMQSLMgSQPAGSTLFVPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTRSAIGKPK 724
Cdd:cd00191     2 CERERASALESL-AGPKLSGLYVPQCDEDGNYEPVQCHGStgYCWCVDPDGEEIPGTRTRGGPPN 65
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1018-1073 2.14e-16

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 75.19  E-value: 2.14e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279 1018 ASALLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARslQIPQC 1073
Cdd:cd00191    13 LAGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRG--GPPNC 66
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
 1465-1510 2.51e-14

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 68.91  E-value: 2.51e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 530389279  1465 GSYSQDE--ECIPCPVGFYQEQAGSLACVPCPVGRTTISAGAFSQTHC 1510
Cdd:pfam07699    1 GTYSNTGlePCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 1151-1210 2.76e-14

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 69.25  E-value: 2.76e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389279  1151 VLKSGVLSRRVSPGYVPACRaEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPAC 1210
Cdd:pfam00086    8 ALEQAASGRPASGLYIPNCD-EDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGDPDC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 1024-1073 3.63e-14

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 68.87  E-value: 3.63e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 530389279  1024 SGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSlqIPQC 1073
Cdd:pfam00086   19 SGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGG--DPDC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 117-162 1.29e-13

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 66.63  E-value: 1.29e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 530389279    117 LPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRCPR 162
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGGDPDCPS 46
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 301-358 1.73e-13

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 66.94  E-value: 1.73e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279   301 CEVERFTA---TSFGHP----YVPSCRRNGDYQAVQCQTE-GPCWCVDAQGKEMHGTRQQGEPPSC 358
Cdd:pfam00086    1 CERERARAleqAASGRPasglYIPNCDEDGFYKPVQCHGStGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1166-1212 2.01e-13

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 66.25  E-value: 2.01e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 530389279   1166 VPACRaEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPACES 1212
Cdd:smart00211    1 IPQCD-EDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGGDPDCPS 46
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 34-92 2.21e-12

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 63.86  E-value: 2.21e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279    34 CELQRETAFLKQAD-------YVPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPVAC 92
Cdd:pfam00086    1 CERERARALEQAASgrpasglYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 49-94 3.34e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 62.78  E-value: 3.34e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 530389279     49 VPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPVACLS 94
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGGDPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 316-360 3.34e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 62.78  E-value: 3.34e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 530389279    316 VPSCRRNGDYQAVQCQTE-GPCWCVDAQGKEMHGTRQQGEPPSCAE 360
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSsGQCWCVDATGREIPGTRTEGGDPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1028-1075 5.04e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 62.40  E-value: 5.04e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 530389279   1028 MPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSlqIPQCPT 1075
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGG--DPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 617-660 9.98e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 61.24  E-value: 9.98e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 530389279    617 VPSCTTEGSYEDVQCF--SGECWCVNSWGKELPGSRVRGGQPRCPT 660
Cdd:smart00211    1 IPQCDEDGNYEPVQCDgsSGQCWCVDATGREIPGTRTEGGDPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 684-728 1.73e-10

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 57.77  E-value: 1.73e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 530389279    684 VPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTRSAIGKPkKCPT 728
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSsgQCWCVDATGREIPGTRTEGGDP-DCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1520-1567 7.27e-08

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 50.45  E-value: 7.27e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 530389279   1520 GLQCDQNGQYRASQKDRGSGKAFCVDGEGRRLPWweTEAPLEDSQCLM 1567
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPG--TRTEGGDPDCPS 46
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1077-1145 1.34e-04

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 41.68  E-value: 1.34e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530389279 1077 CEKSRTSGLLSSwkqarsqENPSPKDLFVPACLETGEYARLQ--ASGAGTWCVDPAsGEELrPGSSS---SAQC 1145
Cdd:cd00191     2 CERERASALESL-------AGPKLSGLYVPQCDEDGNYEPVQchGSTGYCWCVDPD-GEEI-PGTRTrggPPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 892-922 2.00e-03

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 37.74  E-value: 2.00e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 530389279    892 HFDLRNCWCVDEAGQELEGMRSEPSKlPTCP 922
Cdd:smart00211   16 DGSSGQCWCVDATGREIPGTRTEGGD-PDCP 45
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 1522-1552 6.16e-03

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 37.28  E-value: 6.16e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 530389279  1522 QCDQNGQYRASQKDRGSGKAFCVDGEGRRLP 1552
Cdd:pfam00086   25 NCDEDGFYKPVQCHGSTGYCWCVDPEGQEIP 55
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 743-776 6.60e-03

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 36.90  E-value: 6.60e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 530389279   743 QALLSNSSMLPtLSDTYIPQCSTDGQWRQVQCNG 776
Cdd:pfam00086    7 RALEQAASGRP-ASGLYIPNCDEDGFYKPVQCHG 39
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 729-776 8.41e-03

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 36.67  E-value: 8.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 530389279  729 PCQLQSEQAFLRTVQALLSNSsmlptlsdtYIPQCSTDGQWRQVQCNG 776
Cdd:cd00191     1 PCERERASALESLAGPKLSGL---------YVPQCDEDGNYEPVQCHG 39
 
Name Accession Description Interval E-value
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 95-160 4.13e-21

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 88.67  E-value: 4.13e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279   95 FCQLQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRC 160
Cdd:cd00191     1 PCERERASALESLAGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 96-160 2.62e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 80.81  E-value: 2.62e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279    96 CQLQKQQILLS-GYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRC 160
Cdd:pfam00086    1 CERERARALEQaASGRPASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 300-358 3.81e-18

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 80.20  E-value: 3.81e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279  300 KCEVERFTATS------FGHPYVPSCRRNGDYQAVQCQTE-GPCWCVDAQGKEMHGTRQQGEPPSC 358
Cdd:cd00191     1 PCERERASALEslagpkLSGLYVPQCDEDGNYEPVQCHGStGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 662-724 6.17e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 79.65  E-value: 6.17e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530389279   662 CEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTRSAIGKPK 724
Cdd:pfam00086    1 CERERARALEQAASGRPASGLYIPNCDEDGFYKPVQCHGStgYCWCVDPEGQEIPGTRTRGGDPD 65
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1149-1210 1.49e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 78.66  E-value: 1.49e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279 1149 CNVLKSGVLSRRVSPG----YVPACRaEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPAC 1210
Cdd:cd00191     2 CERERASALESLAGPKlsglYVPQCD-EDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 599-658 2.37e-17

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 78.11  E-value: 2.37e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530389279   599 METVLSSQTCEQTPERLFVPSCTTEGSYEDVQCFS--GECWCVNSWGKELPGSRVRGGQPRC 658
Cdd:pfam00086    5 RARALEQAASGRPASGLYIPNCDEDGFYKPVQCHGstGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 33-92 7.45e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 76.73  E-value: 7.45e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279   33 PCELQRETAFLKQA------DYVPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPVAC 92
Cdd:cd00191     1 PCERERASALESLAgpklsgLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGGPPNC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 612-658 7.98e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 76.35  E-value: 7.98e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 530389279  612 PERLFVPSCTTEGSYEDVQCFS--GECWCVNSWGKELPGSRVRGGQPRC 658
Cdd:cd00191    18 LSGLYVPQCDEDGNYEPVQCHGstGYCWCVDPDGEEIPGTRTRGGPPNC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 662-724 1.69e-16

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 75.58  E-value: 1.69e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530389279  662 CEKQRARMQSLMgSQPAGSTLFVPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTRSAIGKPK 724
Cdd:cd00191     2 CERERASALESL-AGPKLSGLYVPQCDEDGNYEPVQCHGStgYCWCVDPDGEEIPGTRTRGGPPN 65
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1018-1073 2.14e-16

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 75.19  E-value: 2.14e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279 1018 ASALLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARslQIPQC 1073
Cdd:cd00191    13 LAGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRG--GPPNC 66
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
 1465-1510 2.51e-14

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 68.91  E-value: 2.51e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 530389279  1465 GSYSQDE--ECIPCPVGFYQEQAGSLACVPCPVGRTTISAGAFSQTHC 1510
Cdd:pfam07699    1 GTYSNTGlePCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 1151-1210 2.76e-14

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 69.25  E-value: 2.76e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389279  1151 VLKSGVLSRRVSPGYVPACRaEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPAC 1210
Cdd:pfam00086    8 ALEQAASGRPASGLYIPNCD-EDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGDPDC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 1024-1073 3.63e-14

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 68.87  E-value: 3.63e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 530389279  1024 SGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSlqIPQC 1073
Cdd:pfam00086   19 SGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGG--DPDC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 117-162 1.29e-13

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 66.63  E-value: 1.29e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 530389279    117 LPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRCPR 162
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGGDPDCPS 46
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 301-358 1.73e-13

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 66.94  E-value: 1.73e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279   301 CEVERFTA---TSFGHP----YVPSCRRNGDYQAVQCQTE-GPCWCVDAQGKEMHGTRQQGEPPSC 358
Cdd:pfam00086    1 CERERARAleqAASGRPasglYIPNCDEDGFYKPVQCHGStGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1166-1212 2.01e-13

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 66.25  E-value: 2.01e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 530389279   1166 VPACRaEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPACES 1212
Cdd:smart00211    1 IPQCD-EDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGGDPDCPS 46
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 34-92 2.21e-12

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 63.86  E-value: 2.21e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530389279    34 CELQRETAFLKQAD-------YVPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPVAC 92
Cdd:pfam00086    1 CERERARALEQAASgrpasglYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 49-94 3.34e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 62.78  E-value: 3.34e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 530389279     49 VPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPVACLS 94
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGGDPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 316-360 3.34e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 62.78  E-value: 3.34e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 530389279    316 VPSCRRNGDYQAVQCQTE-GPCWCVDAQGKEMHGTRQQGEPPSCAE 360
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSsGQCWCVDATGREIPGTRTEGGDPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1028-1075 5.04e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 62.40  E-value: 5.04e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 530389279   1028 MPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSlqIPQCPT 1075
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRTEGG--DPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 617-660 9.98e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 61.24  E-value: 9.98e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 530389279    617 VPSCTTEGSYEDVQCF--SGECWCVNSWGKELPGSRVRGGQPRCPT 660
Cdd:smart00211    1 IPQCDEDGNYEPVQCDgsSGQCWCVDATGREIPGTRTEGGDPDCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 684-728 1.73e-10

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 57.77  E-value: 1.73e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 530389279    684 VPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTRSAIGKPkKCPT 728
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSsgQCWCVDATGREIPGTRTEGGDP-DCPS 46
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1520-1567 7.27e-08

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 50.45  E-value: 7.27e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 530389279   1520 GLQCDQNGQYRASQKDRGSGKAFCVDGEGRRLPWweTEAPLEDSQCLM 1567
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPG--TRTEGGDPDCPS 46
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1077-1145 1.34e-04

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 41.68  E-value: 1.34e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530389279 1077 CEKSRTSGLLSSwkqarsqENPSPKDLFVPACLETGEYARLQ--ASGAGTWCVDPAsGEELrPGSSS---SAQC 1145
Cdd:cd00191     2 CERERASALESL-------AGPKLSGLYVPQCDEDGNYEPVQchGSTGYCWCVDPD-GEEI-PGTRTrggPPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 892-922 2.00e-03

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 37.74  E-value: 2.00e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 530389279    892 HFDLRNCWCVDEAGQELEGMRSEPSKlPTCP 922
Cdd:smart00211   16 DGSSGQCWCVDATGREIPGTRTEGGD-PDCP 45
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 1522-1552 6.16e-03

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 37.28  E-value: 6.16e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 530389279  1522 QCDQNGQYRASQKDRGSGKAFCVDGEGRRLP 1552
Cdd:pfam00086   25 NCDEDGFYKPVQCHGSTGYCWCVDPEGQEIP 55
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 743-776 6.60e-03

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 36.90  E-value: 6.60e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 530389279   743 QALLSNSSMLPtLSDTYIPQCSTDGQWRQVQCNG 776
Cdd:pfam00086    7 RALEQAASGRP-ASGLYIPNCDEDGFYKPVQCHG 39
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 729-776 8.41e-03

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 36.67  E-value: 8.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 530389279  729 PCQLQSEQAFLRTVQALLSNSsmlptlsdtYIPQCSTDGQWRQVQCNG 776
Cdd:cd00191     1 PCERERASALESLAGPKLSGL---------YVPQCDEDGNYEPVQCHG 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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