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Conserved domains on  [gi|530365082|ref|XP_005245399|]
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sugar transporter SWEET1 isoform X4 [Homo sapiens]

Protein Classification

SWEET family sugar transporter( domain architecture ID 20281257)

SWEET family sugar transporter similar to plant SWEET bidirectional sugar transporters that mediate both low-affinity uptake and efflux of sugar across the plasma membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 95-181 3.26e-30

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


:

Pssm-ID: 397278  Cd Length: 87  Bit Score: 106.13  E-value: 3.26e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530365082   95 QQLGLFCSVFTISMYLSPLADLAKVIQTKSTQCLSYPLTIATLLTSASWCLYGFRLRDPYIMVSNFPGIVTSFIRFWLFW 174
Cdd:pfam03083   1 FLLGILCVVFTVAMFLSPLSILRKIIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTIYLILFI 80


                  ....*..
gi 530365082  175 KYPQEQD 181
Cdd:pfam03083  81 VYPPKKA 87
MtN3_slv super family cl46784
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 1-63 9.84e-19

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


The actual alignment was detected with superfamily member pfam03083:

Pssm-ID: 481124  Cd Length: 87  Bit Score: 76.47  E-value: 9.84e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530365082    1 MRMTRSVDNVQFLPFLTTEVNNLGWLSYGALKGDGILIVVNTVGAALQTLYILAYLHYCPRKR 63
Cdd:pfam03083  25 IIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTIYLILFIVYPPKKA 87
 
Name Accession Description Interval E-value
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 95-181 3.26e-30

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


Pssm-ID: 397278  Cd Length: 87  Bit Score: 106.13  E-value: 3.26e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530365082   95 QQLGLFCSVFTISMYLSPLADLAKVIQTKSTQCLSYPLTIATLLTSASWCLYGFRLRDPYIMVSNFPGIVTSFIRFWLFW 174
Cdd:pfam03083   1 FLLGILCVVFTVAMFLSPLSILRKIIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTIYLILFI 80


                  ....*..
gi 530365082  175 KYPQEQD 181
Cdd:pfam03083  81 VYPPKKA 87
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 1-63 9.84e-19

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


Pssm-ID: 397278  Cd Length: 87  Bit Score: 76.47  E-value: 9.84e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530365082    1 MRMTRSVDNVQFLPFLTTEVNNLGWLSYGALKGDGILIVVNTVGAALQTLYILAYLHYCPRKR 63
Cdd:pfam03083  25 IIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTIYLILFIVYPPKKA 87
SWEET COG4095
Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism]; ...
 97-176 6.98e-06

Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism];


Pssm-ID: 443271  Cd Length: 83  Bit Score: 42.48  E-value: 6.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530365082  97 LGLFCSVFTismYLSPLADLAKVIQTKSTQCLSYPLTIATLLTSASWCLYGFRLRDPYIMVSNFPGIVTSFIRFWLFWKY 176
Cdd:COG4095    6 IGLLAGILT---TISFLPQVIKTWKTKSTKDISLGMYLIFTTGVALWLIYGILIGDLPIILANAITLVLALIILVLKLRY 82
 
Name Accession Description Interval E-value
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 95-181 3.26e-30

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


Pssm-ID: 397278  Cd Length: 87  Bit Score: 106.13  E-value: 3.26e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530365082   95 QQLGLFCSVFTISMYLSPLADLAKVIQTKSTQCLSYPLTIATLLTSASWCLYGFRLRDPYIMVSNFPGIVTSFIRFWLFW 174
Cdd:pfam03083   1 FLLGILCVVFTVAMFLSPLSILRKIIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTIYLILFI 80


                  ....*..
gi 530365082  175 KYPQEQD 181
Cdd:pfam03083  81 VYPPKKA 87
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 1-63 9.84e-19

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


Pssm-ID: 397278  Cd Length: 87  Bit Score: 76.47  E-value: 9.84e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530365082    1 MRMTRSVDNVQFLPFLTTEVNNLGWLSYGALKGDGILIVVNTVGAALQTLYILAYLHYCPRKR 63
Cdd:pfam03083  25 IIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTIYLILFIVYPPKKA 87
SWEET COG4095
Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism]; ...
 97-176 6.98e-06

Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism];


Pssm-ID: 443271  Cd Length: 83  Bit Score: 42.48  E-value: 6.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530365082  97 LGLFCSVFTismYLSPLADLAKVIQTKSTQCLSYPLTIATLLTSASWCLYGFRLRDPYIMVSNFPGIVTSFIRFWLFWKY 176
Cdd:COG4095    6 IGLLAGILT---TISFLPQVIKTWKTKSTKDISLGMYLIFTTGVALWLIYGILIGDLPIILANAITLVLALIILVLKLRY 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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