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Conserved domains on  [gi|56788383|ref|NP_996535|]
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myelin-oligodendrocyte glycoprotein isoform alpha2 precursor [Homo sapiens]

Protein Classification

Ig_MOG_like domain-containing protein( domain architecture ID 10145916)

Ig_MOG_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 32-144 4.80e-69

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


:

Pssm-ID: 409378  Cd Length: 114  Bit Score: 206.27  E-value: 4.80e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383  32 FRVIGPRHPIRALVGDEVELPCRISPGKNATGMEVGWYRPPFSRVVHLYRNGKDQDGDQAPEYRGRTELLKDAIGEGKVT 111
Cdd:cd05713   1 FSVIGPTEPILALVGEDAELPCHLSPKMSAEHMEVRWFRSQFSPVVHLYRDGQDQEEEQMPEYRGRTELLKDAIAEGSVA 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 56788383 112 LRIRNVRFSDEGGFTCFFRDHSYQEEAAMELKV 144
Cdd:cd05713  81 LRIHNVRPSDEGQYTCFFRSGSFYEEATLELKV 113
 
Name Accession Description Interval E-value
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 32-144 4.80e-69

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 206.27  E-value: 4.80e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383  32 FRVIGPRHPIRALVGDEVELPCRISPGKNATGMEVGWYRPPFSRVVHLYRNGKDQDGDQAPEYRGRTELLKDAIGEGKVT 111
Cdd:cd05713   1 FSVIGPTEPILALVGEDAELPCHLSPKMSAEHMEVRWFRSQFSPVVHLYRDGQDQEEEQMPEYRGRTELLKDAIAEGSVA 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 56788383 112 LRIRNVRFSDEGGFTCFFRDHSYQEEAAMELKV 144
Cdd:cd05713  81 LRIHNVRPSDEGQYTCFFRSGSFYEEATLELKV 113
IGv smart00406
Immunoglobulin V-Type;
49-129 5.74e-15

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 67.02  E-value: 5.74e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383     49 VELPCRISPGKNaTGMEVGWYR-PPFSRVVHLYRNGKDQDGDQAPEYRGRTELLKDAiGEGKVTLRIRNVRFSDEGGFTC 127
Cdd:smart00406   2 VTLSCKFSGSTF-SSYYVSWVRqPPGKGLEWLGYIGSNGSSYYQESYKGRFTISKDT-SKNDVSLTISNLRVEDTGTYYC 79


                   ..
gi 56788383    128 FF 129
Cdd:smart00406  80 AV 81
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 39-144 2.33e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 55.54  E-value: 2.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383    39 HPIRALVGDEVELPCRISPGKNATGMEVGWYR----PPFSRVVHLYRNGKDQdgdqaPEYRGRTELLKDaIGEGKVTLRI 114
Cdd:pfam07686   4 REVTVALGGSVTLPCTYSSSMSEASTSVYWYRqppgKGPTFLIAYYSNGSEE-----GVKKGRFSGRGD-PSNGDGSLTI 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 56788383   115 RNVRFSDEGGFTCFFRDHSYQ-EEAAMELKV 144
Cdd:pfam07686  78 QNLTLSDSGTYTCAVIPSGEGvFGKGTRLTV 108
 
Name Accession Description Interval E-value
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 32-144 4.80e-69

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 206.27  E-value: 4.80e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383  32 FRVIGPRHPIRALVGDEVELPCRISPGKNATGMEVGWYRPPFSRVVHLYRNGKDQDGDQAPEYRGRTELLKDAIGEGKVT 111
Cdd:cd05713   1 FSVIGPTEPILALVGEDAELPCHLSPKMSAEHMEVRWFRSQFSPVVHLYRDGQDQEEEQMPEYRGRTELLKDAIAEGSVA 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 56788383 112 LRIRNVRFSDEGGFTCFFRDHSYQEEAAMELKV 144
Cdd:cd05713  81 LRIHNVRPSDEGQYTCFFRSGSFYEEATLELKV 113
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 37-148 9.17e-22

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 85.73  E-value: 9.17e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383  37 PRHPIRALVGDEVELPCRISP--GKNATGMEVGWYRPPFSRVVHLYRNGKDQDGDQAPEYRGRTELLKDAIGEGKVTLRI 114
Cdd:cd20934   3 PEDPVVALVGTDATLRCSFSPepGFSLAQLSVFWQLTDTKQLVHSFTESQDQGRDQGSAYANRTALFPDLLAQGNASLRL 82

                        90       100       110
                ....*....|....*....|....*....|....
gi 56788383 115 RNVRFSDEGGFTCFFRDHSYqEEAAMELKVEDPF 148
Cdd:cd20934  83 QRVRVADEGSYTCFVSVQDF-GSAAVSLQVAAPF 115
IgV_B7-H4 cd20984
Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the ...
 43-144 6.52e-21

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H4 (also known as B7-S1, B7x, or Vtcn1). B7-H4 is one of the B7 family of immune-regulatory ligands that act as negative regulators of T cell function; it contains one IgV domain and one IgC domain. The B7-family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. The binding of B7-H4 to unidentified receptors results in the inhibition of TCR-mediated T cell proliferation, cell-cycle progression and IL-2 production. As a co-inhibitory molecule, B7-H4 is widely expressed in tumor tissues and its expression is significantly associated with poor prognosis in human cancers such as glioma, pancreatic cancer, oral squamous cell carcinoma, renal cell carcinoma, and lung cancer.


Pssm-ID: 409576  Cd Length: 110  Bit Score: 83.42  E-value: 6.52e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383  43 ALVGDEVELPCRISPGKNATGMEVGWYRPPFSRVVHLYRNGKDQDGDQAPEYRGRTELLKDAIGEGKVTLRIRNVRFSDE 122
Cdd:cd20984   9 GNIGEDGILSCTFTPDIKLSDIVIQWLKEGDSGLVHEFKEGKDELSRQSPMFRGRTSLFADQVHVGNASLRLKNVQLTDA 88

                        90       100
                ....*....|....*....|..
gi 56788383 123 GGFTCFFRDHSYQEEAAMELKV 144
Cdd:cd20984  89 GTYLCIISNSKGTGNANMEYKT 110
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 40-144 1.73e-20

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 82.44  E-value: 1.73e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383  40 PIRALVGDEVELPCRISPGKNATgmeVGWYRPPFSRVVHLYRNGKDQDGDQAPEYRGRTELLKDAIGEGKVTLRIRNVRF 119
Cdd:cd16091   6 IVVCLLSEDCILPCSFTPGSEVV---IHWYKQDSDIKVHSYYYGKDQLESQDQRYRNRTSLFKDQISNGNASLLLRRVQL 82

                        90       100
                ....*....|....*....|....*
gi 56788383 120 SDEGGFTCFFRDHSYQEEAAMELKV 144
Cdd:cd16091  83 QDEGRYKCYTSTIIGNQESFVNLKV 107
IGv smart00406
Immunoglobulin V-Type;
49-129 5.74e-15

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 67.02  E-value: 5.74e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383     49 VELPCRISPGKNaTGMEVGWYR-PPFSRVVHLYRNGKDQDGDQAPEYRGRTELLKDAiGEGKVTLRIRNVRFSDEGGFTC 127
Cdd:smart00406   2 VTLSCKFSGSTF-SSYYVSWVRqPPGKGLEWLGYIGSNGSSYYQESYKGRFTISKDT-SKNDVSLTISNLRVEDTGTYYC 79


                   ..
gi 56788383    128 FF 129
Cdd:smart00406  80 AV 81
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 39-144 2.33e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 55.54  E-value: 2.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383    39 HPIRALVGDEVELPCRISPGKNATGMEVGWYR----PPFSRVVHLYRNGKDQdgdqaPEYRGRTELLKDaIGEGKVTLRI 114
Cdd:pfam07686   4 REVTVALGGSVTLPCTYSSSMSEASTSVYWYRqppgKGPTFLIAYYSNGSEE-----GVKKGRFSGRGD-PSNGDGSLTI 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 56788383   115 RNVRFSDEGGFTCFFRDHSYQ-EEAAMELKV 144
Cdd:pfam07686  78 QNLTLSDSGTYTCAVIPSGEGvFGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 40-144 2.30e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.51  E-value: 2.30e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383     40 PIRALVGDEVELPCRISPGKNATgmeVGWYRppfsrvvhlyrngkdqDGDQAPEYRGRTELLKDaigEGKVTLRIRNVRF 119
Cdd:smart00410   3 SVTVKEGESVTLSCEASGSPPPE---VTWYK----------------QGGKLLAESGRFSVSRS---GSTSTLTISNVTP 60

                           90       100
                   ....*....|....*....|....*
gi 56788383    120 SDEGGFTCFFRDHSYQEEAAMELKV 144
Cdd:smart00410  61 EDSGTYTCAATNSSGSASSGTTLTV 85
IgV_B7-H2 cd20935
Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2); The members here are composed of ...
 41-127 2.72e-07

Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2); The members here are composed of the immunoglobulin variable (IgV) domain of B7-H2 (B7 homolog 2 also known as ICOSL (inducible T cell costimulator ligand) or CD275). B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS and acts as a costimulatory signal for T-cell proliferation and cytokine secretion. The interaction of ICOS with ICOSL (B7-H2) regulates T cell activation and expansion, is involved in T cell dependent B cell activation, and T-helper cell differentiation. It is a member of the B7 family of immune regulatory proteins and shares homology with other B7 ligands, such as B7-1, B7-2, B7-H1 (PD-L1), PD-L2, and B7-H3. The extracellular domains of B7 proteins contain two Ig-like domains and all members have short cytoplasmic domains. These ligands are typically expressed on antigen presenting cells (such as macrophages, B cells and dendritic cells) and have the ability to regulate T-cell proliferation and function. Tumor cells are also capable of expressing the B7 family members in order to evade immune surveillance.


Pssm-ID: 409529  Cd Length: 113  Bit Score: 47.55  E-value: 2.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383  41 IRALVGDEVELPCrISPGKNA---TGMEVGWYRPPFSRVVHLYRNGKDQDGDQAPEYRGRTELLKDAIGEGKVTLRIRNV 117
Cdd:cd20935   3 VRAMVGSDVELSC-ICPEGSRfdlNDLYVYWQISESETVVTYHLPQNSSLENVDSHYRNRALLSLDSMKQGDFSLRLFNV 81

                        90
                ....*....|
gi 56788383 118 RFSDEGGFTC 127
Cdd:cd20935  82 TPQDEQKFHC 91
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 33-129 1.67e-06

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 45.13  E-value: 1.67e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383  33 RVIGPRHpIRALVGDEVELPCRISPGKNATGMEVGWYRP--PFSRVVHLYRngkDQDGDQAPE-YRGRTELLKDAIGEGK 109
Cdd:cd05718   2 RVQVPTE-VTGFLGGSVTLPCSLTSPGTTKITQVTWMKIgaGSSQNVAVFH---PQYGPSVPNpYAERVEFLAARLGLRN 77

                        90       100
                ....*....|....*....|
gi 56788383 110 VTLRIRNVRFSDEGGFTCFF 129
Cdd:cd05718  78 ATLRIRNLRVEDEGNYICEF 97
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 49-127 1.05e-05

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 43.28  E-value: 1.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383  49 VELPCRISPGKNATGMEVGWYRPPFSRVVHLYRngKDQDGD--QAPEYRGRTELLKDAIGEgkVTLRIRNVRFSDEGGFT 126
Cdd:cd16089  17 VNLPCTYVPEEGYTQVLVKWLVQRDSDPVTIFL--RDSSGDhiQQAKYRGRLEVSKDTPGD--VSLQLDTLEMDDRGHYT 92


                .
gi 56788383 127 C 127
Cdd:cd16089  93 C 93
IgV_1_Nectin-2_NecL-5_like_CD112_CD155 cd20989
First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar ...
 41-129 1.75e-05

First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or Cluster of Differentiation 112 (CD112)), nectin-like protein 5 (CD155), and similar proteins. Nectins and Nectin-like molecules are a family of Ca(2+)-independent immunoglobulin-like transmembrane glycoproteins belonging to the class of adhesion receptors, consisting of nine members (nectins 1 through 4 and nectin-like proteins 1 through 5). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. CD155 is the fifth member in the nectin-like molecule family, and functions as the receptor of poliovirus; therefore, CD155 is also referred to as Necl-5, or PVR. In contrast to all other family members, CD155 lacks self-adhesion capacity, yet it shares with nectins the feature to interact with other nectins. For instance, CD155 heterophilically trans-interacts with nectin-3, thereby contributing significantly to the establishment of adherens junctions between epithelial cells. This group belongs to the Constant 1 (C1)-set of IgSF domains, which has one beta-sheet that is formed by strands A-B-E-D and the other strands by G-F-C-C'.


Pssm-ID: 409581  Cd Length: 112  Bit Score: 42.57  E-value: 1.75e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383  41 IRALVGDEVELPCRISPGKNATGM-EVGWYRPPFSRVVHLYRNGKdqdGDQAPE------YRGRTEL-LKDAigegkvTL 112
Cdd:cd20989   9 VRGFLGGSVTLPCHLLPPNMVTHVsQVTWQRHDEHGSVAVFHPKQ---GPSFPEserlsfVAARLGAeLRNA------SL 79

                        90
                ....*....|....*..
gi 56788383 113 RIRNVRFSDEGGFTCFF 129
Cdd:cd20989  80 AMFGLRVEDEGNYTCEF 96
IgV_PDl1 cd20947
Immunoglobulin Variable (IgV) domain of Programmed death ligand 1 (PD-L1); The members here ...
 46-127 8.34e-05

Immunoglobulin Variable (IgV) domain of Programmed death ligand 1 (PD-L1); The members here are composed of the immunoglobulin variable (IgV) domain of Programmed death ligand 1 (PD-L1; also known as Cluster of Differentiation 274 (CD274)). PD-L1 is a cell-surface ligand that competes with PD-L2 for binding to the immunosuppressive receptor programmed death-1 (PD-1). PD-1 is a member of the B7 family that plays an important role in negatively regulating immune responses upon interaction with its two ligands, PD-L1 or PD-L2. Like PD-L2, PD-L1 interacts with PD-1 and suppresses T cell proliferation and cytokine production. The PD-1 receptor is expressed on the surface of activated T cells, while PD-L1 is expressed on cancer cells. When PD-1 and PD-L1 bind together, they form a molecular shield protecting tumor cells from being destroyed by the immune system. Thus, inhibiting the binding of PD-L1 to PD-1 with an antibody leads to killing of tumor cells by T cells. PD-1 inhibitors (such as Pembrolizumab, Nivolumab, and Cemiplimab) and PD-L1 inhibitors (such as Atezolizumab, Avelumab, and Durvalumab ) are an emerging class of immunotherapy that stimulate lymphocytes against tumor cells.


Pssm-ID: 409539  Cd Length: 110  Bit Score: 40.69  E-value: 8.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383  46 GDEVELPCRISPGK--NATGMEVGWYRPpfSRVVHLYRNGKDQDGDQAPEYRGRTELLKDAIGEGKVTLRIRNVRFSDEG 123
Cdd:cd20947  13 GSNMTIECKFPVEKqlDLAALIVYWEME--DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAG 90


                ....
gi 56788383 124 GFTC 127
Cdd:cd20947  91 VYRC 94
I-set pfam07679
Immunoglobulin I-set domain;
33-144 2.84e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 38.39  E-value: 2.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383    33 RVIGPRHPIRALVGDEVELPCRIspgknaTG---MEVGWYRPpfsrvvhlyrngkDQDGDQAPEYRGRTEllkdaigEGK 109
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCTV------TGtpdPEVSWFKD-------------GQPLRSSDRFKVTYE-------GGT 55

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 56788383   110 VTLRIRNVRFSDEGGFTCFFRDHSYQEEAAMELKV 144
Cdd:pfam07679  56 YTLTISNVQPDDSGKYTCVATNSAGEAEASAELTV 90
IgV_CD86 cd16087
Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here ...
 39-128 3.80e-04

Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 86). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. The CTLA-4 and B7-2 monomers are both two-layer beta-sandwiches that display the chain topology characteristic of the immunoglobulin variable (V-type) domains present in antigen receptors. The front and back sheets of B7-2 are composed of AGFCC'C" and BED strands, respectively. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409508  Cd Length: 108  Bit Score: 38.46  E-value: 3.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383  39 HPIRALVGDEVELPCRISPGKNATGME-VGWYRPPFSRVVH-LYRnGKDQDGDQAPEYRGRTELLKDaigegKVTLRIRN 116
Cdd:cd16087   1 LKIQAYFNETAYLPCQFKNPQNISLSElVVFWQDQKKLVLYeLYL-GKEKLDNVNSKYIGRTSFDQE-----NWTLQLHN 74

                        90
                ....*....|..
gi 56788383 117 VRFSDEGGFTCF 128
Cdd:cd16087  75 VQIKDQGTYQCF 86
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 49-127 6.10e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 37.31  E-value: 6.10e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 56788383  49 VELPCRISPGKNATgmevgwyrppfsrvVHLYRNGKDQDGDQAPEYRgrtellkdaIGEGKVTLRIRNVRFSDEGGFTC 127
Cdd:cd00096   1 VTLTCSASGNPPPT--------------ITWYKNGKPLPPSSRDSRR---------SELGNGTLTISNVTLEDSGTYTC 56
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 33-127 9.61e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.77  E-value: 9.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383    33 RVIGPRHPIRALVGDEVELPCRispgknATGmevgwYRPPfsrVVHLYRNGKDQDGdqapeyrgrTELLKDAIGEGKVTL 112
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCE------ATG-----SPPP---TITWYKNGEPISS---------GSTRSRSLSGSNSTL 59

                          90
                  ....*....|....*
gi 56788383   113 RIRNVRFSDEGGFTC 127
Cdd:pfam13927  60 TISNVTRSDAGTYTC 74
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 41-130 1.28e-03

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 37.37  E-value: 1.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383  41 IRALVGDEVELPCRIS---PGKNATGMEVGWYR-----PPFSRVVHlyrNGKDQDGDqaPEYRGRTELLKDaIGEGKVTL 112
Cdd:cd05712   9 VTVQEGLCVLIPCSFSypaDYWVSNPVHGYWYRggpypKYRPPVAT---NNRTREVH--ESTQGRFRLLGD-PGKKNCSL 82

                        90
                ....*....|....*...
gi 56788383 113 RIRNVRFSDEGGFtcFFR 130
Cdd:cd05712  83 SISDARPEDSGKY--FFR 98
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 37-133 1.78e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 36.40  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383    37 PRHPIRALVGDEVELPCRISPGknatgmevgwyRPPFSrvVHLYRNGK-DQDGDQAPEYRGRTellkdaigeGKVTLRIR 115
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSASTG-----------SPGPD--VTWSKEGGtLIESLKVKHDNGRT---------TQSSLLIS 59

                          90
                  ....*....|....*...
gi 56788383   116 NVRFSDEGGFTCFFRDHS 133
Cdd:pfam00047  60 NVTKEDAGTYTCVVNNPG 77
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 42-127 2.32e-03

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


Pssm-ID: 409574  Cd Length: 107  Bit Score: 36.28  E-value: 2.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56788383  42 RALVGDEVELPCRISPGKNATGMEVGWYR---PPF--SRVVhLYRNGKDQDGDQAPEYRgrtelLKDAIGEGKVTLRIRN 116
Cdd:cd20982   4 RAEVGHNAYLPCSYTTAAPGNLVPVCWGKgacPVSycGNVL-LRTDERDVTYQKSSRYQ-----LKGDFSKGDVSLTIEN 77

                        90
                ....*....|.
gi 56788383 117 VRFSDEGGFTC 127
Cdd:cd20982  78 VTLADSGIYCC 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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