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Conserved domains on  [gi|32996737|ref|NP_775106|]
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protein lin-9 homolog isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LIN9_C pfam19438
LIN9 C-terminal; MuvB transcriptional regulatory complex interacts with B-Myb to form the MMB ...
 283-556 2.33e-174

LIN9 C-terminal; MuvB transcriptional regulatory complex interacts with B-Myb to form the MMB complex during S-phase of the cell cycle to activate genes required for the G2 and M phases. This is a domain found at the C-terminal of LIN9, one of the core members of the MuvB complex that functions as a scaffold protein and forms a subcomplex with the C-terminal of LIN152. This subcomplex forms a binding interface that recruits B-Myb to the MuvB complex which is arranged as a three-stranded antiparallel coiled-coil as the core of the structure. LIN9 contributes two helices (alpha1 and alpha2) that run antiparallel and are connected through a short linker.


:

Pssm-ID: 437270  Cd Length: 272  Bit Score: 493.32  E-value: 2.33e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32996737   283 PDYEVLSNEPHETMPIAAFGQKQRPSRF-FMTPPRlhYTPPLQSPIIDNDPLLGQSPWRSKISGSDTETLGGFPVEFLIQ 361
Cdd:pfam19438   1 PDYEVLSNEPPETIPLSSFQQKFRPRPQpFLSPPR--YTPSLGSPLLDNDPLLSGSPFKSRLTGLDGGTLGGFPIKFLEL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32996737   362 VTRLSKILMIKKEHIKKLREMNTEAEKLKSYSMPISIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPA 441
Cdd:pfam19438  79 VVRLSKILNIKKDKIQQLKEMNTEAEKRKSYGEPITPEFQRKYAGIVLELEKLNKDLNEYLNGVQQYCQEIAPEQGLAPM 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32996737   442 DQPTDMRRRCEEEAQEIVRHANSSTGQPCVENENLTDLISRLTAILLQIKCLAEgGDLNSFEFKSLTDSLNDIKSTIDAS 521
Cdd:pfam19438 159 LQPSELREKCEEEAQEIVERNNSQNGRPTVKNPKVLDLITDLTALMLQIKTLAE-SDLNSYELKSLQDTLEEIKKKLDPS 237

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 32996737   522 NISCFQNNVEIHVAHIQSGLSQMGNLHAFAANNTN 556
Cdd:pfam19438 238 NQSVFQNNVEIHMNHIQSGLSQMGNLHAFAASNTN 272
DIRP pfam06584
DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related ...
 142-247 2.84e-61

DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9 and aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway.


:

Pssm-ID: 461955  Cd Length: 108  Bit Score: 197.44  E-value: 2.84e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32996737   142 WFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVA- 220
Cdd:pfam06584   1 WFYSNIDKPLFESKNDFEEYLNESFPGLKTRRLTRAEWQKIRRSMGKPRRFSAAFFEEEREELERKREKIRQLQQRKLNi 80

                          90       100
                  ....*....|....*....|....*...
gi 32996737   221 DVSQF-KDLPDEIPLPLVIGTKVTARLR 247
Cdd:pfam06584  81 DLSGLlEDLPKDIPLPLVVGTKVTARLP 108
 
Name Accession Description Interval E-value
LIN9_C pfam19438
LIN9 C-terminal; MuvB transcriptional regulatory complex interacts with B-Myb to form the MMB ...
 283-556 2.33e-174

LIN9 C-terminal; MuvB transcriptional regulatory complex interacts with B-Myb to form the MMB complex during S-phase of the cell cycle to activate genes required for the G2 and M phases. This is a domain found at the C-terminal of LIN9, one of the core members of the MuvB complex that functions as a scaffold protein and forms a subcomplex with the C-terminal of LIN152. This subcomplex forms a binding interface that recruits B-Myb to the MuvB complex which is arranged as a three-stranded antiparallel coiled-coil as the core of the structure. LIN9 contributes two helices (alpha1 and alpha2) that run antiparallel and are connected through a short linker.


Pssm-ID: 437270  Cd Length: 272  Bit Score: 493.32  E-value: 2.33e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32996737   283 PDYEVLSNEPHETMPIAAFGQKQRPSRF-FMTPPRlhYTPPLQSPIIDNDPLLGQSPWRSKISGSDTETLGGFPVEFLIQ 361
Cdd:pfam19438   1 PDYEVLSNEPPETIPLSSFQQKFRPRPQpFLSPPR--YTPSLGSPLLDNDPLLSGSPFKSRLTGLDGGTLGGFPIKFLEL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32996737   362 VTRLSKILMIKKEHIKKLREMNTEAEKLKSYSMPISIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPA 441
Cdd:pfam19438  79 VVRLSKILNIKKDKIQQLKEMNTEAEKRKSYGEPITPEFQRKYAGIVLELEKLNKDLNEYLNGVQQYCQEIAPEQGLAPM 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32996737   442 DQPTDMRRRCEEEAQEIVRHANSSTGQPCVENENLTDLISRLTAILLQIKCLAEgGDLNSFEFKSLTDSLNDIKSTIDAS 521
Cdd:pfam19438 159 LQPSELREKCEEEAQEIVERNNSQNGRPTVKNPKVLDLITDLTALMLQIKTLAE-SDLNSYELKSLQDTLEEIKKKLDPS 237

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 32996737   522 NISCFQNNVEIHVAHIQSGLSQMGNLHAFAANNTN 556
Cdd:pfam19438 238 NQSVFQNNVEIHMNHIQSGLSQMGNLHAFAASNTN 272
DIRP pfam06584
DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related ...
 142-247 2.84e-61

DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9 and aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway.


Pssm-ID: 461955  Cd Length: 108  Bit Score: 197.44  E-value: 2.84e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32996737   142 WFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVA- 220
Cdd:pfam06584   1 WFYSNIDKPLFESKNDFEEYLNESFPGLKTRRLTRAEWQKIRRSMGKPRRFSAAFFEEEREELERKREKIRQLQQRKLNi 80

                          90       100
                  ....*....|....*....|....*...
gi 32996737   221 DVSQF-KDLPDEIPLPLVIGTKVTARLR 247
Cdd:pfam06584  81 DLSGLlEDLPKDIPLPLVVGTKVTARLP 108
 
Name Accession Description Interval E-value
LIN9_C pfam19438
LIN9 C-terminal; MuvB transcriptional regulatory complex interacts with B-Myb to form the MMB ...
 283-556 2.33e-174

LIN9 C-terminal; MuvB transcriptional regulatory complex interacts with B-Myb to form the MMB complex during S-phase of the cell cycle to activate genes required for the G2 and M phases. This is a domain found at the C-terminal of LIN9, one of the core members of the MuvB complex that functions as a scaffold protein and forms a subcomplex with the C-terminal of LIN152. This subcomplex forms a binding interface that recruits B-Myb to the MuvB complex which is arranged as a three-stranded antiparallel coiled-coil as the core of the structure. LIN9 contributes two helices (alpha1 and alpha2) that run antiparallel and are connected through a short linker.


Pssm-ID: 437270  Cd Length: 272  Bit Score: 493.32  E-value: 2.33e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32996737   283 PDYEVLSNEPHETMPIAAFGQKQRPSRF-FMTPPRlhYTPPLQSPIIDNDPLLGQSPWRSKISGSDTETLGGFPVEFLIQ 361
Cdd:pfam19438   1 PDYEVLSNEPPETIPLSSFQQKFRPRPQpFLSPPR--YTPSLGSPLLDNDPLLSGSPFKSRLTGLDGGTLGGFPIKFLEL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32996737   362 VTRLSKILMIKKEHIKKLREMNTEAEKLKSYSMPISIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPA 441
Cdd:pfam19438  79 VVRLSKILNIKKDKIQQLKEMNTEAEKRKSYGEPITPEFQRKYAGIVLELEKLNKDLNEYLNGVQQYCQEIAPEQGLAPM 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32996737   442 DQPTDMRRRCEEEAQEIVRHANSSTGQPCVENENLTDLISRLTAILLQIKCLAEgGDLNSFEFKSLTDSLNDIKSTIDAS 521
Cdd:pfam19438 159 LQPSELREKCEEEAQEIVERNNSQNGRPTVKNPKVLDLITDLTALMLQIKTLAE-SDLNSYELKSLQDTLEEIKKKLDPS 237

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 32996737   522 NISCFQNNVEIHVAHIQSGLSQMGNLHAFAANNTN 556
Cdd:pfam19438 238 NQSVFQNNVEIHMNHIQSGLSQMGNLHAFAASNTN 272
DIRP pfam06584
DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related ...
 142-247 2.84e-61

DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9 and aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway.


Pssm-ID: 461955  Cd Length: 108  Bit Score: 197.44  E-value: 2.84e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32996737   142 WFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVA- 220
Cdd:pfam06584   1 WFYSNIDKPLFESKNDFEEYLNESFPGLKTRRLTRAEWQKIRRSMGKPRRFSAAFFEEEREELERKREKIRQLQQRKLNi 80

                          90       100
                  ....*....|....*....|....*...
gi 32996737   221 DVSQF-KDLPDEIPLPLVIGTKVTARLR 247
Cdd:pfam06584  81 DLSGLlEDLPKDIPLPLVVGTKVTARLP 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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