NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|28605137|ref|NP_736606|]
View 

26S proteasome non-ATPase regulatory subunit 10 isoform 2 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat (ANK) domain-containing protein is involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  33435370|17176038

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-150 5.38e-35

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.14  E-value: 5.38e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137  13 LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92
Cdd:COG0666  93 AAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 28605137  93 LGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
Cdd:COG0666 173 LEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-150 5.38e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.14  E-value: 5.38e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137  13 LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92
Cdd:COG0666  93 AAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 28605137  93 LGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
Cdd:COG0666 173 LEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230
Ank_2 pfam12796
Ankyrin repeats (3 copies);
44-136 1.74e-25

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 92.87  E-value: 1.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137    44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLgKGAQVNAVNqNGCTPLHYAASKNRHEIAV 123
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 28605137   124 MLLEGGANPDAKD 136
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 56-138 2.74e-18

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 80.09  E-value: 2.74e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   56 VEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAK 135
Cdd:PHA03100 175 VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTI 254


                 ...
gi 28605137  136 DHY 138
Cdd:PHA03100 255 IET 257
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 42-144 7.73e-10

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 55.79  E-value: 7.73e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137  42 TALHWACSAGHTEIVEFLLQ-----LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCT-------- 108
Cdd:cd22192  53 TALHVAALYDNLEAAVVLMEaapelVNEPMTSDLYQGETALHIAVVNQNLNLVRELIARGADVVSPRATGTFfrpgpknl 132

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 28605137 109 ------PLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
Cdd:cd22192 133 iyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLH 174
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 105-134 9.15e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 9.15e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 28605137    105 NGCTPLHYAASKNRHEIAVMLLEGGANPDA 134
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 42-136 1.47e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.83  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137    42 TALHwACSAGHTEIVEFLLQLGVPVNDKDDAGW--------------SPLHIAASAGRDEIVKALLGKGAQVNA-VNQNG 106
Cdd:TIGR00870  84 TLLH-AISLEYVDAVEAILLHLLAAFRKSGPLElandqytseftpgiTALHLAAHRQNYEIVKLLLERGASVPArACGDF 162

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 28605137   107 CT-------------PLHYAASKNRHEIAVMLLEGGANPDAKD 136
Cdd:TIGR00870 163 FVksqgvdsfyhgesPLNAAACLGSPSIVALLSEDPADILTAD 205
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-150 5.38e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.14  E-value: 5.38e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137  13 LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92
Cdd:COG0666  93 AAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 28605137  93 LGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
Cdd:COG0666 173 LEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
12-150 3.68e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.83  E-value: 3.68e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137  12 NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA 91
Cdd:COG0666  59 LAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKL 138

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 28605137  92 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
Cdd:COG0666 139 LLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENG 197
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-150 3.87e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 107.73  E-value: 3.87e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137  36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAAS 115
Cdd:COG0666 149 QDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAE 228

                        90       100       110
                ....*....|....*....|....*....|....*
gi 28605137 116 KNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
Cdd:COG0666 229 NGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAG 263
Ank_2 pfam12796
Ankyrin repeats (3 copies);
44-136 1.74e-25

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 92.87  E-value: 1.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137    44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLgKGAQVNAVNqNGCTPLHYAASKNRHEIAV 123
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 28605137   124 MLLEGGANPDAKD 136
Cdd:pfam12796  79 LLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-150 2.90e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.02  E-value: 2.90e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137  13 LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92
Cdd:COG0666  27 AAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLL 106

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 28605137  93 LGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
Cdd:COG0666 107 LEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-143 2.26e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.23  E-value: 2.26e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137  36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAAS 115
Cdd:COG0666 182 RDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAA 261

                        90       100
                ....*....|....*....|....*...
gi 28605137 116 KNRHEIAVMLLEGGANPDAKDHYEATAM 143
Cdd:COG0666 262 AGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
8-103 2.55e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.38  E-value: 2.55e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137     8 LMVCnlAYSGKLEELKEsILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPvnDKDDAGWSPLHIAASAGRDE 87
Cdd:pfam12796   1 LHLA--AKNGNLELVKL-LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 28605137    88 IVKALLGKGAQVNAVN 103
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 56-138 2.74e-18

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 80.09  E-value: 2.74e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   56 VEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAK 135
Cdd:PHA03100 175 VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTI 254


                 ...
gi 28605137  136 DHY 138
Cdd:PHA03100 255 IET 257
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 20-151 6.46e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 79.34  E-value: 6.46e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   20 EELKESILA-DKSLATRTDQDSR-TALHWACSAGH-TEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRD-EIVKALLGK 95
Cdd:PHA02876 251 EDLETSLLLyDAGFSVNSIDDCKnTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDtENIRTLIML 330

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 28605137   96 GAQVNAVNQNGCTPLHYAASKNRH-EIAVMLLEGGANPDAKDHYEATAMHRAAAKDT 151
Cdd:PHA02876 331 GADVNAADRLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDKTPIHYAAVRNN 387
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 37-146 1.76e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 77.70  E-value: 1.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASK 116
Cdd:PHA02874 121 DAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEY 200

                         90       100       110
                 ....*....|....*....|....*....|
gi 28605137  117 NRHEIAVMLLEGGANPDAKDHYEATAMHRA 146
Cdd:PHA02874 201 GDYACIKLLIDHGNHIMNKCKNGFTPLHNA 230
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 28-146 5.92e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 73.38  E-value: 5.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   28 ADKSLATRtDQDSrTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGC 107
Cdd:PHA02878 158 ADINMKDR-HKGN-TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGN 235

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 28605137  108 TPLHYAASK-NRHEIAVMLLEGGANPDAKDHYEA-TAMHRA 146
Cdd:PHA02878 236 TPLHISVGYcKDYDILKLLLEHGVDVNAKSYILGlTALHSS 276
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 42-149 5.96e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.55  E-value: 5.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   42 TALHWACSA--GHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRD--EIVKALLGKGAQVNA---------------- 101
Cdd:PHA03100 108 TPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDINAknrvnyllsygvpini 187

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 28605137  102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
Cdd:PHA03100 188 KDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILN 235
PHA03095 PHA03095
ankyrin-like protein; Provisional
 41-144 2.78e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 2.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   41 RTALHWACSAGH---TEIVEFLLQLGVPVNDKDDAGWSPLHI-AASAGRDEIVKALLGKGAQVNAVNQNGCTPLH-YAAS 115
Cdd:PHA03095  48 KTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHvYLSG 127

                         90       100       110
                 ....*....|....*....|....*....|
gi 28605137  116 KNRHE-IAVMLLEGGANPDAKDHYEATAMH 144
Cdd:PHA03095 128 FNINPkVIRLLLRKGADVNALDLYGMTPLA 157
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 54-147 3.10e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 68.45  E-value: 3.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   54 EIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
Cdd:PHA02874 105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYAN 184

                         90
                 ....*....|....
gi 28605137  134 AKDHYEATAMHRAA 147
Cdd:PHA02874 185 VKDNNGESPLHNAA 198
PHA03095 PHA03095
ankyrin-like protein; Provisional
 42-144 6.37e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 67.74  E-value: 6.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   42 TALH-WACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAAS--AGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNR 118
Cdd:PHA03095  85 TPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRN 164

                         90       100
                 ....*....|....*....|....*...
gi 28605137  119 HEIAV--MLLEGGANPDAKDHYEATAMH 144
Cdd:PHA03095 165 ANVELlrLLIDAGADVYAVDDRFRSLLH 192
Ank_4 pfam13637
Ankyrin repeats (many copies);
41-93 1.07e-13

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 61.52  E-value: 1.07e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 28605137    41 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL 93
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 36-136 2.85e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 65.84  E-value: 2.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   36 TDQDSRTALHWACSAGHT-----EIVEFLLQLGVPVNDKDDAGWSPLHIAASA--GRDEIVKALLGKGAQVNAVNQNGCT 108
Cdd:PHA03100  64 STKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGEN 143

                         90       100       110
                 ....*....|....*....|....*....|
gi 28605137  109 PLHYAASKNRH--EIAVMLLEGGANPDAKD 136
Cdd:PHA03100 144 LLHLYLESNKIdlKILKLLIDKGVDINAKN 173
PHA03095 PHA03095
ankyrin-like protein; Provisional
 41-148 4.07e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.43  E-value: 4.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   41 RTALHwACSAG---HTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGR--DEIVKALLGKGAQVNAVNQNGCTPLHYAA- 114
Cdd:PHA03095 118 RTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRFRSLLHHHLq 196

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 28605137  115 -SKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
Cdd:PHA03095 197 sFKPRARIVRELIRAGCDPAATDMLGNTPLHSMAT 231
Ank_4 pfam13637
Ankyrin repeats (many copies);
73-126 4.36e-13

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 59.98  E-value: 4.36e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 28605137    73 GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLL 126
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
20-150 4.51e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.59  E-value: 4.51e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137  20 EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQV 99
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 28605137 100 NAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
Cdd:COG0666  81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 37-144 5.34e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 65.07  E-value: 5.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA----ASAGRD-EIVKALLGKGAQVNAVNQNGCTPLH 111
Cdd:PHA03100  32 YKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLsnikYNLTDVkEIVKLLLEYGANVNAPDNNGITPLL 111

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 28605137  112 YAASK--NRHEIAVMLLEGGANPDAKDHYEATAMH 144
Cdd:PHA03100 112 YAISKksNSYSIVEYLLDNGANVNIKNSDGENLLH 146
PHA03095 PHA03095
ankyrin-like protein; Provisional
 26-143 5.82e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.96  E-value: 5.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   26 ILADKSLATRtDQDSRTALHWACSAGHT--EIVEFLLQLGVPVNDKDDAGWSPLHIAA--SAGRDEIVKALLGKGAQVNA 101
Cdd:PHA03095 174 IDAGADVYAV-DDRFRSLLHHHLQSFKPraRIVRELIRAGCDPAATDMLGNTPLHSMAtgSSCKRSLVLPLLIAGISINA 252

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 28605137  102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143
Cdd:PHA03095 253 RNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 13-131 5.96e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.93  E-value: 5.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   13 LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92
Cdd:PHA02875 108 LATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKML 187

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 28605137   93 LGKGAQVNAVNQNGC-TPLHYAASKNRHEIAVMLLEGGAN 131
Cdd:PHA02875 188 LDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGAD 227
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 17-133 1.49e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 60.78  E-value: 1.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   17 GKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG----VPVNDKddagWSPLHIAASAGRDEIVKAL 92
Cdd:PHA02875  79 GDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGadpdIPNTDK----FSPLHLAVMMGDIKGIELL 154

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 28605137   93 LGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
Cdd:PHA02875 155 IDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANID 195
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 6-150 2.50e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 60.27  E-value: 2.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137    6 SNLM-VCNLAYSGKLEELkesiLADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84
Cdd:PLN03192 527 SNLLtVASTGNAALLEEL----LKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAK 602

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28605137   85 RDEIVKALLGKGAQVNAvnQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
Cdd:PLN03192 603 HHKIFRILYHFASISDP--HAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAED 666
PHA03095 PHA03095
ankyrin-like protein; Provisional
 54-144 4.75e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 59.27  E-value: 4.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   54 EIVEFLLQLGVPVNDKDDAGWSPLHI---AASAGRDEIVKALLGKGAQVNAVNQNGCTPLH-YAASKNRHEIAVMLLEGG 129
Cdd:PHA03095  28 EEVRRLLAAGADVNFRGEYGKTPLHLylhYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAG 107

                         90
                 ....*....|....*
gi 28605137  130 ANPDAKDHYEATAMH 144
Cdd:PHA03095 108 ADVNAKDKVGRTPLH 122
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 36-150 8.19e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.92  E-value: 8.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   36 TDQDSRTALHWACSAG-HTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYA- 113
Cdd:PHA02876 337 ADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAl 416

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 28605137  114 ASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
Cdd:PHA02876 417 CGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKN 453
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 42-144 7.73e-10

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 55.79  E-value: 7.73e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137  42 TALHWACSAGHTEIVEFLLQ-----LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCT-------- 108
Cdd:cd22192  53 TALHVAALYDNLEAAVVLMEaapelVNEPMTSDLYQGETALHIAVVNQNLNLVRELIARGADVVSPRATGTFfrpgpknl 132

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 28605137 109 ------PLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
Cdd:cd22192 133 iyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLH 174
Ank_5 pfam13857
Ankyrin repeats (many copies);
35-80 1.71e-09

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.81  E-value: 1.71e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 28605137    35 RTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
Cdd:pfam13857  11 RLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 21-134 8.68e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.98  E-value: 8.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   21 ELKESILA--DKSLATRTDQDSRTA-------LHWACSaGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA 91
Cdd:PTZ00322  55 EATENKDAtpDHNLTTEEVIDPVVAhmltvelCQLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRV 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 28605137   92 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLL-------EGGAN--PDA 134
Cdd:PTZ00322 134 LLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSrhsqchfELGANakPDS 185
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 42-105 1.23e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 52.36  E-value: 1.23e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28605137   42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN 105
Cdd:PHA03100 194 TPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIET 257
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 20-136 1.97e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.99  E-value: 1.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   20 EELKESILADKSLATRTDQDsrtalhwacsagHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQV 99
Cdd:PHA02876 137 DKINESIEYMKLIKERIQQD------------ELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADV 204

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 28605137  100 NAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136
Cdd:PHA02876 205 NIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKND 241
Ank_5 pfam13857
Ankyrin repeats (many copies);
59-113 2.45e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.73  E-value: 2.45e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 28605137    59 LLQLG-VPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYA 113
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 44-149 4.83e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 50.65  E-value: 4.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASA------------------------------GRD------- 86
Cdd:PHA02878  41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEpnklgmkemirsinkcsvfytlvaikdafnNRNveifkii 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   87 ---------------------------EIVKALLGKGAQVNAVNQN-GCTPLHYAASKNRHEIAVMLLEGGANPDAKDHY 138
Cdd:PHA02878 121 ltnrykniqtidlvyidkkskddiieaEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKT 200

                        170
                 ....*....|.
gi 28605137  139 EATAMHRAAAK 149
Cdd:PHA02878 201 NNSPLHHAVKH 211
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 76-149 1.59e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 49.28  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   76 PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAaSKNRH------EIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
Cdd:PHA03100  38 PLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYL-SNIKYnltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISK 116
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 54-144 2.33e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 47.89  E-value: 2.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   54 EIVEFLLQLGVPVNDK-DDAGWSPLHIAASAGRD---EIVKALLGKGAQVNAVNQNGCTPLH-YAASKN-RHEIAVMLLE 127
Cdd:PHA02859  67 EILKFLIENGADVNFKtRDNNLSALHHYLSFNKNvepEILKILIDSGSSITEEDEDGKNLLHmYMCNFNvRINVIKLLID 146

                         90
                 ....*....|....*..
gi 28605137  128 GGANPDAKDHYEATAMH 144
Cdd:PHA02859 147 SGVSFLNKDFDNNNILY 163
PHA02946 PHA02946
ankyin-like protein; Provisional
 56-112 2.73e-07

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.51  E-value: 2.73e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 28605137   56 VEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHY 112
Cdd:PHA02946  55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYY 111
PHA03095 PHA03095
ankyrin-like protein; Provisional
 14-135 3.83e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.10  E-value: 3.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   14 AYSGKLEELkesiLADKSLATRTDQDSRTALHWA---CSAGHTEIVEFLLQlGVPVNDKDDAGWSPLHIAASAGRDEIVK 90
Cdd:PHA03095 200 PRARIVREL----IRAGCDPAATDMLGNTPLHSMatgSSCKRSLVLPLLIA-GISINARNRYGQTPLHYAAVFNNPRACR 274

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 28605137   91 ALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEggANPDAK 135
Cdd:PHA03095 275 RLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALA--KNPSAE 317
PHA03095 PHA03095
ankyrin-like protein; Provisional
 79-144 7.85e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.33  E-value: 7.85e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28605137   79 IAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHY---AASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
Cdd:PHA03095  20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLylhYSSEKVKDIVRLLLEAGADVNAPERCGFTPLH 88
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 54-144 1.19e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 46.68  E-value: 1.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137  54 EIVEFLLQ-------LGVPVN----DKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA---------VNQNGC-----T 108
Cdd:cd22194 111 EIVRILLAfaeengiLDRFINaeytEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAhakgvffnpKYKHEGfyfgeT 190

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 28605137 109 PLHYAASKNRHEIAVMLLEGGANPDA-KDHYEATAMH 144
Cdd:cd22194 191 PLALAACTNQPEIVQLLMEKESTDITsQDSRGNTVLH 227
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 105-137 1.26e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 42.66  E-value: 1.26e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 28605137   105 NGCTPLHYAASKNRH-EIAVMLLEGGANPDAKDH 137
Cdd:pfam00023   1 DGNTPLHLAAGRRGNlEIVKLLLSKGADVNARDK 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
108-149 2.02e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 2.02e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 28605137   108 TPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASN 44
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 15-136 2.46e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.72  E-value: 2.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   15 YSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL-- 92
Cdd:PHA02874  10 YSGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLid 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28605137   93 ---------------------LGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136
Cdd:PHA02874  90 ngvdtsilpipciekdmiktiLDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIED 154
PHA02946 PHA02946
ankyin-like protein; Provisional
 84-150 2.66e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 45.82  E-value: 2.66e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28605137   84 GRDE-IVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
Cdd:PHA02946  49 GLDErFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTD 116
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 78-151 4.84e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 4.84e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28605137   78 HIAASaGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKDT 151
Cdd:PTZ00322  88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGF 160
Ank_5 pfam13857
Ankyrin repeats (many copies);
97-146 5.00e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 5.00e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 28605137    97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 21-113 6.03e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.57  E-value: 6.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIvkALLGKGAQVN 100
Cdd:PHA02874 171 DIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI--ELLINNASIN 248

                         90
                 ....*....|...
gi 28605137  101 AVNQNGCTPLHYA 113
Cdd:PHA02874 249 DQDIDGSTPLHHA 261
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 42-130 7.19e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.67  E-value: 7.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   42 TALHWA-CSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG-RDEIVKALLGKGAQVNAVNQNGCTPLHYAASknRH 119
Cdd:PHA02876 410 TALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALE--YH 487

                         90
                 ....*....|.
gi 28605137  120 EIAVMLLEGGA 130
Cdd:PHA02876 488 GIVNILLHYGA 498
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 105-134 9.15e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 9.15e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 28605137    105 NGCTPLHYAASKNRHEIAVMLLEGGANPDA 134
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 41-67 1.02e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 40.32  E-value: 1.02e-05
                          10        20
                  ....*....|....*....|....*..
gi 28605137    41 RTALHWACSAGHTEIVEFLLQLGVPVN 67
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGADIN 29
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 41-71 1.66e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.58  E-value: 1.66e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 28605137    41 RTALHWAC-SAGHTEIVEFLLQLGVPVNDKDD 71
Cdd:pfam00023   3 NTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 73-101 1.75e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.55  E-value: 1.75e-05
                          10        20
                  ....*....|....*....|....*....
gi 28605137    73 GWSPLHIAASAGRDEIVKALLGKGAQVNA 101
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 73-103 2.57e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.19  E-value: 2.57e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 28605137    73 GWSPLHIAA-SAGRDEIVKALLGKGAQVNAVN 103
Cdd:pfam00023   2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 39-68 3.16e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 3.16e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 28605137     39 DSRTALHWACSAGHTEIVEFLLQLGVPVND 68
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
13-60 3.19e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 3.19e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 28605137    13 LAYSGKLEELKeSILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60
Cdd:pfam13637   8 AAASGHLELLR-LLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 105-134 5.12e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 5.12e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 28605137   105 NGCTPLHYAASKNRHEIAVMLLEGGANPDA 134
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 73-101 5.26e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 5.26e-05
                           10        20
                   ....*....|....*....|....*....
gi 28605137     73 GWSPLHIAASAGRDEIVKALLGKGAQVNA 101
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-110 6.08e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.48  E-value: 6.08e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28605137  34 TRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPL 110
Cdd:COG0666 213 NAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
110-147 1.33e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.56  E-value: 1.33e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 28605137   110 LHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAA 38
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 42-136 1.47e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.83  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137    42 TALHwACSAGHTEIVEFLLQLGVPVNDKDDAGW--------------SPLHIAASAGRDEIVKALLGKGAQVNA-VNQNG 106
Cdd:TIGR00870  84 TLLH-AISLEYVDAVEAILLHLLAAFRKSGPLElandqytseftpgiTALHLAAHRQNYEIVKLLLERGASVPArACGDF 162

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 28605137   107 CT-------------PLHYAASKNRHEIAVMLLEGGANPDAKD 136
Cdd:TIGR00870 163 FVksqgvdsfyhgesPLNAAACLGSPSIVALLSEDPADILTAD 205
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 42-116 1.79e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 40.25  E-value: 1.79e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28605137   42 TALHWACSA-GHTEIVEFLLQLGVPVNDKDDA-GWSPLHIAASAGRdeIVKALLGKGAQVNAVNQNGCTPLHYAASK 116
Cdd:PHA02878 236 TPLHISVGYcKDYDILKLLLEHGVDVNAKSYIlGLTALHSSIKSER--KLKLLLEYGADINSLNSYKLTPLSSAVKQ 310
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 65-144 2.32e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 40.25  E-value: 2.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137  65 PVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA------VNQNGCT-------PLHYAASKNRHEIAVMLLEGGAN 131
Cdd:cd21882  65 PCTDEFYQGQTALHIAIENRNLNLVRLLVENGADVSAratgrfFRKSPGNlfyfgelPLSLAACTNQEEIVRLLLENGAQ 144

                        90
                ....*....|....*.
gi 28605137 132 P---DAKDHYEATAMH 144
Cdd:cd21882 145 PaalEAQDSLGNTVLH 160
PHA02946 PHA02946
ankyin-like protein; Provisional
 20-150 2.88e-04

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 39.65  E-value: 2.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   20 EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIaASAGRDEIVKA---LLGKG 96
Cdd:PHA02946  52 ERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYY-LSGTDDEVIERinlLVQYG 130

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 28605137   97 AQV-NAVNQNGCTPLhYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
Cdd:PHA02946 131 AKInNSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSD 184
PHA02798 PHA02798
ankyrin-like protein; Provisional
 53-143 4.41e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 39.05  E-value: 4.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   53 TEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRD-----EIVKALLGKGAQVNAVNQNGCTPLHYAASK---NRHEIAVM 124
Cdd:PHA02798  51 TDIVKLFINLGANVNGLDNEYSTPLCTILSNIKDykhmlDIVKILIENGADINKKNSDGETPLYCLLSNgyiNNLEILLF 130

                         90
                 ....*....|....*....
gi 28605137  125 LLEGGANPDAKDHYEATAM 143
Cdd:PHA02798 131 MIENGADTTLLDKDGFTML 149
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 76-127 1.63e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 37.55  E-value: 1.63e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 28605137   76 PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASK-NRHEIAVMLLE 127
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEpNKLGMKEMIRS 92
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 68-148 2.32e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 37.15  E-value: 2.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   68 DKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
Cdd:PLN03192 520 HDDPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAI 599


                 .
gi 28605137  148 A 148
Cdd:PLN03192 600 S 600
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 37-110 4.40e-03

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 36.43  E-value: 4.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28605137   37 DQDSRTALHWACSAGH--TEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG--------------RDEIVKALLGKGAQVN 100
Cdd:PHA02716 314 DSAGRTCLHQYILRHNisTDIIKLLHEYGNDLNEPDNIGNTVLHTYLSMLsvvnildpetdndiRLDVIQCLISLGADIT 393

                         90
                 ....*....|
gi 28605137  101 AVNQNGCTPL 110
Cdd:PHA02716 394 AVNCLGYTPL 403
PHA02741 PHA02741
hypothetical protein; Provisional
 66-122 6.38e-03

hypothetical protein; Provisional


Pssm-ID: 165108 [Multi-domain]  Cd Length: 169  Bit Score: 35.40  E-value: 6.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28605137   66 VNDKDDAGWSPLHIAASAGRD----EIVKALLGKGAQVNAVNQ-NGCTPLHYAASKNRHEIA 122
Cdd:PHA02741  53 LNATDDAGQMCIHIAAEKHEAqlaaEIIDHLIELGADINAQEMlEGDTALHLAAHRRDHDLA 114
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 55-125 6.85e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 35.87  E-value: 6.85e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28605137   55 IVEFLLQLgVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAAsknRHEIAVML 125
Cdd:PHA02989 239 VLNFILKY-IKINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTYAI---KHGNIDML 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH