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Conserved domains on  [gi|262205168|ref|NP_689961|]
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endosome/lysosome-associated apoptosis and autophagy regulator family member 2 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ephrin_rec_like super family cl06646
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
235-265 1.75e-04

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


The actual alignment was detected with superfamily member pfam07699:

Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 40.02  E-value: 1.75e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 262205168  235 FYNNGSSSCHPCPPGTFSD--GTKECRPCPAGT 265
Cdd:pfam07699   3 YSNTGLEPCIPCPRGTYQPeeGQLSCLACPLGT 35
 
Name Accession Description Interval E-value
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
235-265 1.75e-04

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 40.02  E-value: 1.75e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 262205168  235 FYNNGSSSCHPCPPGTFSD--GTKECRPCPAGT 265
Cdd:pfam07699   3 YSNTGLEPCIPCPRGTYQPeeGQLSCLACPLGT 35
TNFRSF19L cd13419
tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor ...
228-260 6.35e-03

tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT); TNFRSF19L (also known as receptor expressed in lymphoid tissues (RELT)) is especially abundant in hematologic tissues and can stimulate the proliferation of T-cells. It serves as a substrate for the closely related kinases, odd-skipped related transcription factor 1 (OSR1) and STE20/SPS1-related proline/alanine-rich kinase (SPAK); RELT binds SPAK and uses it to mediate p38 and JNK activation, rather than rely on the canonical TRAF pathways for its function. RELT is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. It interacts with phospholipid scramblase 1 (PLSCR1), an interferon-inducible protein that mediates antiviral activity against DNA and RNA viruses; PLSCR1 is a regulator of hepatitis B virus X (HBV X) protein. RELT and PLSCR1 co-localize in intracellular regions of human embryonic kidney-293 cells, with RELT over-expression appearing to alter the localization of PLSCR1.


Pssm-ID: 276924  Cd Length: 91  Bit Score: 36.62  E-value: 6.35e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 262205168 228 CPPCNPG--------FYNNGSSSCHPCPPGTFSD--GTKECRP 260
Cdd:cd13419    4 CLQCPPGqepdracgQGQGLGVLCRSCPPGTFSDslGSEPCRP 46
 
Name Accession Description Interval E-value
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
235-265 1.75e-04

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 40.02  E-value: 1.75e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 262205168  235 FYNNGSSSCHPCPPGTFSD--GTKECRPCPAGT 265
Cdd:pfam07699   3 YSNTGLEPCIPCPRGTYQPeeGQLSCLACPLGT 35
TNFRSF19L cd13419
tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor ...
228-260 6.35e-03

tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT); TNFRSF19L (also known as receptor expressed in lymphoid tissues (RELT)) is especially abundant in hematologic tissues and can stimulate the proliferation of T-cells. It serves as a substrate for the closely related kinases, odd-skipped related transcription factor 1 (OSR1) and STE20/SPS1-related proline/alanine-rich kinase (SPAK); RELT binds SPAK and uses it to mediate p38 and JNK activation, rather than rely on the canonical TRAF pathways for its function. RELT is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. It interacts with phospholipid scramblase 1 (PLSCR1), an interferon-inducible protein that mediates antiviral activity against DNA and RNA viruses; PLSCR1 is a regulator of hepatitis B virus X (HBV X) protein. RELT and PLSCR1 co-localize in intracellular regions of human embryonic kidney-293 cells, with RELT over-expression appearing to alter the localization of PLSCR1.


Pssm-ID: 276924  Cd Length: 91  Bit Score: 36.62  E-value: 6.35e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 262205168 228 CPPCNPG--------FYNNGSSSCHPCPPGTFSD--GTKECRP 260
Cdd:cd13419    4 CLQCPPGqepdracgQGQGLGVLCRSCPPGTFSDslGSEPCRP 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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