NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|188528684|ref|NP_660323|]
View 

protein N-lysine methyltransferase METTL21A isoform 1 [Homo sapiens]

Protein Classification

protein N-lysine methyltransferase family protein( domain architecture ID 10563300)

protein N-lysine methyltransferase family protein is a class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to human METTL21D that specifically trimethylates 'Lys-315' of VCP/p97

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 25-190 7.26e-73

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


:

Pssm-ID: 313513  Cd Length: 172  Bit Score: 218.36  E-value: 7.26e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528684   25 SFANHTIQIRQDWRHlGVAAVVWDAAIVLSTYLEM------GAVELRGRSAVELGAGTGLVGIVAALL--GAHVTITDRK 96
Cdd:pfam10294   1 KLDNPGLRIEEDTGN-GIGGHVWDAAVVLSKYLEMkifkelGANNLSGLNVLELGSGTGLVGIAVALLlpGASVTITDLE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528684   97 VALEFLKSNVQANlppHIQTKTVVKELTWGQNLGS--FSPGEFDLILGADIIYLEETFTDLLQTLEHLCSNHSVILLACR 174
Cdd:pfam10294  80 EALELLKKNIELN---ALSSKVVVKVLDWGENLPPdlFDGHPVDLILAADCVYNEDSFPLLEKTLKDLLGKESVILVAYK 156

                         170
                  ....*....|....*.
gi 188528684  175 IRYERDNNFLAMLERQ 190
Cdd:pfam10294 157 KRREAEKKFFKLLERF 172
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 25-190 7.26e-73

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 218.36  E-value: 7.26e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528684   25 SFANHTIQIRQDWRHlGVAAVVWDAAIVLSTYLEM------GAVELRGRSAVELGAGTGLVGIVAALL--GAHVTITDRK 96
Cdd:pfam10294   1 KLDNPGLRIEEDTGN-GIGGHVWDAAVVLSKYLEMkifkelGANNLSGLNVLELGSGTGLVGIAVALLlpGASVTITDLE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528684   97 VALEFLKSNVQANlppHIQTKTVVKELTWGQNLGS--FSPGEFDLILGADIIYLEETFTDLLQTLEHLCSNHSVILLACR 174
Cdd:pfam10294  80 EALELLKKNIELN---ALSSKVVVKVLDWGENLPPdlFDGHPVDLILAADCVYNEDSFPLLEKTLKDLLGKESVILVAYK 156

                         170
                  ....*....|....*.
gi 188528684  175 IRYERDNNFLAMLERQ 190
Cdd:pfam10294 157 KRREAEKKFFKLLERF 172
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 66-141 7.77e-06

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 44.80  E-value: 7.77e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 188528684  66 GRSAVELGAGTGLVGIVAALL--GAHVTITDR-KVALEFLKSNVQANLPPHIQTktvvkelTWGQNLGSFSPGEFDLIL 141
Cdd:COG2813   50 GGRVLDLGCGYGVIGLALAKRnpEARVTLVDVnARAVELARANAAANGLENVEV-------LWSDGLSGVPDGSFDLIL 121
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 54-109 5.02e-03

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 36.37  E-value: 5.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 188528684   54 STYLEMGAVELRGRSAVELGAGTGLVGIVAALLGAHVTITD-RKVALEFLKSNVQAN 109
Cdd:TIGR00537   8 SLLLEANLRELKPDDVLEIGAGTGLVAIRLKGKGKCILTTDiNPFAVKELRENAKLN 64
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
54-146 7.17e-03

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 36.67  E-value: 7.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528684  54 STYL---EMGAVELRGRSAVELGAGTGLVGIVAALLGA-HVTITD-RKVALEFLKSNVQANlppHIQTKTvvkeltwgqN 128
Cdd:PRK00517 105 TTRLcleALEKLVLPGKTVLDVGCGSGILAIAAAKLGAkKVLAVDiDPQAVEAARENAELN---GVELNV---------Y 172

                         90
                 ....*....|....*...
gi 188528684 129 LGSFSPgEFDLILgADII 146
Cdd:PRK00517 173 LPQGDL-KADVIV-ANIL 188
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 25-190 7.26e-73

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 218.36  E-value: 7.26e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528684   25 SFANHTIQIRQDWRHlGVAAVVWDAAIVLSTYLEM------GAVELRGRSAVELGAGTGLVGIVAALL--GAHVTITDRK 96
Cdd:pfam10294   1 KLDNPGLRIEEDTGN-GIGGHVWDAAVVLSKYLEMkifkelGANNLSGLNVLELGSGTGLVGIAVALLlpGASVTITDLE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528684   97 VALEFLKSNVQANlppHIQTKTVVKELTWGQNLGS--FSPGEFDLILGADIIYLEETFTDLLQTLEHLCSNHSVILLACR 174
Cdd:pfam10294  80 EALELLKKNIELN---ALSSKVVVKVLDWGENLPPdlFDGHPVDLILAADCVYNEDSFPLLEKTLKDLLGKESVILVAYK 156

                         170
                  ....*....|....*.
gi 188528684  175 IRYERDNNFLAMLERQ 190
Cdd:pfam10294 157 KRREAEKKFFKLLERF 172
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 66-141 7.77e-06

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 44.80  E-value: 7.77e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 188528684  66 GRSAVELGAGTGLVGIVAALL--GAHVTITDR-KVALEFLKSNVQANLPPHIQTktvvkelTWGQNLGSFSPGEFDLIL 141
Cdd:COG2813   50 GGRVLDLGCGYGVIGLALAKRnpEARVTLVDVnARAVELARANAAANGLENVEV-------LWSDGLSGVPDGSFDLIL 121
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 63-141 7.55e-05

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 41.81  E-value: 7.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528684   63 ELRGRSAVELGAGTGLVGIVAALLGAHVTIT---DRKVALEFLKSNVQANLPPHIqtktvvkELTWGQNLGSFSPGEFDL 139
Cdd:pfam05175  29 KDLSGKVLDLGCGAGVLGAALAKESPDAELTmvdINARALESARENLAANGLENG-------EVVASDVYSGVEDGKFDL 101


                  ..
gi 188528684  140 IL 141
Cdd:pfam05175 102 II 103
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
42-105 8.12e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 41.81  E-value: 8.12e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 188528684  42 VAAVVWDAAIvlstyleMGAVElrGRSAVELGAGTGLVGIVAALLGAHVTI---TDRKvALEFLKSN 105
Cdd:COG2263   31 AAELLHLAYL-------RGDIE--GKTVLDLGCGTGMLAIGAALLGAKKVVgvdIDPE-ALEIAREN 87
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 47-164 1.34e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 40.39  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528684  47 WDAAivLSTYLEmgAVELRGRSAVELGAGTGLVGIVAALLGAHVTITDR-KVALEFLKSNVQAnLPPHIQTKTVvkeltw 125
Cdd:COG2227   10 WDRR--LAALLA--RLLPAGGRVLDVGCGTGRLALALARRGADVTGVDIsPEALEIARERAAE-LNVDFVQGDL------ 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 188528684 126 gQNLgSFSPGEFDLILGADIIyleETFTDLLQTLEHLCS 164
Cdd:COG2227   79 -EDL-PLEDGSFDLVICSEVL---EHLPDPAALLRELAR 112
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 54-109 5.02e-03

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 36.37  E-value: 5.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 188528684   54 STYLEMGAVELRGRSAVELGAGTGLVGIVAALLGAHVTITD-RKVALEFLKSNVQAN 109
Cdd:TIGR00537   8 SLLLEANLRELKPDDVLEIGAGTGLVAIRLKGKGKCILTTDiNPFAVKELRENAKLN 64
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 65-218 5.26e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 36.66  E-value: 5.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528684  65 RGRSAVELGAGTGLVGIVAA--LLGAHVTITDR-KVALEFLKSNVQAN-LPPHIQTKTV-VKELTwgqnlGSFSPGEFDL 139
Cdd:COG4123   37 KGGRVLDLGTGTGVIALMLAqrSPGARITGVEIqPEAAELARRNVALNgLEDRITVIHGdLKEFA-----AELPPGSFDL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528684 140 IL--------GADII-----------YLEETFTDLLQTLEHLCSNH---SVILlacriRYERDNNFLAMLERQ----FTV 193
Cdd:COG4123  112 VVsnppyfkaGSGRKspdearaiarhEDALTLEDLIRAAARLLKPGgrfALIH-----PAERLAEILAALRKYglgpKRL 186

                        170       180
                 ....*....|....*....|....*..
gi 188528684 194 RKVHYDPEKDVH--IYEAQKrNQKEDL 218
Cdd:COG4123  187 RPVHPRPGKPAKrvLLEARK-GGRAGL 212
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
54-146 7.17e-03

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 36.67  E-value: 7.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528684  54 STYL---EMGAVELRGRSAVELGAGTGLVGIVAALLGA-HVTITD-RKVALEFLKSNVQANlppHIQTKTvvkeltwgqN 128
Cdd:PRK00517 105 TTRLcleALEKLVLPGKTVLDVGCGSGILAIAAAKLGAkKVLAVDiDPQAVEAARENAELN---GVELNV---------Y 172

                         90
                 ....*....|....*...
gi 188528684 129 LGSFSPgEFDLILgADII 146
Cdd:PRK00517 173 LPQGDL-KADVIV-ANIL 188
PRK14968 PRK14968
putative methyltransferase; Provisional
 61-141 9.66e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 35.64  E-value: 9.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528684  61 AVELRGRSAVELGAGTGLVGIVAALLGAHVTITD-----RKVALEFLKSNVQANLPphiqTKTVVKELtwgqnLGSFSPG 135
Cdd:PRK14968  19 AVDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDinpyaVECAKCNAKLNNIRNNG----VEVIRSDL-----FEPFRGD 89


                 ....*.
gi 188528684 136 EFDLIL 141
Cdd:PRK14968  90 KFDVIL 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH