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Conserved domains on  [gi|20336274|ref|NP_602297|]
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sulfate anion transporter 1 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11660 super family cl46980
putative transporter; Provisional
 55-196 6.19e-44

putative transporter; Provisional


The actual alignment was detected with superfamily member TIGR00815:

Pssm-ID: 481320 [Multi-domain]  Cd Length: 552  Bit Score: 154.41  E-value: 6.19e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336274    55 PATRWLRQYRPREyLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVG 134
Cdd:TIGR00815   1 PVLRWLRKYRLKK-FKGDLMAGLTVGILLIPQAIAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLG 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20336274   135 QVVDRELQLAGFDpsqdglqpgansstlngsaamldcgrdcYAIRVATALTLMTGLYQTSWG 196
Cdd:TIGR00815  80 SLVQREGLQGLFD----------------------------DYIRLAFTATLLAGIFQVIMG 113
 
Name Accession Description Interval E-value
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
 55-196 6.19e-44

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 154.41  E-value: 6.19e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336274    55 PATRWLRQYRPREyLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVG 134
Cdd:TIGR00815   1 PVLRWLRKYRLKK-FKGDLMAGLTVGILLIPQAIAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLG 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20336274   135 QVVDRELQLAGFDpsqdglqpgansstlngsaamldcgrdcYAIRVATALTLMTGLYQTSWG 196
Cdd:TIGR00815  80 SLVQREGLQGLFD----------------------------DYIRLAFTATLLAGIFQVIMG 113
Sulfate_transp pfam00916
Sulfate permease family; This family of integral membrane proteins are known as the Sulfate ...
 69-196 2.94e-34

Sulfate permease family; This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.


Pssm-ID: 459995 [Multi-domain]  Cd Length: 379  Bit Score: 125.44  E-value: 2.94e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336274    69 LAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQlagfdp 148
Cdd:pfam00916   1 LKGDLIAGITVAILAIPQALAYAILAGLPPIYGLYSSFVPGFVYALFGTSRHLAIGPVAVLSLMVGAAIAKLAA------ 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 20336274   149 sqdglqpgansstlngsaamldcGRDCYAIRVATALTLMTGLYQTSWG 196
Cdd:pfam00916  75 -----------------------KDPELGIALAFTLTFLAGIIQLALG 99
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
 66-137 3.50e-17

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 79.38  E-value: 3.50e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20336274  66 REYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVV 137
Cdd:COG0659   4 RSNLRGDLLAGLTVALVALPLALAFAIAAGLPPEAGLYAAIVGGIVYALFGGSRLLISGPTAALAVVVAAAV 75
PRK11660 PRK11660
putative transporter; Provisional
 69-119 4.33e-05

putative transporter; Provisional


Pssm-ID: 183265 [Multi-domain]  Cd Length: 568  Bit Score: 43.78  E-value: 4.33e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 20336274   69 LAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSR 119
Cdd:PRK11660  29 FTRDLIAGITVGIIAIPLAMALAIASGVPPQYGLYTAAVAGIVIALTGGSR 79
 
Name Accession Description Interval E-value
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
 55-196 6.19e-44

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 154.41  E-value: 6.19e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336274    55 PATRWLRQYRPREyLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVG 134
Cdd:TIGR00815   1 PVLRWLRKYRLKK-FKGDLMAGLTVGILLIPQAIAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLG 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20336274   135 QVVDRELQLAGFDpsqdglqpgansstlngsaamldcgrdcYAIRVATALTLMTGLYQTSWG 196
Cdd:TIGR00815  80 SLVQREGLQGLFD----------------------------DYIRLAFTATLLAGIFQVIMG 113
Sulfate_transp pfam00916
Sulfate permease family; This family of integral membrane proteins are known as the Sulfate ...
 69-196 2.94e-34

Sulfate permease family; This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.


Pssm-ID: 459995 [Multi-domain]  Cd Length: 379  Bit Score: 125.44  E-value: 2.94e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336274    69 LAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQlagfdp 148
Cdd:pfam00916   1 LKGDLIAGITVAILAIPQALAYAILAGLPPIYGLYSSFVPGFVYALFGTSRHLAIGPVAVLSLMVGAAIAKLAA------ 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 20336274   149 sqdglqpgansstlngsaamldcGRDCYAIRVATALTLMTGLYQTSWG 196
Cdd:pfam00916  75 -----------------------KDPELGIALAFTLTFLAGIIQLALG 99
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
 66-137 3.50e-17

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 79.38  E-value: 3.50e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20336274  66 REYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVV 137
Cdd:COG0659   4 RSNLRGDLLAGLTVALVALPLALAFAIAAGLPPEAGLYAAIVGGIVYALFGGSRLLISGPTAALAVVVAAAV 75
PRK11660 PRK11660
putative transporter; Provisional
 69-119 4.33e-05

putative transporter; Provisional


Pssm-ID: 183265 [Multi-domain]  Cd Length: 568  Bit Score: 43.78  E-value: 4.33e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 20336274   69 LAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSR 119
Cdd:PRK11660  29 FTRDLIAGITVGIIAIPLAMALAIASGVPPQYGLYTAAVAGIVIALTGGSR 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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