Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574   219 EPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGensqlqraGVTLRVLRMMRIFW 298
Cdd:pfam00520  33 TVLEILDYVFTGIFTLEMLLKIIAAGFKKRYFRSPWNILDFVVVLPSLISLVLSSVGS--------LSGLRVLRLLRLLR 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574   299 VIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKD-----FTSIPAACWWVIISMTT 373
Cdd:pfam00520 105 LLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWENPDngrtnFDNFPNAFLWLFQTMTT 184

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 19071574   374 VGYGDMYPITVPGR-------ILGGVCVVSGIVLLALPITFIYHSFVQCYHELK 420
Cdd:pfam00520 185 EGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574   219 EPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGensqlqraGVTLRVLRMMRIFW 298
Cdd:pfam00520  33 TVLEILDYVFTGIFTLEMLLKIIAAGFKKRYFRSPWNILDFVVVLPSLISLVLSSVGS--------LSGLRVLRLLRLLR 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574   299 VIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKD-----FTSIPAACWWVIISMTT 373
Cdd:pfam00520 105 LLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWENPDngrtnFDNFPNAFLWLFQTMTT 184

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 19071574   374 VGYGDMYPITVPGR-------ILGGVCVVSGIVLLALPITFIYHSFVQCYHELK 420
Cdd:pfam00520 185 EGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574     11 VVLNVGGARYSLSRELLKdfplrrvsrlhgCRSE--RDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRgHGKLRFaPR 88
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLA------------AHSPyfKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLY-TGKLDL-PE 67

                           90       100       110
                   ....*....|....*....|....*....|.
gi 19071574     89 MCELSFYNEMIYWGLEGaHLEYCCQRRLDDR 119
Cdd:smart00225  68 ENVEELLELADYLQIPG-LVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  11 VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGhGKLRFAPRMC 90
Cdd:cd18382   1 VIINVGGARYSLPWSTLDRFPLTRLSRLKACRSEDDILRVCDDYDVERNEFFFDRSPEAFGVILLFLRA-GKLRLLREMC 79

                        90       100       110
                ....*....|....*....|....*....|
gi 19071574  91 ELSFYNEMIYWGLEGAHLEYCCQRRLDDRM 120
Cdd:cd18382  80 ALSFQEELAYWGIEEAHLERCCKRRLLRRL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2; KCNG1, also called voltage-gated potassium channel subunit Kv6.1 or kH2, functions as a regulatory alpha-subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit or voltage-gated potassium channel subunit Kv6.2, is a new gamma-subunit of voltage-gated potassium channels that can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG1 and KCNG2 are regulatory alpha subunits and do not form homomultimers. They form heteromultimers (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  11 VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGhGKLRFAPRMC 90
Cdd:cd18421   6 VIINVGGIKYRIPWTTLEEFPLTRLGQLKSCNNFDEIMDICDDYDVTCNEFFFDRNPCAFRTILTFLRA-GKLRLLREMC 84

                        90       100       110
                ....*....|....*....|....*....|
gi 19071574  91 ELSFYNEMIYWGLEGAHLEYCCQRRLDDRM 120
Cdd:cd18421  85 ALSFQEELLYWGIEEENLEWCCRRRLLQKE 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  11 VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGhGKLRFAPRMC 90
Cdd:cd18378   4 VLLNVGGVRHEVLWRTLDRLPRTRLGRLRECNTHESLLELCDDYDLEDNEYFFDRHPGAFTSILNFYRT-GKLHMPEEMC 82

                        90       100
                ....*....|....*....|....*
gi 19071574  91 ELSFYNEMIYWGLEGAHLEYCCQRR 115
Cdd:cd18378  83 VLSFSQELEYWGIDEIYLESCCQHR 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  11 VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSerdvlevcdDYDRERNEYFFDRHSEAFGFILLYVRgHGKLRFAPRMC 90
Cdd:cd18317   1 VVLNVGGTRFELSRSTLLRFPDTRLGKLAKESH---------AYDESTNEYFFDRNPEVFEAILDYYR-TGELHLPSNVC 70

                        90
                ....*....|..
gi 19071574  91 ELSFYNEMIYWG 102
Cdd:cd18317  71 PASFKEELEFWG 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  12 VLNVGGARYSLSRELLKDFPLRRVSRLhGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGhGKLRFAPRMCE 91
Cdd:cd18424   2 TINVGGSRFVLSQQVLSSHPETRLGKL-AVSVRDSVLELCDDANFVDNEYFFDRSSQAFKYIMNYYKT-GHLHVMEELCA 79

                        90       100
                ....*....|....*....|....
gi 19071574  92 LSFYNEMIYWGLEGAHLEYCCQRR 115
Cdd:cd18424  80 ISFLQEIEYWGIDELSIDSCCRER 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 1 (KCNS1); KCNS1, also called delayed-rectifier K(+) channel alpha subunit 1 or voltage-gated potassium channel subunit Kv9.1, is a modulatory alpha subunit of voltage-gated potassium channel that mediates neuropathic pain following nerve injury. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  13 LNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGhGKLRFAPRMCEL 92
Cdd:cd18426   3 INVGGLKRRLSSSTLSKFPDTRLGRLLSCDSEESILQICDDYDVSAKEFYFDRNPGLFPYVLHFYQT-GKLHIMEELCVF 81

                        90       100
                ....*....|....*....|...
gi 19071574  93 SFYNEMIYWGLEGAHLEYCCQRR 115
Cdd:cd18426  82 SFSQEIEYWGINEFFLDSCCSYR 104

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574    11 VVLNVGGARYSLSRELLKDFPLRRVSRLhgcrserdVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGHGKLRFAPRMC 90
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRL--------LELECDDYDDDTNEYFFDRSPKHFETILNFYRTGGKLHRPEEVC 72

                          90       100
                  ....*....|....*....|.
gi 19071574    91 ELSFYNEMIYWGLEGAHLEYC 111
Cdd:pfam02214  73 LDEFLEEAEFYGLDELALELC 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  13 LNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGhGKLRFAPRMCEL 92
Cdd:cd18384   3 INVGGFRRRLSASALLRFPGTRLGRLLACHSEEAILELCDDYDVAAREFYFDRNPGFFLYVLHFYRT-GKLHVMDELCVF 81

                        90       100
                ....*....|....*....|...
gi 19071574  93 SFYNEMIYWGLEGAHLEYCCQRR 115
Cdd:cd18384  82 SFSQEIEYWGINEFFLDSCCSYR 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  11 VVLNVGGARYSLSRELLKDFPLRRVSRLhgCRSERDVLevcdDYDRERNEYFFDRHSEAFGFILLYVRGhGKLRFAPRMC 90
Cdd:cd18379   1 IVINVGGVRHETYKSTLRNLPDTRLAWL--TETEASAF----DYDPVTGEFFFDRHPGVFAQILNYYRT-GKLHCPADVC 73

                        90       100
                ....*....|....*....|..
gi 19071574  91 ELSFYNEMIYWGLEGAHLEYCC 112
Cdd:cd18379  74 GPLFEEELAFWGIDETQIEPCC 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 2 (KCNV2); KCNV2, also called voltage-gated potassium channel subunit Kv8.2, is a modulatory voltage-gated potassium channel alpha subunit that modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNV2 is essential for visual function and cone survival. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  13 LNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGhGKLRFAPRMCEL 92
Cdd:cd18425   3 INVGGTSYQISYRVAASYPKTRIGRLATYTDRSRKLDLCDDYNVQNDEYFFDRDPAVFHHIYNFYRT-GVLWVKDELCPR 81

                        90       100
                ....*....|....*....|....*..
gi 19071574  93 SFYNEMIYWGLEGAHLEYCCQRRLDDR 119
Cdd:cd18425  82 NFLEEINYWGVRIKNTPRCCRISFEER 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  11 VVLNVGGARYSLSRELLKDFPlrrvSRLHGcRSERDVLevcddYDRERNEYFFDRHSEAFGFILLYVRgHGKLRFAPRMC 90
Cdd:cd18380   2 IVINVSGRRFETWKNTLEKYP----DTLLG-STEKEFF-----YDDDTKEYFFDRDPEIFRHILNFYR-TGKLHYPRHEC 70

                        90       100
                ....*....|....*....|....*....
gi 19071574  91 ELSFYNEMIYWGLEGAHLEYCCQRRLDDR 119
Cdd:cd18380  71 ISAYDDELAFFGILPEIIGDCCYEDYRDR 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  11 VVLNVGGARYSLSRELLKDFPlrrvSRLHGcRSERDVLevcddYDRERNEYFFDRHSEAFGFILLYVRGhGKLRFAPRMC 90
Cdd:cd18418   2 IVLNVSGTRFQTWRNTLERYP----DTLLG-SSERDFF-----YHEETQEYFFDRDPDIFRHILNFYRT-GKLHYPRHEC 70

                        90       100
                ....*....|....*....|....*....
gi 19071574  91 ELSFYNEMIYWGLEGAHLEYCCQRRLDDR 119
Cdd:cd18418  71 ISAYDEELAFFGIIPEIIGDCCYEEYKDR 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 7 (KCNA7); KCNA7, also called voltage-gated potassium channel subunit Kv1.7, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA7 plays an important role in the repolarization of cell membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA7 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  11 VVLNVGGARY-SLSRELLKdFPlrrvSRLHGCRSERDVLevcddYDRERNEYFFDRHSEAFGFILLYVRGHGKLRFAPRM 89
Cdd:cd18408   8 VVLNVAGLRFeTRARTLGR-FP----DTLLGDPARRGRF-----YDDRRREYFFDRHRPSFDAVLYYYQSGGRLRRPAHV 77

                        90
                ....*....|....*....
gi 19071574  90 CELSFYNEMIYWGLEGAHL 108
Cdd:cd18408  78 PLDVFLEEVAFYGLGAAAL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574   5 RSGAASVVLNVGGARYSLSRELLKDFPlrrvSRLHGcRSERDVLevcddYDRERNEYFFDRHSEAFGFILLYVRGhGKLR 84
Cdd:cd18420  32 RTDDEKLIINVSGRRFETWRNTLEKYP----DTLLG-SNEREFF-----YDEETKEYFFDRDPDIFRHILNYYRT-GKLH 100

                        90       100       110
                ....*....|....*....|....*....|....*
gi 19071574  85 FAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDR 119
Cdd:cd18420 101 YPKHECLTAYDEELAFFGIMPDIIGDCCYEDYRDR 135

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNA/Kv1 subfamily of Shaker-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv1, also known as subfamily A, contains eight alpha subunit members, Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.4 (KCNA4), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), and Kv1.8 (KCNA10), which are orthologs of the Shaker gene in Drosophila. They are delayed rectifiers except for Kv1.4 (KCNA4), which is an A-type potassium channel. Delayed rectifiers are slow opening and closing voltage-gated potassium channels. Because of their delayed activation kinetics, they play an important role in controlling action potential duration. A-type channels are fast/rapidly inactivating potassium channels. Kv1/KCNA subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19071574  11 VVLNVGGARYSLSRELLKDFPlrrvSRLHGCRSERDVLevcddYDRERNEYFFDRHSEAFGFILLYVRGHGKLR 84
Cdd:cd18377   3 VVINVSGLRFETQLKTLAQFP----NTLLGDPNKRMRF-----FDPLRNEYFFDRNRPSFDAILYYYQSGGRLR 67

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  11 VVLNVGGARYSLSRELLKDFPLrrvSRLHGCRSERDVLEVCDDydrerNEYFFDRHSEAFGFILLYVRgHGKLRFAPR-- 88
Cdd:cd18316   1 VKLNVGGTLFTTSRSTLLKDPD---SLLAALFSGRWPLPRDED-----GSIFIDRDPELFRHILNFLR-TGKLPLPSDfv 71

                        90
                ....*....|..
gi 19071574  89 -----MCELSFY 95
Cdd:cd18316  72 eleelLAEAEFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 10 (KCNA10); KCNA10, also called voltage-gated potassium channel subunit Kv1.8, is a cyclic nucleotide-gated, voltage-activated potassium channel that mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA10 is expressed in proximal tubular cells, glomerular and vascular endothelial cells, as well as in vascular smooth muscle cells. It may facilitate proximal tubular sodium absorption by stabilizing cell membrane voltage. The channel activity is up-regulated by cAMP. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA10 is an alpha subunit that forms functional homotetrameric channels through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  11 VVLNVGGARYSLSRELLKDFPlrrvSRLHGCRSERdvlevCDDYDRERNEYFFDRHSEAFGFILLYVRGHGKLRFAPRMC 90
Cdd:cd18409   3 VIINIAGLRFETQLKTLDQFP----DTLLGDPEKR-----MKYFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVP 73

                        90
                ....*....|...
gi 19071574  91 ELSFYNEMIYWGL 103
Cdd:cd18409  74 LDVFADEIIFYEL 86

voltage-gated potassium channel protein;

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 19071574  358 TSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFI 408
Cdd:PRK10537 167 ESLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSISAI 217

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A members 2 (KCNA2) and 3 (KCNA3); KCNA2 is also called NGK1, voltage-gated K(+) channel HuKIV, voltage-gated potassium channel HBK5, or voltage-gated potassium channel subunit Kv1.2. KCNA3 is also called HGK5, HLK3, HPCN3, voltage-gated K(+) channel HuKIII, or voltage-gated potassium channel subunit Kv1.3. KCNA2 and KCNA3 mediate transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA2 primarily functions in the brain and the central nervous system, but also in the cardiovascular system. It prevents aberrant action potential firing and regulates neuronal output. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA2 and KCNA3 are alpha subunits that form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  11 VVLNVGGARYSLSRELLKDFPlrrvSRLHGCRSERdvlevCDDYDRERNEYFFDRHSEAFGFILLYVRGHGKLRfAPRMC 90
Cdd:cd18403   3 VVINISGLRFETQLKTLAQFP----ETLLGDPKKR-----MRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLR-RPVNV 72

                ....*....
gi 19071574  91 ELSFYNEMI 99
Cdd:cd18403  73 PLDIFSEEI 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 5 (KCNA5); KCNA5, also called HPCN1, voltage-gated potassium channel HK2, or voltage-gated potassium channel subunit Kv1.5, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA5 may play a role in regulating the secretion of insulin in normal pancreatic islets. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA5 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19071574  11 VVLNVGGARYSLSRELLKDFPlrrvSRLHGCRSERdvlevCDDYDRERNEYFFDRHSEAFGFILLYVRGHGKLR 84
Cdd:cd18406   3 VIINIAGLRFETQLGTLNQFP----DTLLGDPDKR-----MRYFDPLRNEYFFDRNRPSFDGILYFYQSGGKIR 67

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574   9 ASVVLNVGGARYSLSRELLKDFPLRRVSRLHGcRSERDVLevcddyDRERNEYFFDRHSEAFGFILLYVRGhGKLRFAPR 88
Cdd:cd18388   2 APVHIDVGGHMYTSSLATLTKYPDSRISRLFN-GTEPIVL------DSLKQHYFIDRDGEIFRYILSFLRT-SKLLLPED 73

                        90
                ....*....|....*..
gi 19071574  89 MCELS-FYNEMIYWGLE 104
Cdd:cd18388  74 FKDFNlLYEEAKYYQLQ 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  11 VVLNVGGARYSLSRELLKDFPLRRVSRL-HGcrSERDVLevcddyDRERNEYFFDRHSEAFGFILLYVRgHGKLRFAPRM 89
Cdd:cd18361   1 VHIDVGGHIYTSSLETLTKYPESRLGKLfNG--SIPIVL------DSLKQHYFIDRDGKMFRHILNFLR-TSKLLLPDDF 71

                        90       100
                ....*....|....*....|...
gi 19071574  90 CELS-FYNEMIYWGLEG--AHLE 109
Cdd:cd18361  72 TEFDlLYEEARYYELQPmvKQLE 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574   5 RSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLhgCRSERDVlevcdDYDR-ERNEYFFDRHSEAFGFILLYVRgHGKL 83
Cdd:cd18390   1 GGVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRL--CQADPDL-----DSDKdETGAYLIDRDPTYFGPVLNYLR-HGKL 72

                        90
                ....*....|....*....
gi 19071574  84 RFAPRMC------ELSFYN 96
Cdd:cd18390  73 VINKDLAeegvleEAEFYN 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  11 VVLNVGGARYSLSRELL----KDFpLRRVSRLHGCRSERDvlevcddydrERNEYFFDRHSEAFGFILLYVRgHGKLRFA 86
Cdd:cd18391   3 VRLNVGGTVFLTTRQTLcreqKSF-LSRLCQGEELQSDRD----------ETGAYLIDRDPTYFGPILNFLR-HGKLVLD 70

                        90
                ....*....|....*.
gi 19071574  87 PRMC------ELSFYN 96
Cdd:cd18391  71 KDMAeegvleEAEFYN 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 14 (KCTD14); KCTD14 is a BTB/POZ domain-containing protein with unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071574  11 VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVlevcddyDRErNEYFFDRHSEAFGFILLYVRGhGKLrfaPRMC 90
Cdd:cd18371   4 VSLNVGGHIYTTTLSTLRKFPGSKLAELFNGQPKLRT-------DSE-GRYFIDRDGTYFRYILEYLRT-NQV---PTQH 71

                        90
                ....*....|....
gi 19071574  91 ELSFYNEMIYWGLE 104
Cdd:cd18371  72 IQEVYKEALFYDIE 85