NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|18375676|ref|NP_542166|]
View 

regulator of nonsense transcripts 2 [Homo sapiens]

Protein Classification

MIF4G domain-containing protein( domain architecture ID 10650500)

protein containing domains DUF1451, MIF4G, and Upf2

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 776-986 1.23e-44

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


:

Pssm-ID: 397130  Cd Length: 203  Bit Score: 160.61  E-value: 1.23e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676    776 RKLLYKDLSKVT---TEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLY-QEDVGIHVVDGVLE 851
Cdd:pfam02854    1 LKKVKGILNKLSpenFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRnPTDFGIHLLNRLQE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676    852 DI--RLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDgspssldPPEHLFRIRLVCTILDTC 929
Cdd:pfam02854   81 EFekRFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLSSLTKED-------LKRDLFNLECLLTLLTTI 153

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 18375676    930 GQYFDRGSSKRKLDCFLVYFQRYVWWKkslevwtKDHPFPIDIDYMISDTLELLRPK 986
Cdd:pfam02854  154 GKLLENEKLPKLMDQFLDEIQKYVLSK-------DDPKLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 571-758 6.28e-39

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


:

Pssm-ID: 214713  Cd Length: 200  Bit Score: 144.04  E-value: 6.28e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     571 FLQQLPNCVNRDLIDKAAMDFCM-NMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFR 649
Cdd:smart00543    3 KVKGLINKLSPSNFESIIKELLKlNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKNPDFGSLLLERLQEEFE 82

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     650 FHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDF-------SHHHIEMACTLLETCGRFLFRsPESHL 722
Cdd:smart00543   83 KGLESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELLNDLtkldpprSDFSVECLLSLLPTCGKDLER-EKSPK 161

                           170       180       190
                    ....*....|....*....|....*....|....*....
gi 18375676     723 RTSVLLEQMMR---KKQAMHLDARYVTMVENAYYYCNPP 758
Cdd:smart00543  162 LLDEILERLQDyllKKDKTELSSRLRFMLELLIELRKNK 200
Upf2 pfam04050
Up-frameshift suppressor 2; Transcripts harbouring premature signals for translation ...
 1095-1218 5.64e-37

Up-frameshift suppressor 2; Transcripts harbouring premature signals for translation termination are recognized and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3) are required for nonsense-mediated mRNA decay.


:

Pssm-ID: 461146  Cd Length: 133  Bit Score: 135.95  E-value: 5.64e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676   1095 VMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGG------EGEAESADT 1168
Cdd:pfam04050    4 GEEVRRGEEEVDPEEEAEFERELAKMMQESLESRKNERKTVPQLDVPLPMNVKAKKKSGSGDDGGaegdaeEPETNPSGK 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 18375676   1169 MPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLD 1218
Cdd:pfam04050   84 VAFTLLTKKGNKQQTKTLELPSDSSFAVNTREQEEAEKEEKQRIKRLVLN 133
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 168-363 5.54e-25

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


:

Pssm-ID: 214713  Cd Length: 200  Bit Score: 103.98  E-value: 5.54e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     168 LKKNTAFVKKL-KTITEQQRDSLSHDFNGL-NLSKYIAEAVASIVEAKLkiSDVNCAVHLCSLFHQRYADFAPSLLQVWK 245
Cdd:smart00543    1 EKKVKGLINKLsPSNFESIIKELLKLNNSDkNLRKYILELIFEKAVEEP--NFIPAYARLCALLNAKNPDFGSLLLERLQ 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     246 KHFEARKE-EKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKNIINADR-ESHTHVSVVISFCRHCGDDIA-GL 322
Cdd:smart00543   79 EEFEKGLEsEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELLNDLTKLDPpRSDFSVECLLSLLPTCGKDLErEK 158

                           170       180       190       200
                    ....*....|....*....|....*....|....*....|.
gi 18375676     323 VPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSL 363
Cdd:smart00543  159 SPKLLDEILERLQDYLLKKDKTELSSRLRFMLELLIELRKN 199
DUF1451 super family cl19727
Zinc-ribbon containing domain; This family consists of several hypothetical bacterial proteins ...
 358-421 9.35e-03

Zinc-ribbon containing domain; This family consists of several hypothetical bacterial proteins of around 160 residues in length. Members of this family contain four highly conserved cysteine resides toward the C-terminal region of the protein.


The actual alignment was detected with superfamily member PRK11032:

Pssm-ID: 450347  Cd Length: 160  Bit Score: 38.44  E-value: 9.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676   358 EYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQ--------YEEFAMSYQ------------KLLANS--QS 415
Cdd:PRK11032   10 ELVASLTERLRNGERDIDALVESARKRVDAAGELTRDEVDLitravrrdLEEFARSYEeskeefsdsvfmRVIKESlwQE 89


                  ....*.
gi 18375676   416 LADLLD 421
Cdd:PRK11032   90 LADITD 95
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 776-986 1.23e-44

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 160.61  E-value: 1.23e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676    776 RKLLYKDLSKVT---TEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLY-QEDVGIHVVDGVLE 851
Cdd:pfam02854    1 LKKVKGILNKLSpenFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRnPTDFGIHLLNRLQE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676    852 DI--RLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDgspssldPPEHLFRIRLVCTILDTC 929
Cdd:pfam02854   81 EFekRFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLSSLTKED-------LKRDLFNLECLLTLLTTI 153

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 18375676    930 GQYFDRGSSKRKLDCFLVYFQRYVWWKkslevwtKDHPFPIDIDYMISDTLELLRPK 986
Cdd:pfam02854  154 GKLLENEKLPKLMDQFLDEIQKYVLSK-------DDPKLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 773-986 3.17e-44

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 159.06  E-value: 3.17e-44
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     773 EYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLED 852
Cdd:smart00543    1 EKKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKNPDFGSLLLERLQEE 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     853 IRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNpdgspssLDPPEHLFRIRLVCTILDTCGQY 932
Cdd:smart00543   81 FEKGLESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELLNDLTK-------LDPPRSDFSVECLLSLLPTCGKD 153

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|....
gi 18375676     933 FDRGSSKRKLDCFLVYFQRYVWWKKSLEVwtkdhpfPIDIDYMISDTLELLRPK 986
Cdd:smart00543  154 LEREKSPKLLDEILERLQDYLLKKDKTEL-------SSRLRFMLELLIELRKNK 200
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 571-758 6.28e-39

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 144.04  E-value: 6.28e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     571 FLQQLPNCVNRDLIDKAAMDFCM-NMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFR 649
Cdd:smart00543    3 KVKGLINKLSPSNFESIIKELLKlNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKNPDFGSLLLERLQEEFE 82

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     650 FHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDF-------SHHHIEMACTLLETCGRFLFRsPESHL 722
Cdd:smart00543   83 KGLESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELLNDLtkldpprSDFSVECLLSLLPTCGKDLER-EKSPK 161

                           170       180       190
                    ....*....|....*....|....*....|....*....
gi 18375676     723 RTSVLLEQMMR---KKQAMHLDARYVTMVENAYYYCNPP 758
Cdd:smart00543  162 LLDEILERLQDyllKKDKTELSSRLRFMLELLIELRKNK 200
Upf2 pfam04050
Up-frameshift suppressor 2; Transcripts harbouring premature signals for translation ...
 1095-1218 5.64e-37

Up-frameshift suppressor 2; Transcripts harbouring premature signals for translation termination are recognized and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3) are required for nonsense-mediated mRNA decay.


Pssm-ID: 461146  Cd Length: 133  Bit Score: 135.95  E-value: 5.64e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676   1095 VMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGG------EGEAESADT 1168
Cdd:pfam04050    4 GEEVRRGEEEVDPEEEAEFERELAKMMQESLESRKNERKTVPQLDVPLPMNVKAKKKSGSGDDGGaegdaeEPETNPSGK 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 18375676   1169 MPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLD 1218
Cdd:pfam04050   84 VAFTLLTKKGNKQQTKTLELPSDSSFAVNTREQEEAEKEEKQRIKRLVLN 133
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 571-758 1.57e-25

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 105.52  E-value: 1.57e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676    571 FLQQLPNCVNRDLIDKAAMDFC-MNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCM-SDVAEDLCSMLRGDF 648
Cdd:pfam02854    3 KVKGILNKLSPENFEKLIKELLkLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRNpTDFGIHLLNRLQEEF 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676    649 --RFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDF-------SHHHIEMACTLLETCGRFLFRsPE 719
Cdd:pfam02854   83 ekRFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLSSLtkedlkrDLFNLECLLTLLTTIGKLLEN-EK 161

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 18375676    720 SHLRTSVLLEQM---MRKKQAMHLDARYVTMVENAYYYCNPP 758
Cdd:pfam02854  162 LPKLMDQFLDEIqkyVLSKDDPKLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 168-363 5.54e-25

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 103.98  E-value: 5.54e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     168 LKKNTAFVKKL-KTITEQQRDSLSHDFNGL-NLSKYIAEAVASIVEAKLkiSDVNCAVHLCSLFHQRYADFAPSLLQVWK 245
Cdd:smart00543    1 EKKVKGLINKLsPSNFESIIKELLKLNNSDkNLRKYILELIFEKAVEEP--NFIPAYARLCALLNAKNPDFGSLLLERLQ 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     246 KHFEARKE-EKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKNIINADR-ESHTHVSVVISFCRHCGDDIA-GL 322
Cdd:smart00543   79 EEFEKGLEsEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELLNDLTKLDPpRSDFSVECLLSLLPTCGKDLErEK 158

                           170       180       190       200
                    ....*....|....*....|....*....|....*....|.
gi 18375676     323 VPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSL 363
Cdd:smart00543  159 SPKLLDEILERLQDYLLKKDKTELSSRLRFMLELLIELRKN 199
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 168-316 1.59e-06

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 50.05  E-value: 1.59e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676    168 LKKNTAFVKKLK-----TITEQQRDSLSHDfngLNLSKYIAEAVASIVEAKLkiSDVNCAVHLCS-LFHQRYADFAPSLL 241
Cdd:pfam02854    1 LKKVKGILNKLSpenfeKLIKELLKLIMSD---PELLKYLIELIFEKAVEEP--NFIPAYARLCSgLNLRNPTDFGIHLL 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18375676    242 QVWKKHFEARK---EEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKNIINAD-RESHTHVSVVISFCRHCG 316
Cdd:pfam02854   76 NRLQEEFEKRFeleENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLSSLTKEDlKRDLFNLECLLTLLTTIG 154
PRK11032 PRK11032
zinc ribbon-containing protein;
358-421 9.35e-03

zinc ribbon-containing protein;


Pssm-ID: 182915  Cd Length: 160  Bit Score: 38.44  E-value: 9.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676   358 EYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQ--------YEEFAMSYQ------------KLLANS--QS 415
Cdd:PRK11032   10 ELVASLTERLRNGERDIDALVESARKRVDAAGELTRDEVDLitravrrdLEEFARSYEeskeefsdsvfmRVIKESlwQE 89


                  ....*.
gi 18375676   416 LADLLD 421
Cdd:PRK11032   90 LADITD 95
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 776-986 1.23e-44

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 160.61  E-value: 1.23e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676    776 RKLLYKDLSKVT---TEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLY-QEDVGIHVVDGVLE 851
Cdd:pfam02854    1 LKKVKGILNKLSpenFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRnPTDFGIHLLNRLQE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676    852 DI--RLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDgspssldPPEHLFRIRLVCTILDTC 929
Cdd:pfam02854   81 EFekRFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLSSLTKED-------LKRDLFNLECLLTLLTTI 153

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 18375676    930 GQYFDRGSSKRKLDCFLVYFQRYVWWKkslevwtKDHPFPIDIDYMISDTLELLRPK 986
Cdd:pfam02854  154 GKLLENEKLPKLMDQFLDEIQKYVLSK-------DDPKLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 773-986 3.17e-44

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 159.06  E-value: 3.17e-44
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     773 EYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLED 852
Cdd:smart00543    1 EKKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKNPDFGSLLLERLQEE 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     853 IRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNpdgspssLDPPEHLFRIRLVCTILDTCGQY 932
Cdd:smart00543   81 FEKGLESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELLNDLTK-------LDPPRSDFSVECLLSLLPTCGKD 153

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|....
gi 18375676     933 FDRGSSKRKLDCFLVYFQRYVWWKKSLEVwtkdhpfPIDIDYMISDTLELLRPK 986
Cdd:smart00543  154 LEREKSPKLLDEILERLQDYLLKKDKTEL-------SSRLRFMLELLIELRKNK 200
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 571-758 6.28e-39

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 144.04  E-value: 6.28e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     571 FLQQLPNCVNRDLIDKAAMDFCM-NMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFR 649
Cdd:smart00543    3 KVKGLINKLSPSNFESIIKELLKlNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKNPDFGSLLLERLQEEFE 82

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     650 FHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDF-------SHHHIEMACTLLETCGRFLFRsPESHL 722
Cdd:smart00543   83 KGLESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELLNDLtkldpprSDFSVECLLSLLPTCGKDLER-EKSPK 161

                           170       180       190
                    ....*....|....*....|....*....|....*....
gi 18375676     723 RTSVLLEQMMR---KKQAMHLDARYVTMVENAYYYCNPP 758
Cdd:smart00543  162 LLDEILERLQDyllKKDKTELSSRLRFMLELLIELRKNK 200
Upf2 pfam04050
Up-frameshift suppressor 2; Transcripts harbouring premature signals for translation ...
 1095-1218 5.64e-37

Up-frameshift suppressor 2; Transcripts harbouring premature signals for translation termination are recognized and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3) are required for nonsense-mediated mRNA decay.


Pssm-ID: 461146  Cd Length: 133  Bit Score: 135.95  E-value: 5.64e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676   1095 VMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGG------EGEAESADT 1168
Cdd:pfam04050    4 GEEVRRGEEEVDPEEEAEFERELAKMMQESLESRKNERKTVPQLDVPLPMNVKAKKKSGSGDDGGaegdaeEPETNPSGK 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 18375676   1169 MPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLD 1218
Cdd:pfam04050   84 VAFTLLTKKGNKQQTKTLELPSDSSFAVNTREQEEAEKEEKQRIKRLVLN 133
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 571-758 1.57e-25

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 105.52  E-value: 1.57e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676    571 FLQQLPNCVNRDLIDKAAMDFC-MNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCM-SDVAEDLCSMLRGDF 648
Cdd:pfam02854    3 KVKGILNKLSPENFEKLIKELLkLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRNpTDFGIHLLNRLQEEF 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676    649 --RFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDF-------SHHHIEMACTLLETCGRFLFRsPE 719
Cdd:pfam02854   83 ekRFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLSSLtkedlkrDLFNLECLLTLLTTIGKLLEN-EK 161

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 18375676    720 SHLRTSVLLEQM---MRKKQAMHLDARYVTMVENAYYYCNPP 758
Cdd:pfam02854  162 LPKLMDQFLDEIqkyVLSKDDPKLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 168-363 5.54e-25

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 103.98  E-value: 5.54e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     168 LKKNTAFVKKL-KTITEQQRDSLSHDFNGL-NLSKYIAEAVASIVEAKLkiSDVNCAVHLCSLFHQRYADFAPSLLQVWK 245
Cdd:smart00543    1 EKKVKGLINKLsPSNFESIIKELLKLNNSDkNLRKYILELIFEKAVEEP--NFIPAYARLCALLNAKNPDFGSLLLERLQ 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676     246 KHFEARKE-EKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKNIINADR-ESHTHVSVVISFCRHCGDDIA-GL 322
Cdd:smart00543   79 EEFEKGLEsEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELLNDLTKLDPpRSDFSVECLLSLLPTCGKDLErEK 158

                           170       180       190       200
                    ....*....|....*....|....*....|....*....|.
gi 18375676     323 VPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSL 363
Cdd:smart00543  159 SPKLLDEILERLQDYLLKKDKTELSSRLRFMLELLIELRKN 199
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 168-316 1.59e-06

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 50.05  E-value: 1.59e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676    168 LKKNTAFVKKLK-----TITEQQRDSLSHDfngLNLSKYIAEAVASIVEAKLkiSDVNCAVHLCS-LFHQRYADFAPSLL 241
Cdd:pfam02854    1 LKKVKGILNKLSpenfeKLIKELLKLIMSD---PELLKYLIELIFEKAVEEP--NFIPAYARLCSgLNLRNPTDFGIHLL 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18375676    242 QVWKKHFEARK---EEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKNIINAD-RESHTHVSVVISFCRHCG 316
Cdd:pfam02854   76 NRLQEEFEKRFeleENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLSSLTKEDlKRDLFNLECLLTLLTTIG 154
PRK11032 PRK11032
zinc ribbon-containing protein;
358-421 9.35e-03

zinc ribbon-containing protein;


Pssm-ID: 182915  Cd Length: 160  Bit Score: 38.44  E-value: 9.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18375676   358 EYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQ--------YEEFAMSYQ------------KLLANS--QS 415
Cdd:PRK11032   10 ELVASLTERLRNGERDIDALVESARKRVDAAGELTRDEVDLitravrrdLEEFARSYEeskeefsdsvfmRVIKESlwQE 89


                  ....*.
gi 18375676   416 LADLLD 421
Cdd:PRK11032   90 LADITD 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH