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Conserved domains on  [gi|14149760|ref|NP_115485|]
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homeobox protein orthopedia [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 11079034)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes; also contains an OAR domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
106-156 6.88e-23

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 89.48  E-value: 6.88e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 14149760   106 RHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNRR 156
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 303-320 6.76e-05

OAR motif; The entry represents the OAR motif.


:

Pssm-ID: 461067  Cd Length: 19  Bit Score: 39.32  E-value: 6.76e-05
                          10
                  ....*....|....*...
gi 14149760   303 WRGTSIASLRRKALEHTV 320
Cdd:pfam03826   2 RRSSSIASLRLKAKEHSA 19
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
106-156 6.88e-23

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 89.48  E-value: 6.88e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 14149760   106 RHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNRR 156
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 106-155 1.39e-20

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 83.45  E-value: 1.39e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 14149760    106 RHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNR 155
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNR 52
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 106-156 4.47e-20

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 82.29  E-value: 4.47e-20
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 14149760 106 RHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNRR 156
Cdd:cd00086   2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRR 52
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
106-154 1.20e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.07  E-value: 1.20e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 14149760 106 RHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQN 154
Cdd:COG5576  53 SKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQN 101
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 303-320 6.76e-05

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 39.32  E-value: 6.76e-05
                          10
                  ....*....|....*...
gi 14149760   303 WRGTSIASLRRKALEHTV 320
Cdd:pfam03826   2 RRSSSIASLRLKAKEHSA 19
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
106-156 6.88e-23

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 89.48  E-value: 6.88e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 14149760   106 RHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNRR 156
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 106-155 1.39e-20

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 83.45  E-value: 1.39e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 14149760    106 RHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNR 155
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNR 52
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 106-156 4.47e-20

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 82.29  E-value: 4.47e-20
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 14149760 106 RHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNRR 156
Cdd:cd00086   2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRR 52
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
106-154 1.20e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.07  E-value: 1.20e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 14149760 106 RHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQN 154
Cdd:COG5576  53 SKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQN 101
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 303-320 6.76e-05

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 39.32  E-value: 6.76e-05
                          10
                  ....*....|....*...
gi 14149760   303 WRGTSIASLRRKALEHTV 320
Cdd:pfam03826   2 RRSSSIASLRLKAKEHSA 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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