NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|157671945|ref|NP_079189|]
View 

cadherin-like and PC-esterase domain-containing protein 1 isoform 1 precursor [Homo sapiens]

Protein Classification

cadherin-like beta sandwich domain-containing protein( domain architecture ID 10579057)

cadherin-like beta sandwich domain-containing protein similar to human cadherin-like and PC-esterase domain-containing protein 1 (CPED1)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cadherin-like pfam12733
Cadherin-like beta sandwich domain; This domain is found in several bacterial, metazoan and ...
 583-667 1.27e-07

Cadherin-like beta sandwich domain; This domain is found in several bacterial, metazoan and chlorophyte algal proteins. A profile-profile comparison recovered the cadherin domain and a comparison of the predicted structure of this domain with the crystal structure of the cadherin showed a congruent seven stranded secondary structure. The domain is widespread in bacteria and seen in the firmicutes, actinobacteria, certain proteobacteria, bacteroides and chlamydiae with an expansion in Clostridium. In contrast, it is limited in its distribution in eukaryotes suggesting that it was derived through lateral transfer from bacteria. In prokaryotes, this domain is widely fused to other domains such as FNIII (Fibronectin Type III), TIG, SLH (S-layer homology), discoidin, cell-wall-binding repeat domain and alpha-amylase-like glycohydrolases. These associations are suggestive of a carbohydrate-binding function for this cadherin-like domain. In animal proteins it is associated with an ATP-grasp domain.


:

Pssm-ID: 403821 [Multi-domain]  Cd Length: 89  Bit Score: 50.10  E-value: 1.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157671945   583 LELNPDFHPKIKDYYCEVPFDVVTVTIGVETPKCLCKVHLYEQAGPS---FASYPLGLGMNK-ISIFVVDEspaHGETLI 658
Cdd:pfam12733    4 LTVSPAFDPDTLEYTATVDYDVTSVTVTATAANSGATVTVNGVAVESggeSQDVNLNEGRNTvIEIVVTAE---DGTTTT 80


                   ....*....
gi 157671945   659 TYKLTIYRE 667
Cdd:pfam12733   81 TYTLTVTRL 89
 
Name Accession Description Interval E-value
Cadherin-like pfam12733
Cadherin-like beta sandwich domain; This domain is found in several bacterial, metazoan and ...
 583-667 1.27e-07

Cadherin-like beta sandwich domain; This domain is found in several bacterial, metazoan and chlorophyte algal proteins. A profile-profile comparison recovered the cadherin domain and a comparison of the predicted structure of this domain with the crystal structure of the cadherin showed a congruent seven stranded secondary structure. The domain is widespread in bacteria and seen in the firmicutes, actinobacteria, certain proteobacteria, bacteroides and chlamydiae with an expansion in Clostridium. In contrast, it is limited in its distribution in eukaryotes suggesting that it was derived through lateral transfer from bacteria. In prokaryotes, this domain is widely fused to other domains such as FNIII (Fibronectin Type III), TIG, SLH (S-layer homology), discoidin, cell-wall-binding repeat domain and alpha-amylase-like glycohydrolases. These associations are suggestive of a carbohydrate-binding function for this cadherin-like domain. In animal proteins it is associated with an ATP-grasp domain.


Pssm-ID: 403821 [Multi-domain]  Cd Length: 89  Bit Score: 50.10  E-value: 1.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157671945   583 LELNPDFHPKIKDYYCEVPFDVVTVTIGVETPKCLCKVHLYEQAGPS---FASYPLGLGMNK-ISIFVVDEspaHGETLI 658
Cdd:pfam12733    4 LTVSPAFDPDTLEYTATVDYDVTSVTVTATAANSGATVTVNGVAVESggeSQDVNLNEGRNTvIEIVVTAE---DGTTTT 80


                   ....*....
gi 157671945   659 TYKLTIYRE 667
Cdd:pfam12733   81 TYTLTVTRL 89
 
Name Accession Description Interval E-value
Cadherin-like pfam12733
Cadherin-like beta sandwich domain; This domain is found in several bacterial, metazoan and ...
 583-667 1.27e-07

Cadherin-like beta sandwich domain; This domain is found in several bacterial, metazoan and chlorophyte algal proteins. A profile-profile comparison recovered the cadherin domain and a comparison of the predicted structure of this domain with the crystal structure of the cadherin showed a congruent seven stranded secondary structure. The domain is widespread in bacteria and seen in the firmicutes, actinobacteria, certain proteobacteria, bacteroides and chlamydiae with an expansion in Clostridium. In contrast, it is limited in its distribution in eukaryotes suggesting that it was derived through lateral transfer from bacteria. In prokaryotes, this domain is widely fused to other domains such as FNIII (Fibronectin Type III), TIG, SLH (S-layer homology), discoidin, cell-wall-binding repeat domain and alpha-amylase-like glycohydrolases. These associations are suggestive of a carbohydrate-binding function for this cadherin-like domain. In animal proteins it is associated with an ATP-grasp domain.


Pssm-ID: 403821 [Multi-domain]  Cd Length: 89  Bit Score: 50.10  E-value: 1.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157671945   583 LELNPDFHPKIKDYYCEVPFDVVTVTIGVETPKCLCKVHLYEQAGPS---FASYPLGLGMNK-ISIFVVDEspaHGETLI 658
Cdd:pfam12733    4 LTVSPAFDPDTLEYTATVDYDVTSVTVTATAANSGATVTVNGVAVESggeSQDVNLNEGRNTvIEIVVTAE---DGTTTT 80


                   ....*....
gi 157671945   659 TYKLTIYRE 667
Cdd:pfam12733   81 TYTLTVTRL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH