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Conserved domains on  [gi|145553976|ref|NP_078933|]
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MORC family CW-type zinc finger protein 4 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 266-400 1.26e-63

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


:

Pssm-ID: 465579  Cd Length: 139  Bit Score: 210.86  E-value: 1.26e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145553976  266 YSLRAFCGILYMK--PRMKIFLRQKKVTTQMIAKSLANVEYDTYKPTF---TNKQVRITFGF--SCKNSNQFGIMMYHNN 338
Cdd:pfam17942   1 YSLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKITYKPQVgggKEVVVITTIGFlkEAPHINVHGFNVYHKN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145553976  339 RLIKSFEKVGCQVKptrGEGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINALAQKLNAYW 400
Cdd:pfam17942  81 RLIKPFWRVGNQAG---SKGRGVIGVLEANFIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
HATPase super family cl00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 39-156 1.95e-53

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


The actual alignment was detected with superfamily member cd16931:

Pssm-ID: 469604 [Multi-domain]  Cd Length: 118  Bit Score: 181.45  E-value: 1.95e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145553976  39 YLQSNSSSHTRPFSAIAELLDNAVDPDVSARTVFIDVEEV-KNKSCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQcP 117
Cdd:cd16931    1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLlRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHD-H 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 145553976 118 IGVFGNGFKSGSMRLGKDALVFTKNGGTLTVGLLSQTYL 156
Cdd:cd16931   80 IGRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 425-470 5.28e-22

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 89.68  E-value: 5.28e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 145553976  425 TWVQCDECLKWRKLPGKIDPSMLPARWFCYYNSHPKYRRCSVPEEQ 470
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEIDPYELPEPWYCSMNPDPKYNSCDAPEEI 46
ZapB pfam06005
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is ...
 766-810 2.62e-03

Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.


:

Pssm-ID: 428718 [Multi-domain]  Cd Length: 71  Bit Score: 37.25  E-value: 2.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 145553976  766 QRELEELKRTTEKLERvlaERNLFQQKVEELEQERNHWQSEFKKV 810
Cdd:pfam06005  24 QMENEELKEENEELKE---EANELEEENQQLKQERNQWQERIRGL 65
 
Name Accession Description Interval E-value
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 266-400 1.26e-63

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 210.86  E-value: 1.26e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145553976  266 YSLRAFCGILYMK--PRMKIFLRQKKVTTQMIAKSLANVEYDTYKPTF---TNKQVRITFGF--SCKNSNQFGIMMYHNN 338
Cdd:pfam17942   1 YSLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKITYKPQVgggKEVVVITTIGFlkEAPHINVHGFNVYHKN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145553976  339 RLIKSFEKVGCQVKptrGEGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINALAQKLNAYW 400
Cdd:pfam17942  81 RLIKPFWRVGNQAG---SKGRGVIGVLEANFIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 39-156 1.95e-53

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 181.45  E-value: 1.95e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145553976  39 YLQSNSSSHTRPFSAIAELLDNAVDPDVSARTVFIDVEEV-KNKSCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQcP 117
Cdd:cd16931    1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLlRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHD-H 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 145553976 118 IGVFGNGFKSGSMRLGKDALVFTKNGGTLTVGLLSQTYL 156
Cdd:cd16931   80 IGRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 425-470 5.28e-22

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 89.68  E-value: 5.28e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 145553976  425 TWVQCDECLKWRKLPGKIDPSMLPARWFCYYNSHPKYRRCSVPEEQ 470
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEIDPYELPEPWYCSMNPDPKYNSCDAPEEI 46
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 50-184 2.50e-17

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 79.30  E-value: 2.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145553976   50 PFSAIAELLDNAVDPDVSARTVFIDVEEVKNKSClTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQCPIGVFGNGFKSGS 129
Cdd:pfam13589   1 LEGALAELIDNSIDADATNIKIEVNKNRGGGTEI-VIEDDGHGMSPEELINALRLATSAKEAKRGSTDLGRYGIGLKLAS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 145553976  130 MRLGKDALVFTKNGGTLTVGLLSQTYLECVQAqAVIVPIVPFNQQNKKMIITEDS 184
Cdd:pfam13589  80 LSLGAKLTVTSKKEGKSSTLTLDRDKISNEND-WLLPLLTPAPIENFDELDKDAH 133
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 53-107 1.85e-06

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 47.64  E-value: 1.85e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 145553976    53 AIAELLDNAVDPDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHRMLSFGFT 107
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFR 63
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 57-101 3.39e-04

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 44.02  E-value: 3.39e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 145553976  57 LLDNAVD--PDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHRM 101
Cdd:COG4191  264 LLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERI 310
ZapB pfam06005
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is ...
 766-810 2.62e-03

Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.


Pssm-ID: 428718 [Multi-domain]  Cd Length: 71  Bit Score: 37.25  E-value: 2.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 145553976  766 QRELEELKRTTEKLERvlaERNLFQQKVEELEQERNHWQSEFKKV 810
Cdd:pfam06005  24 QMENEELKEENEELKE---EANELEEENQQLKQERNQWQERIRGL 65
 
Name Accession Description Interval E-value
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 266-400 1.26e-63

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 210.86  E-value: 1.26e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145553976  266 YSLRAFCGILYMK--PRMKIFLRQKKVTTQMIAKSLANVEYDTYKPTF---TNKQVRITFGF--SCKNSNQFGIMMYHNN 338
Cdd:pfam17942   1 YSLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKITYKPQVgggKEVVVITTIGFlkEAPHINVHGFNVYHKN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145553976  339 RLIKSFEKVGCQVKptrGEGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINALAQKLNAYW 400
Cdd:pfam17942  81 RLIKPFWRVGNQAG---SKGRGVIGVLEANFIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 39-156 1.95e-53

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 181.45  E-value: 1.95e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145553976  39 YLQSNSSSHTRPFSAIAELLDNAVDPDVSARTVFIDVEEV-KNKSCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQcP 117
Cdd:cd16931    1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLlRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHD-H 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 145553976 118 IGVFGNGFKSGSMRLGKDALVFTKNGGTLTVGLLSQTYL 156
Cdd:cd16931   80 IGRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 425-470 5.28e-22

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 89.68  E-value: 5.28e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 145553976  425 TWVQCDECLKWRKLPGKIDPSMLPARWFCYYNSHPKYRRCSVPEEQ 470
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEIDPYELPEPWYCSMNPDPKYNSCDAPEEI 46
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 50-184 2.50e-17

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 79.30  E-value: 2.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145553976   50 PFSAIAELLDNAVDPDVSARTVFIDVEEVKNKSClTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQCPIGVFGNGFKSGS 129
Cdd:pfam13589   1 LEGALAELIDNSIDADATNIKIEVNKNRGGGTEI-VIEDDGHGMSPEELINALRLATSAKEAKRGSTDLGRYGIGLKLAS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 145553976  130 MRLGKDALVFTKNGGTLTVGLLSQTYLECVQAqAVIVPIVPFNQQNKKMIITEDS 184
Cdd:pfam13589  80 LSLGAKLTVTSKKEGKSSTLTLDRDKISNEND-WLLPLLTPAPIENFDELDKDAH 133
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 51-100 1.21e-06

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 47.60  E-value: 1.21e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 145553976  51 FSAIAELLDNAVDPDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHR 100
Cdd:cd00075    2 EQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLER 51
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 53-107 1.85e-06

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 47.64  E-value: 1.85e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 145553976    53 AIAELLDNAVDPDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHRMLSFGFT 107
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFR 63
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 48-101 1.12e-05

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 45.05  E-value: 1.12e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 145553976   48 TRPFSAIAELLDNAVDPDVSARTVFIDVEEVKNKsCLTFTDDGCGMTPHKLHRM 101
Cdd:pfam02518   4 LRLRQVLSNLLDNALKHAAKAGEITVTLSEGGEL-TLTVEDNGIGIPPEDLPRI 56
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 48-106 1.75e-05

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 46.28  E-value: 1.75e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145553976  48 TRPFSAIAELLDNAVDPDvsARTVFIDVEEVKNKScLTFTDDGCGMTP------------------HKLHRMLSFGF 106
Cdd:cd16926   12 ERPASVVKELVENSIDAG--ATRIDVEIEEGGLKL-IRVTDNGSGISRedlelaferhatskissfEDLFSITTLGF 85
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 57-101 3.39e-04

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 44.02  E-value: 3.39e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 145553976  57 LLDNAVD--PDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHRM 101
Cdd:COG4191  264 LLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERI 310
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 52-109 5.04e-04

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 43.68  E-value: 5.04e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145553976  52 SAIAELLDNAVD----PDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHRMLSFGFTDK 109
Cdd:COG3290  284 TILGNLLDNAIEavekLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTK 345
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
49-95 5.42e-04

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 43.49  E-value: 5.42e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 145553976  49 RPFSAIAELLDNAVDPDvsARTvfIDVeEVKN--KSCLTFTDDGCGMTP 95
Cdd:COG0323   23 RPASVVKELVENAIDAG--ATR--IEV-EIEEggKSLIRVTDNGCGMSP 66
ZapB pfam06005
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is ...
 766-810 2.62e-03

Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.


Pssm-ID: 428718 [Multi-domain]  Cd Length: 71  Bit Score: 37.25  E-value: 2.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 145553976  766 QRELEELKRTTEKLERvlaERNLFQQKVEELEQERNHWQSEFKKV 810
Cdd:pfam06005  24 QMENEELKEENEELKE---EANELEEENQQLKQERNQWQERIRGL 65
Fez1 pfam06818
Fez1; This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper ...
 764-810 6.50e-03

Fez1; This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth. Note that some family members contain more than one copy of this region.


Pssm-ID: 462015 [Multi-domain]  Cd Length: 198  Bit Score: 38.83  E-value: 6.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 145553976  764 KNQRELEELKRTTEKLERVLA-ERNLFQQKVEELEQERNHWQSEFKKV 810
Cdd:pfam06818 125 QEEADLGSLRREVERLRAELReERQRRERQASSFEQERRTWQEEKEKV 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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