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Conserved domains on  [gi|11559925|ref|NP_071381|]
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xaa-Pro aminopeptidase 3 isoform 1 [Homo sapiens]

Protein Classification

aminopeptidase P family protein( domain architecture ID 10659798)

aminopeptidase family protein P (peptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

CATH:  3.40.350.10|3.90.230.10
EC:  3.4.11.-
Gene Ontology:  GO:0004177|GO:0016020|GO:0070006|GO:0046872|GO:0006508
MEROPS:  M24
PubMed:  30066404|9434107|12475202

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 252-490 1.32e-120

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


:

Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 353.42  E-value: 1.32e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 252 IERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADiLAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD 331
Cdd:cd01087   1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGAR-LAYSYIVAAGSNAAILHYVHNDQPLKDGDLVLID 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 332 GGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKE-NNA 410
Cdd:cd01087  80 AGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDVDeIVE 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 411 FKAARKYCPHHVGHYLGMDVHDTPDMPRSL----PLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPL 486
Cdd:cd01087 160 SGAYAKFFPHGLGHYLGLDVHDVGGYLRYLrrarPLEPGMVITIEPGIYFIPDLLDVPEYFRGGGIRIEDDVLVTEDGPE 239


                ....
gi 11559925 487 ILSA 490
Cdd:cd01087 240 NLTR 243
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 67-210 5.28e-48

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


:

Pssm-ID: 198079  Cd Length: 135  Bit Score: 162.41  E-value: 5.28e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925     67 LSQVEYALRRHKLMSLIQKeaqgqsgtDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQslpgKQLPS 146
Cdd:smart01011   1 IPAAEYAARRRRLAAKLFP--------GSVAVLPAGPEKVRSNDTDYPFRQDSDFYYLTGFDEPDAVLVLD----PSGGG 68

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 11559925    147 HKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPS 210
Cdd:smart01011  69 GKSTLFVPPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDAVLPGLLAGAGTVYYLLGRDP 132
 
Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 252-490 1.32e-120

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 353.42  E-value: 1.32e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 252 IERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADiLAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD 331
Cdd:cd01087   1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGAR-LAYSYIVAAGSNAAILHYVHNDQPLKDGDLVLID 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 332 GGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKE-NNA 410
Cdd:cd01087  80 AGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDVDeIVE 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 411 FKAARKYCPHHVGHYLGMDVHDTPDMPRSL----PLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPL 486
Cdd:cd01087 160 SGAYAKFFPHGLGHYLGLDVHDVGGYLRYLrrarPLEPGMVITIEPGIYFIPDLLDVPEYFRGGGIRIEDDVLVTEDGPE 239


                ....
gi 11559925 487 ILSA 490
Cdd:cd01087 240 NLTR 243
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 67-506 9.29e-87

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 273.91  E-value: 9.29e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925   67 LSQVEYALRRHKLMsliqkeAQGQSGTdqTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQslpgKQLPS 146
Cdd:PRK10879   1 MTQQEFQRRRQALL------AKMQPGS--AALIFAAPEATRSADSEYPYRQNSDFWYFTGFNEPEAVLVLI----KSDDT 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  147 HK-AILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWydwmrpsHAQLHSDYMQPLT-E 224
Cdd:PRK10879  69 HNhSVLFNRVRDLTAEIWFGRRLGQDAAPEKLGVDRALPFSEINQQLYQLLNGLDVVY-------HAQGEYAYADEIVfS 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  225 AKAKSKNKVRgvQQL------------IQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRA 292
Cdd:PRK10879 142 ALEKLRKGSR--QNLtapatltdwrpwVHEMRLFKSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHEFNR 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  293 RGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCL 372
Cdd:PRK10879 220 HGARYPSYNTIVGSGENGCILHYTENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTPAQREIYDIVLESLETSL 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  373 ALCFPGTSLENIYSMMLTLIGQKLKDLGIMK-NIKENNAFKAARKYCPHHVGHYLGMDVHDTPD--MPRSLPLQPGMVIT 449
Cdd:PRK10879 300 RLYRPGTSIREVTGEVVRIMVSGLVKLGILKgDVDQLIAENAHRPFFMHGLSHWLGLDVHDVGVygQDRSRILEPGMVLT 379

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 11559925  450 IEPGIYIPEdDKDAPEKFRGLGVRIEDDVVVTQDSPLILSADCPKEMNDIEQICSQA 506
Cdd:PRK10879 380 VEPGLYIAP-DADVPEQYRGIGIRIEDDIVITETGNENLTASVVKKPDEIEALMAAA 435
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
231-499 1.72e-72

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 232.02  E-value: 1.72e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 231 NKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPPVVAGGNRS 310
Cdd:COG0006  58 RELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGAEGPSFDTIVASGENA 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 311 NTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVnGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYsmmlT 390
Cdd:COG0006 138 AIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAV-GEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVD----A 212

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 391 LIGQKLKDLGImknikennafkaaRKYCPHHVGHYLGMDVHDTPDM--PRSLPLQPGMVITIEPGIYIPEDdkdapekfr 468
Cdd:COG0006 213 AARDVLAEAGY-------------GEYFPHGTGHGVGLDVHEGPQIspGNDRPLEPGMVFTIEPGIYIPGI--------- 270

                       250       260       270
                ....*....|....*....|....*....|.
gi 11559925 469 gLGVRIEDDVVVTQDSPLILSaDCPKEMNDI 499
Cdd:COG0006 271 -GGVRIEDTVLVTEDGAEVLT-RLPRELLEL 299
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 253-481 6.51e-63

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 204.01  E-value: 6.51e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925   253 ERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFE-FECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD 331
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEaARLRRGGARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925   332 GGCE-SSCYVSDITRTWpVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIgqklKDLGIMknikenna 410
Cdd:pfam00557  81 VGAEyDGGYCSDITRTF-VVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVL----EEAGLG-------- 147

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 11559925   411 fkaarKYCPHHVGHYLGMDVHDTPDMPRS---LPLQPGMVITIEPGIYIPEDDKdapekfrglGVRIEDDVVVT 481
Cdd:pfam00557 148 -----EYFPHGLGHGIGLEVHEGPYISRGgddRVLEPGMVFTIEPGIYFIPGWG---------GVRIEDTVLVT 207
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 67-210 5.28e-48

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


Pssm-ID: 198079  Cd Length: 135  Bit Score: 162.41  E-value: 5.28e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925     67 LSQVEYALRRHKLMSLIQKeaqgqsgtDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQslpgKQLPS 146
Cdd:smart01011   1 IPAAEYAARRRRLAAKLFP--------GSVAVLPAGPEKVRSNDTDYPFRQDSDFYYLTGFDEPDAVLVLD----PSGGG 68

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 11559925    147 HKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPS 210
Cdd:smart01011  69 GKSTLFVPPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDAVLPGLLAGAGTVYYLLGRDP 132
AMP_N pfam05195
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 72-203 9.44e-47

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain (pfam01321). However, little or no sequence similarity exists between the two families.


Pssm-ID: 461581 [Multi-domain]  Cd Length: 121  Bit Score: 158.44  E-value: 9.44e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925    72 YALRRHKLMSLIQKeaqgqsgtDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQslpGKQLPSHKAIL 151
Cdd:pfam05195   1 YAERRARLLAKLPP--------NSVAILPGAPEKYRNGDVFYPFRQDSDFYYLTGFNEPDAVLVLE---GGDIDSGKETL 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 11559925   152 FVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVW 203
Cdd:pfam05195  70 FVPPKDPEDEIWDGPRLGPEEAKELFGVDEVYPIDELDEVLPKLLKGRDTVY 121
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 246-490 3.68e-14

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 72.38  E-value: 3.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925   246 IKSPAEIERMQIAGKLTSQAfIETMFTSKAP----VEEAFLYAKFEFECRARGA--DILAYPPVVAGGNRSNTLHYVKNN 319
Cdd:TIGR00500   3 LKSPDEIEKIRKAGRLAAEV-LEELEREVKPgvstKELDRIAKDFIEKHGAKPAflGYYGFPGSVCISVNEVVIHGIPDK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925   320 QLIKDGEMVLLDGGCESSCYVSDITRTWPVNGrfTAPQAE-LYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIgqklkd 398
Cdd:TIGR00500  82 KVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGK--ISPEAEkLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYA------ 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925   399 lgimknikENNAFKAARKYCphhvGHYLGMDVHDTPDMPR------SLPLQPGMVITIEPGIYI-PEDDKDAPEKF---- 467
Cdd:TIGR00500 154 --------EAKGFSVVREYC----GHGIGRKFHEEPQIPNygkkftNVRLKEGMVFTIEPMVNTgTEEITTAADGWtvkt 221

                         250       260
                  ....*....|....*....|....*
gi 11559925   468 --RGLGVRIEDDVVVTQDSPLILSA 490
Cdd:TIGR00500 222 kdGSLSAQFEHTIVITDNGPEILTE 246
 
Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 252-490 1.32e-120

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 353.42  E-value: 1.32e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 252 IERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADiLAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD 331
Cdd:cd01087   1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGAR-LAYSYIVAAGSNAAILHYVHNDQPLKDGDLVLID 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 332 GGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKE-NNA 410
Cdd:cd01087  80 AGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDVDeIVE 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 411 FKAARKYCPHHVGHYLGMDVHDTPDMPRSL----PLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPL 486
Cdd:cd01087 160 SGAYAKFFPHGLGHYLGLDVHDVGGYLRYLrrarPLEPGMVITIEPGIYFIPDLLDVPEYFRGGGIRIEDDVLVTEDGPE 239


                ....
gi 11559925 487 ILSA 490
Cdd:cd01087 240 NLTR 243
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 67-506 9.29e-87

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 273.91  E-value: 9.29e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925   67 LSQVEYALRRHKLMsliqkeAQGQSGTdqTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQslpgKQLPS 146
Cdd:PRK10879   1 MTQQEFQRRRQALL------AKMQPGS--AALIFAAPEATRSADSEYPYRQNSDFWYFTGFNEPEAVLVLI----KSDDT 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  147 HK-AILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWydwmrpsHAQLHSDYMQPLT-E 224
Cdd:PRK10879  69 HNhSVLFNRVRDLTAEIWFGRRLGQDAAPEKLGVDRALPFSEINQQLYQLLNGLDVVY-------HAQGEYAYADEIVfS 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  225 AKAKSKNKVRgvQQL------------IQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRA 292
Cdd:PRK10879 142 ALEKLRKGSR--QNLtapatltdwrpwVHEMRLFKSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHEFNR 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  293 RGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCL 372
Cdd:PRK10879 220 HGARYPSYNTIVGSGENGCILHYTENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTPAQREIYDIVLESLETSL 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  373 ALCFPGTSLENIYSMMLTLIGQKLKDLGIMK-NIKENNAFKAARKYCPHHVGHYLGMDVHDTPD--MPRSLPLQPGMVIT 449
Cdd:PRK10879 300 RLYRPGTSIREVTGEVVRIMVSGLVKLGILKgDVDQLIAENAHRPFFMHGLSHWLGLDVHDVGVygQDRSRILEPGMVLT 379

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 11559925  450 IEPGIYIPEdDKDAPEKFRGLGVRIEDDVVVTQDSPLILSADCPKEMNDIEQICSQA 506
Cdd:PRK10879 380 VEPGLYIAP-DADVPEQYRGIGIRIEDDIVITETGNENLTASVVKKPDEIEALMAAA 435
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
231-499 1.72e-72

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 232.02  E-value: 1.72e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 231 NKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPPVVAGGNRS 310
Cdd:COG0006  58 RELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGAEGPSFDTIVASGENA 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 311 NTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVnGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYsmmlT 390
Cdd:COG0006 138 AIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAV-GEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVD----A 212

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 391 LIGQKLKDLGImknikennafkaaRKYCPHHVGHYLGMDVHDTPDM--PRSLPLQPGMVITIEPGIYIPEDdkdapekfr 468
Cdd:COG0006 213 AARDVLAEAGY-------------GEYFPHGTGHGVGLDVHEGPQIspGNDRPLEPGMVFTIEPGIYIPGI--------- 270

                       250       260       270
                ....*....|....*....|....*....|.
gi 11559925 469 gLGVRIEDDVVVTQDSPLILSaDCPKEMNDI 499
Cdd:COG0006 271 -GGVRIEDTVLVTEDGAEVLT-RLPRELLEL 299
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 253-481 6.51e-63

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 204.01  E-value: 6.51e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925   253 ERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFE-FECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD 331
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEaARLRRGGARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925   332 GGCE-SSCYVSDITRTWpVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIgqklKDLGIMknikenna 410
Cdd:pfam00557  81 VGAEyDGGYCSDITRTF-VVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVL----EEAGLG-------- 147

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 11559925   411 fkaarKYCPHHVGHYLGMDVHDTPDMPRS---LPLQPGMVITIEPGIYIPEDDKdapekfrglGVRIEDDVVVT 481
Cdd:pfam00557 148 -----EYFPHGLGHGIGLEVHEGPYISRGgddRVLEPGMVFTIEPGIYFIPGWG---------GVRIEDTVLVT 207
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 67-210 5.28e-48

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


Pssm-ID: 198079  Cd Length: 135  Bit Score: 162.41  E-value: 5.28e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925     67 LSQVEYALRRHKLMSLIQKeaqgqsgtDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQslpgKQLPS 146
Cdd:smart01011   1 IPAAEYAARRRRLAAKLFP--------GSVAVLPAGPEKVRSNDTDYPFRQDSDFYYLTGFDEPDAVLVLD----PSGGG 68

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 11559925    147 HKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPS 210
Cdd:smart01011  69 GKSTLFVPPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDAVLPGLLAGAGTVYYLLGRDP 132
AMP_N pfam05195
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 72-203 9.44e-47

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain (pfam01321). However, little or no sequence similarity exists between the two families.


Pssm-ID: 461581 [Multi-domain]  Cd Length: 121  Bit Score: 158.44  E-value: 9.44e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925    72 YALRRHKLMSLIQKeaqgqsgtDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQslpGKQLPSHKAIL 151
Cdd:pfam05195   1 YAERRARLLAKLPP--------NSVAILPGAPEKYRNGDVFYPFRQDSDFYYLTGFNEPDAVLVLE---GGDIDSGKETL 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 11559925   152 FVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVW 203
Cdd:pfam05195  70 FVPPKDPEDEIWDGPRLGPEEAKELFGVDEVYPIDELDEVLPKLLKGRDTVY 121
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 252-485 4.59e-46

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 159.60  E-value: 4.59e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 252 IERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD 331
Cdd:cd01092   1 IELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLGAEGPSFDTIVASGPNSALPHGVPSDRKIEEGDLVLID 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 332 GGCESSCYVSDITRTWPVnGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIysmmltligqklkDlgimknikennaf 411
Cdd:cd01092  81 FGAIYDGYCSDITRTVAV-GEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEV-------------D------------- 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 412 KAAR---------KYCPHHVGHYLGMDVHDTPD-MPRS-LPLQPGMVITIEPGIYIPEddkdapekfRGlGVRIEDDVVV 480
Cdd:cd01092 134 KAARdvieeagygEYFIHRTGHGVGLEVHEAPYiSPGSdDVLEEGMVFTIEPGIYIPG---------KG-GVRIEDDVLV 203


                ....*
gi 11559925 481 TQDSP 485
Cdd:cd01092 204 TEDGC 208
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 252-481 3.70e-36

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 133.35  E-value: 3.70e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 252 IERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGAdILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD 331
Cdd:cd01066   1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGG-YPAGPTIVGSGARTALPHYRPDDRRLQEGDLVLVD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 332 GGCESSCYVSDITRTWPVnGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMmltligqklkdlgIMKNIKENNaf 411
Cdd:cd01066  80 LGGVYDGYHADLTRTFVI-GEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAA-------------AREVLEEHG-- 143

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 11559925 412 kaARKYCPHHVGHYLGMDVHDTPDMPR--SLPLQPGMVITIEPGIYIPEddkdapekfrGLGVRIEDDVVVT 481
Cdd:cd01066 144 --LGPNFGHRTGHGIGLEIHEPPVLKAgdDTVLEPGMVFAVEPGLYLPG----------GGGVRIEDTVLVT 203
PRK09795 PRK09795
aminopeptidase; Provisional
 243-496 2.18e-28

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 115.81  E-value: 2.18e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  243 LRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLI 322
Cdd:PRK09795 124 LRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKASFDTIVASGWRGALPHGKASDKIV 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  323 KDGEMVLLDGGCESSCYVSDITRTWPVNGRfTAPQAE-----LYEAVLEIQRDCLALCFPGTSLENIYSMmltligqklk 397
Cdd:PRK09795 204 AAGEFVTLDFGALYQGYCSDMTRTLLVNGE-GVSAEShplfnVYQIVLQAQLAAISAIRPGVRCQQVDDA---------- 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  398 dlgiMKNIKENNAFKaarKYCPHHVGHYLGMDVHDTPDM-PR-SLPLQPGMVITIEPGIYIPEddkdapekfRGlGVRIE 475
Cdd:PRK09795 273 ----ARRVITEAGYG---DYFGHNTGHAIGIEVHEDPRFsPRdTTTLQPGMLLTVEPGIYLPG---------QG-GVRIE 335

                        250       260
                 ....*....|....*....|.
gi 11559925  476 DDVVVTQDSPLILSAdCPKEM 496
Cdd:PRK09795 336 DVVLVTPQGAEVLYA-MPKTV 355
PRK13607 PRK13607
proline dipeptidase; Provisional
 244-492 3.20e-25

proline dipeptidase; Provisional


Pssm-ID: 237444 [Multi-domain]  Cd Length: 443  Bit Score: 108.06  E-value: 3.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  244 RLIKSPAEIERMQIAGKLTSQAFIetmftskaPVEEAFLYAKFEFECRAR-------GADILAYPPVVAGGNRSNTLHYV 316
Cdd:PRK13607 159 RAYKTDYELACMREAQKIAVAGHR--------AAKEAFRAGMSEFDINLAyltatgqRDNDVPYGNIVALNEHAAVLHYT 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  317 KNNQLiKDGEM--VLLDGGCESSCYVSDITRTW--PVNGRFtapqAELYEAVLEIQrdcLALC---FPGTSLENIYSMML 389
Cdd:PRK13607 231 KLDHQ-APAEMrsFLIDAGAEYNGYAADITRTYaaKEDNDF----AALIKDVNKEQ---LALIatmKPGVSYVDLHIQMH 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  390 TLIGQKLKDLGIMKNIKENNAFKA--ARKYCPHHVGHYLGMDVHDT--------------PDMPRSL----PLQPGMVIT 449
Cdd:PRK13607 303 QRIAKLLRKFQIVTGLSEEAMVEQgiTSPFFPHGLGHPLGLQVHDVagfmqddrgthlaaPEKHPYLrctrVLEPGMVLT 382

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 11559925  450 IEPGIY-IP---EDDKDAP----------EKFR--GlGVRIEDDVVVTQDSPLILSADC 492
Cdd:PRK13607 383 IEPGLYfIDsllAPLREGPfskhfnwqkiDALKpfG-GIRIEDNVVVHENGVENMTRDL 440
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 265-482 7.08e-16

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 76.83  E-value: 7.08e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 265 AFIETMFTSKAPVEEAFLYAKFEfECRARGADI--LAYPPVVAGGNRSNTLHY---VKNNQLIKDGEMVLLDGGcesSCY 339
Cdd:cd01085  18 AWLEQEVPKGETITELSAADKLE-EFRRQQKGYvgLSFDTISGFGPNGAIVHYsptEESNRKISPDGLYLIDSG---GQY 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 340 V---SDITRTWPVnGRFTAPQAELYEAVLEIQRDCLALCFP----GTSLENIYSMMLtligqklkdlgimknikennaFK 412
Cdd:cd01085  94 LdgtTDITRTVHL-GEPTAEQKRDYTLVLKGHIALARAKFPkgttGSQLDALARQPL---------------------WK 151

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 11559925 413 AARKYcPH---H-VGHYLGmdVHDTP----DMPRSLPLQPGMVITIEPGIYIpeddkdaPEKFrglGVRIEDDVVVTQ 482
Cdd:cd01085 152 AGLDY-GHgtgHgVGSFLN--VHEGPqsisPAPNNVPLKAGMILSNEPGYYK-------EGKY---GIRIENLVLVVE 216
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 246-490 3.68e-14

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 72.38  E-value: 3.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925   246 IKSPAEIERMQIAGKLTSQAfIETMFTSKAP----VEEAFLYAKFEFECRARGA--DILAYPPVVAGGNRSNTLHYVKNN 319
Cdd:TIGR00500   3 LKSPDEIEKIRKAGRLAAEV-LEELEREVKPgvstKELDRIAKDFIEKHGAKPAflGYYGFPGSVCISVNEVVIHGIPDK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925   320 QLIKDGEMVLLDGGCESSCYVSDITRTWPVNGrfTAPQAE-LYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIgqklkd 398
Cdd:TIGR00500  82 KVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGK--ISPEAEkLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYA------ 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925   399 lgimknikENNAFKAARKYCphhvGHYLGMDVHDTPDMPR------SLPLQPGMVITIEPGIYI-PEDDKDAPEKF---- 467
Cdd:TIGR00500 154 --------EAKGFSVVREYC----GHGIGRKFHEEPQIPNygkkftNVRLKEGMVFTIEPMVNTgTEEITTAADGWtvkt 221

                         250       260
                  ....*....|....*....|....*
gi 11559925   468 --RGLGVRIEDDVVVTQDSPLILSA 490
Cdd:TIGR00500 222 kdGSLSAQFEHTIVITDNGPEILTE 246
PRK05716 PRK05716
methionine aminopeptidase; Validated
 246-489 4.24e-13

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 69.01  E-value: 4.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  246 IKSPAEIERMQIAGKLTSQA------FIETMFTSKAPVEEAFLYAkfefecRARGAdI---LAYPP-----------VVA 305
Cdd:PRK05716   5 IKTPEEIEKMRVAGRLAAEVldeiepHVKPGVTTKELDRIAEEYI------RDQGA-IpapLGYHGfpksictsvneVVC 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  306 ggnrsntlHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVngrftAPQAELYEAVLEIQRDCLALcfpgtSLENIY 385
Cdd:PRK05716  78 --------HGIPSDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGV-----GEISPEDKRLCEVTKEALYL-----GIAAVK 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  386 SmmltliGQKLKDLG--IMKNIKENNaFKAARKYCphhvGHYLGMDVHDTPDMP------RSLPLQPGMVITIEP----- 452
Cdd:PRK05716 140 P------GARLGDIGhaIQKYAEAEG-FSVVREYC----GHGIGRKFHEEPQIPhygapgDGPVLKEGMVFTIEPminag 208

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 11559925  453 --GIYIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPLILS 489
Cdd:PRK05716 209 krEVKTLKDGWTVVTKDGSLSAQYEHTVAVTEDGPEILT 247
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
246-490 3.65e-11

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 63.49  E-value: 3.65e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 246 IKSPAEIERMQIAGKLTSQAFIEtmftskapVEEaflYAK------------FEFeCRARGAdilayppvvaggnRSNTL 313
Cdd:COG0024   3 IKTPEEIEKMREAGRIVAEVLDE--------LAE---AVKpgvttleldriaEEF-IRDHGA-------------IPAFL 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 314 HY------------------VKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVnGRfTAPQAElyeAVLEIQRDCL--- 372
Cdd:COG0024  58 GYygfpksictsvnevvvhgIPSDRVLKDGDIVNIDVGAILDGYHGDSARTFVV-GE-VSPEAR---RLVEVTEEALyag 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 373 -ALCFPGTsleniysmmltligqKLKDLG--IMKNIKENNaFKAARKYCphhvGHYLGMDVHDTPDMP------RSLPLQ 443
Cdd:COG0024 133 iAAAKPGN---------------RLGDIGhaIQSYAESNG-YSVVREFV----GHGIGREMHEEPQVPnygrpgRGPRLK 192

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 11559925 444 PGMVITIEP-------GIYIPEDD-----KDapekfRGLGVRIEDDVVVTQDSPLILSA 490
Cdd:COG0024 193 PGMVLAIEPminagtpEVKVLDDGwtvvtKD-----GSLSAQFEHTVAVTEDGPEILTL 246
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 314-489 2.81e-09

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 57.50  E-value: 2.81e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 314 HYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGrfTAPQAElyeAVLEIQRDCLALcfpgtSLENIysmmltLIG 393
Cdd:cd01086  68 HGIPDDRVLKDGDIVNIDVGVELDGYHGDSARTFIVGE--VSEEAK---KLVEVTEEALYK-----GIEAV------KPG 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 394 QKLKDLG--IMKNIKENNaFKAARKYCphhvGHYLGMDVHDTPDMP------RSLPLQPGMVITIEPGI-------YIPE 458
Cdd:cd01086 132 NRIGDIGhaIEKYAEKNG-YSVVREFG----GHGIGRKFHEEPQIPnygrpgTGPKLKPGMVFTIEPMInlgtyevVTLP 206

                       170       180       190
                ....*....|....*....|....*....|.
gi 11559925 459 DDKDAPEKFRGLGVRIEDDVVVTQDSPLILS 489
Cdd:cd01086 207 DGWTVVTKDGSLSAQFEHTVLITEDGPEILT 237
CDC68-like cd01091
Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in ...
 300-488 2.53e-08

Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in cell division control protein 68, a transcription factor.


Pssm-ID: 238524 [Multi-domain]  Cd Length: 243  Bit Score: 54.66  E-value: 2.53e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 300 YPPVV-AGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGrfTAPQAELYEAVLEIQRDCLALCFPG 378
Cdd:cd01091  65 YPPIIqSGGNYDLLKSSSSSDKLLYHFGVIICSLGARYKSYCSNIARTFLIDP--TSEQQKNYNFLLALQEEILKELKPG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925 379 TSLENIYSMMLTLIGQKLKDLgiMKNIKENnafkaarkycphhVGHYLGMDVHDT-----PDMPRSlpLQPGMVITIEPG 453
Cdd:cd01091 143 AKLSDVYQKTLDYIKKKKPEL--EPNFTKN-------------LGFGIGLEFRESsliinAKNDRK--LKKGMVFNLSIG 205

                       170       180       190
                ....*....|....*....|....*....|....*
gi 11559925 454 IYIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPLIL 488
Cdd:cd01091 206 FSNLQNPEPKDKESKTYALLLSDTILVTEDEPAIV 240
PRK15173 PRK15173
peptidase; Provisional
 239-455 1.18e-05

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 47.40  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  239 LIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILA-YPPVVAGGNRSNTLhyVK 317
Cdd:PRK15173  88 IFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFSrFHLISVGADFSPKL--IP 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  318 NNQLIKDGEMVLLDGGCESSCYVSDITRTWPVnGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSmmltligqklk 397
Cdd:PRK15173 166 SNTKACSGDLIKFDCGVDVDGYGADIARTFVV-GEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFD----------- 233

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 11559925  398 dlGIMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIY 455
Cdd:PRK15173 234 --STMEVIKKSGLPNYNRGHLGHGNGVFLGLEESPFVSTHATESFTSGMVLSLETPYY 289
PRK14575 PRK14575
putative peptidase; Provisional
 239-455 1.92e-05

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 47.01  E-value: 1.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  239 LIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILA-YPPVVAGGNRSNTLhyVK 317
Cdd:PRK14575 171 IFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFSrFHLISVGADFSPKL--IP 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  318 NNQLIKDGEMVLLDGGCESSCYVSDITRTWPVnGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSmmltligqklk 397
Cdd:PRK14575 249 SNTKACSGDLIKFDCGVDVDGYGADIARTFVV-GEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFD----------- 316

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 11559925  398 dlGIMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIY 455
Cdd:PRK14575 317 --STMEVIKKSGLPNYNRGHLGHGNGVFLGLEESPFVSTHATESFTSGMVLSLETPYY 372
PRK12318 PRK12318
methionyl aminopeptidase;
245-454 2.43e-05

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 46.35  E-value: 2.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  245 LIKSPAEIERMQIAGKLTSQAFIETMFTSKAPV--EEAFLYAKfefECRARGADILA--------YPPVVAGGNRSNTLH 314
Cdd:PRK12318  42 IIKTPEQIEKIRKACQVTARILDALCEAAKEGVttNELDELSR---ELHKEYNAIPAplnygsppFPKTICTSLNEVICH 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  315 YVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVnGRFTAPQAELYEAVLEIQRDCLALCFPGtsleniysMMLTLIGQ 394
Cdd:PRK12318 119 GIPNDIPLKNGDIMNIDVSCIVDGYYGDCSRMVMI-GEVSEIKKKVCQASLECLNAAIAILKPG--------IPLYEIGE 189

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 11559925  395 klkdlgIMKNIKENNAFKAARKYcphhVGHYLGMDVHDTPDMPR-----SLPLQPGMVITIEPGI 454
Cdd:PRK12318 190 ------VIENCADKYGFSVVDQF----VGHGVGIKFHENPYVPHhrnssKIPLAPGMIFTIEPMI 244
PRK07281 PRK07281
methionyl aminopeptidase;
391-490 3.54e-05

methionyl aminopeptidase;


Pssm-ID: 180918  Cd Length: 286  Bit Score: 45.61  E-value: 3.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  391 LIGQKLKDLGI-MKNIKENNAFKAARKYcphhVGHYLGMDVHDTPDMP------RSLPLQPGMVITIEPGIYIP--EDDK 461
Cdd:PRK07281 169 VVGNRIGDIGAaIQEYAESRGYGVVRDL----VGHGVGPTMHEEPMVPnygtagRGLRLREGMVLTIEPMINTGtwEIDT 244

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 11559925  462 DAPEKFR------GLGVRIEDDVVVTQDSPLILSA 490
Cdd:PRK07281 245 DMKTGWAhktldgGLSCQYEHQFVITKDGPVILTS 279
PRK12897 PRK12897
type I methionyl aminopeptidase;
391-489 1.20e-04

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 43.87  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  391 LIGQKLKDLG-IMKNIKENNAFKAARKYcphhVGHYLGMDVHDTPDM------PRSLPLQPGMVITIEP----GIYIPED 459
Cdd:PRK12897 138 VIGNRVGDIGyAIESYVANEGFSVARDF----TGHGIGKEIHEEPAIfhfgkqGQGPELQEGMVITIEPivnvGMRYSKV 213

                         90       100       110
                 ....*....|....*....|....*....|...
gi 11559925  460 DKD--APEKFRG-LGVRIEDDVVVTQDSPLILS 489
Cdd:PRK12897 214 DLNgwTARTMDGkLSAQYEHTIAITKDGPIILT 246
PRK14576 PRK14576
putative endopeptidase; Provisional
 239-489 3.11e-04

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 43.08  E-value: 3.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  239 LIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEfecrargADILAYPP--------VVAGGNRS 310
Cdd:PRK14576 170 LFNEIRMIKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFK-------AAVMSFPEtnfsrfnlISVGDNFS 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  311 NTLhyVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWpVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSmmlt 390
Cdd:PRK14576 243 PKI--IADTTPAKVGDLIKFDCGIDVAGYGADLARTF-VLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFD---- 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  391 ligqklkdlGIMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYipeddkdapekfrGL 470
Cdd:PRK14576 316 ---------STMAVIKTSGLPHYNRGHLGHGDGVFLGLEEVPFVSTQATETFCPGMVLSLETPYY-------------GI 373

                        250       260
                 ....*....|....*....|..
gi 11559925  471 GV---RIEDDVVVTQDSPLILS 489
Cdd:PRK14576 374 GVgsiMLEDMILITDSGFEFLS 395
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 246-488 3.17e-04

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 42.52  E-value: 3.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  246 IKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFL--YAKfEFECR--ARGADILAYP----------PVVAggnrsn 311
Cdd:PRK12896  10 IKSPRELEKMRKIGRIVATALKEMGKAVEPGMTTKELdrIAE-KRLEEhgAIPSPEGYYGfpgstcisvnEEVA------ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  312 tlHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVngrftAPQAELYEAVLEIQRDCLAlcfpgTSLENIYSmmltl 391
Cdd:PRK12896  83 --HGIPGPRVIKDGDLVNIDVSAYLDGYHGDTGITFAV-----GPVSEEAEKLCRVAEEALW-----AGIKQVKA----- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11559925  392 iGQKLKDLG-IMKNIKENNAFKAARKYCPHHVGHYL--GMDV--HDTPDMPRSLpLQPGMVITIEPGI------YIPEDD 460
Cdd:PRK12896 146 -GRPLNDIGrAIEDFAKKNGYSVVRDLTGHGVGRSLheEPSVilTYTDPLPNRL-LRPGMTLAVEPFLnlgakdAETLDD 223

                        250       260       270
                 ....*....|....*....|....*....|....
gi 11559925  461 ------KDapekfRGLGVRIEDDVVVTQDSPLIL 488
Cdd:PRK12896 224 gwtvvtPD-----KSLSAQFEHTVVVTRDGPEIL 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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