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Conserved domains on  [gi|17530787|ref|NP_068754|]
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prokineticin-2 isoform b precursor [Homo sapiens]

Protein Classification

Prokineticin domain-containing protein( domain architecture ID 10535121)

Prokineticin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prokineticin pfam06607
Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. ...
 23-105 2.26e-41

Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock.


:

Pssm-ID: 148298  Cd Length: 97  Bit Score: 131.43  E-value: 2.26e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17530787    23 RAGDAAVITGACDKDSQCGGGMCCAVSIWVKSIRICTPMGKLGDSCHPLTRKVPFFGRRMHHTCPCLPGLACLRTSFNRF 102
Cdd:pfam06607  15 SASDGAVITGACDKDVQCGGGMCCAVSLWLRGLRMCTPLGNEGDECHPLSHKVPFFGKRQHHTCPCLPNLTCSRFSDSKY 94


                  ...
gi 17530787   103 ICL 105
Cdd:pfam06607  95 RCL 97
 
Name Accession Description Interval E-value
Prokineticin pfam06607
Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. ...
 23-105 2.26e-41

Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock.


Pssm-ID: 148298  Cd Length: 97  Bit Score: 131.43  E-value: 2.26e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17530787    23 RAGDAAVITGACDKDSQCGGGMCCAVSIWVKSIRICTPMGKLGDSCHPLTRKVPFFGRRMHHTCPCLPGLACLRTSFNRF 102
Cdd:pfam06607  15 SASDGAVITGACDKDVQCGGGMCCAVSLWLRGLRMCTPLGNEGDECHPLSHKVPFFGKRQHHTCPCLPNLTCSRFSDSKY 94


                  ...
gi 17530787   103 ICL 105
Cdd:pfam06607  95 RCL 97
Dkk_Cys2 cd23012
second cysteine-rich (Cys-2) domain of Dickkopf proteins; The Dickkopf (Dkk) family comprises ...
 32-96 6.75e-05

second cysteine-rich (Cys-2) domain of Dickkopf proteins; The Dickkopf (Dkk) family comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the Cys-2 domain of Dickkopf proteins 1- 4.


Pssm-ID: 437997  Cd Length: 77  Bit Score: 38.11  E-value: 6.75e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17530787  32 GACDKDSQCGGGMCCAVSIWVKsirICTPMGKLGDSCHPLTRK---VPFFGRrmhhtCPCLPGLACLR 96
Cdd:cd23012   6 ESCLRSRDCAEGLCCARHLWSK---RCKPILLEGDVCTKPRRKksrGLIFQR-----CDCGSGLSCRP 65
 
Name Accession Description Interval E-value
Prokineticin pfam06607
Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. ...
 23-105 2.26e-41

Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock.


Pssm-ID: 148298  Cd Length: 97  Bit Score: 131.43  E-value: 2.26e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17530787    23 RAGDAAVITGACDKDSQCGGGMCCAVSIWVKSIRICTPMGKLGDSCHPLTRKVPFFGRRMHHTCPCLPGLACLRTSFNRF 102
Cdd:pfam06607  15 SASDGAVITGACDKDVQCGGGMCCAVSLWLRGLRMCTPLGNEGDECHPLSHKVPFFGKRQHHTCPCLPNLTCSRFSDSKY 94


                  ...
gi 17530787   103 ICL 105
Cdd:pfam06607  95 RCL 97
Dkk_Cys2 cd23012
second cysteine-rich (Cys-2) domain of Dickkopf proteins; The Dickkopf (Dkk) family comprises ...
 32-96 6.75e-05

second cysteine-rich (Cys-2) domain of Dickkopf proteins; The Dickkopf (Dkk) family comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the Cys-2 domain of Dickkopf proteins 1- 4.


Pssm-ID: 437997  Cd Length: 77  Bit Score: 38.11  E-value: 6.75e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17530787  32 GACDKDSQCGGGMCCAVSIWVKsirICTPMGKLGDSCHPLTRK---VPFFGRrmhhtCPCLPGLACLR 96
Cdd:cd23012   6 ESCLRSRDCAEGLCCARHLWSK---RCKPILLEGDVCTKPRRKksrGLIFQR-----CDCGSGLSCRP 65
Dkk4_Cys2 cd23275
second cysteine-rich (Cys-2) domain of Dickkopf-related protein 4; Dickkopf 4 (Dkk4) is a ...
 34-94 2.37e-04

second cysteine-rich (Cys-2) domain of Dickkopf-related protein 4; Dickkopf 4 (Dkk4) is a secreted protein which directly binds to LRP5/6 (low-density lipoprotein receptor related protein 5 and 6), and is an inhibitor of Wnt/beta-catenin signaling. Dkk4, which is upregulated by the activated Wnt pathway, contributes to tumor malignancy in variable tumors, promoting tumor cell invasion and progression. Aberrant accumulation of Dkk4 has been shown to promote tumor progression by forming the immune suppressive microenvironment in gastrointestinal stromal tumor, and thus Dkk4 may be used as a tumor biomarker for prognosis prediction and recurrence monitoring. Dkk4 belongs to the Dickkopf (Dkk) family that comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the Cys-2 domain of Dkk4.


Pssm-ID: 438001  Cd Length: 94  Bit Score: 36.89  E-value: 2.37e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17530787  34 CDKDSQCGGGMCCAVSIWVKsirICTPMGKLGDSCHPLTRKVPFFGRRMHHTCPCLPGLAC 94
Cdd:cd23275  18 CLRTSDCGPGLCCARHFWTK---ICKPVLLEGQVCSRRGHKDTAQGPEIFQRCDCGPGLSC 75
CLPS_Dkk_Cys2 cd23008
Colipase and the second cysteine-rich (Cys-2) domain of Dickkopf proteins; Colipase (also ...
 34-94 6.53e-03

Colipase and the second cysteine-rich (Cys-2) domain of Dickkopf proteins; Colipase (also called CLPS) is a cysteine-rich protein that adopts a similar fold to a cysteine-rich domain (Cys-2) of the Dickkopf (Dkk) family proteins. Colipase functions to prevent the inhibitory effect of bile salts on lipase-catalyzed intraduodenal hydrolysis of dietary long-chain triglycerides. Dickkopf proteins are a discrete class of secreted Wnt inhibitors that are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. They possess an N-terminal signal peptide and contain two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. The Dickkopf Cys-2 domain is similar to proteins in the colipase family and it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function.


Pssm-ID: 437995  Cd Length: 82  Bit Score: 33.05  E-value: 6.53e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17530787  34 CDKDSQCGGGMCCAVSIWVKsirICTPMGKLGDSCHPLTRKvPFFGRRMHHTCPCLPGLAC 94
Cdd:cd23008   8 CLRSSDCKSGNCCARHFWLK---ICKPVLREGSVCTKFRLK-GSHGLEIFQRCPCERGLSC 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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