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Conserved domains on  [gi|10863973|ref|NP_066998|]
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hepcidin preproprotein [Homo sapiens]

Protein Classification

Hepcidin domain-containing protein( domain architecture ID 10534199)

Hepcidin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hepcidin pfam06446
Hepcidin; Hepcidin is a antibacterial and antifungal protein expressed in the liver and is ...
 33-84 4.86e-17

Hepcidin; Hepcidin is a antibacterial and antifungal protein expressed in the liver and is also a signaling molecule in iron metabolism. The hepcidin protein is cysteine-rich and forms a distorted beta-sheet with an unusual disulphide bond found at the turn of the hairpin.


:

Pssm-ID: 461915  Cd Length: 53  Bit Score: 67.81  E-value: 4.86e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 10863973   33 QLAELQPQDRAGARA-SWMPMFQRRRRRDTHFPICIFCCGCCHRSKCGMCCKT 84
Cdd:pfam06446  1 QSTDLPPAATEEASVdSWMMPYHIRRKRDTHLPICRFCCGCCKNKGCGICCKT 53
 
Name Accession Description Interval E-value
Hepcidin pfam06446
Hepcidin; Hepcidin is a antibacterial and antifungal protein expressed in the liver and is ...
 33-84 4.86e-17

Hepcidin; Hepcidin is a antibacterial and antifungal protein expressed in the liver and is also a signaling molecule in iron metabolism. The hepcidin protein is cysteine-rich and forms a distorted beta-sheet with an unusual disulphide bond found at the turn of the hairpin.


Pssm-ID: 461915  Cd Length: 53  Bit Score: 67.81  E-value: 4.86e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 10863973   33 QLAELQPQDRAGARA-SWMPMFQRRRRRDTHFPICIFCCGCCHRSKCGMCCKT 84
Cdd:pfam06446  1 QSTDLPPAATEEASVdSWMMPYHIRRKRDTHLPICRFCCGCCKNKGCGICCKT 53
 
Name Accession Description Interval E-value
Hepcidin pfam06446
Hepcidin; Hepcidin is a antibacterial and antifungal protein expressed in the liver and is ...
 33-84 4.86e-17

Hepcidin; Hepcidin is a antibacterial and antifungal protein expressed in the liver and is also a signaling molecule in iron metabolism. The hepcidin protein is cysteine-rich and forms a distorted beta-sheet with an unusual disulphide bond found at the turn of the hairpin.


Pssm-ID: 461915  Cd Length: 53  Bit Score: 67.81  E-value: 4.86e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 10863973   33 QLAELQPQDRAGARA-SWMPMFQRRRRRDTHFPICIFCCGCCHRSKCGMCCKT 84
Cdd:pfam06446  1 QSTDLPPAATEEASVdSWMMPYHIRRKRDTHLPICRFCCGCCKNKGCGICCKT 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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