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Conserved domains on  [gi|93102377|ref|NP_060897|]
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RNA polymerase I-specific transcription initiation factor RRN3 isoform 1 [Homo sapiens]

Protein Classification

RNA polymerase I-specific transcription initiation factor RRN3 family protein( domain architecture ID 10526375)

RNA polymerase I-specific transcription initiation factor RRN3 family protein similar to human RRN3 that is required for efficient transcription initiation by RNA polymerase I, and for the formation of the competent preinitiation complex (PIC).

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 60-585 1.53e-147

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


:

Pssm-ID: 461623  Cd Length: 548  Bit Score: 438.97  E-value: 1.53e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377    60 LLKYKKGETNDFELLKNQL-LDPD----IKDDQIINWLLEFRSSIMYLTKDFEQLISIILRLPWLNRSQTVVEEYLAFLG 134
Cdd:pfam05327  16 LEEHEKGDSEQYDELKEQFsPDPEspdaPSTALLKQLLKALSSNVSRLDRSCSGLVEAILSLSWLGRDESFVKAYIRFLG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377   135 NLVSAQTVFLRPCLSMIASHFVPPRVIIKEGDVDVSDSDDEDdnlpanFDTCHRALQIIARYVPSTPWFLMPILVEKFPF 214
Cdd:pfam05327  96 VLASAHPKYLSLVLSMLVSNFTPQPESSGRLPGYPPVTRREV------YERVHEALKYILRLIPTAPSVLLPILSRKFPH 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377   215 VRKSERTLECYVHNLLRISVYFPTLRHEILELIIEKLLKLDVnasrqGI--------EDAEETATQTCGGTDSTEGLFNM 286
Cdd:pfam05327 170 KRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDV-----EIqveledldDDEDEELLEQLDEDDDDDDDDDS 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377   287 DEDEETEHETKAGPERLD-----QMVHPVAERLDILMSLVLSYMKDVCY--VDGKVDNGKTKDLYRDLINIFDKLLLPTH 359
Cdd:pfam05327 245 DDDSDSSDDGLDDDEEDDevqriKKIKELVEKLDAILDLLFEHLDSKFSsgSPEELNEGEGVEVFNTLLSLFKSTILPTY 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377   360 ASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPSNPAIIRQAAGNYIGSFLARAKFIPLITVKSCLDLLVNWLHIYLNN 439
Cdd:pfam05327 325 RSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFVARAKFVSRSQVRFVLSYLCDWLNRYVDE 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377   440 QDSGTKAfCDVALHGPFYSACQAVFYTFVFRHKQLL---SGNLKEGLQYLQSLN--FERIVMSQLNPLKICLPSVVNFFA 514
Cdd:pfam05327 405 REEECRG-PDLKRHGVFYAVCQALLYIFCFRWRDLTdadDDEEGGDLEWLPGLDefLQRAIYSKLNPLKVCSPNVVTEFA 483

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 93102377   515 AITNKYQLVFCYTIIERNNRqmlpviRSTAGGDSVQIcTNPLDTFFPFDPCVLKRSKKFIDPIYQVWEDMS 585
Cdd:pfam05327 484 RIAHHLQFAYCFSIIESNKR------EETAGTATGQE-FEQLDAYFPFDPYLLPRSKRWIEPDYVEWSEVA 547
 
Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 60-585 1.53e-147

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 438.97  E-value: 1.53e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377    60 LLKYKKGETNDFELLKNQL-LDPD----IKDDQIINWLLEFRSSIMYLTKDFEQLISIILRLPWLNRSQTVVEEYLAFLG 134
Cdd:pfam05327  16 LEEHEKGDSEQYDELKEQFsPDPEspdaPSTALLKQLLKALSSNVSRLDRSCSGLVEAILSLSWLGRDESFVKAYIRFLG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377   135 NLVSAQTVFLRPCLSMIASHFVPPRVIIKEGDVDVSDSDDEDdnlpanFDTCHRALQIIARYVPSTPWFLMPILVEKFPF 214
Cdd:pfam05327  96 VLASAHPKYLSLVLSMLVSNFTPQPESSGRLPGYPPVTRREV------YERVHEALKYILRLIPTAPSVLLPILSRKFPH 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377   215 VRKSERTLECYVHNLLRISVYFPTLRHEILELIIEKLLKLDVnasrqGI--------EDAEETATQTCGGTDSTEGLFNM 286
Cdd:pfam05327 170 KRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDV-----EIqveledldDDEDEELLEQLDEDDDDDDDDDS 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377   287 DEDEETEHETKAGPERLD-----QMVHPVAERLDILMSLVLSYMKDVCY--VDGKVDNGKTKDLYRDLINIFDKLLLPTH 359
Cdd:pfam05327 245 DDDSDSSDDGLDDDEEDDevqriKKIKELVEKLDAILDLLFEHLDSKFSsgSPEELNEGEGVEVFNTLLSLFKSTILPTY 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377   360 ASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPSNPAIIRQAAGNYIGSFLARAKFIPLITVKSCLDLLVNWLHIYLNN 439
Cdd:pfam05327 325 RSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFVARAKFVSRSQVRFVLSYLCDWLNRYVDE 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377   440 QDSGTKAfCDVALHGPFYSACQAVFYTFVFRHKQLL---SGNLKEGLQYLQSLN--FERIVMSQLNPLKICLPSVVNFFA 514
Cdd:pfam05327 405 REEECRG-PDLKRHGVFYAVCQALLYIFCFRWRDLTdadDDEEGGDLEWLPGLDefLQRAIYSKLNPLKVCSPNVVTEFA 483

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 93102377   515 AITNKYQLVFCYTIIERNNRqmlpviRSTAGGDSVQIcTNPLDTFFPFDPCVLKRSKKFIDPIYQVWEDMS 585
Cdd:pfam05327 484 RIAHHLQFAYCFSIIESNKR------EETAGTATGQE-FEQLDAYFPFDPYLLPRSKRWIEPDYVEWSEVA 547
 
Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 60-585 1.53e-147

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 438.97  E-value: 1.53e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377    60 LLKYKKGETNDFELLKNQL-LDPD----IKDDQIINWLLEFRSSIMYLTKDFEQLISIILRLPWLNRSQTVVEEYLAFLG 134
Cdd:pfam05327  16 LEEHEKGDSEQYDELKEQFsPDPEspdaPSTALLKQLLKALSSNVSRLDRSCSGLVEAILSLSWLGRDESFVKAYIRFLG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377   135 NLVSAQTVFLRPCLSMIASHFVPPRVIIKEGDVDVSDSDDEDdnlpanFDTCHRALQIIARYVPSTPWFLMPILVEKFPF 214
Cdd:pfam05327  96 VLASAHPKYLSLVLSMLVSNFTPQPESSGRLPGYPPVTRREV------YERVHEALKYILRLIPTAPSVLLPILSRKFPH 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377   215 VRKSERTLECYVHNLLRISVYFPTLRHEILELIIEKLLKLDVnasrqGI--------EDAEETATQTCGGTDSTEGLFNM 286
Cdd:pfam05327 170 KRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDV-----EIqveledldDDEDEELLEQLDEDDDDDDDDDS 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377   287 DEDEETEHETKAGPERLD-----QMVHPVAERLDILMSLVLSYMKDVCY--VDGKVDNGKTKDLYRDLINIFDKLLLPTH 359
Cdd:pfam05327 245 DDDSDSSDDGLDDDEEDDevqriKKIKELVEKLDAILDLLFEHLDSKFSsgSPEELNEGEGVEVFNTLLSLFKSTILPTY 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377   360 ASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPSNPAIIRQAAGNYIGSFLARAKFIPLITVKSCLDLLVNWLHIYLNN 439
Cdd:pfam05327 325 RSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFVARAKFVSRSQVRFVLSYLCDWLNRYVDE 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102377   440 QDSGTKAfCDVALHGPFYSACQAVFYTFVFRHKQLL---SGNLKEGLQYLQSLN--FERIVMSQLNPLKICLPSVVNFFA 514
Cdd:pfam05327 405 REEECRG-PDLKRHGVFYAVCQALLYIFCFRWRDLTdadDDEEGGDLEWLPGLDefLQRAIYSKLNPLKVCSPNVVTEFA 483

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 93102377   515 AITNKYQLVFCYTIIERNNRqmlpviRSTAGGDSVQIcTNPLDTFFPFDPCVLKRSKKFIDPIYQVWEDMS 585
Cdd:pfam05327 484 RIAHHLQFAYCFSIIESNKR------EETAGTATGQE-FEQLDAYFPFDPYLLPRSKRWIEPDYVEWSEVA 547
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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